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Annals of Behavioral Medicine
Erschienen in: Annals of Behavioral Medicine 2/2011

01.10.2011 | Original Article

Sleep and Inflammation: Psychoneuroimmunology in the Context of Cardiovascular Disease

verfasst von: Sarosh J. Motivala, Ph.D.

Erschienen in: Annals of Behavioral Medicine | Ausgabe 2/2011

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Abstract

Background

Poor sleep is prospectively linked to all-cause and cardiovascular mortality. Inflammatory processes may be an important biological mechanism linking poor sleep to cardiovascular disease. Such processes involve active participation of signaling molecules called cytokines in development of atherosclerotic plaques.

Purpose

I review evidence from experimental sleep deprivation and clinical observational studies suggesting a bidirectional relationship between sleep and inflammatory cytokines.

Results

Findings from sleep deprivation studies indicate that sleep loss is associated with increases in these cytokines. Similarly, studies in clinical populations with sleep problems, such as primary insomnia patients and those diagnosed with major depression, also show elevations in these same cytokines.

Conclusions

Bidirectional communication between the brain and the immune system is carried out through a complex network of autonomic nerves, endocrine hormones, and cytokines. Disturbed sleep appears to perturb the functioning of this network and therefore contribute to elevations in inflammatory mediators linked to cardiovascular disease.
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Metadaten
Titel
Sleep and Inflammation: Psychoneuroimmunology in the Context of Cardiovascular Disease
verfasst von
Sarosh J. Motivala, Ph.D.
Publikationsdatum
01.10.2011
Verlag
Springer-Verlag
Erschienen in
Annals of Behavioral Medicine / Ausgabe 2/2011
Print ISSN: 0883-6612
Elektronische ISSN: 1532-4796
DOI
https://doi.org/10.1007/s12160-011-9280-2

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