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16.11.2016 | Leitthema

Sentinel node biopsy and lymphatic mapping in penile and prostate cancer

verfasst von: H. G. van der Poel, P. Meershoek, N. Grivas, G. KleinJan, F. W. B. van Leeuwen, S. Horenblas

Erschienen in: Die Urologie | Ausgabe 1/2017

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Abstract

Background

Nodal metastases are linked to poor outcome in men with penile or prostate cancer. Early detection and resection are important for staging and for the prognosis. However, lymphadenectomy is associated with morbidity and may miss metastases when performed solely on the basis of anatomical templates.

Methods

In this article we describe the technique and benefits of sentinel node biopsy (SNB) and provide a review of the literature.

Results

Dynamic sentinel node techniques using both radioactive and optical (hybrid) tracers have been proven effective in penile cancer. For prostate cancer, SNB added to extended nodal dissection may further tailor dissection to the highly variable lymphatic drainage patterns in the pelvis. The sensitivity of SNB was found to be superior to conventional imaging methods; however, false-negative SNB procedures can occur and a complementary extensive lymphadenectomy is required to remove additional positive nodes that were not detected in the SNB template.

Conclusion

SNB is a standard method for early detection of nodal metastases in penile cancer and provides superior diagnostic accuracy to conventional imaging modalities in prostate cancer.

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Titel: Sentinel node biopsy and lymphatic mapping in penile and prostate cancer
verfasst von: H. G. van der Poel
P. Meershoek
N. Grivas
G. KleinJan
F. W. B. van Leeuwen
S. Horenblas
Publikationsdatum: 16.11.2016
Verlag: Springer Medizin
Erschienen in: Die Urologie / Ausgabe 1/2017
Print ISSN: 2731-7064
Elektronische ISSN: 2731-7072
DOI: https://doi.org/10.1007/s00120-016-0270-7

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Springer Medizin

Sentinel node biopsy and lymphatic mapping in penile and prostate cancer

Abstract

Background

Methods

Results

Conclusion

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Background

Methods

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Conclusion

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