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Erschienen in: Zeitschrift für Rheumatologie 6/2016

30.06.2016 | Rheumatoide Arthritis | Leitthema: Meilensteine in der Rheumatologie: 75 Bände Innovation

„Treat to target“ und personalisierte Medizin („precision medicine“)

verfasst von: Dr. J. Detert, MHBA, G. R. Burmester

Erschienen in: Zeitschrift für Rheumatologie | Ausgabe 6/2016

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Auszug

In der Behandlung der rheumatoiden Arthritis (RA) entstehen europaweit jährlich ca. 14 Billionen € direkter Kosten durch Hospitalisation, Diagnostik und Therapie und ca. 17 Billionen € indirekte Kosten durch Arbeitsausfall, Frühberentung usw. Ein RA-Patient in Deutschland ist innerhalb von 10 Jahren nicht mehr arbeitsfähig, wenn die RA durch einen instabilen und nicht ausreichenden Behandlungsverlauf gekennzeichnet ist [1]. Hinzu kommt, dass Patienten diese chronische Erkrankung durchaus 30 Jahre und länger bewältigen müssen, da die RA nicht selten in jungen Jahren beginnt. Für RA-Patienten resultieren daraus unter anderem eingeschränkte soziale Beziehungen, geringe Umsetzungsmöglichkeiten aller Zukunftspläne und eine vergleichbare schlechte Lebensqualität, die der eines Patienten mit multipler Sklerose entspricht [1]. …
Literatur
1.
Zurück zum Zitat Lundkvist J, Kastäng F, Kobelt G (2008) The burden of rheumatoid arthritis and access to treatment: health burden and costs. Eur J Health Econ 8(Suppl 2):S49–60. doi:10.1007/s10198-007-0088-8CrossRefPubMed Lundkvist J, Kastäng F, Kobelt G (2008) The burden of rheumatoid arthritis and access to treatment: health burden and costs. Eur J Health Econ 8(Suppl 2):S49–60. doi:10.1007/s10198-007-0088-8CrossRefPubMed
2.
Zurück zum Zitat Wolfe F (1996) The natural history of rheumatoid arthritis. J Rheumatol Suppl 44:13–22PubMed Wolfe F (1996) The natural history of rheumatoid arthritis. J Rheumatol Suppl 44:13–22PubMed
3.
Zurück zum Zitat Wolfe F, Hawley DJ (1998) The longterm outcomes of rheumatoid arthritis: Work disability: a prospective 18 year study of 823 patients. J Rheumatol 25(11):2108–2117PubMed Wolfe F, Hawley DJ (1998) The longterm outcomes of rheumatoid arthritis: Work disability: a prospective 18 year study of 823 patients. J Rheumatol 25(11):2108–2117PubMed
4.
Zurück zum Zitat Sokka T, Kautiainen H, Möttönen T et al (1999) Work disability in rheumatoid arthritis 10 years after the diagnosis. J Rheumatol 26(8):1681–1685PubMed Sokka T, Kautiainen H, Möttönen T et al (1999) Work disability in rheumatoid arthritis 10 years after the diagnosis. J Rheumatol 26(8):1681–1685PubMed
5.
Zurück zum Zitat Goldbach-Mansky R, Mahadevan V, Yao L et al (2003) The evaluation of bone damage in rheumatoid arthritis with magnetic resonance imaging. Clin Exp Rheumatol 21(5 Suppl 31):S50–3PubMed Goldbach-Mansky R, Mahadevan V, Yao L et al (2003) The evaluation of bone damage in rheumatoid arthritis with magnetic resonance imaging. Clin Exp Rheumatol 21(5 Suppl 31):S50–3PubMed
6.
Zurück zum Zitat Smolen JS, Emery P, Fleischmann R et al (2014) Adjustment of therapy in rheumatoid arthritis on the basis of achievement of stable low disease activity with adalimumab plus methotrexate or methotrexate alone: the randomised controlled OPTIMA trial. Lancet 383(9914):321–332. doi:10.1016/S0140-6736(13)61751-1CrossRefPubMed Smolen JS, Emery P, Fleischmann R et al (2014) Adjustment of therapy in rheumatoid arthritis on the basis of achievement of stable low disease activity with adalimumab plus methotrexate or methotrexate alone: the randomised controlled OPTIMA trial. Lancet 383(9914):321–332. doi:10.1016/S0140-6736(13)61751-1CrossRefPubMed
7.
Zurück zum Zitat Hetland ML, Lindegaard HM, Hansen A et al (2008) Do changes in prescription practice in patients with rheumatoid arthritis treated with biological agents affect treatment response and adherence to therapy? Results from the nationwide Danish DANBIO Registry. Ann Rheum Dis 67(7):1023–1026. doi:10.1136/ard.2007.087262CrossRefPubMed Hetland ML, Lindegaard HM, Hansen A et al (2008) Do changes in prescription practice in patients with rheumatoid arthritis treated with biological agents affect treatment response and adherence to therapy? Results from the nationwide Danish DANBIO Registry. Ann Rheum Dis 67(7):1023–1026. doi:10.1136/ard.2007.087262CrossRefPubMed
8.
Zurück zum Zitat Hetland ML, Jensen DV, Krogh NS (2014) Monitoring patients with rheumatoid arthritis in routine care: experiences from a treat-to-target strategy using the DANBIO registry. Clin Exp Rheumatol 32(5 Suppl 85):S141–S146 Hetland ML, Jensen DV, Krogh NS (2014) Monitoring patients with rheumatoid arthritis in routine care: experiences from a treat-to-target strategy using the DANBIO registry. Clin Exp Rheumatol 32(5 Suppl 85):S141–S146
9.
Zurück zum Zitat Huscher D, Mittendorf T, Hinüber U von et al (2015) Evolution of cost structures in rheumatoid arthritis over the past decade. Ann Rheum Dis 74(4):738–745. doi:10.1136/annrheumdis-2013-204311CrossRefPubMed Huscher D, Mittendorf T, Hinüber U von et al (2015) Evolution of cost structures in rheumatoid arthritis over the past decade. Ann Rheum Dis 74(4):738–745. doi:10.1136/annrheumdis-2013-204311CrossRefPubMed
10.
Zurück zum Zitat Haschka J, Englbrecht M, Hueber AJ et al (2016) Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping antirheumatic therapy: interim results from the prospective randomised controlled RETRO study. Ann Rheum Dis 75(1):45–51. doi:10.1136/annrheumdis-2014-206439CrossRefPubMed Haschka J, Englbrecht M, Hueber AJ et al (2016) Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping antirheumatic therapy: interim results from the prospective randomised controlled RETRO study. Ann Rheum Dis 75(1):45–51. doi:10.1136/annrheumdis-2014-206439CrossRefPubMed
11.
Zurück zum Zitat Pincus T, O’Dell JR, Kremer JM (1999) Combination therapy with multiple disease-modifying antirheumatic drugs in rheumatoid arthritis: a preventive strategy. Ann Intern Med 131(10):768–774CrossRefPubMed Pincus T, O’Dell JR, Kremer JM (1999) Combination therapy with multiple disease-modifying antirheumatic drugs in rheumatoid arthritis: a preventive strategy. Ann Intern Med 131(10):768–774CrossRefPubMed
12.
Zurück zum Zitat Kooij SM van der, Le Cessie S, Goekoop-Ruiterman YPM et al (2009) Clinical and radiological efficacy of initial vs delayed treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis. Ann Rheum Dis 68(7):1153–1158. doi:10.1136/ard.2008.093294CrossRefPubMed Kooij SM van der, Le Cessie S, Goekoop-Ruiterman YPM et al (2009) Clinical and radiological efficacy of initial vs delayed treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis. Ann Rheum Dis 68(7):1153–1158. doi:10.1136/ard.2008.093294CrossRefPubMed
13.
Zurück zum Zitat Abasolo L, Ivorra-Cortes J, Leon L et al (2015) Influence of demographic and clinical factors on the mortality rate of a rheumatoid arthritis cohort: A 20-year survival study. Semin Arthritis Rheum doi:10.1016/j.semarthrit.2015.10.016 Abasolo L, Ivorra-Cortes J, Leon L et al (2015) Influence of demographic and clinical factors on the mortality rate of a rheumatoid arthritis cohort: A 20-year survival study. Semin Arthritis Rheum doi:10.1016/j.semarthrit.2015.10.016
14.
Zurück zum Zitat Schneider M, Abholz H, Caratti R et al (2007) Interdisziplinäre Leitlinie Management der frühen rheumatoiden Arthritis, 2. überarbeitete Auflage. Aufl. Steinkopff Verlag Darmstadt, Darmstadt Schneider M, Abholz H, Caratti R et al (2007) Interdisziplinäre Leitlinie Management der frühen rheumatoiden Arthritis, 2. überarbeitete Auflage. Aufl. Steinkopff Verlag Darmstadt, Darmstadt
15.
Zurück zum Zitat Ziegler S, Huscher D, Karberg K et al (2010) Trends in treatment and outcomes of rheumatoid arthritis in Germany 1997–2007: results from the National Database of the German Collaborative Arthritis Centres. Ann Rheum Dis 69(10):1803–1808. doi:10.1136/ard.2009.122101CrossRefPubMed Ziegler S, Huscher D, Karberg K et al (2010) Trends in treatment and outcomes of rheumatoid arthritis in Germany 1997–2007: results from the National Database of the German Collaborative Arthritis Centres. Ann Rheum Dis 69(10):1803–1808. doi:10.1136/ard.2009.122101CrossRefPubMed
16.
Zurück zum Zitat Albrecht K, Callhoff J, Edelmann E et al (2015) Klinische Remission bei rheumatoider Arthritis. Daten aus der Früharthritiskohortenstudie CAPEA (Clinical remission in rheumatoid arthritis : Data from the early arthritis cohort study CAPEA). Z Rheumatol doi:10.1007/s00393-015-0019-5 Albrecht K, Callhoff J, Edelmann E et al (2015) Klinische Remission bei rheumatoider Arthritis. Daten aus der Früharthritiskohortenstudie CAPEA (Clinical remission in rheumatoid arthritis : Data from the early arthritis cohort study CAPEA). Z Rheumatol doi:10.1007/s00393-015-0019-5
17.
Zurück zum Zitat Combe B, Logeart I, Belkacemi MC et al (2015) Comparison of the long-term outcome for patients with rheumatoid arthritis with persistent moderate disease activity or disease remission during the first year after diagnosis: data from the ESPOIR cohort. Ann Rheum Dis 74(4):724–729. doi:10.1136/annrheumdis-2013-204178CrossRefPubMed Combe B, Logeart I, Belkacemi MC et al (2015) Comparison of the long-term outcome for patients with rheumatoid arthritis with persistent moderate disease activity or disease remission during the first year after diagnosis: data from the ESPOIR cohort. Ann Rheum Dis 74(4):724–729. doi:10.1136/annrheumdis-2013-204178CrossRefPubMed
18.
Zurück zum Zitat Heimans L, Akdemir G, Wevers-de Boer KVC et al (2016) Two-year results of disease activity score (DAS)-remission-steered treatment strategies aiming at drug-free remission in early arthritis patients (the IMPROVED-study). Arthritis Res Ther 18(1):23 doi:10.1186/s13075-015-0912-yCrossRefPubMedPubMedCentral Heimans L, Akdemir G, Wevers-de Boer KVC et al (2016) Two-year results of disease activity score (DAS)-remission-steered treatment strategies aiming at drug-free remission in early arthritis patients (the IMPROVED-study). Arthritis Res Ther 18(1):23 doi:10.1186/s13075-015-0912-yCrossRefPubMedPubMedCentral
19.
Zurück zum Zitat The Diabetes Control and Complications Trial Research Group. (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329(14):977–986. doi:10.1056/NEJM199309303291401CrossRef The Diabetes Control and Complications Trial Research Group. (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329(14):977–986. doi:10.1056/NEJM199309303291401CrossRef
20.
Zurück zum Zitat Fullerton B, Pöhlmann B, Krohn R et al (2016) The comparison of matching methods using different measures of balance: benefits and risks exemplified within a study to evaluate the effects of german disease management programs on long-term outcomes of patients with type 2 diabetes. Health Serv Res doi:10.1111/1475-6773.12452PubMed Fullerton B, Pöhlmann B, Krohn R et al (2016) The comparison of matching methods using different measures of balance: benefits and risks exemplified within a study to evaluate the effects of german disease management programs on long-term outcomes of patients with type 2 diabetes. Health Serv Res doi:10.1111/1475-6773.12452PubMed
21.
Zurück zum Zitat Grigor C, Capell H, Stirling A et al (2004) Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial. Lancet 364(9430):263–269. doi:10.1016/S0140-6736(04)16676-2CrossRefPubMed Grigor C, Capell H, Stirling A et al (2004) Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial. Lancet 364(9430):263–269. doi:10.1016/S0140-6736(04)16676-2CrossRefPubMed
22.
Zurück zum Zitat Emery P, Kavanaugh A, Bao Y et al (2015) Comprehensive disease control (CDC): what does achieving CDC mean for patients with rheumatoid arthritis? Ann Rheum Dis 74(12):2165–2174. doi:10.1136/annrheumdis-2014-205302CrossRefPubMed Emery P, Kavanaugh A, Bao Y et al (2015) Comprehensive disease control (CDC): what does achieving CDC mean for patients with rheumatoid arthritis? Ann Rheum Dis 74(12):2165–2174. doi:10.1136/annrheumdis-2014-205302CrossRefPubMed
23.
Zurück zum Zitat Gul HL, Ferreira JF, Emery P (2015) Remission in rheumatoid arthritis: is it all the same? Expert Rev Clin Pharmacol 8(5):575–586. doi:10.1586/17512433.2015.1061429CrossRefPubMed Gul HL, Ferreira JF, Emery P (2015) Remission in rheumatoid arthritis: is it all the same? Expert Rev Clin Pharmacol 8(5):575–586. doi:10.1586/17512433.2015.1061429CrossRefPubMed
24.
Zurück zum Zitat Sheehy C, Evans V, Hasthorpe H et al (2014) Revising DAS28 scores for remission in rheumatoid arthritis. Clin Rheumatol 33(2):269–272. doi:10.1007/s10067-013-2468-zCrossRefPubMed Sheehy C, Evans V, Hasthorpe H et al (2014) Revising DAS28 scores for remission in rheumatoid arthritis. Clin Rheumatol 33(2):269–272. doi:10.1007/s10067-013-2468-zCrossRefPubMed
25.
Zurück zum Zitat Pincus T, Castrejón I (2015) Are patient self-report questionnaires as “scientific” as biomarkers in “treat-to-target” and prognosis in rheumatoid arthritis? Curr Pharm Des 21(2):241–256CrossRefPubMed Pincus T, Castrejón I (2015) Are patient self-report questionnaires as “scientific” as biomarkers in “treat-to-target” and prognosis in rheumatoid arthritis? Curr Pharm Des 21(2):241–256CrossRefPubMed
26.
Zurück zum Zitat Smolen JS, Breedveld FC, Burmester GR et al (2015) Treating rheumatoid arthritis to target. 2014 update of the recommendations of an international task force. Ann Rheum Dis 75(1):3–15. doi:10.1136/annrheumdis-2015-207524CrossRefPubMedPubMedCentral Smolen JS, Breedveld FC, Burmester GR et al (2015) Treating rheumatoid arthritis to target. 2014 update of the recommendations of an international task force. Ann Rheum Dis 75(1):3–15. doi:10.1136/annrheumdis-2015-207524CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Knowles SE, Chew-Graham C, Adeyemi I et al (2015) Managing depression in people with multimorbidity. A qualitative evaluation of an integrated collaborative care model. BMC Fam Pract 16(1):32 doi:10.1186/s12875-015-0246-5CrossRefPubMedPubMedCentral Knowles SE, Chew-Graham C, Adeyemi I et al (2015) Managing depression in people with multimorbidity. A qualitative evaluation of an integrated collaborative care model. BMC Fam Pract 16(1):32 doi:10.1186/s12875-015-0246-5CrossRefPubMedPubMedCentral
28.
Zurück zum Zitat Gromnica-Ihle E, Rink M (2011) „Treat-to-Target“ aus Sicht der Betroffenen. Z Rheumatol 70(8):678–684. doi:10.1007/s00393-011-0773-yCrossRefPubMed Gromnica-Ihle E, Rink M (2011) „Treat-to-Target“ aus Sicht der Betroffenen. Z Rheumatol 70(8):678–684. doi:10.1007/s00393-011-0773-yCrossRefPubMed
29.
Zurück zum Zitat Solomon DH, Bitton A, Fraenkel L et al (2014) Roles of nurse practitioners and physician assistants in rheumatology practices in the US. Arthritis Care Res 66(7):1108–1113. doi:10.1002/acr.22255CrossRef Solomon DH, Bitton A, Fraenkel L et al (2014) Roles of nurse practitioners and physician assistants in rheumatology practices in the US. Arthritis Care Res 66(7):1108–1113. doi:10.1002/acr.22255CrossRef
30.
Zurück zum Zitat Kalden JR, Burkhardt H, Buß B et al (2011) Strategien zur verbesserten Versorgung von Menschen mit der Volkskrankheit „Rheuma“ am Beispiel der rheumatoiden Arthritis. Z Rheumatol 70(8):641–650. doi:10.1007/s00393-011-0763-0CrossRefPubMed Kalden JR, Burkhardt H, Buß B et al (2011) Strategien zur verbesserten Versorgung von Menschen mit der Volkskrankheit „Rheuma“ am Beispiel der rheumatoiden Arthritis. Z Rheumatol 70(8):641–650. doi:10.1007/s00393-011-0763-0CrossRefPubMed
31.
Zurück zum Zitat Gesetz zur Verbesserung der Rechte von Patientinnen und Patienten vom 20. Februar 2013. In: Bundesgesetzblatt (BGBl). Bundesanzeiger Verlag, 25. Februar 2013, S 277 Gesetz zur Verbesserung der Rechte von Patientinnen und Patienten vom 20. Februar 2013. In: Bundesgesetzblatt (BGBl). Bundesanzeiger Verlag, 25. Februar 2013, S 277
32.
Zurück zum Zitat Evans DA, Manley KA, McKusick VA (1960) Genetic control of isoniazid metabolism in man. Br Med J 2(5197):485–491 Evans DA, Manley KA, McKusick VA (1960) Genetic control of isoniazid metabolism in man. Br Med J 2(5197):485–491
33.
Zurück zum Zitat Cascorbi I, Brockmöller J, Mrozikiewicz PM, Müller A, Roots I (1999) Arylamine N-acetyltransferase activity in man. Drug Metab Rev 31(2):489–502. doi:10.1081/DMR-100101932 Cascorbi I, Brockmöller J, Mrozikiewicz PM, Müller A, Roots I (1999) Arylamine N-acetyltransferase activity in man. Drug Metab Rev 31(2):489–502. doi:10.1081/DMR-100101932
34.
Zurück zum Zitat Kinzig-Schippers M, Tomalik-Scharte D, Jetter A, Scheidel B, Jakob V, Rodamer M, Cascorbi I, Doroshyenko O, Sörgel F, Fuhr U (2005) Should we use N-acetyltransferase type 2 genotyping to personalize isoniazid doses? Antimicrob Agents Chemother 49(5):1733–1738. doi:10.1128/AAC.49.5.1733–1738.2005 Kinzig-Schippers M, Tomalik-Scharte D, Jetter A, Scheidel B, Jakob V, Rodamer M, Cascorbi I, Doroshyenko O, Sörgel F, Fuhr U (2005) Should we use N-acetyltransferase type 2 genotyping to personalize isoniazid doses? Antimicrob Agents Chemother 49(5):1733–1738. doi:10.1128/AAC.49.5.1733–1738.2005
35.
Zurück zum Zitat Donald PR, Parkin DP, Seifart HI, Schaaf HS, van Helden PD, Werely CJ, Sirgel FA, Venter A, Maritz JS (2007) The influence of dose and N-acetyltransferase-2 (NAT2) genotype and phenotype on the pharmacokinetics and pharmacodynamics of isoniazid. Eur J Clin Pharmacol 63(7):633–639CrossRef Donald PR, Parkin DP, Seifart HI, Schaaf HS, van Helden PD, Werely CJ, Sirgel FA, Venter A, Maritz JS (2007) The influence of dose and N-acetyltransferase-2 (NAT2) genotype and phenotype on the pharmacokinetics and pharmacodynamics of isoniazid. Eur J Clin Pharmacol 63(7):633–639CrossRef
36.
Zurück zum Zitat Schleidgen S, Marckmann G (2013) Old wine in new bottles? Ethical implications of individualized medicine. Ethik Med 25(3):223–231CrossRef Schleidgen S, Marckmann G (2013) Old wine in new bottles? Ethical implications of individualized medicine. Ethik Med 25(3):223–231CrossRef
37.
Zurück zum Zitat Schleidgen S, Marckmann G (2014) Kriterien für eine ethisch angemessene Priorisierung individualisierter Therapiemaßnahmen. Gesundheitswesen 76(11):e57–e64. doi:10.1055/s-0034-1390000CrossRefPubMed Schleidgen S, Marckmann G (2014) Kriterien für eine ethisch angemessene Priorisierung individualisierter Therapiemaßnahmen. Gesundheitswesen 76(11):e57–e64. doi:10.1055/s-0034-1390000CrossRefPubMed
38.
Zurück zum Zitat Rogowski WH, Schleidgen S (2015) Using needs-based frameworks for evaluating new technologies. An application to genetic tests. Health Policy 119(2):147–155. doi:10.1016/j.healthpol.2014.11.006CrossRefPubMed Rogowski WH, Schleidgen S (2015) Using needs-based frameworks for evaluating new technologies. An application to genetic tests. Health Policy 119(2):147–155. doi:10.1016/j.healthpol.2014.11.006CrossRefPubMed
39.
Zurück zum Zitat Lander ES, Linton LM, Birren B, Nusbaum C et al (2001) Initial sequencing and analysis of the human genome. Nature 409(6822):860–921CrossRefPubMed Lander ES, Linton LM, Birren B, Nusbaum C et al (2001) Initial sequencing and analysis of the human genome. Nature 409(6822):860–921CrossRefPubMed
40.
Zurück zum Zitat Nefiodow LA, Nefiodow S (2014) Der sechste Kondratieff. Die neue lange Welle der Weltwirtschaft; die langen Wellen der weltwirtschaftlichen Entwicklung, 7., aktualisierte Aufl. Aufl. Rhein-Sieg-Verl., Sankt Augustin Nefiodow LA, Nefiodow S (2014) Der sechste Kondratieff. Die neue lange Welle der Weltwirtschaft; die langen Wellen der weltwirtschaftlichen Entwicklung, 7., aktualisierte Aufl. Aufl. Rhein-Sieg-Verl., Sankt Augustin
41.
Zurück zum Zitat Garrod AE. The Lancet (1975) The incidence of alkaptonuria: a study in chemical individuality. Nutr Rev 33(3):81–83 Garrod AE. The Lancet (1975) The incidence of alkaptonuria: a study in chemical individuality. Nutr Rev 33(3):81–83
42.
Zurück zum Zitat Pegram MD, Pauletti G, Slamon DJ (1998) HER-2/neu as a predictive marker of response to breast cancer therapy. Breast Cancer Res Treat 52(1–3):65–77 Pegram MD, Pauletti G, Slamon DJ (1998) HER-2/neu as a predictive marker of response to breast cancer therapy. Breast Cancer Res Treat 52(1–3):65–77
44.
Zurück zum Zitat Silman AJ, MacGregor AJ, Thomson W, Holligan S, Carthy D, Farhan A, Ollier WE (1993) Twin concordance rates for rheumatoid arthritis: results from a nationwide study. Br J Rheumatol 32(10):903–907 Silman AJ, MacGregor AJ, Thomson W, Holligan S, Carthy D, Farhan A, Ollier WE (1993) Twin concordance rates for rheumatoid arthritis: results from a nationwide study. Br J Rheumatol 32(10):903–907
45.
Zurück zum Zitat MacGregor AJ, Snieder H, Rigby AS, Koskenvuo M, Kaprio J, Aho K, Silman AJ (2000) Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum 43(1):30–37 MacGregor AJ, Snieder H, Rigby AS, Koskenvuo M, Kaprio J, Aho K, Silman AJ (2000) Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum 43(1):30–37
46.
Zurück zum Zitat Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447(7145):661–678 Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447(7145):661–678
47.
Zurück zum Zitat Eyre S, Bowes J, Diogo D et al (2012) High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet 44(12):1336–1340. doi:10.1038/ng.2462CrossRefPubMedPubMedCentral Eyre S, Bowes J, Diogo D et al (2012) High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet 44(12):1336–1340. doi:10.1038/ng.2462CrossRefPubMedPubMedCentral
48.
Zurück zum Zitat Orozco G, Hinks A, Eyre S et al (2009) Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Hum Mol Genet 18(14):2693–2699. doi:10.1093/hmg/ddp193CrossRefPubMedPubMedCentral Orozco G, Hinks A, Eyre S et al (2009) Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Hum Mol Genet 18(14):2693–2699. doi:10.1093/hmg/ddp193CrossRefPubMedPubMedCentral
49.
Zurück zum Zitat Okada Y (2014) From the era of genome analysis to the era of genomic drug discovery: a pioneering example of rheumatoid arthritis. Clin Genet 86(5):432–440. doi:10.1111/cge.12465CrossRefPubMed Okada Y (2014) From the era of genome analysis to the era of genomic drug discovery: a pioneering example of rheumatoid arthritis. Clin Genet 86(5):432–440. doi:10.1111/cge.12465CrossRefPubMed
50.
Zurück zum Zitat Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, Ding B, Liew A et al (2007) TRAF1-C5 as a risk locus for rheumatoid arthritis – a genomewide study. N Engl J Med 357(12):1199–1209 Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, Ding B, Liew A et al (2007) TRAF1-C5 as a risk locus for rheumatoid arthritis – a genomewide study. N Engl J Med 357(12):1199–1209
51.
Zurück zum Zitat Martínez A, Varadé J, Márquez A et al (2008) Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases. Arthritis Rheum 58(9):2598–2602. doi:10.1002/art.23792CrossRefPubMed Martínez A, Varadé J, Márquez A et al (2008) Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases. Arthritis Rheum 58(9):2598–2602. doi:10.1002/art.23792CrossRefPubMed
52.
Zurück zum Zitat Raychaudhuri S, Remmers EF, Lee AT et al (2008) Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet 40(10):1216–1223. doi:10.1038/ng.233CrossRefPubMedPubMedCentral Raychaudhuri S, Remmers EF, Lee AT et al (2008) Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet 40(10):1216–1223. doi:10.1038/ng.233CrossRefPubMedPubMedCentral
53.
Zurück zum Zitat Barton A, Eyre S, Ke X et al (2009) Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes. Hum Mol Genet 18(13):2518–2522. doi:10.1093/hmg/ddp177CrossRefPubMedPubMedCentral Barton A, Eyre S, Ke X et al (2009) Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes. Hum Mol Genet 18(13):2518–2522. doi:10.1093/hmg/ddp177CrossRefPubMedPubMedCentral
54.
Zurück zum Zitat Orozco G, Hinks A, Eyre S et al (2009) Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Hum Mol Genet 18(14):2693–2699. doi:10.1093/hmg/ddp193CrossRefPubMedPubMedCentral Orozco G, Hinks A, Eyre S et al (2009) Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Hum Mol Genet 18(14):2693–2699. doi:10.1093/hmg/ddp193CrossRefPubMedPubMedCentral
55.
Zurück zum Zitat Cobb JE, Plant D, Flynn E et al (2013) Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans. PLOS ONE 8(6):e66456 doi:10.1371/journal.pone.0066456CrossRefPubMedPubMedCentral Cobb JE, Plant D, Flynn E et al (2013) Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans. PLOS ONE 8(6):e66456 doi:10.1371/journal.pone.0066456CrossRefPubMedPubMedCentral
56.
Zurück zum Zitat Cortes A, Brown MA (2010) Promise and pitfalls of the Immunochip. Arthritis Res Ther 13(1):101 doi:10.1186/ar3204CrossRef Cortes A, Brown MA (2010) Promise and pitfalls of the Immunochip. Arthritis Res Ther 13(1):101 doi:10.1186/ar3204CrossRef
57.
Zurück zum Zitat Knevel R, Krabben A, Brouwer E et al (2012) Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis. A multicohort study. Ann Rheum Dis 71(10):1651–1657. doi:10.1136/annrheumdis-2011-200724CrossRefPubMed Knevel R, Krabben A, Brouwer E et al (2012) Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis. A multicohort study. Ann Rheum Dis 71(10):1651–1657. doi:10.1136/annrheumdis-2011-200724CrossRefPubMed
58.
Zurück zum Zitat Krabben A, Knevel R, Huizinga TWJ et al (2013) Serum pyridinoline levels and prediction of severity of joint destruction in rheumatoid arthritis. J Rheumatol 40(8):1303–1306. doi:10.3899/jrheum.121392CrossRefPubMed Krabben A, Knevel R, Huizinga TWJ et al (2013) Serum pyridinoline levels and prediction of severity of joint destruction in rheumatoid arthritis. J Rheumatol 40(8):1303–1306. doi:10.3899/jrheum.121392CrossRefPubMed
59.
Zurück zum Zitat Knevel R, Rooy DPC de, Zhernakova A et al (2013) Association of variants in IL2RA with progression of joint destruction in rheumatoid arthritis. Arthritis Rheum 65(7):1684–1693. doi:10.1002/art.37938CrossRefPubMed Knevel R, Rooy DPC de, Zhernakova A et al (2013) Association of variants in IL2RA with progression of joint destruction in rheumatoid arthritis. Arthritis Rheum 65(7):1684–1693. doi:10.1002/art.37938CrossRefPubMed
60.
Zurück zum Zitat Knevel R, Krabben A, Wilson AG et al (2013) A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis. Arthritis Rheum 65(3):582–589. doi:10.1002/art.37808CrossRefPubMed Knevel R, Krabben A, Wilson AG et al (2013) A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis. Arthritis Rheum 65(3):582–589. doi:10.1002/art.37808CrossRefPubMed
61.
Zurück zum Zitat Rooy DPC de, Yeremenko NG, Wilson AG et al (2013) Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis. Ann Rheum Dis 72(5):769–775. doi:10.1136/annrheumdis-2012-202184CrossRefPubMed Rooy DPC de, Yeremenko NG, Wilson AG et al (2013) Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis. Ann Rheum Dis 72(5):769–775. doi:10.1136/annrheumdis-2012-202184CrossRefPubMed
62.
Zurück zum Zitat Knevel R, Klein K, Somers K et al (2014) Identification of a genetic variant for joint damage progression in autoantibody-positive rheumatoid arthritis. Ann Rheum Dis 73(11):2038–2046. doi:10.1136/annrheumdis-2013-204050CrossRefPubMed Knevel R, Klein K, Somers K et al (2014) Identification of a genetic variant for joint damage progression in autoantibody-positive rheumatoid arthritis. Ann Rheum Dis 73(11):2038–2046. doi:10.1136/annrheumdis-2013-204050CrossRefPubMed
63.
Zurück zum Zitat Knevel R, Rooy DPC de, Saxne T et al (2014) A genetic variant in osteoprotegerin is associated with progression of joint destruction in rheumatoid arthritis. Arthritis Res Ther 16(3):R108 doi:10.1186/ar4558CrossRefPubMedPubMedCentral Knevel R, Rooy DPC de, Saxne T et al (2014) A genetic variant in osteoprotegerin is associated with progression of joint destruction in rheumatoid arthritis. Arthritis Res Ther 16(3):R108 doi:10.1186/ar4558CrossRefPubMedPubMedCentral
64.
Zurück zum Zitat Rodriguez-Rodriguez L, Ivorra-Cortes J, Carmona FD et al (2015) PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients. A genetic study of six cohorts. Arthritis Res Ther 17(1):137 doi:10.1186/s13075-015-0830-zCrossRef Rodriguez-Rodriguez L, Ivorra-Cortes J, Carmona FD et al (2015) PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients. A genetic study of six cohorts. Arthritis Res Ther 17(1):137 doi:10.1186/s13075-015-0830-zCrossRef
65.
Zurück zum Zitat Steenbergen HW van, Rodríguez-Rodríguez L, Berglin E et al (2015) A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis. Arthritis Res Ther 17(1):1 doi:10.1186/s13075-014-0514-0CrossRefPubMedPubMedCentral Steenbergen HW van, Rodríguez-Rodríguez L, Berglin E et al (2015) A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis. Arthritis Res Ther 17(1):1 doi:10.1186/s13075-014-0514-0CrossRefPubMedPubMedCentral
66.
Zurück zum Zitat Visser K, Goekoop-Ruiterman YPM, Vries-Bouwstra JK de et al (2010) A matrix risk model for the prediction of rapid radiographic progression in patients with rheumatoid arthritis receiving different dynamic treatment strategies. Post hoc analyses from the BeSt study. Ann Rheum Dis 69(7):1333–1337. doi:10.1136/ard.2009.121160CrossRefPubMed Visser K, Goekoop-Ruiterman YPM, Vries-Bouwstra JK de et al (2010) A matrix risk model for the prediction of rapid radiographic progression in patients with rheumatoid arthritis receiving different dynamic treatment strategies. Post hoc analyses from the BeSt study. Ann Rheum Dis 69(7):1333–1337. doi:10.1136/ard.2009.121160CrossRefPubMed
67.
Zurück zum Zitat van der Helm-van Mil AH, Huizinga TW (2008) Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets. Arthritis Res Ther 10(2):205. doi:10.1186/ar2384 van der Helm-van Mil AH, Huizinga TW (2008) Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets. Arthritis Res Ther 10(2):205. doi:10.1186/ar2384
68.
Zurück zum Zitat Daha NA, Toes REM (2011) Rheumatoid arthritis. Are ACPA-positive and ACPA-negative RA the same disease? Nat Rev Rheumatol 7(4):202–203. doi:10.1038/nrrheum.2011.28CrossRefPubMed Daha NA, Toes REM (2011) Rheumatoid arthritis. Are ACPA-positive and ACPA-negative RA the same disease? Nat Rev Rheumatol 7(4):202–203. doi:10.1038/nrrheum.2011.28CrossRefPubMed
69.
Zurück zum Zitat Klareskog L, Stolt P, Lundberg K, Källberg H, Bengtsson C, Grunewald J et al (2006) A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 54(1):38–46 Klareskog L, Stolt P, Lundberg K, Källberg H, Bengtsson C, Grunewald J et al (2006) A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 54(1):38–46
70.
Zurück zum Zitat Pratesi F, Petit Teixeira E, Sidney J et al (2013) HLA shared epitope and ACPA. Just a marker or an active player? Autoimmun Rev 12(12):1182–1187. doi:10.1016/j.autrev.2013.08.002CrossRefPubMed Pratesi F, Petit Teixeira E, Sidney J et al (2013) HLA shared epitope and ACPA. Just a marker or an active player? Autoimmun Rev 12(12):1182–1187. doi:10.1016/j.autrev.2013.08.002CrossRefPubMed
71.
Zurück zum Zitat Padyukov L, Seielstad M, Ong RTH et al (2011) A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. Ann Rheum Dis 70(2):259–265. doi:10.1136/ard.2009.126821CrossRefPubMed Padyukov L, Seielstad M, Ong RTH et al (2011) A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. Ann Rheum Dis 70(2):259–265. doi:10.1136/ard.2009.126821CrossRefPubMed
72.
Zurück zum Zitat Laki J, Lundström E, Snir O et al (2012) Very high levels of anti-citrullinated protein antibodies are associated with HLA-DRB1*15 non-shared epitope allele in patients with rheumatoid arthritis. Arthritis Rheum 64(7):2078–2084. doi:10.1002/art.34421CrossRefPubMed Laki J, Lundström E, Snir O et al (2012) Very high levels of anti-citrullinated protein antibodies are associated with HLA-DRB1*15 non-shared epitope allele in patients with rheumatoid arthritis. Arthritis Rheum 64(7):2078–2084. doi:10.1002/art.34421CrossRefPubMed
73.
Zurück zum Zitat Bukhari M, Thomson W, Naseem H, Bunn D, Silman A, Symmons D, Barton A (2007) The performance of anti-cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: results from the Norfolk Arthritis Register. Arthritis Rheum 56(9):2929–2935 Bukhari M, Thomson W, Naseem H, Bunn D, Silman A, Symmons D, Barton A (2007) The performance of anti-cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: results from the Norfolk Arthritis Register. Arthritis Rheum 56(9):2929–2935
74.
Zurück zum Zitat Klareskog L, Catrina AI, Paget S (2009) Rheumatoid arthritis. Lancet 373(9664):659–672. doi:10.1016/S0140-6736(09)60008-8CrossRefPubMed Klareskog L, Catrina AI, Paget S (2009) Rheumatoid arthritis. Lancet 373(9664):659–672. doi:10.1016/S0140-6736(09)60008-8CrossRefPubMed
75.
Zurück zum Zitat Potter C, Gibbons LJ, Bowes JD et al (2010) Polymorphisms spanning the TNFR2 and TACE genes do not contribute towards variable anti-TNF treatment response. Pharmacogenet Genomics 20(5):338–341. doi:10.1097/FPC.0b013e32833878d7CrossRefPubMed Potter C, Gibbons LJ, Bowes JD et al (2010) Polymorphisms spanning the TNFR2 and TACE genes do not contribute towards variable anti-TNF treatment response. Pharmacogenet Genomics 20(5):338–341. doi:10.1097/FPC.0b013e32833878d7CrossRefPubMed
76.
Zurück zum Zitat Viatte S, Plant D, Bowes J et al (2012) Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients. Ann Rheum Dis 71(12):1984–1990. doi:10.1136/annrheumdis-2011-201225CrossRefPubMedPubMedCentral Viatte S, Plant D, Bowes J et al (2012) Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients. Ann Rheum Dis 71(12):1984–1990. doi:10.1136/annrheumdis-2011-201225CrossRefPubMedPubMedCentral
77.
Zurück zum Zitat Symmons DP, Bankhead CR, Harrison BJ, Brennan P, Barrett EM, Scott DG, Silman AJ (1997) Blood transfusion, smoking, and obesity as risk factors for the development of rheumatoid arthritis: results from a primary care-based incident case-control study in Norfolk, England. Arthritis Rheum 40(11):1955–1961 Symmons DP, Bankhead CR, Harrison BJ, Brennan P, Barrett EM, Scott DG, Silman AJ (1997) Blood transfusion, smoking, and obesity as risk factors for the development of rheumatoid arthritis: results from a primary care-based incident case-control study in Norfolk, England. Arthritis Rheum 40(11):1955–1961
78.
Zurück zum Zitat Sugiyama D, Nishimura K, Tamaki K et al (2009) Impact of smoking as a risk factor for developing rheumatoid arthritis. A meta-analysis of observational studies. Ann Rheum Dis 69(01):70–81. doi:10.1136/ard.2008.096487CrossRef Sugiyama D, Nishimura K, Tamaki K et al (2009) Impact of smoking as a risk factor for developing rheumatoid arthritis. A meta-analysis of observational studies. Ann Rheum Dis 69(01):70–81. doi:10.1136/ard.2008.096487CrossRef
79.
Zurück zum Zitat Heliövaara M, Aho K, Aromaa A, Knekt P, Reunanen A (1993) Smoking and risk of rheumatoid arthritis. J Rheumatol 20(11):1830–1835 Heliövaara M, Aho K, Aromaa A, Knekt P, Reunanen A (1993) Smoking and risk of rheumatoid arthritis. J Rheumatol 20(11):1830–1835
80.
Zurück zum Zitat Stolt P, Bengtsson C, Nordmark B, Lindblad S, Lundberg I, Klareskog L, Alfredsson L; EIRA study group (2003) Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases. Ann Rheum Dis 62(9):835–841 Stolt P, Bengtsson C, Nordmark B, Lindblad S, Lundberg I, Klareskog L, Alfredsson L; EIRA study group (2003) Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases. Ann Rheum Dis 62(9):835–841
81.
Zurück zum Zitat Costenbader KH, Feskanich D, Mandl LA, Karlson EW (2006) Smoking intensity, duration, and cessation, and the risk of rheumatoid arthritis in women. Am J Med 119(6):503.e1–503.e9 Costenbader KH, Feskanich D, Mandl LA, Karlson EW (2006) Smoking intensity, duration, and cessation, and the risk of rheumatoid arthritis in women. Am J Med 119(6):503.e1–503.e9
82.
Zurück zum Zitat Pedersen M, Jacobsen S, Klarlund M, Pedersen BV, Wiik A, Wohlfahrt J, Frisch M (2006) Environmental risk factors differ between rheumatoid arthritis with and without auto-antibodies against cyclic citrullinated peptides. Arthritis Res Ther 8(4):R133 Pedersen M, Jacobsen S, Klarlund M, Pedersen BV, Wiik A, Wohlfahrt J, Frisch M (2006) Environmental risk factors differ between rheumatoid arthritis with and without auto-antibodies against cyclic citrullinated peptides. Arthritis Res Ther 8(4):R133
83.
Zurück zum Zitat Di Giuseppe D, Orsini N, Alfredsson L et al (2013) Cigarette smoking and smoking cessation in relation to risk of rheumatoid arthritis in women. Arthritis Res Ther 15(2):R56 doi:10.1186/ar4218CrossRefPubMedPubMedCentral Di Giuseppe D, Orsini N, Alfredsson L et al (2013) Cigarette smoking and smoking cessation in relation to risk of rheumatoid arthritis in women. Arthritis Res Ther 15(2):R56 doi:10.1186/ar4218CrossRefPubMedPubMedCentral
84.
Zurück zum Zitat Di Giuseppe D, Discacciati A, Orsini N et al (2014) Cigarette smoking and risk of rheumatoid arthritis: a dose-response meta-analysis. Arthritis Res Ther 16(2):R61 doi:10.1186/ar4498CrossRefPubMedPubMedCentral Di Giuseppe D, Discacciati A, Orsini N et al (2014) Cigarette smoking and risk of rheumatoid arthritis: a dose-response meta-analysis. Arthritis Res Ther 16(2):R61 doi:10.1186/ar4498CrossRefPubMedPubMedCentral
85.
Zurück zum Zitat Kallberg H, Padyukov L, Plenge RM, Ronnelid J, Gregersen PK, van der Helm-van Mil AH et al (2007) Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. Am J Hum Genet 80(5):867–875 Kallberg H, Padyukov L, Plenge RM, Ronnelid J, Gregersen PK, van der Helm-van Mil AH et al (2007) Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. Am J Hum Genet 80(5):867–875
86.
Zurück zum Zitat Tobón GJ, Youinou P, Saraux A (2010) The environment, geo-epidemiology, and autoimmune disease. Rheumatoid arthritis. J Autoimmun 35(1):10–14. doi:10.1016/j.jaut.2009.12.009CrossRefPubMed Tobón GJ, Youinou P, Saraux A (2010) The environment, geo-epidemiology, and autoimmune disease. Rheumatoid arthritis. J Autoimmun 35(1):10–14. doi:10.1016/j.jaut.2009.12.009CrossRefPubMed
87.
Zurück zum Zitat Karlson EW, Costenbader KH (2010) Epidemiology. Interpreting studies of interactions between RA risk factors. Nat Rev Rheumatol 6(2):72–73. doi:10.1038/nrrheum.2009.276CrossRefPubMed Karlson EW, Costenbader KH (2010) Epidemiology. Interpreting studies of interactions between RA risk factors. Nat Rev Rheumatol 6(2):72–73. doi:10.1038/nrrheum.2009.276CrossRefPubMed
88.
Zurück zum Zitat Shi J, Stadt LA van de, Levarht EWN et al (2014) Anti-carbamylated protein (anti-CarP) antibodies precede the onset of rheumatoid arthritis. Ann Rheum Dis 73(4):780–783. doi:10.1136/annrheumdis-2013-204154CrossRefPubMed Shi J, Stadt LA van de, Levarht EWN et al (2014) Anti-carbamylated protein (anti-CarP) antibodies precede the onset of rheumatoid arthritis. Ann Rheum Dis 73(4):780–783. doi:10.1136/annrheumdis-2013-204154CrossRefPubMed
89.
Zurück zum Zitat Gan RW, Trouw LA, Shi J et al (2015) Anti-carbamylated protein antibodies are present prior to rheumatoid arthritis and are associated with its future diagnosis. J Rheumatol 42(4):572–579. doi:10.3899/jrheum.140767CrossRefPubMedPubMedCentral Gan RW, Trouw LA, Shi J et al (2015) Anti-carbamylated protein antibodies are present prior to rheumatoid arthritis and are associated with its future diagnosis. J Rheumatol 42(4):572–579. doi:10.3899/jrheum.140767CrossRefPubMedPubMedCentral
90.
Zurück zum Zitat Alessandri C, Bartosiewicz I, Pendolino M, Mancini R, Colasanti T, Pecani A et al (2015) Anti-carbamylated protein antibodies in unaffected first-degree relatives of rheumatoid arthritis patients: lack of correlation with anti-cyclic citrullinated protein antibodies and rheumatoid factor. Clin Exp Rheumatol 33(6):824–830 Alessandri C, Bartosiewicz I, Pendolino M, Mancini R, Colasanti T, Pecani A et al (2015) Anti-carbamylated protein antibodies in unaffected first-degree relatives of rheumatoid arthritis patients: lack of correlation with anti-cyclic citrullinated protein antibodies and rheumatoid factor. Clin Exp Rheumatol 33(6):824–830
91.
Zurück zum Zitat Miller WD (1891) The human mouth as a focus of infection. Dent Cosmos 33:689–713 Miller WD (1891) The human mouth as a focus of infection. Dent Cosmos 33:689–713
92.
Zurück zum Zitat Billings F (1916) Focal infection: the lane medical lectures. Appleton and Company, New York. S 1854–1932 Billings F (1916) Focal infection: the lane medical lectures. Appleton and Company, New York. S 1854–1932
93.
Zurück zum Zitat Ogrendik M (2009) Rheumatoid arthritis is linked to oral bacteria. Etiological association. Mod Rheumatol 19(5):453–456. doi:10.1007/s10165-009-0194-9CrossRefPubMed Ogrendik M (2009) Rheumatoid arthritis is linked to oral bacteria. Etiological association. Mod Rheumatol 19(5):453–456. doi:10.1007/s10165-009-0194-9CrossRefPubMed
94.
Zurück zum Zitat Ogrendik M, Karagoz N (2015) Treatment of rheumatoid arthritis with roxithromycin. A randomized trial. Postgrad Med 123(5):220–227. doi:10.3810/pgm.2011.09.2478CrossRef Ogrendik M, Karagoz N (2015) Treatment of rheumatoid arthritis with roxithromycin. A randomized trial. Postgrad Med 123(5):220–227. doi:10.3810/pgm.2011.09.2478CrossRef
95.
Zurück zum Zitat Detert J, Pischon N, Burmester GR et al (2010) The association between rheumatoid arthritis and periodontal disease. Arthritis Res Ther 12(5):218 doi:10.1186/ar3106CrossRefPubMedPubMedCentral Detert J, Pischon N, Burmester GR et al (2010) The association between rheumatoid arthritis and periodontal disease. Arthritis Res Ther 12(5):218 doi:10.1186/ar3106CrossRefPubMedPubMedCentral
96.
Zurück zum Zitat Konig MF, Paracha AS, Moni M et al (2015) Defining the role of porphyromonas gingivalis peptidylarginine deiminase (PPAD) in rheumatoid arthritis through the study of PPAD biology. Ann Rheum Dis 74(11):2054–2061. doi:10.1136/annrheumdis-2014-205385CrossRefPubMed Konig MF, Paracha AS, Moni M et al (2015) Defining the role of porphyromonas gingivalis peptidylarginine deiminase (PPAD) in rheumatoid arthritis through the study of PPAD biology. Ann Rheum Dis 74(11):2054–2061. doi:10.1136/annrheumdis-2014-205385CrossRefPubMed
97.
Zurück zum Zitat Shimada A, Kobayashi T, Ito S et al (2016) Expression of anti- porphyromonas gingivalis peptidylarginine deiminase immunoglobulin G and peptidylarginine deiminase-4 in patients with rheumatoid arthritis and periodontitis. J Periodont Res 51(1):103–111. doi:10.1111/jre.12288CrossRefPubMed Shimada A, Kobayashi T, Ito S et al (2016) Expression of anti- porphyromonas gingivalis peptidylarginine deiminase immunoglobulin G and peptidylarginine deiminase-4 in patients with rheumatoid arthritis and periodontitis. J Periodont Res 51(1):103–111. doi:10.1111/jre.12288CrossRefPubMed
98.
Zurück zum Zitat Heap GA, Heel DA van (2009) The genetics of chronic inflammatory diseases. Hum Mol Genet 18(R1):R101–R106. doi:10.1093/hmg/ddp001CrossRefPubMed Heap GA, Heel DA van (2009) The genetics of chronic inflammatory diseases. Hum Mol Genet 18(R1):R101–R106. doi:10.1093/hmg/ddp001CrossRefPubMed
99.
Zurück zum Zitat Harper AR, Topol EJ (2012) Pharmacogenomics in clinical practice and drug development. Nat Biotechnol 30(11):1117–1124. doi:10.1038/nbt.2424CrossRefPubMed Harper AR, Topol EJ (2012) Pharmacogenomics in clinical practice and drug development. Nat Biotechnol 30(11):1117–1124. doi:10.1038/nbt.2424CrossRefPubMed
100.
Zurück zum Zitat Silverman GJ, Pelzek A (2014) Rheumatoid arthritis clinical benefits from abatacept, cytokine blockers, and rituximab are all linked to modulation of memory B cell responses. J Rheumatol 41(5):825–828. doi:10.3899/jrheum.140022CrossRefPubMedPubMedCentral Silverman GJ, Pelzek A (2014) Rheumatoid arthritis clinical benefits from abatacept, cytokine blockers, and rituximab are all linked to modulation of memory B cell responses. J Rheumatol 41(5):825–828. doi:10.3899/jrheum.140022CrossRefPubMedPubMedCentral
101.
Zurück zum Zitat Berkun Y, Levartovsky D, Rubinow A, Orbach H, Aamar S, Grenader T et al (2004) Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene. Ann Rheum Dis 63(10):1227–1231 Berkun Y, Levartovsky D, Rubinow A, Orbach H, Aamar S, Grenader T et al (2004) Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene. Ann Rheum Dis 63(10):1227–1231
102.
Zurück zum Zitat Dervieux T, Kremer J, Lein DO, Capps R, Barham R, Meyer G et al (2004) Contribution of common polymorphisms in reduced folate carrier and gamma-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis. Pharmacogenetics 14(11):733–739 Dervieux T, Kremer J, Lein DO, Capps R, Barham R, Meyer G et al (2004) Contribution of common polymorphisms in reduced folate carrier and gamma-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis. Pharmacogenetics 14(11):733–739
103.
Zurück zum Zitat Stamp L, Roberts R, Kennedy M, Barclay M, O‘Donnell J, Chapman P (2006) The use of low dose methotrexate in rheumatoid arthritis – are we entering a new era of therapeutic drug monitoring and pharmacogenomics? Biomed Pharmacother 60(10):678–687CrossRefPubMed Stamp L, Roberts R, Kennedy M, Barclay M, O‘Donnell J, Chapman P (2006) The use of low dose methotrexate in rheumatoid arthritis – are we entering a new era of therapeutic drug monitoring and pharmacogenomics? Biomed Pharmacother 60(10):678–687CrossRefPubMed
104.
Zurück zum Zitat Goodman S (2010) Measuring methotrexate polyglutamates. Clin Exp Rheumatol 28(5 Suppl 61):S24–S26 Goodman S (2010) Measuring methotrexate polyglutamates. Clin Exp Rheumatol 28(5 Suppl 61):S24–S26
105.
Zurück zum Zitat Kurkó J, Besenyei T, Laki J et al (2013) Genetics of rheumatoid arthritis – A comprehensive review. Clin Rev Allergy Immunol 45(2):170–179. doi:10.1007/s12016-012-8346-7CrossRefPubMedPubMedCentral Kurkó J, Besenyei T, Laki J et al (2013) Genetics of rheumatoid arthritis – A comprehensive review. Clin Rev Allergy Immunol 45(2):170–179. doi:10.1007/s12016-012-8346-7CrossRefPubMedPubMedCentral
106.
Zurück zum Zitat Salazar J, Moya P, Altés A et al (2014) Polymorphisms in genes involved in the mechanism of action of methotrexate. Are they associated with outcome in rheumatoid arthritis patients? Pharmacogenomics 15(8):1079–1090. doi:10.2217/pgs.14.67CrossRefPubMed Salazar J, Moya P, Altés A et al (2014) Polymorphisms in genes involved in the mechanism of action of methotrexate. Are they associated with outcome in rheumatoid arthritis patients? Pharmacogenomics 15(8):1079–1090. doi:10.2217/pgs.14.67CrossRefPubMed
107.
Zurück zum Zitat Owen SA, Hider SL, Martin P et al (2012) Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients. Pharmacogenomics J 13(3):227–234. doi:10.1038/tpj.2012.7CrossRefPubMed Owen SA, Hider SL, Martin P et al (2012) Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients. Pharmacogenomics J 13(3):227–234. doi:10.1038/tpj.2012.7CrossRefPubMed
108.
Zurück zum Zitat Gurwitz D, Pirmohamed M (2010) Pharmacogenomics: The importance of accurate phenotypes. Pharmacogenomics 11(4):469–470. doi:10.2217/pgs.10.41CrossRefPubMed Gurwitz D, Pirmohamed M (2010) Pharmacogenomics: The importance of accurate phenotypes. Pharmacogenomics 11(4):469–470. doi:10.2217/pgs.10.41CrossRefPubMed
109.
Zurück zum Zitat Crews KR, Hicks JK, Pui C et al (2012) Pharmacogenomics and individualized medicine. Translating science into practice. Clin Pharmacol Ther doi:10.1038/clpt.2012.120 Crews KR, Hicks JK, Pui C et al (2012) Pharmacogenomics and individualized medicine. Translating science into practice. Clin Pharmacol Ther doi:10.1038/clpt.2012.120
110.
Zurück zum Zitat Sing CW, Cheung CL, Wong IC (2015) Pharmacogenomics – how close/far are we to practising individualized medicine for children? Br J Clin Pharmacol 79(3):419–428 Sing CW, Cheung CL, Wong IC (2015) Pharmacogenomics – how close/far are we to practising individualized medicine for children? Br J Clin Pharmacol 79(3):419–428
Metadaten
Titel
„Treat to target“ und personalisierte Medizin („precision medicine“)
verfasst von
Dr. J. Detert, MHBA
G. R. Burmester
Publikationsdatum
30.06.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Zeitschrift für Rheumatologie / Ausgabe 6/2016
Print ISSN: 0340-1855
Elektronische ISSN: 1435-1250
DOI
https://doi.org/10.1007/s00393-016-0137-8

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Standardisierte Outcomeparameter

Leitthema: Meilensteine in der Rheumatologie: 75 Bände Innovation

Molekulare physikalische Medizin bei rheumatischen Krankheitsbildern

Mitteilungen der DRL

Mitteilungen der DRL

Leitthema: Meilensteine in der Rheumatologie: 75 Bände Innovation

Synoviale Fibroblasten

Leitlinien kompakt für die Innere Medizin

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Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Reizdarmsyndrom: Diäten wirksamer als Medikamente

29.04.2024 Reizdarmsyndrom Nachrichten

Bei Reizdarmsyndrom scheinen Diäten, wie etwa die FODMAP-arme oder die kohlenhydratreduzierte Ernährung, effektiver als eine medikamentöse Therapie zu sein. Das hat eine Studie aus Schweden ergeben, die die drei Therapieoptionen im direkten Vergleich analysierte.

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

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