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Intensive Care Medicine

Erschienen in:

01.10.2005 | Experimental

Response of acoustic transmission to positive airway pressure therapy in experimental lung injury

verfasst von: Jukka Räsänen, Noam Gavriely

Erschienen in: Intensive Care Medicine | Ausgabe 10/2005

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Abstract

Objective

To evaluate the effect of positive end-expiratory pressure on the sound filtering characteristics of injured lungs.

Design and setting

Prospective experimental study in the animal laboratory in an academic medical center.

Patients and participants

Six 35- to 45-kg anesthetized, intubated pigs.

Interventions

Acute lung injury with intravenous oleic acid.

Measurements and results

We injected a multifrequency broad-band sound signal into the airway while recording transmitted sound at three locations bilaterally on the chest wall. Oleic acid injections effected a severe pulmonary edema predominantly in the dependent lung regions, with an average increase in venous admixture from 16±14% to 57±13% and a reduction in static respiratory system compliance from 31±6 to 16±3 ml/cmH₂O. A significant concomitant increase in sound transfer function amplitude was seen in the dependent and lateral lung regions; little change occurred in the nondependent areas. The application of PEEP resulted in a decrease in venous admixture, increase in respiratory system compliance, and return of the sound transmission to preinjury levels.

Conclusions

Acute lung injury causes regional acoustic transmission abnormalities that are reversed during alveolar recruitment with PEEP.

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Titel: Response of acoustic transmission to positive airway pressure therapy in experimental lung injury
verfasst von: Jukka Räsänen
Noam Gavriely
Publikationsdatum: 01.10.2005
Verlag: Springer-Verlag
Erschienen in: Intensive Care Medicine / Ausgabe 10/2005
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-005-2745-7

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Springer Medizin

Response of acoustic transmission to positive airway pressure therapy in experimental lung injury

Abstract

Objective

Design and setting

Patients and participants

Interventions

Measurements and results

Conclusions

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Update AINS

Springer Medizin

Abstract

Objective

Design and setting

Patients and participants

Interventions

Measurements and results

Conclusions

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