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14.03.2018 | Cardiac

Reference ranges of left ventricular structure and function assessed by contrast-enhanced cardiac MR and changes related to ageing and hypertension in a population-based study

verfasst von: Robin Bülow, Till Ittermann, Marcus Dörr, Axel Poesch, Sönke Langner, Henry Völzke, Norbert Hosten, Marc Dewey

Erschienen in: European Radiology | Ausgabe 9/2018

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Abstract

Objectives

Reference ranges of left ventricular (LV) parameters from cardiac magnetic resonance (CMR) were established to investigate the impact of ageing and hypertension as important determinants of cardiac structure and function.

Methods

One thousand five hundred twenty-five contrast-enhanced CMRs were conducted in the Study of Health in Pomerania. LV end-diastolic volume (LVEDV), end-systolic volume (LVESV), stroke volume (LVSV), ejection fraction (LVEF), and myocardial mass (LVMM) were determined using long- and short-axis steady-state free-precession sequences. The reference population was defined as participants without late enhancement, hypertension, and prior cardiovascular diseases. Reference ranges were established by quantile regression (5th and 95th percentile) and compared with an additional sample of treated and untreated hypertensives.

Results

LV volumes in the reference population (n = 634, 300 males, 334 females, 52.1 ± 13.3 years) aged between 20-69 years were lower with higher age (p = 0.001), whereas LVEFs were higher (p ≤ 0.020). LVMM was lower only in males (p = 0.002). Compared with the reference population, hypertension was associated with lower LVEDV in males (n = 258, p ≤ 0.032). Antihypertensive therapy was associated with higher LVEF in males (n = 258, +2.5%, p = 0.002) and females (n = 180, +2.1%, p = 0.001).

Conclusions

Population-based LV reference ranges were derived from contrast-enhanced CMR. Hypertension-related changes were identified by comparing these values with those of hypertensives, and they might be used to monitor cardiac function in these patients.

Key Points

• Left ventricular function changed slightly but significantly between 20-69 years.

• Reference values of BSA-indexed myocardial mass decreased with age in males.

• Hypertension was associated with lower LV end-diastolic volume only in males.

• CMR may allow assessing remodelling related to hypertension or antihypertensive treatment.

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Titel: Reference ranges of left ventricular structure and function assessed by contrast-enhanced cardiac MR and changes related to ageing and hypertension in a population-based study
verfasst von: Robin Bülow
Till Ittermann
Marcus Dörr
Axel Poesch
Sönke Langner
Henry Völzke
Norbert Hosten
Marc Dewey
Publikationsdatum: 14.03.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 9/2018
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5345-y

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Reference ranges of left ventricular structure and function assessed by contrast-enhanced cardiac MR and changes related to ageing and hypertension in a population-based study