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Immunologic Research
Erschienen in: Immunologic Research 1/2011

01.10.2011

Regulation of major histocompatibility complex class I molecule expression on cancer cells by amyloid precursor-like protein 2

verfasst von: Haley L. Peters, Amit Tuli, Mahak Sharma, Naava Naslavsky, Steve Caplan, Richard G. MacDonald, Joyce C. Solheim

Erschienen in: Immunologic Research | Ausgabe 1/2011

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Abstract

The three members of the amyloid precursor protein family in mammals [amyloid precursor protein, amyloid precursor-like protein 1, and amyloid precursor-like protein 2 (APLP2)] have been implicated in a large array of intracellular processes, which include development, transcription, apoptosis, metabolism, and the cell cycle. A series of studies by our laboratories has demonstrated that APLP2 is highly expressed by many cancer cell lines (with the highest expression in pancreatic cancer cell lines) and that it facilitates major histocompatibility complex (MHC) class I molecule endocytosis. This review focuses on this recently revealed function of APLP2 relevant to tumor immunology: that it acts as a novel regulator of MHC class I molecule surface expression.
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Metadaten
Titel
Regulation of major histocompatibility complex class I molecule expression on cancer cells by amyloid precursor-like protein 2
verfasst von
Haley L. Peters
Amit Tuli
Mahak Sharma
Naava Naslavsky
Steve Caplan
Richard G. MacDonald
Joyce C. Solheim
Publikationsdatum
01.10.2011
Verlag
Humana Press Inc
Erschienen in
Immunologic Research / Ausgabe 1/2011
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-011-8238-6

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