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09.10.2017 | Original Article

Shaping somatosensory responses in awake rats: cortical modulation of thalamic neurons

verfasst von: Daichi Hirai, Kouichi C. Nakamura, Ken-ichi Shibata, Takuma Tanaka, Hiroyuki Hioki, Takeshi Kaneko, Takahiro Furuta

Erschienen in: Brain Structure and Function | Ausgabe 2/2018

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Abstract

Massive corticothalamic afferents originating from layer 6a of primary sensory cortical areas modulate sensory responsiveness of thalamocortical neurons and are pivotal for shifting neuronal firing between burst and tonic modes. The influence of the corticothalamic pathways on the firing mode and sensory gain of thalamic neurons has only been extensively examined in anesthetized animals, but has yet to be established in the awake state. We made lesions of the rat barrel cortex and on the following day recorded responses of single thalamocortical and thalamic reticular neurons to a single vibrissal deflection in the somatosensory system during wakefulness. Our results showed that the cortical lesions shifted the response of thalamic neurons towards bursting, elevated the response probability and the gain of thalamocortical neurons, predominantly of recurring responses. In addition, after the lesions, the spontaneous activities of the vibrissa-responsive thalamic neurons, but not those of vibrissa-unresponsive cells, were typified by waxing-and-waning spindle-like rhythmic spiking with frequent bursting. In awake rats with intact cortex, identified layer 6a corticothalamic neurons responded to a single vibrissal deflection with short latencies that matched those of layer 4 neurons, strongly suggesting the existence of an immediate corticothalamic feedback. The present results show the importance of corticothalamic neurons in shaping thalamic activities during wakefulness.

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Titel: Shaping somatosensory responses in awake rats: cortical modulation of thalamic neurons
verfasst von: Daichi Hirai
Kouichi C. Nakamura
Ken-ichi Shibata
Takuma Tanaka
Hiroyuki Hioki
Takeshi Kaneko
Takahiro Furuta
Publikationsdatum: 09.10.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Brain Structure and Function / Ausgabe 2/2018
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-017-1522-z

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