nach oben

Erschienen in:

21.05.2019 | Experimental

Safety of exposure to high static magnetic fields (2 T–12 T): a study on mice

verfasst von: Shenghang Wang, Jie Luo, Huanhuan Lv, Zhihao Zhang, Jiancheng Yang, Dandan Dong, Yanwen Fang, Lijiang Hu, Mengyu Liu, Zhongcai Liao, Jun Li, Zhicai Fang, Yunpeng Wei, Wei Han, Atik Badshah Shaikh, Dachuan Yin, Peng Shang

Erschienen in: European Radiology | Ausgabe 11/2019

Einloggen, um Zugang zu erhalten

Abstract

Objectives

We aimed to evaluate the biological effects of high static magnetic field (HiSMF, 2–12 Tesla [T]) exposure on mice in a stable and effective breeding environment in the chamber of a superconducting magnet.

Methods

C57BL/6 mice were bred in the geomagnetic field and HiSMF with different magnetic field strengths (2–4 T, 6–8 T, and 10–12 T) for 28 days. The body weight, blood indices, organ coefficients, and histomorphology of major organs were analyzed.

Results

The results showed that the HiSMF had no significant effect on the body weight, organ coefficients, or histomorphology of major organs in mice. The HiSMF had no effect on most routine blood and biochemical indices, but the value of the mean corpuscular hemoglobin (MCH) was increased in the 2–4 T group compared with that of the other groups, and the uric acid level (UA) was decreased in the three HiSMF groups compared with that of the control group.

Conclusion

The C57BL/6 mice were not affected when they were exposed to different HiSMF environments for 28 days.

Key Points

• No physiological problems were observed in mice with long-term whole-body exposure to HiSMF.

Stuchly MA (1986) Human exposure to static and time-varying magnetic fields. Health Phys 51(2):215–225CrossRef

Lohmann KJ (2010) Q&A animal behaviour magnetic-field perception. Nature 464(7292):1140–1142CrossRef

Heinrich A, Szostek A, Nees F, Meyer P, Semmler W, Flor H (2011) Effects of static magnetic fields on cognition, vital signs, and sensory perception: a meta-analysis. J Magn Reson Imaging 34(4):758–763CrossRef

Yamaguchi-Sekino S, Sekino M, Ueno S (2011) Biological effects of electromagnetic fields and recently updated safety guidelines for strong static magnetic fields. Magn Reson Med Sci 10(1):1–10CrossRef

Mészáros S, Tabák AG, Horváth C, Szathmári M, László JF (2013) Influence of local exposure to static magnetic field on pain perception and bone turnover of osteoporotic patients with vertebral deformity - a randomized controlled trial. Int J Radiat Biol 89(10):877–885

International Commission on Non-Ionizing Radiation Protection (2009) (2009) Guidelines on limits of exposure to static magnetic fields. Health Phys 96(4):504–514

Chakeres DW, Kangarlu A, Boudoulas H, Young DC (2003) Effect of static magnetic field exposure of up to 8 tesla on sequential human vital sign measurements. J Magn Reson Imaging 18(3):346–352CrossRef

Balchandani P, Naidich TP (2015) Ultra-high-field MR neuroimaging. AJNR Am J Neuroradiol 36(7):1204–1215CrossRef

Eryaman Y, Zhang P, Utecht L et al (2018) Investigating the physiological effects of 10.5 Tesla static field exposure on anesthetized swine. Magn Reson Med 79(1):511–514CrossRef

10.

Nowogrodzki A (2018) The world’s strongest MRI machines are pushing human imaging to new limits. Nature 563(7729):24–26CrossRef

11.

de Vocht F, van-Wendel-de-Joode B, Engels H, Kromhout H (2003) Neurobehavioral effects among subjects exposed to high static and gradient magnetic fields from a 1.5 Tesla magnetic resonance imaging system--a case-crossover pilot study. Magn Reson Med 50(4):670–674CrossRef

12.

Atkinson IC, Renteria L, Burd H, Pliskin NH, Thulborn KR (2007) Safety of human MRI at static fields above the FDA 8 T guideline: sodium imaging at 9.4 T does not affect vital signs or cognitive ability. J Magn Reson Imaging 26(5):1222–1227CrossRef

13.

de Vocht F, Batistatou E, Mölter A et al (2015) Transient health symptoms of MRI staff working with 1.5 and 3.0 Tesla scanners in the UK. Eur Radiol 25(9):2718–2726CrossRef

14.

Lepsien J, Müller K, von Cramon DY, Möller HE (2012) Investigation of higher-order cognitive functions during exposure to a high static magnetic field. J Magn Reson Imaging 36(4):835–840CrossRef

15.

Zilberti L, Bottauscio O, Chiampi M (2016) Assessment of exposure to MRI motion-induced fields based on the international commission on non-ionizing radiation protection (ICNIRP) guidelines. Magn Reson Med 76(4):1291–1300CrossRef

16.

Zahedi Y, Zaun G, Maderwald S et al (2014) Impact of repetitive exposure to strong static magnetic fields on pregnancy and embryonic development of mice. J Magn Reson Imaging 39(3):691–699CrossRef

17.

Antunes A, Glover PM, Li Y, Mian OS, Day BL (2012) Magnetic field effects on the vestibular system: calculation of the pressure on the cupula due to ionic current-induced Lorentz force. Phys Med Biol 57(14):4477–4487CrossRef

18.

High WB, Sikora J, Ugurbil K, Garwood M (2000) Subchronic in vivo effects of a high static magnetic field (9.4 T) in rats. J Magn Reson Imaging 12(1):122–139CrossRef

19.

Yamaguchi-Sekino S, Kira T, Sekino M, Akahane M (2019) Effects of 7 T static magnetic fields on the expression of biological markers and the formation of bone in rats. Bioelectromagnetics 40(1):16–26CrossRef

20.

Freymann J, Tsai PP, Stelzer HD, Mischke R, Hackbarth H (2017) Impact of bedding volume on physiological and behavioural parameters in laboratory mice. Lab Anim 51(6):601–612CrossRef

21.

Djordjevich DM, De Luka SR, Milovanovich ID et al (2012) Hematological parameters’ changes in mice subchronically exposed to static magnetic fields of different orientations. Ecotoxicol Environ Saf 81:98–105CrossRef

22.

Milovanovich ID, Ćirković S, De Luka SR et al (2016) Homogeneous static magnetic field of different orientation induces biological changes in subacutely exposed mice. Environ Sci Pollut Res Int 23(2):1584–1597CrossRef

23.

World Health Organization (2006) Environmental Health Criteria 232 Static fields. Geneva, World Health Organization, Switzerland. Available via https://www.who.int/peh-emf/publications/reports/ehcstatic/en/. Accessed 11 Apr 2019

24.

Naarala J, Kesari KK, McClure I, Chavarriaga C, Juutilainen J, Martino CF (2017) Direction-dependent effects of combined static and ELF magnetic fields on cell proliferation and superoxide radical production. Biomed Res Int 2017:5675086CrossRef

25.

Tian X, Wang D, Zha M et al (2018) Magnetic field direction differentially impacts the growth of different cell types. Electromagn Biol Med 37(2):114–125CrossRef

26.

Kangarlu A, Robitaille PML (2015) Biological effects and health implications in magnetic resonance imaging. Concepts Magn Reson 12(5):321–359CrossRef

27.

Ward BK, Roberts DC, Della Santina CC, Carey JP, Zee DS (2015) Vestibular stimulation by magnetic fields. Ann N Y Acad Sci 1343:69–79CrossRef

28.

de Vocht F, Glover P, Engels H, Kromhout H (2007) Pooled analyses of effects on visual and visuomotor performance from exposure to magnetic stray fields from MRI scanners: application of the Bayesian framework. J Magn Reson Imaging 26(5):1255–1260CrossRef

Titel: Safety of exposure to high static magnetic fields (2 T–12 T): a study on mice
verfasst von: Shenghang Wang
Jie Luo
Huanhuan Lv
Zhihao Zhang
Jiancheng Yang
Dandan Dong
Yanwen Fang
Lijiang Hu
Mengyu Liu
Zhongcai Liao
Jun Li
Zhicai Fang
Yunpeng Wei
Wei Han
Atik Badshah Shaikh
Dachuan Yin
Peng Shang
Publikationsdatum: 21.05.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 11/2019
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-019-06256-y

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Safety of exposure to high static magnetic fields (2 T–12 T): a study on mice