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Critical Care
Erschienen in: Critical Care 5/2007

01.12.2007 | Review

Recombinant human activated protein C: current insights into its mechanism of action

verfasst von: Marcel Levi, Tom van der Poll

Erschienen in: Critical Care | Sonderheft 5/2007

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Abstract

Impairment of the protein C pathway plays a central role in the pathogenesis of sepsis. Administration of recombinant human activated protein C (rhAPC) may correct the dysregulated anticoagulant mechanism and prevent propagation of thrombin generation and formation of microvascular thrombosis. Furthermore, it may simultaneously modulate the inflammatory response. It is likely that the beneficial effect of rhAPC observed in experimental and clinical studies of severe sepsis results from a combination of mechanisms that modulate the entangled processes of coagulation and inflammation. This review presents an analysis of the various mechanisms of action of rhAPC in sepsis.
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Metadaten
Titel
Recombinant human activated protein C: current insights into its mechanism of action
verfasst von
Marcel Levi
Tom van der Poll
Publikationsdatum
01.12.2007
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe Sonderheft 5/2007
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc6154

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Practical aspects of treatment with drotrecogin alfa (activated)

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The safety profile of drotrecogin alfa (activated)

Introduction

Introduction: severe sepsis and drotrecogin alfa (activated)

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The protein C pathway: implications for the design of the RESPOND study

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