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Sleep and Biological Rhythms

Erschienen in:

01.01.2017 | Original Article

Repeated pre-training sleep restriction in adolescent rats impaired spatial performance

verfasst von: Su-Rong Yang, Huan-Xin Sun, Zhen-Zhen Hu, Si-Heng Wang, Hui Sun, Yin-Jia Xue, Chen-Bo Ye

Erschienen in: Sleep and Biological Rhythms | Ausgabe 1/2017

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Abstract

Chronic sleep deprivation (SD) is an overwhelming problem in young students. Firstly, we investigated whether different levels of pre-training SD had effects on spatial performance in adolescent rats. Rats were subjected to 2 or 4 h/day SD for 15 consecutive days. Morris water maze tests were conducted immediately after SD on experimental days 9–15. During the last 3 trials on the first training day, compared with their respective control animals, the rats with prior 4 h SD, but not 2 h SD, showed a significant reduction in percentage of the trials landing the platform without guidance (landing rate). During the whole 6 training days, the rats subjected to 4 h SD, not 2 h SD, spent longer time to locate the platform than the control rats did. In the probe test, the rats with 4 h SD and 2 h SD showed no significant difference with their respective control in time spent in the target quadrant and numbers of platform crossings. These results indicated that chronic prior 4 h SD, but not 2 h SD, impaired spatial acquisition capability in adolescent rats. Secondly, we explored whether huperzine A (Hup A), which has been proved to improve cognitive impairment in dementia, could prevent adolescent rats from chronic 4 h SD-induced learning decline. Hup A (0.1 mg/kg/day) was administered by gavage 30 min before the end of 4 h SD. With hup A treatment, the reduced landing rate was increased and the prolonged escape latency and distance were shortened, which suggested that hup A was promising in preventing the spatial cognitive deficits induced by repeated sleep restriction in adolescents.

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Titel: Repeated pre-training sleep restriction in adolescent rats impaired spatial performance
verfasst von: Su-Rong Yang
Huan-Xin Sun
Zhen-Zhen Hu
Si-Heng Wang
Hui Sun
Yin-Jia Xue
Chen-Bo Ye
Publikationsdatum: 01.01.2017
Verlag: Springer Japan
Erschienen in: Sleep and Biological Rhythms / Ausgabe 1/2017
Print ISSN: 1446-9235
Elektronische ISSN: 1479-8425
DOI: https://doi.org/10.1007/s41105-016-0080-8

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