Acta Neuropathologica Communications

Clinical and neuropathological phenotype associated with the novel V189I mutation in the prion protein gene

Giuseppe Di Fede, Marcella Catania, Cristiana Atzori, Fabio Moda, Claudio Pasquali, Antonio Indaco, Marina Grisoli, Marta Zuffi, Maria Cristina Guaita, Roberto Testi, Stefano Taraglio, Maria Sessa, Graziano Gusmaroli, Mariacarmela Spinelli, Giulia Salzano, Giuseppe Legname, Roberto Tarletti, Laura Godi, Maurizio Pocchiari, Fabrizio Tagliavini, Daniele Imperiale, Giorgio Giaccone

A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response

Tong Guo, Dina Dakkak, Teresa Rodriguez-Martin, Wendy Noble, Diane P. Hanger

‘Dusty core disease’ (DuCD): expanding morphological spectrum of RYR1 recessive myopathies

Matteo Garibaldi, John Rendu, Julie Brocard, Emmanuelle Lacene, Julien Fauré, Guy Brochier, Maud Beuvin, Clemence Labasse, Angeline Madelaine, Edoardo Malfatti, Jorge Alfredo Bevilacqua, Fabiana Lubieniecki, Soledad Monges, Ana Lia Taratuto, Jocelyn Laporte, Isabelle Marty, Giovanni Antonini, Norma Beatriz Romero

Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia

Ian F. Harrison, Rozalind Whitaker, Pietro Maria Bertelli, James M. O’Callaghan, Lajos Csincsik, Martina Bocchetta, Da Ma, Alice Fisher, Zeshan Ahmed, Tracey K. Murray, Michael J. O’Neill, Jonathan D. Rohrer, Mark F. Lythgoe, Imre Lengyel

Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration

Nicholas J. Ashton, Antoine Leuzy, Yau Mun Lim, Claire Troakes, Tibor Hortobágyi, Kina Höglund, Dag Aarsland, Simon Lovestone, Michael Schöll, Kaj Blennow, Henrik Zetterberg, Abdul Hye

Low-level blast exposure disrupts gliovascular and neurovascular connections and induces a chronic vascular pathology in rat brain

Miguel A. Gama Sosa, Rita De Gasperi, Georgina S. Perez Garcia, Gissel M. Perez, Courtney Searcy, Danielle Vargas, Alicia Spencer, Pierce L. Janssen, Anna E. Tschiffely, Richard M. McCarron, Benjamin Ache, Rajaram Manoharan, William G. Janssen, Susan J. Tappan, Russell W. Hanson, Sam Gandy, Patrick R. Hof, Stephen T. Ahlers, Gregory A. Elder

ALS-linked FUS mutations confer loss and gain of function in the nucleus by promoting excessive formation of dysfunctional paraspeckles

Haiyan An, Lucy Skelt, Antonietta Notaro, J. Robin Highley, Archa H. Fox, Vincenzo La Bella, Vladimir L. Buchman, Tatyana A. Shelkovnikova

Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia

Rhyomi C. Sellnow, Jordan H. Newman, Nicole Chambers, Anthony R. West, Kathy Steece-Collier, Ivette M. Sandoval, Matthew J. Benskey, Christopher Bishop, Fredric P. Manfredsson

Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth

Olivier Cerles, Tânia Cristina Gonçalves, Sandrine Chouzenoux, Evelyne Benoit, Alain Schmitt, Nathaniel Edward Bennett Saidu, Niloufar Kavian, Christiane Chéreau, Camille Gobeaux, Bernard Weill, Romain Coriat, Carole Nicco, Frédéric Batteux

Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

Yari Carlomagno, Dah-eun Chloe Chung, Mei Yue, Aishe Kurti, Nicole M. Avendano, Monica Castanedes-Casey, Kelly M. Hinkle, Karen Jansen-West, Lillian M. Daughrity, Jimei Tong, Virginia Phillips, Rosa Rademakers, Michael DeTure, John D. Fryer, Dennis W. Dickson, Leonard Petrucelli, Casey Cook

Absence of endothelial α5β1 integrin triggers early onset of experimental autoimmune encephalomyelitis due to reduced vascular remodeling and compromised vascular integrity

Ravi Kant, Sebok K. Halder, Gregory J. Bix, Richard Milner

Apolipoprotein E and clusterin inhibit the early phase of amyloid-β aggregation in an in vitro model of cerebral amyloid angiopathy

Yoshinori Endo, Kazuhiro Hasegawa, Ryo Nomura, Hidetaka Arishima, Ken-ichiro Kikuta, Taro Yamashita, Yasuteru Inoue, Mitsuharu Ueda, Yukio Ando, Mark R. Wilson, Tadanori Hamano, Yasunari Nakamoto, Hironobu Naiki

The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer’s disease

Hermeto Gerber, Sebastien Mosser, Benjamin Boury-Jamot, Michael Stumpe, Alessandra Piersigilli, Christine Goepfert, Joern Dengjel, Urs Albrecht, Fulvio Magara, Patrick C. Fraering

Microglia pre-activation and neurodegeneration precipitate neuroinflammation without exacerbating tissue injury in experimental autoimmune encephalomyelitis

Isabella Wimmer, Cornelia Scharler, Tobias Zrzavy, Taro Kadowaki, Verena Mödlagl, Kim Rojc, Anna R. Tröscher, Maja Kitic, Shuichi Ueda, Monika Bradl, Hans Lassmann

EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke

Anne-Sophie Ernst, Laura-Inés Böhler, Anna M. Hagenston, Angelika Hoffmann, Sabine Heiland, Carsten Sticht, Martin Bendszus, Markus Hecker, Hilmar Bading, Hugo H. Marti, Thomas Korff, Reiner Kunze

White matter capillaries in vascular and neurodegenerative dementias

Yoshiki Hase, Ren Ding, Gina Harrison, Emily Hawthorne, Amilia King, Sean Gettings, Charlotte Platten, William Stevenson, Lucinda J. L. Craggs, Raj N. Kalaria

Endothelial edema precedes blood-brain barrier breakdown in early time points after experimental focal cerebral ischemia

Martin Krueger, Bianca Mages, Constance Hobusch, Dominik Michalski

Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS

Lauren M. Gittings, Sandrine C. Foti, Bridget C. Benson, Priya Gami-Patel, Adrian M. Isaacs, Tammaryn Lashley

Young adult-onset, very slowly progressive cognitive decline with spastic paraparesis in Alzheimer’s disease with cotton wool plaques due to a novel presenilin1 G417S mutation

Tomoko Miki, Osamu Yokota, Takashi Haraguchi, Takeshi Ikeuchi, Bin Zhu, Shintaro Takenoshita, Seishi Terada, Norihito Yamada

Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma

Verena Haage, Marcus Semtner, Ramon Oliveira Vidal, Daniel Perez Hernandez, Winnie W. Pong, Zhihong Chen, Dolores Hambardzumyan, Vincent Magrini, Amy Ly, Jason Walker, Elaine Mardis, Philipp Mertins, Sascha Sauer, Helmut Kettenmann, David H. Gutmann

SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitive impairments

Min Qin, Honglian Li, Jian Bao, Yiyuan Xia, Dan Ke, Qun Wang, Rong Liu, Jian-Zhi Wang, Bin Zhang, Xiji Shu, Xiaochuan Wang

A walk through tau therapeutic strategies

Santosh Jadhav, Jesus Avila, Michael Schöll, Gabor G. Kovacs, Enikö Kövari, Rostislav Skrabana, Lewis D Evans, Eva Kontsekova, Barbara Malawska, Rohan de Silva, Luc Buee, Norbert Zilka

Mural cell-derived laminin-α5 plays a detrimental role in ischemic stroke

Abhijit Nirwane, Jessica Johnson, Benjamin Nguyen, Jeffrey H. Miner, Yao Yao

Methylation array profiling of adult brain tumours: diagnostic outcomes in a large, single centre

Zane Jaunmuktane, David Capper, David T. W. Jones, Daniel Schrimpf, Martin Sill, Monika Dutt, Nirosha Suraweera, Stefan M. Pfister, Andreas von Deimling, Sebastian Brandner

Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer’s disease

Sarmi Sri, Chrysia-Maria Pegasiou, Chantal Abbigail Cave, Katie Hough, Natalie Wood, Diego Gomez-Nicola, Katrin Deinhardt, David Bannerman, V. Hugh Perry, Mariana Vargas-Caballero

Tau as a mediator of neurotoxicity associated to cerebral amyloid angiopathy

Yingjian You, Abigail Perkins, Pablo Cisternas, Braulio Muñoz, Xavier Taylor, Yanwen You, Holly J. Garringer, Adrian L. Oblak, Brady K. Atwood, Ruben Vidal, Cristian A. Lasagna-Reeves

Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology

H. Jürgen Wenzel, Karl D. Murray, Saif N. Haify, Michael R. Hunsaker, Jared J. Schwartzer, Kyoungmi Kim, Albert R. La Spada, Bryce L. Sopher, Paul J. Hagerman, Christopher Raske, Lies-Anne W.F.M. Severijnen, Rob Willemsen, Renate K. Hukema, Robert F. Berman

LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

Michael X. Henderson, Medha Sengupta, Ian McGeary, Bin Zhang, Modupe F. Olufemi, Hannah Brown, John Q. Trojanowski, Virginia M. Y. Lee

Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways

Kyle R. Christensen, Thomas G. Beach, Geidy E. Serrano, Nicholas M. Kanaan

Altered myogenesis and premature senescence underlie human TRIM32-related myopathy

E. Servián-Morilla, M. Cabrera-Serrano, E. Rivas-Infante, A. Carvajal, P. J. Lamont, A. L. Pelayo-Negro, G. Ravenscroft, R. Junckerstorff, J. M. Dyke, S. Fletcher, A. M. Adams, F. Mavillard, M. A. Fernández-García, J. L. Nieto-González, N. G. Laing, C. Paradas

The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?

Yann Fichou, Youssra K. Al-Hilaly, François Devred, Caroline Smet-Nocca, Philipp O. Tsvetkov, Joke Verelst, Joris Winderickx, Nick Geukens, Eugeen Vanmechelen, Audrey Perrotin, Louise Serpell, Bernard J Hanseeuw, Miguel Medina, Luc Buée, Isabelle Landrieu

C9orf72 deficiency promotes motor deficits of a C9ALS/FTD mouse model in a dose-dependent manner

Qiang Shao, Chen Liang, Qing Chang, Wei Zhang, Mei Yang, Jian-Fu Chen

A simplified approach using Taqman low-density array for medulloblastoma subgrouping

Gustavo Alencastro Veiga Cruzeiro, Karina Bezerra Salomão, Carlos Alberto Oliveira de Biagi Jr, Martin Baumgartner, Dominik Sturm, Régia Caroline Peixoto Lira, Taciani de Almeida Magalhães, Mirella Baroni Milan, Vanessa da Silva Silveira, Fabiano Pinto Saggioro, Ricardo Santos de Oliveira, Paulo Henrique dos Santos Klinger, Ana Luiza Seidinger, José Andrés Yunes, Rosane Gomes de Paula Queiroz, Sueli Mieko Oba-Shinjo, Carlos Alberto Scrideli, Suely Marie Kazue Nagahashi, Luiz Gonzaga Tone, Elvis Terci Valera

Detection of Alzheimer’s disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau)

Garrett S. Gibbons, Soo-Jung Kim, John L. Robinson, Lakshmi Changolkar, David J. Irwin, Leslie M. Shaw, Virginia M.-Y. Lee, John Q. Trojanowski

The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity

Patricia Gómez-Suaga, Beatriz G. Pérez-Nievas, Elizabeth B. Glennon, Dawn H. W. Lau, Sebastien Paillusson, Gábor M. Mórotz, Tito Calì, Paola Pizzo, Wendy Noble, Christopher C. J. Miller

Tau exhibits unique seeding properties in globular glial tauopathy

Dah-eun Chloe Chung, Yari Carlomagno, Casey N. Cook, Karen Jansen-West, Lillian Daughrity, Laura J. Lewis-Tuffin, Monica Castanedes-Casey, Michael DeTure, Dennis W. Dickson, Leonard Petrucelli

Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue

Cinthya Aguero, Maeva Dhaynaut, Marc D. Normandin, Ana C. Amaral, Nicolas J. Guehl, Ramesh Neelamegam, Marta Marquie, Keith A. Johnson, Georges El Fakhri, Matthew P. Frosch, Teresa Gomez-Isla

Immunopathological characterization of ovarian teratomas associated with anti-N-methyl-D-aspartate receptor encephalitis

Aude Chefdeville, Isabelle Treilleux, Marie-Eve Mayeur, Coline Couillault, Géraldine Picard, Chloé Bost, Karima Mokhtari, Alexandre Vasiljevic, David Meyronet, Véronique Rogemond, Dimitri Psimaras, Bertrand Dubois, Jérôme Honnorat, Virginie Desestret

HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis

Frederike W. Riemslagh, Hannes Lans, Harro Seelaar, Lies-Anne W. F. M. Severijnen, Shamiram Melhem, Wim Vermeulen, Eleonora Aronica, R. Jeroen Pasterkamp, John C. van Swieten, Rob Willemsen

Postnatal development and maturation of layer 1 in the lateral prefrontal cortex and its disruption in autism

Iris Margalit Trutzer, Miguel Ángel García-Cabezas, Basilis Zikopoulos

Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration

Xinhe Wang, Katelyn Becker, Nathan Levine, Michelle Zhang, Andrew P. Lieberman, Darren J. Moore, Jiyan Ma

Genomic analysis demonstrates that histologically-defined astroblastomas are molecularly heterogeneous and that tumors with MN1 rearrangement exhibit the most favorable prognosis

Norman L. Lehman, Aisulu Usubalieva, Tong Lin, Sariah J. Allen, Quynh T. Tran, Bret C. Mobley, Roger E. McLendon, Matthew J. Schniederjan, Maria-Magdalena Georgescu, Marta Couce, Mohanpal S. Dulai, Jack M. Raisanen, Mousa Al Abbadi, Cheryl A. Palmer, Eyas M. Hattab, Brent A. Orr

Tumor cell-free DNA detection in CSF for primary CNS lymphoma diagnosis

V. Rimelen, G. Ahle, E. Pencreach, N. Zinniger, A. Debliquis, L. Zalmaï, I. Harzallah, R. Hurstel, I. Alamome, F. Lamy, J. Voirin, B. Drénou

Assembly of transgenic human P301S Tau is necessary for neurodegeneration in murine spinal cord

Jennifer A. Macdonald, Iraad F. Bronner, Lesley Drynan, Juan Fan, Annabelle Curry, Graham Fraser, Isabelle Lavenir, Michel Goedert

Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis

Jeremy A. Garson, Louise Usher, Ammar Al-Chalabi, Jim Huggett, Edmund F. Day, Adele L. McCormick

Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice

Benoît Souchet, Mickael Audrain, Jean Marie Billard, Julien Dairou, Romain Fol, Nicola Salvatore Orefice, Satoru Tada, Yuchen Gu, Gaelle Dufayet-Chaffaud, Emmanuelle Limanton, François Carreaux, Jean-Pierre Bazureau, Sandro Alves, Laurent Meijer, Nathalie Janel, Jérôme Braudeau, Nathalie Cartier

Clinicopathological features of the rare form of Creutzfeldt-Jakob disease in R208H-V129V PRNP carrier

Dorina Tiple, Anna Poleggi, Vittorio Mellina, Antonino Morocutti, Livia Brusa, Cesare Iani, Elisa Colaizzo, Luana Vaianella, Simone Baiardi, Anna Ladogana, Piero Parchi, Maurizio Pocchiari

Microglia are not required for prion-induced retinal photoreceptor degeneration

James F. Striebel, Brent Race, Katie Williams, James A. Carroll, Mikael Klingeborn, Bruce Chesebro

Tau and TDP-43 accumulation of the basal nucleus of Meynert in individuals with cerebral lobar infarcts or hemorrhage

Hiroyuki Hatsuta, Masaki Takao, Akane Nogami, Akiko Uchino, Hiroyuki Sumikura, Tadayuki Takata, Satoru Morimoto, Kazutomi Kanemaru, Tadashi Adachi, Tomio Arai, Masato Hasegawa, Shigeo Murayama

Transcriptomopathies of pre- and post-symptomatic frontotemporal dementia-like mice with TDP-43 depletion in forebrain neurons

Lien-Szu Wu, Wei-Cheng Cheng, Chia-Ying Chen, Ming-Che Wu, Yi-Chi Wang, Yu-Hsiang Tseng, Trees-Juen Chuang, C.-K. James Shen

AQP4ex is crucial for the anchoring of AQP4 at the astrocyte end-feet and for neuromyelitis optica antibody binding

Claudia Palazzo, Cinzia Buccoliero, Maria Grazia Mola, Pasqua Abbrescia, Grazia Paola Nicchia, Maria Trojano, Antonio Frigeri

Downregulation of miR-204 expression defines a highly aggressive subset of Group 3/Group 4 medulloblastomas

Harish Shrikrishna Bharambe, Raikamal Paul, Pooja Panwalkar, Rakesh Jalali, Epari Sridhar, Tejpal Gupta, Aliasgar Moiyadi, Prakash Shetty, Sadaf Kazi, Akash Deogharkar, Shalaka Masurkar, Kedar Yogi, Ratika Kunder, Nikhil Gadewal, Atul Goel, Naina Goel, Girish Chinnaswamy, Vijay Ramaswamy, Neelam Vishwanath Shirsat

The characterization of AD/PART co-pathology in CJD suggests independent pathogenic mechanisms and no cross-seeding between misfolded Aβ and prion proteins

Marcello Rossi, Hideaki Kai, Simone Baiardi, Anna Bartoletti-Stella, Benedetta Carlà, Corrado Zenesini, Sabina Capellari, Tetsuyuki Kitamoto, Piero Parchi

Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure

Joshua J. Sanchez, Jacob E. Sanchez, Shahani Noor, Chaselyn D. Ruffaner-Hanson, Suzy Davies, Carston R. Wagner, Lauren L. Jantzie, Nikolaos Mellios, Daniel D. Savage, Erin D. Milligan

Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis

Terje Sundstrøm, Lars Prestegarden, Francisco Azuaje, Synnøve Nymark Aasen, Gro Vatne Røsland, Jobin K. Varughese, Marzieh Bahador, Simon Bernatz, Yannick Braun, Patrick N. Harter, Kai Ove Skaftnesmo, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah Tam, Clifford G. Tepper, Kjell Petersen, Katherine W. Ferrara, Karl Johan Tronstad, Morten Lund-Johansen, Rudi Beschorner, Rolf Bjerkvig, Frits Thorsen

Neurodegeneration and contralateral α-synuclein induction after intracerebral α-synuclein injections in the anterior olfactory nucleus of a Parkinson’s disease A53T mouse model

Alicia Flores-Cuadrado, Daniel Saiz-Sanchez, Alicia Mohedano-Moriano, Alino Martinez-Marcos, Isabel Ubeda-Bañon

Divergence in the activity of the N- and C- catalytic domains of ACE1 - implications for the role of the renin-angiotensin system in Alzheimer’s disease

Noura S. AL Mulhim, Patrick G. Kehoe, J. Scott Miners

RETRACTED ARTICLE: Unique RNA signature of different lesion types in the brain white matter in progressive multiple sclerosis

Maria L. Elkjaer, Tobias Frisch, Richard Reynolds, Tim Kacprowski, Mark Burton, Torben A. Kruse, Mads Thomassen, Jan Baumbach, Zsolt Illes

DNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development

H. Binder, E. Willscher, H. Loeffler-Wirth, L. Hopp, D. T. W. Jones, S. M. Pfister, M. Kreuz, D. Gramatzki, E. Fortenbacher, B. Hentschel, M. Tatagiba, U. Herrlinger, H. Vatter, J. Matschke, M. Westphal, D. Krex, G. Schackert, J. C. Tonn, U. Schlegel, H.-J. Steiger, W. Wick, R. G. Weber, M. Weller, M. Loeffler

Transcriptome analysis of normal-appearing white matter reveals cortisol- and disease-associated gene expression profiles in multiple sclerosis

Jeroen Melief, Marie Orre, Koen Bossers, Corbert G. van Eden, Karianne G. Schuurman, Matthew R. J. Mason, Joost Verhaagen, Jörg Hamann, Inge Huitinga

Hippocampal CA2 Lewy pathology is associated with cholinergic degeneration in Parkinson’s disease with cognitive decline

Alan King Lun Liu, Tsz Wing Chau, Ernest Junwei Lim, Idil Ahmed, Raymond Chuen-Chung Chang, Michail E. Kalaitzakis, Manuel B. Graeber, Steve M. Gentleman, Ronald K. B. Pearce

eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS

Lindsey D. Goodman, Mercedes Prudencio, Ananth R. Srinivasan, Olivia M. Rifai, Virginia M.-Y. Lee, Leonard Petrucelli, Nancy M. Bonini

Coexisting FGFR3 p.K650T mutation in two FGFR3-TACC3 fusion glioma cases

Leomar Y. Ballester, Soheil Zorofchian Moghadamtousi, Norman E. Leeds, Jason T. Huse, Gregory N. Fuller

Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models

Naiara Martinez-Velez, Miguel Marigil, Marc García-Moure, Marisol Gonzalez-Huarriz, Jose Javier Aristu, Luis-Isaac Ramos-García, Sonia Tejada, Ricardo Díez-Valle, Ana Patiño-García, Oren J. Becher, Candelaria Gomez-Manzano, Juan Fueyo, Marta M. Alonso

Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies

Amit Berson, Lindsey D. Goodman, Ashley N. Sartoris, Charlton G. Otte, James A. Aykit, Virginia M.-Y. Lee, John Q. Trojanowski, Nancy M. Bonini

PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma

Shota Tanaka, Tracy T. Batchelor, A. John Iafrate, Dora Dias-Santagata, Darrell R. Borger, Leif W. Ellisen, Daniel Yang, David N. Louis, Daniel P. Cahill, Andrew S. Chi

Transcriptome signatures associated with meningioma progression

Angela N. Viaene, Bo Zhang, Maria Martinez-Lage, Chaomei Xiang, Umberto Tosi, Jayesh P. Thawani, Busra Gungor, Yuankun Zhu, Laura Roccograndi, Logan Zhang, Robert L. Bailey, Phillip B. Storm, Donald M. O’Rourke, Adam C. Resnick, M. Sean Grady, Nadia Dahmane

Parkinson’s disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes

Jee Hoon Lee, Ji-hye Han, Hyunmi Kim, Sang Myun Park, Eun-hye Joe, Ilo Jou

Histologic, immunohistochemical, and molecular features of pituicytomas and atypical pituicytomas

Angela N. Viaene, Edward B. Lee, Jason N. Rosenbaum, Ilya M. Nasrallah, MacLean P. Nasrallah

Iatrogenic early onset cerebral amyloid angiopathy 30 years after cerebral trauma with neurosurgery: vascular amyloid deposits are made up of both Aβ40 and Aβ42

Giorgio Giaccone, Emanuela Maderna, Gianluca Marucci, Marcella Catania, Alessandra Erbetta, Luisa Chiapparini, Antonio Indaco, Paola Caroppo, Anna Bersano, Eugenio Parati, Giuseppe Di Fede, Luigi Caputi

How to demix Alzheimer-type and PSP-type tau lesions out of their mixture -hybrid approach to dissect comorbidity-

Momoko Ebashi, Yoshinori Ito, Miho Uematsu, Ayako Nakamura, Katsuiku Hirokawa, Satoshi Kamei, Toshiki Uchihara

Cerebrospinal fluid from Alzheimer’s disease patients promotes tau aggregation in transgenic mice

Zhiva Skachokova, Alfonso Martinisi, Martin Flach, Frederik Sprenger, Yvonne Naegelin, Viviane Steiner-Monard, Marc Sollberger, Andreas U. Monsch, Michel Goedert, Markus Tolnay, David T. Winkler

LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains

Gábor M. Mórotz, Elizabeth B. Glennon, Patricia Gomez-Suaga, Dawn H. W. Lau, Eleanor D. Robinson, Éva Sedlák, Alessio Vagnoni, Wendy Noble, Christopher C. J. Miller

Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer’s disease by remodeling peri-plaque astrocyte structure

Alex J. Smith, Tianjiao Duan, Alan S. Verkman

Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease

J. Qi, D. R. Esfahani, T. Huang, P. Ozark, E. Bartom, R. Hashizume, E. R. Bonner, S. An, C. M. Horbinski, C. D. James, A. M. Saratsis

Identification of patient-derived glioblastoma stem cell (GSC) lines with the alternative lengthening of telomeres phenotype

Ahsan Farooqi, Jie Yang, Vladislav Sharin, Ravesanker Ezhilarasan, Carla Danussi, Christian Alvarez, Sharvari Dharmaiah, David Irvin, Jason Huse, Erik P. Sulman

Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease

Niraj M. Shanbhag, Mark D. Evans, Wenjie Mao, Alissa L. Nana, William W. Seeley, Anthony Adame, Robert A. Rissman, Eliezer Masliah, Lennart Mucke

H3F3A-G34R mutant high grade neuroepithelial neoplasms with glial and dysplastic ganglion cell components

Felipe Andreiuolo, Tomo Lisner, Jozef Zlocha, Christof Kramm, Arend Koch, Brigitte Bison, Albane Gareton, Marc Zanello, Andreas Waha, Pascale Varlet, Torsten Pietsch

Endogenous mouse huntingtin is highly abundant in cranial nerve nuclei, co-aggregates to Abeta plaques and is induced in reactive astrocytes in a transgenic mouse model of Alzheimer’s disease

Maike Hartlage-Rübsamen, Veronika Ratz, Ulrike Zeitschel, Lukas Finzel, Lisa Machner, Janett Köppen, Anja Schulze, Hans-Ulrich Demuth, Stephan von Hörsten, Corinna Höfling, Steffen Roßner

Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils

Jess-Karan S. Dhillon, Jorge A. Trejo-Lopez, Cara Riffe, Yona Levites, Amanda N. Sacino, David R. Borchelt, Anthony Y. Yachnis, Benoit I. Giasson

Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein

Zuzana Krejciova, George A. Carlson, Kurt Giles, Stanley B. Prusiner

APOE genotype and sex affect microglial interactions with plaques in Alzheimer’s disease mice

T. L. Stephen, M. Cacciottolo, D. Balu, T. E. Morgan, M. J. LaDu, C. E. Finch, C. J. Pike

Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia

Kristin Hartmann, Diego Sepulveda-Falla, Indigo V. L. Rose, Charlotte Madore, Christiane Muth, Jakob Matschke, Oleg Butovsky, Shane Liddelow, Markus Glatzel, Susanne Krasemann

Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson’s disease

Vanessa Donega, Saskia M. Burm, Miriam E. van Strien, Emma J. van Bodegraven, Iryna Paliukhovich, Hanneke Geut, Wilma D. J. van de Berg, Ka Wan Li, August B. Smit, Onur Basak, Elly M. Hol

Integrative analysis of DNA methylation suggests down-regulation of oncogenic pathways and reduced somatic mutation rates in survival outliers of glioblastoma

Taeyoung Hwang, Dimitrios Mathios, Kerrie L. McDonald, Irene Daris, Sung-Hye Park, Peter C. Burger, Sojin Kim, Yun-Sik Dho, Hruban Carolyn, Chetan Bettegowda, Joo Heon Shin, Michael Lim, Chul-Kee Park

Gerstmann-Sträussler-Scheinker disease revisited: accumulation of covalently-linked multimers of internal prion protein fragments

Laura Cracco, Xiangzhu Xiao, Satish K. Nemani, Jody Lavrich, Ignazio Cali, Bernardino Ghetti, Silvio Notari, Witold K. Surewicz, Pierluigi Gambetti

c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism

Ashirwad Merve, Xinyu Zhang, Nicola Pomella, Serena Acquati, Joerg D. Hoeck, Anaelle Dumas, Gabriel Rosser, Yichen Li, Jennie Jeyapalan, Silvia Vicenzi, Qianhai Fan, Zeng Jie Yang, Arianna Sabò, Denise Sheer, Axel Behrens, Silvia Marino

In vivo real-time dynamics of ATP and ROS production in axonal mitochondria show decoupling in mouse models of peripheral neuropathies

Gerben van Hameren, Graham Campbell, Marie Deck, Jade Berthelot, Benoit Gautier, Patrice Quintana, Roman Chrast, Nicolas Tricaud

An integrative radiological, histopathological and molecular analysis of pediatric pontine histone-wildtype glioma with MYCN amplification (HGG-MYCN)

A. Tauziède-Espariat, M-A Debily, D. Castel, J. Grill, S. Puget, M. Sabel, K. Blomgren, A. Gareton, V. Dangouloff-Ros, E. Lechapt, N. Boddaert, P. Varlet

Distribution differences in prognostic copy number alteration profiles in IDH-wild-type glioblastoma cause survival discrepancies across cohorts

Toru Umehara, Hideyuki Arita, Ema Yoshioka, Tomoko Shofuda, Daisuke Kanematsu, Manabu Kinoshita, Yoshinori Kodama, Masayuki Mano, Naoki Kagawa, Yasunori Fujimoto, Yoshiko Okita, Masahiro Nonaka, Kosuke Nakajo, Takehiro Uda, Naohiro Tsuyuguchi, Junya Fukai, Koji Fujita, Daisuke Sakamoto, Kanji Mori, Haruhiko Kishima, Yonehiro Kanemura

Intrathecal delivery of recombinant AAV1 encoding hepatocyte growth factor improves motor functions and protects neuromuscular system in the nerve crush and SOD1-G93A transgenic mouse models

Sang Hwan Lee, Subin Kim, Nayeon Lee, Junghun Lee, Seung Shin Yu, Jin Hong Kim, Sunyoung Kim

High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity

Marlies Verschuuren, Peter Verstraelen, Gerardo García-Díaz Barriga, Ines Cilissen, Emma Coninx, Mieke Verslegers, Peter H. Larsen, Rony Nuydens, Winnok H. De Vos

Predictive MGMT status in a homogeneous cohort of IDH wildtype glioblastoma patients

Josefine Radke, Arend Koch, Fabienne Pritsch, Elisa Schumann, Martin Misch, Claudia Hempt, Klaus Lenz, Franziska Löbel, Fabienne Paschereit, Frank L. Heppner, Peter Vajkoczy, Randi Koll, Julia Onken

Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids

Bradley R. Groveman, Simote T. Foliaki, Christina D. Orru, Gianluigi Zanusso, James A. Carroll, Brent Race, Cathryn L. Haigh

Resistance and resilience to Alzheimer’s disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort

Caitlin S. Latimer, Bridget T. Burke, Nicole F. Liachko, Heather N. Currey, Mitchell D. Kilgore, Laura E. Gibbons, Jonathan Henriksen, Martin Darvas, Kimiko Domoto-Reilly, Suman Jayadev, Tom J. Grabowski, Paul K. Crane, Eric B. Larson, Brian C. Kraemer, Thomas D. Bird, C. Dirk Keene

Total copy number variation as a prognostic factor in adult astrocytoma subtypes

Kanish Mirchia, Adwait Amod Sathe, Jamie M. Walker, Yelena Fudym, Kristyn Galbraith, Mariano S. Viapiano, Robert J. Corona, Matija Snuderl, Chao Xing, Kimmo J. Hatanpaa, Timothy E. Richardson

Chronic traumatic encephalopathy in two former Australian National Rugby League players

Michael E. Buckland, Joanne Sy, Istvan Szentmariay, Alexandra Kullen, Maggie Lee, Antony Harding, Glenda Halliday, Catherine M. Suter

Neutrophil extracellular trap induced by HMGB1 exacerbates damages in the ischemic brain

Seung-Woo Kim, Hahnbie Lee, Hye-Kyung Lee, Il-Doo Kim, Ja-Kyeong Lee

Alzheimer’s disease neuropathological change and loss of matrix/neuropil in patients with idiopathic Normal Pressure Hydrocephalus, a model of Alzheimer’s disease

Sylwia Libard, Irina Alafuzoff

C-terminal and full length TDP-43 specie differ according to FTLD-TDP lesion type but not genetic mutation

Keith A. Josephs, Yong-Jie Zhang, Matthew Baker, Rosa Rademakers, Leonard Petrucelli, Dennis W. Dickson

Technical considerations in detection of HERV-K in amyotrophic lateral sclerosis: selection of controls and the perils of qPCR

Marta Garcia-Montojo, Wenxue Li, Avindra Nath

Response to the Letter from Garcia-Montojo and colleagues concerning our paper entitled, Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis

Jeremy A. Garson, Louise Usher, Ammar Al-Chalabi, Jim Huggett, Edmund F. Day, Adele L. McCormick

Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia

Laurence Renaud, Vincent Picher-Martel, Philippe Codron, Jean-Pierre Julien

Alzheimer’s disease frequency peaks in the tenth decade and is lower afterwards

Jose M. Farfel, Lei Yu, Patricia A. Boyle, Sue Leurgans, Raj C. Shah, Julie A. Schneider, David A. Bennett

COX2 expression is associated with proliferation and tumor extension in vestibular schwannoma but is not influenced by acetylsalicylic acid intake

Felix Behling, Vanessa Ries, Marco Skardelly, Irina Gepfner-Tuma, Martin Schuhmann, Florian-Heinrich Ebner, Ghazaleh Tabatabai, Antje Bornemann, Jens Schittenhelm, Marcos Tatagiba

Loss of USP18 in microglia induces white matter pathology

Marius Schwabenland, Omar Mossad, Adam G. Peres, Franziska Kessler, Feres Jose Mocayar Maron, Laura-Adela Harsan, Thomas Bienert, Dominik von Elverfeldt, Klaus-Peter Knobeloch, Ori Staszewski, Frank L. Heppner, Marije E. C. Meuwissen, Grazia M. S. Mancini, Marco Prinz, Thomas Blank

Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model

Elisabeth Rossaert, Eveliina Pollari, Tom Jaspers, Lawrence Van Helleputte, Matthew Jarpe, Philip Van Damme, Katrien De Bock, Matthieu Moisse, Ludo Van Den Bosch

Nanomedicine-driven neuropathic pain relief in a rat model is associated with macrophage polarity and mast cell activation

Muzamil Saleem, Brooke Deal, Emily Nehl, Jelena M. Janjic, John A. Pollock

Intersection of pathological tau and microglia at the synapse

Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádka

An unusual recurrent high-grade glioneuronal tumor with MAP2K1 mutation and CDKN2A/B homozygous deletion

Barry Cheaney II, Stephen Bowden, Katie Krause, Emily A. Sloan, Arie Perry, David A. Solomon, Seunggu Jude Han, Matthew D. Wood

A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington’s disease patients

Peng Liu, Benjamin R. Smith, Eric S. Huang, Abhishek Mahesh, Jean Paul G. Vonsattel, Ashley J. Petersen, Rocio Gomez-Pastor, Karen H. Ashe

Complement-independent bystander injury in AQP4-IgG seropositive neuromyelitis optica produced by antibody-dependent cellular cytotoxicity

Tianjiao Duan, Alex J. Smith, Alan S. Verkman

Understanding the pathogenesis of multiple system atrophy: state of the art and future perspectives

Giacomo Monzio Compagnoni, Alessio Di Fonzo

Reduction of ephrin-A5 aggravates disease progression in amyotrophic lateral sclerosis

Laura Rué, Patrick Oeckl, Mieke Timmers, Annette Lenaerts, Jasmijn van der Vos, Silke Smolders, Lindsay Poppe, Antina de Boer, Ludo Van Den Bosch, Philip Van Damme, Jochen H. Weishaupt, Albert C. Ludolph, Markus Otto, Wim Robberecht, Robin Lemmens

C9orf72 intermediate expansions of 24–30 repeats are associated with ALS

Alfredo Iacoangeli, Ahmad Al Khleifat, Ashley R. Jones, William Sproviero, Aleksey Shatunov, Sarah Opie-Martin, Karen E. Morrison, Pamela J. Shaw, Christopher E. Shaw, Isabella Fogh, Richard J. Dobson, Stephen J. Newhouse, Ammar Al-Chalabi

Retinal pathology in experimental optic neuritis is characterized by retrograde degeneration and gliosis

Praveena Manogaran, Marijana Samardzija, Anaïs Nura Schad, Carla Andrea Wicki, Christine Walker-Egger, Markus Rudin, Christian Grimm, Sven Schippling

Cross-examining candidate genes implicated in multiple system atrophy

Jared S. Katzeff, Katherine Phan, Sivaraman Purushothuman, Glenda M. Halliday, Woojin Scott Kim

Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1−Akt signaling pathway

Kohei Nishino, Seiji Watanabe, Jin Shijie, Yuri Murata, Kotaro Oiwa, Okiru Komine, Fumito Endo, Hitomi Tsuiji, Manabu Abe, Kenji Sakimura, Amit Mishra, Koji Yamanaka

Dramatic response of BRAF V600E-mutant epithelioid glioblastoma to combination therapy with BRAF and MEK inhibitor: establishment and xenograft of a cell line to predict clinical efficacy

Yu Kanemaru, Manabu Natsumeda, Masayasu Okada, Rie Saito, Daiki Kobayashi, Takeyoshi Eda, Jun Watanabe, Shoji Saito, Yoshihiro Tsukamoto, Makoto Oishi, Hirotake Saito, Masayuki Nagahashi, Takahiro Sasaki, Rintaro Hashizume, Hidefumi Aoyama, Toshifumi Wakai, Akiyoshi Kakita, Yukihiko Fujii

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression

Suman De, Daniel R. Whiten, Francesco S. Ruggeri, Craig Hughes, Margarida Rodrigues, Dimitrios I. Sideris, Christopher G. Taylor, Francesco A. Aprile, Serge Muyldermans, Tuomas P. J. Knowles, Michele Vendruscolo, Clare Bryant, Kaj Blennow, Ingmar Skoog, Silke Kern, Henrik Zetterberg, David Klenerman

Establishing a prognostic threshold for total copy number variation within adult IDH-mutant grade II/III astrocytomas

Kanish Mirchia, Matija Snuderl, Kristyn Galbraith, Kimmo J. Hatanpaa, Jamie M. Walker, Timothy E. Richardson

Correction to: Chronic traumatic encephalopathy in two former Australian National Rugby League players

Michael E. Buckland, Joanne Sy, Istvan Szentmariay, Alexandra Kullen, Maggie Lee, Antony Harding, Glenda Halliday, Catherine M. Suter

Phase I and phase II sonidegib and vismodegib clinical trials for the treatment of paediatric and adult MB patients: a systemic review and meta-analysis

Yuchen Li, Qingkun Song, Bryan W. Day

A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease

Benjamin R. Smith, Kathryn M. Nelson, Lisa J. Kemper, Kailee Leinonen-Wright, Ashley Petersen, C. Dirk Keene, Karen H. Ashe

Glial pathology and retinal neurotoxicity in the anterior visual pathway in experimental autoimmune encephalomyelitis

Jing Jin, Matthew D. Smith, Calvin J. Kersbergen, Tae-In Kam, Mayuri Viswanathan, Kyle Martin, Ted M. Dawson, Valina L. Dawson, Donald J. Zack, Katharine Whartenby, Peter A. Calabresi

Encephalopathy induced by Alzheimer brain inoculation in a non-human primate

Charlotte Gary, Suzanne Lam, Anne-Sophie Hérard, James E. Koch, Fanny Petit, Pauline Gipchtein, Stephen J. Sawiak, Raphaëlle Caillierez, Sabiha Eddarkaoui, Morvane Colin, Fabienne Aujard, Jean-Philippe Deslys, Charles Duyckaerts, Véronique Sazdovitch, Sabrina Leclère-Turbant, Marie-Claire Artaud-Botté, Anne Vital, Françoise Chapon, Jean-Louis Kemeny, Claude-Alain Maurage, Vincent Deramecourt, David Meyronet, Nathalie Streichenberger, André Maues de Paula, Valérie Rigau, Fanny Vandenbos-Burel, Danielle Seilhean, Serge Milin, Dan Christian Chiforeanu, Annie Laquerrière, Béatrice Lannes, Marie-Bernadette Delisle, Emmanuelle Uro-Coste, Emmanuel Brouillet, Luc Buée, Emmanuel E. Comoy, Fabien Pifferi, Jean-Luc Picq, Marc Dhenain

Correction to: Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia

Ian F. Harrison, Rozalind Whitaker, Pietro Maria Bertelli, James M. O’Callaghan, Lajos Csincsik, Jack A. Wells, Martina Bocchetta, Da Ma, Alice Fisher, Zeshan Ahmed, Tracey K. Murray, Michael J. O’Neill, Jonathan D. Rohrer, Mark F. Lythgoe, Imre Lengyel

TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAFV600E/TERT promoter double-mutated glioma

Lisa Gabler, Daniela Lötsch, Dominik Kirchhofer, Sushilla van Schoonhoven, Hannah M. Schmidt, Lisa Mayr, Christine Pirker, Katharina Neumayer, Carina Dinhof, Lucia Kastler, Amedeo A. Azizi, Christian Dorfer, Thomas Czech, Christine Haberler, Andreas Peyrl, Rajiv Kumar, Irene Slavc, Sabine Spiegl-Kreinecker, Johannes Gojo, Walter Berger

Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans

Petronela Weisová, Ondrej Cehlár, Rostislav Škrabana, Monika Žilková, Peter Filipčík, Branislav Kováčech, Michal Prčina, Ľubica Wojčiaková, Ľubica Fialová, Tomáš Smolek, Eva Kontseková, Norbert Žilka, Michal Novák

The landscape of myeloid and astrocyte phenotypes in acute multiple sclerosis lesions

Calvin Park, Gerald Ponath, Maya Levine-Ritterman, Edward Bull, Eric C. Swanson, Philip L. De Jager, Benjamin M. Segal, David Pitt

Publisher Correction to: Acta Neuropathologica Communications, volume 7

Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations

Janne Koskimäki, Dongdong Zhang, Yan Li, Laleh Saadat, Thomas Moore, Rhonda Lightle, Sean P. Polster, Julián Carrión-Penagos, Seán B. Lyne, Hussein A. Zeineddine, Changbin Shi, Robert Shenkar, Sharbel Romanos, Kenneth Avner, Abhinav Srinath, Le Shen, Matthew R. Detter, Daniel Snellings, Ying Cao, Miguel A. Lopez-Ramirez, Gregory Fonseca, Alan T. Tang, Pieter Faber, Jorge Andrade, Mark Ginsberg, Mark L. Kahn, Douglas A. Marchuk, Romuald Girard, Issam A. Awad

Response of the neurovascular unit to brain metastatic breast cancer cells

János Haskó, Csilla Fazakas, Kinga Molnár, Ádám Mészáros, Roland Patai, Gábor Szabó, Ferenc Erdélyi, Ádám Nyúl-Tóth, Fanni Győri, Mihály Kozma, Attila E. Farkas, István A. Krizbai, Imola Wilhelm

Retinal ischemia induces α-SMA-mediated capillary pericyte contraction coincident with perivascular glycogen depletion

Luis Alarcon-Martinez, Sinem Yilmaz-Ozcan, Muge Yemisci, Jesse Schallek, Kıvılcım Kılıç, Deborah Villafranca-Baughman, Alp Can, Adriana Di Polo, Turgay Dalkara

Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation

Eric Y. Hayden, Jennifer Putman, Stefanie Nunez, Woo Shik Shin, Mandavi Oberoi, Malena Charreton, Suman Dutta, Zizheng Li, Yutaro Komuro, Mary Teena Joy, Gal Bitan, Allan MacKenzie-Graham, Lin Jiang, Jason D. Hinman

Retraction Note: Unique RNA signature of different lesion types in the brain white matter in progressive multiple sclerosis

Maria L. Elkjaer, Tobias Frisch, Richard Reynolds, Tim Kacprowski, Mark Burton, Torben A. Kruse, Mads Thomassen, Jan Baumbach, Zsolt Illes

Downregulation of Nodal inhibits metastatic progression in retinoblastoma

Laura Asnaghi, David T. White, Lynn Yoon, Antoinette Price, Grace Y. Lee, Arpan Sahoo, Jeff S. Mumm, Charles G. Eberhart

Clinical, histological, and genetic characterization of PYROXD1-related myopathy

Xavière Lornage, Vanessa Schartner, Inès Balbueno, Valérie Biancalana, Tracey Willis, Andoni Echaniz-Laguna, Sophie Scheidecker, Ros Quinlivan, Michel Fardeau, Edoardo Malfatti, Béatrice Lannes, Caroline Sewry, Norma B. Romero, Jocelyn Laporte, Johann Böhm

Telomere alterations in neurofibromatosis type 1-associated solid tumors

Fausto J. Rodriguez, Mindy K. Graham, Jacqueline A. Brosnan-Cashman, John R. Barber, Christine Davis, M. Adelita Vizcaino, Doreen N. Palsgrove, Caterina Giannini, Melike Pekmezci, Sonika Dahiya, Murat Gokden, Michael Noë, Laura D. Wood, Christine A. Pratilas, Carol D. Morris, Allan Belzberg, Jaishri Blakeley, Christopher M. Heaphy

Intraventricular meningiomas frequently harbor NF2 mutations but lack common genetic alterations in TRAF7, AKT1, SMO, KLF4, PIK3CA, and TERT

Gerhard Jungwirth, Rolf Warta, Christopher Beynon, Felix Sahm, Andreas von Deimling, Andreas Unterberg, Christel Herold-Mende, Christine Jungk

Aβ43 in human Alzheimer’s disease: effects of active Aβ42 immunization

Lieke Jäkel, Delphine Boche, James A. R. Nicoll, Marcel M. Verbeek

Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression

Zachary A. Sorrentino, Marshall S. Goodwin, Cara J. Riffe, Jess-Karan S. Dhillon, Yuxing Xia, Kimberly-Marie Gorion, Niran Vijayaraghavan, Karen N. McFarland, Lawrence I. Golbe, Anthony T. Yachnis, Benoit I. Giasson

Composition of the Intranuclear Inclusions of Fragile X-associated Tremor/Ataxia Syndrome

Lisa Ma, Anthony W. Herren, Glenda Espinal, Jamie Randol, Bridget McLaughlin, Veronica Martinez-Cerdeño, Isaac N. Pessah, Randi J. Hagerman, Paul J. Hagerman

Optimization of ultrastructural preservation of human brain for transmission electron microscopy after long post-mortem intervals

Mariella Sele, Stefan Wernitznig, Saška Lipovšek, Snježana Radulović, Johannes Haybaeck, Anna Maria Birkl-Toeglhofer, Christina Wodlej, Florian Kleinegger, Stephan Sygulla, Marlene Leoni, Stefan Ropele, Gerd Leitinger

Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination

Fiona Tea, Joseph A. Lopez, Sudarshini Ramanathan, Vera Merheb, Fiona X. Z. Lee, Alicia Zou, Deepti Pilli, Ellis Patrick, Anneke van der Walt, Mastura Monif, Esther M. Tantsis, Eppie M. Yiu, Steve Vucic, Andrew P. D. Henderson, Anthony Fok, Clare L. Fraser, Jeanette Lechner-Scott, Stephen W. Reddel, Simon Broadley, Michael H. Barnett, David A. Brown, Jan D. Lunemann, Russell C. Dale, Fabienne Brilot, Adriane Sinclair, Allan G. Kermode, Andrew Kornberg, Annie Bye, Benjamin McGettigan, Benjamin Trewin, Bruce Brew, Bruce Taylor, Chris Bundell, Christina Miteff, Christopher Troedson, Clair Pridmore, Claire Spooner, Con Yiannikas, Cullen O’Gorman, Damian Clark, Dan Suan, Dean Jones, Dean Kilfoyle, Deepak Gill, Denis Wakefield, Dirk Hofmann, Emily Mathey, Gina O’Grady, Hannah F. Jones, Heidi Beadnall, Helmut Butzkueven, Himanshu Joshi, Ian Andrews, Ian Sutton, Jennifer MacIntyre, Jennifer M. Sandbach, Jeremy Freeman, John King, John H. O’Neill, John Parratt, Joshua Barton, Justin Garber, Kate Ahmad, Kate Riney, Katherine Buzzard, Kavitha Kothur, Laurence C. Cantrill, Manoj P. Menezes, Mark A. Paine, Mark Marriot, Mahtab Ghadiri, Michael Boggild, Mitchell Lawlor, Monica Badve, Monique Ryan, Muhammed Aaqib, Neil Shuey, Nerissa Jordan, Nicholas Urriola, Nicholas Lawn, Owen White, Pamela McCombe, Rakesh Patel, Richard Leventer, Richard Webster, Robert Smith, Sachin Gupta, Shekeeb S. Mohammad, Sekhar Pillai, Simon Hawke, Sumu Simon, Sophie Calvert, Stefan Blum, Stephen Malone, Suzanne Hodgkinson, Tina K. Nguyen, Todd A. Hardy, Tomas Kalincik, Tyson Ware, Victor S. C. Fung, William Huynh

Perfusion fixation in brain banking: a systematic review

Whitney C. McFadden, Hadley Walsh, Felix Richter, Céline Soudant, Clare H. Bryce, Patrick R. Hof, Mary Fowkes, John F. Crary, Andrew T. McKenzie

The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability

Viviana Pérez, Francisca Bermedo-Garcia, Diego Zelada, Felipe A. Court, Miguel Ángel Pérez, Marco Fuenzalida, Johanna Ábrigo, Claudio Cabello-Verrugio, Guillermo Moya-Alvarado, Juan Carlos Tapia, Vicente Valenzuela, Claudio Hetz, Francisca C. Bronfman, Juan Pablo Henríquez

Silver staining (Campbell-Switzer) of neuronal α-synuclein assemblies induced by multiple system atrophy and Parkinson’s disease brain extracts in transgenic mice

Isabelle Lavenir, Daniela Passarella, Masami Masuda-Suzukake, Annabelle Curry, Janice L. Holton, Bernardino Ghetti, Michel Goedert

Epigenetic downregulation of STAT6 increases HIF-1α expression via mTOR/S6K/S6, leading to enhanced hypoxic viability of glioma cells

Soo Jung Park, Hyunmi Kim, Se Hyuk Kim, Eun-hye Joe, Ilo Jou

Extensive transcriptomic study emphasizes importance of vesicular transport in C9orf72 expansion carriers

Dennis W. Dickson, Matthew C. Baker, Jazmyne L. Jackson, Mariely DeJesus-Hernandez, NiCole A. Finch, Shulan Tian, Michael G. Heckman, Cyril Pottier, Tania F. Gendron, Melissa E. Murray, Yingxue Ren, Joseph S. Reddy, Neill R. Graff-Radford, Bradley F. Boeve, Ronald C. Petersen, David S. Knopman, Keith A. Josephs, Leonard Petrucelli, Björn Oskarsson, John W. Sheppard, Yan W. Asmann, Rosa Rademakers, Marka van Blitterswijk

Profiling the unique protective properties of intracranial arterial endothelial cells

Dorien M. A. Hermkens, Olga C. G. Stam, Nienke M. de Wit, Ruud D. Fontijn, Aldo Jongejan, Perry D. Moerland, Claire Mackaaij, Ingeborg S. E. Waas, Mat J. A. P. Daemen, Helga E. de Vries

Neuropathology of RAN translation proteins in fragile X-associated tremor/ataxia syndrome

Amy Krans, Geena Skariah, Yuan Zhang, Bryana Bayly, Peter K. Todd

Plasminogen Activator Inhibitor-1 (PAI-1) deficiency predisposes to depression and resistance to treatments

Hélène Party, Cléo Dujarrier, Marie Hébert, Sophie Lenoir, Sara Martinez de Lizarrondo, Raphaël Delépée, Claudine Fauchon, Marie-Christine Bouton, Pauline Obiang, Olivier Godefroy, Etienne Save, Laurent Lecardeur, Joëlle Chabry, Denis Vivien, Véronique Agin

Muscle regulates mTOR dependent axonal local translation in motor neurons via CTRP3 secretion: implications for a neuromuscular disorder, spinal muscular atrophy

Wiebke A. Rehorst, Maximilian P. Thelen, Hendrik Nolte, Clara Türk, Sebahattin Cirak, Jonathan M. Peterson, G. William Wong, Brunhilde Wirth, Marcus Krüger, Dominic Winter, Min Jeong Kye

Capture at the single cell level of metabolic modules distinguishing aggressive and indolent glioblastoma cells

Mirca S. Saurty-Seerunghen, Léa Bellenger, Elias A. El-Habr, Virgile Delaunay, Delphine Garnier, Hervé Chneiweiss, Christophe Antoniewski, Ghislaine Morvan-Dubois, Marie-Pierre Junier

The prognostic role of IDH mutations in homogeneously treated patients with anaplastic astrocytomas and glioblastomas

Arne Christians, Antonia Adel-Horowski, Rouzbeh Banan, Ulrich Lehmann, Stephan Bartels, Felix Behling, Alonso Barrantes-Freer, Christine Stadelmann, Veit Rohde, Florian Stockhammer, Christian Hartmann

Correction to: Retinal pathology in experimental optic neuritis is characterized by retrograde degeneration and gliosis

Praveena Manogaran, Marijana Samardzija, Anaïs Nura Schad, Carla Andrea Wicki, Christine Walker-Egger, Markus Rudin, Christian Grimm, Sven Schippling

Fragile X-associated tremor ataxia syndrome with co-occurrent progressive supranuclear palsy-like neuropathology

Amanda N. Sacino, Stefan Prokop, Meggen A. Walsh, Jennifer Adamson, S. H. Subramony, Amy Krans, Peter K. Todd, Benoit I. Giasson, Anthony T. Yachnis

Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants

Li-Chun Lin, Alissa L. Nana, Mackenzie Hepker, Ji-Hye Lee Hwang, Stephanie E. Gaus, Salvatore Spina, Celica G. Cosme, Li Gan, Lea T. Grinberg, Daniel H. Geschwind, Giovanni Coppola, Howard J. Rosen, Bruce L. Miller, William W. Seeley

Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an α-synuclein based rat model for Parkinson’s disease

Teresa Torre-Muruzabal, Jens Devoght, Chris Van den Haute, Bert Brône, Anke Van der Perren, Veerle Baekelandt

Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels

Shangxi Xiao, Paul M. McKeever, Agnes Lau, Janice Robertson

Dynein activating adaptor BICD2 controls radial migration of upper-layer cortical neurons in vivo

Lena Will, Sybren Portegies, Jasper van Schelt, Merel van Luyk, Dick Jaarsma, Casper C. Hoogenraad

Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities

Annekathrin Reinhardt, Damian Stichel, Daniel Schrimpf, Christian Koelsche, Annika K. Wefers, Azadeh Ebrahimi, Philipp Sievers, Kristin Huang, M. Belén Casalini, Francisco Fernández-Klett, Abigail Suwala, Michael Weller, Dorothee Gramatzki, Joerg Felsberg, Guido Reifenberger, Albert Becker, Volkmar H. Hans, Marco Prinz, Ori Staszewski, Till Acker, Hildegard Dohmen, Christian Hartmann, Werner Paulus, Katharina Heß, Benjamin Brokinkel, Jens Schittenhelm, Rolf Buslei, Martina Deckert, Christian Mawrin, Ekkehard Hewer, Ute Pohl, Zane Jaunmuktane, Sebastian Brandner, Andreas Unterberg, Daniel Hänggi, Michael Platten, Stefan M. Pfister, Wolfgang Wick, Christel Herold-Mende, Andrey Korshunov, David E. Reuss, Felix Sahm, David T. W. Jones, David Capper, Andreas von Deimling

[18F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series

Marta Marquié, Cinthya Agüero, Ana C. Amaral, Alberto Villarejo-Galende, Prianca Ramanan, Michael Siao Tick Chong, Nil Sáez-Calveras, Rachel E. Bennett, Eline E. Verwer, Sally Ji Who Kim, Maeva Dhaynaut, Victor E. Alvarez, Keith A. Johnson, Ann C. McKee, Matthew P. Frosch, Teresa Gómez-Isla

Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions

Fumiaki Mori, Mari Tada, Tomoya Kon, Yasuo Miki, Kunikazu Tanji, Hidekachi Kurotaki, Masahiko Tomiyama, Tomohiko Ishihara, Osamu Onodera, Akiyoshi Kakita, Koichi Wakabayashi

Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss

Matthew A. White, Ziqiang Lin, Eugene Kim, Christopher M. Henstridge, Emiliano Pena Altamira, Camille K. Hunt, Ella Burchill, Isobel Callaghan, Andrea Loreto, Heledd Brown-Wright, Richard Mead, Camilla Simmons, Diana Cash, Michael P. Coleman, Jemeen Sreedharan

Deep morphological analysis of muscle biopsies from type III glycogenesis (GSDIII), debranching enzyme deficiency, revealed stereotyped vacuolar myopathy and autophagy impairment

Pascal Laforêt, Michio Inoue, Evelyne Goillot, Claire Lefeuvre, Umut Cagin, Nathalie Streichenberger, Sarah Leonard-Louis, Guy Brochier, Angeline Madelaine, Clemence Labasse, Carola Hedberg-Oldfors, Thomas Krag, Louisa Jauze, Julien Fabregue, Philippe Labrune, Jose Milisenda, Aleksandra Nadaj-Pakleza, Sabrina Sacconi, Federico Mingozzi, Giuseppe Ronzitti, François Petit, Benedikt Schoser, Anders Oldfors, John Vissing, Norma B. Romero, Ichizo Nishino, Edoardo Malfatti

BRAF V600E mutation in Juvenile Xanthogranuloma family neoplasms of the central nervous system (CNS-JXG): a revised diagnostic algorithm to include pediatric Erdheim-Chester disease

J. Picarsic, T. Pysher, H. Zhou, M. Fluchel, T. Pettit, M. Whitehead, L. F. Surrey, B. Harding, G. Goldstein, Y. Fellig, M. Weintraub, B. C. Mobley, P. M. Sharples, M. L. Sulis, E. L. Diamond, R. Jaffe, K. Shekdar, M. Santi

Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer’s disease

Christopher D. Whelan, Niklas Mattsson, Michael W. Nagle, Swetha Vijayaraghavan, Craig Hyde, Shorena Janelidze, Erik Stomrud, Julie Lee, Lori Fitz, Tarek A. Samad, Gayathri Ramaswamy, Richard A. Margolin, Anders Malarstig, Oskar Hansson

Synergistic toxicity in an in vivo model of neurodegeneration through the co-expression of human TDP-43M337V and tauT175D protein

Alexander J. Moszczynski, Madeline Harvey, Niveen Fulcher, Cleusa de Oliveira, Patrick McCunn, Neil Donison, Robert Bartha, Susanne Schmid, Michael J. Strong, Kathryn Volkening

In vivo detection of tau fibrils and amyloid β aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy

Maria Calvo-Rodriguez, Steven S. Hou, Austin C. Snyder, Simon Dujardin, Hamid Shirani, K. Peter R. Nilsson, Brian J. Bacskai

Chemokines modulate the tumour microenvironment in pituitary neuroendocrine tumours

Pedro Marques, Sayka Barry, Eivind Carlsen, David Collier, Amy Ronaldson, Sherine Awad, Neil Dorward, Joan Grieve, Nigel Mendoza, Samiul Muquit, Ashley B. Grossman, Frances Balkwill, Márta Korbonits

Region-specific interneuron demyelination and heightened anxiety-like behavior induced by adolescent binge alcohol treatment

James Rice, Laurence Coutellier, Jeffrey L. Weiner, Chen Gu

Microglial motility in Alzheimer’s disease and after Aβ42 immunotherapy: a human post-mortem study

Diana K. Franco-Bocanegra, Bethany George, Laurie C. Lau, Clive Holmes, James A. R. Nicoll, Delphine Boche

The level of activity of the alternative lengthening of telomeres correlates with patient age in IDH-mutant ATRX-loss-of-expression anaplastic astrocytomas

Nathalie Grandin, Bruno Pereira, Camille Cohen, Pauline Billard, Caroline Dehais, Catherine Carpentier, Ahmed Idbaih, Franck Bielle, François Ducray, Dominique Figarella-Branger, Jean-Yves Delattre, Marc Sanson, Patrick Lomonte, Delphine Poncet, Pierre Verrelle, Michel Charbonneau, C. Desenclos, H. Sevestre, P. Menei, A. Rousseau, T. Cruel, S. Lopez, M-I Mihai, A. Petit, C. Adam, F. Parker, P. Dam-Hieu, I. Quintin-Roué, S. Eimer, H. Loiseau, L. Bekaert, F. Chapon, D. Ricard, C. Godfraind, T. Khalil, D. Cazals-Hatem, T. Faillot, C. Gaultier, M. C. Tortel, I. Carpiuc, P. Richard, W. Lahiani, H. Aubriot-Lorton, F. Ghiringhelli, C. A. Maurage, C. Ramirez, E. M. Gueye, F. Labrousse, O. Chinot, L. Bauchet, V. Rigau, P. Beauchesne, G. Gauchotte, M. Campone, D. Loussouarn, D. Fontaine, F. Vandenbos-Burel, A. Le Floch, P. Roger, C. Blechet, M. Fesneau, A. Carpentier, J. Y. Delattre, S. Elouadhani-Hamdi, M. Polivka, D. Larrieu-Ciron, S. Milin, P. Colin, M. D. Diebold, D. Chiforeanu, E. Vauleon, O. Langlois, A. Laquerriere, F. Forest, M. J. Motso-Fotso, M. Andraud, G. Runavot, B. Lhermitte, G. Noel, S. Gaillard, C. Villa, N. Desse, C. Rousselot-Denis, I. Zemmoura, E. Cohen-Moyal, E. Uro-Coste, F. Dhermain

Pediatric methylation class HGNET-MN1: unresolved issues with terminology and grading

Arnault Tauziède-Espariat, Mélanie Pagès, Alexandre Roux, Aurore Siegfried, Emmanuelle Uro-Coste, Yvan Nicaise, Annick Sevely, Marion Gambart, Sergio Boetto, Martin Dupuy, Pomone Richard, Romain Perbet, Matthieu Vinchon, Sabine Caron, Felipe Andreiuolo, Albane Gareton, Emmanuèle Lechapt, Fabrice Chrétien, Stéphanie Puget, Jacques Grill, Nathalie Boddaert, Pascale Varlet

N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain

Kerstin Schlegel, Khader Awwad, Roland G. Heym, David Holzinger, Annika Doell, Stefan Barghorn, Thomas R. Jahn, Corinna Klein, Yulia Mordashova, Michael Schulz, Laura Gasparini

Different aspects of Alzheimer’s disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia

Dietmar Rudolf Thal, Alicja Ronisz, Thomas Tousseyn, Ajeet Rijal Upadhaya, Karthikeyan Balakrishnan, Rik Vandenberghe, Mathieu Vandenbulcke, Christine A. F. von Arnim, Markus Otto, Thomas G. Beach, Johan Lilja, Kerstin Heurling, Aruna Chakrabarty, Azzam Ismail, Christopher Buckley, Adrian P. L. Smith, Sathish Kumar, Gill Farrar, Jochen Walter

Correction to: c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism

Ashirwad Merve, Xinyu Zhang, Nicola Pomella, Serena Acquati, Joerg D. Hoeck, Anaelle Dumas, Gabriel Rosser, Yichen Li, Jennie Jeyapalan, Silvia Vicenzi, Qianhai Fan, Zeng Jie Yang, Arianna Sabò, Denise Sheer, Axel Behrens, Silvia Marino

Increased soluble amyloid-beta causes early aberrant brain network hypersynchronisation in a mature-onset mouse model of amyloidosis

Inès R. H. Ben-Nejma, Aneta J. Keliris, Jasmijn Daans, Peter Ponsaerts, Marleen Verhoye, Annemie Van der Linden, Georgios A. Keliris

Improved risk-stratification for posterior fossa ependymoma of childhood considering clinical, histological and genetic features – a retrospective analysis of the HIT ependymoma trial cohort

Stephanie T. Jünger, Martin Mynarek, Inken Wohlers, Evelyn Dörner, Anja zur Mühlen, Natalia Velez-Char, Katja von Hoff, Stefan Rutkowski, Monika Warmuth-Metz, Rolf-Dieter Kortmann, Beate Timmermann, Sven Rahmann, Ludger Klein-Hitpass, Andre O. von Bueren, Torsten Pietsch

DNA repair deficiency and senescence in concussed professional athletes involved in contact sports

Nicole Schwab, Karl Grenier, Lili-Naz Hazrati

Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease

Michael X. Henderson, Medha Sengupta, John Q. Trojanowski, Virginia M. Y. Lee

Exosome release and neuropathology induced by α-synuclein: new insights into protective mechanisms of Drp1 inhibition

Rebecca Z. Fan, Min Guo, Shouqing Luo, Mei Cui, Kim Tieu

Mapping actionable pathways and mutations in brain tumours using targeted RNA next generation sequencing

Krissie Lenting, Corina N. A. M. van den Heuvel, Anne van Ewijk, Duaa ElMelik, Remco de Boer, Elizabeth Tindall, Ge Wei, Benno Kusters, Maarten te Dorsthorst, Mark ter Laan, Martijn A. Huynen, William P. Leenders

Attenuation of neuroinflammation reverses Adriamycin-induced cognitive impairments

Barrett D. Allen, Lauren A. Apodaca, Amber R. Syage, Mineh Markarian, Al Anoud D. Baddour, Harutyun Minasyan, Leila Alikhani, Celine Lu, Brian L. West, Erich Giedzinski, Janet E. Baulch, Munjal M. Acharya

Blood brain barrier leakage is not a consistent feature of white matter lesions in CADASIL

Rikesh M. Rajani, Julien Ratelade, Valérie Domenga-Denier, Yoshiki Hase, Hannu Kalimo, Raj N. Kalaria, Anne Joutel

An AARS variant as the likely cause of Swedish type hereditary diffuse leukoencephalopathy with spheroids

Christina Sundal, Susana Carmona, Maria Yhr, Odd Almström, Maria Ljungberg, John Hardy, Carola Hedberg-Oldfors, Åsa Fred, José Brás, Anders Oldfors, Oluf Andersen, Rita Guerreiro

Circadian sleep/wake-associated cells show dipeptide repeat protein aggregates in C9orf72-related ALS and FTLD cases

Lieselot Dedeene, Evelien Van Schoor, Rik Vandenberghe, Philip Van Damme, Koen Poesen, Dietmar Rudolf Thal

Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer’s disease related pathology

Amit U. Joshi, Lauren D. Van Wassenhove, Kelsey R. Logas, Paras S. Minhas, Katrin I. Andreasson, Kenneth I. Weinberg, Che-Hong Chen, Daria Mochly-Rosen

Mosaic PTEN alteration in the neural crest during embryogenesis results in multiple nervous system hamartomas

Alice Goldenberg, Florent Marguet, Vianney Gilard, Aude-Marie Cardine, Adnan Hassani, François Doz, Sophie Radi, Stéphanie Vasseur, Jacqueline Bou, Maud Branchaud, Claude Houdayer, Stéphanie Baert-Desurmont, Annie Laquerriere, Thierry Frebourg

A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer’s disease brain

Ebru Ercan-Herbst, Jens Ehrig, David C. Schöndorf, Annika Behrendt, Bernd Klaus, Borja Gomez Ramos, Nuria Prat Oriol, Christian Weber, Dagmar E. Ehrnhoefer

Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson’s disease and multiple system atrophy

Therése Klingstedt, Bernardino Ghetti, Janice L. Holton, Helen Ling, K. Peter R. Nilsson, Michel Goedert

The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer’s disease

Tunahan Kirabali, Serena Rigotti, Alessandro Siccoli, Filip Liebsch, Adeola Shobo, Christoph Hock, Roger M. Nitsch, Gerhard Multhaup, Luka Kulic

Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer’s disease and not in other tauopathies

Geoffrey Pires, Sacha McElligott, Shiron Drusinsky, Glenda Halliday, Marie-Claude Potier, Thomas Wisniewski, Eleanor Drummond

KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients

Lisa Hinz, Joan Torrella Barrufet, Vivi M. Heine

A metastable subproteome underlies inclusion formation in muscle proteinopathies

Prajwal Ciryam, Matthew Antalek, Fernando Cid, Gian Gaetano Tartaglia, Christopher M. Dobson, Anne-Katrin Guettsches, Britta Eggers, Matthias Vorgerd, Katrin Marcus, Rudolf A. Kley, Richard I. Morimoto, Michele Vendruscolo, Conrad C. Weihl

Epidemiological pathology of Aβ deposition in the ageing brain in CFAS: addition of multiple Aβ-derived measures does not improve dementia assessment using logistic regression and machine learning approaches

S. B. Wharton, D. Wang, C. Parikh, F. E. Matthews, C. Brayne, P. G. Ince

The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration

Melanie Schoof, Michael Launspach, Dörthe Holdhof, Lynhda Nguyen, Verena Engel, Severin Filser, Finn Peters, Jana Immenschuh, Malte Hellwig, Judith Niesen, Volker Mall, Birgit Ertl-Wagner, Christian Hagel, Michael Spohn, Beat Lutz, Jan Sedlacik, Daniela Indenbirken, Daniel J. Merk, Ulrich Schüller

Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer’s disease and regulates axonal transport and processing of the amyloid precursor protein

Gábor M. Mórotz, Elizabeth B. Glennon, Jenny Greig, Dawn H. W. Lau, Nishita Bhembre, Francesca Mattedi, Nadine Muschalik, Wendy Noble, Alessio Vagnoni, Christopher C. J. Miller

Single-nucleus chromatin accessibility reveals intratumoral epigenetic heterogeneity in IDH1 mutant gliomas

Ruslan Al-Ali, Katharina Bauer, Jong-Whi Park, Ruba Al Abdulla, Valentina Fermi, Andreas von Deimling, Christel Herold-Mende, Jan-Philipp Mallm, Carl Herrmann, Wolfgang Wick, Şevin Turcan

Tau- but not Aß -pathology enhances NMDAR-dependent depotentiation in AD-mouse models

Enrico Faldini, Tariq Ahmed, Luc Bueé, David Blum, Detlef Balschun

Immune landscapes associated with different glioblastoma molecular subtypes

Maria Martinez-Lage, Timothy M. Lynch, Yingtao Bi, Carolina Cocito, Gregory P. Way, Sharmistha Pal, Josephine Haller, Rachel E. Yan, Amy Ziober, Aivi Nguyen, Manoj Kandpal, Donald M. O’Rourke, Jeffrey P. Greenfield, Casey S. Greene, Ramana V. Davuluri, Nadia Dahmane

Magnetic resonance imaging brain atrophy assessment in primary age-related tauopathy (PART)

Miguel Quintas-Neves, Merilee A. Teylan, Lilah Besser, João Soares-Fernandes, Charles N. Mock, Walter A. Kukull, John F. Crary, Tiago Gil Oliveira

Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis

Maria L. Elkjaer, Tobias Frisch, Richard Reynolds, Tim Kacprowski, Mark Burton, Torben A. Kruse, Mads Thomassen, Jan Baumbach, Zsolt Illes

Regulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment

Thecla A. van Wageningen, Eva Vlaar, Gijs Kooij, Cornelis A. M. Jongenelen, Jeroen J. G. Geurts, Anne-Marie van Dam

Tau pathology in the medial temporal lobe of athletes with chronic traumatic encephalopathy: a chronic effects of neurotrauma consortium study

Christy M. Kelley, Sylvia E. Perez, Elliott J. Mufson

Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene

Margarita Chumarina, Kaspar Russ, Carla Azevedo, Andreas Heuer, Maria Pihl, Anna Collin, Eleonor Åsander Frostner, Eskil Elmer, Poul Hyttel, Graziella Cappelletti, Michela Zini, Stefano Goldwurm, Laurent Roybon

Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain

Javier Morón-Oset, Tessa Supèr, Jacqueline Esser, Adrian M. Isaacs, Sebastian Grönke, Linda Partridge

Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice

Libin Zhou, Joseph Flores, Anastasia Noël, Olivier Beauchet, P. Jesper Sjöström, Andrea C. LeBlanc

Bi-allelic mutations in uncoordinated mutant number-45 myosin chaperone B are a cause for congenital myopathy

Hormos Salimi Dafsari, Nur Mehpare Kocaturk, Hülya-Sevcan Daimagüler, Anna Brunn, Jörg Dötsch, Joachim Weis, Martina Deckert, Sebahattin Cirak

Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential

Katja Thümmler, Eran Rom, Thomas Zeis, Maren Lindner, Sarah Brunner, John J. Cole, Diana Arseni, Steve Mücklisch, Julia M. Edgar, Nicole Schaeren-Wiemers, Avner Yayon, Christopher Linington

Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates

Sara Elfarrash, Nanna Møller Jensen, Nelson Ferreira, Cristine Betzer, Jervis Vermal Thevathasan, Robin Diekmann, Mohamed Adel, Nisreen Mansour Omar, Mohamed Z. Boraie, Sabry Gad, Jonas Ries, Deniz Kirik, Sadegh Nabavi, Poul Henning Jensen

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Raphael Hesse, Maica Llavero Hurtado, Rosemary J. Jackson, Samantha L. Eaton, Abigail G. Herrmann, Marti Colom-Cadena, Makis Tzioras, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher M. Henstridge, Douglas Lamont, Thomas M. Wishart, Tara L. Spires-Jones

Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer’s disease and aged brains: increased levels correlate with neuropathology

Anarmaa Mendsaikhan, Ikuo Tooyama, Jean-Pierre Bellier, Geidy E. Serrano, Lucia I. Sue, Lih-Fen Lue, Thomas G. Beach, Douglas G. Walker

Triiodothyronine modulates neuronal plasticity mechanisms to enhance functional outcome after stroke

Daniela Talhada, Joana Feiteiro, Ana Raquel Costa, Tiago Talhada, Elisa Cairrão, Tadeusz Wieloch, Elisabet Englund, Cecília Reis Santos, Isabel Gonçalves, Karsten Ruscher

Sleep deprivation of rats increases postsurgical expression and activity of L-type calcium channel in the dorsal root ganglion and slows recovery from postsurgical pain

Qi Li, Zi-yu Zhu, Jian Lu, Yu-Chieh Chao, Xiao-xin Zhou, Ying Huang, Xue-mei Chen, Dian-san Su, Wei-feng Yu, Xi-yao Gu

Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations

Andrew E. Arrant, Jonathan R. Roth, Nicholas R. Boyle, Shreya N. Kashyap, Madelyn Q. Hoffmann, Charles F. Murchison, Eliana Marisa Ramos, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Erik D. Roberson

Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing

Diego Perez-Rodriguez, Maria Kalyva, Melissa Leija-Salazar, Tammaryn Lashley, Maxime Tarabichi, Viorica Chelban, Steve Gentleman, Lucia Schottlaender, Hannah Franklin, George Vasmatzis, Henry Houlden, Anthony H. V. Schapira, Thomas T. Warner, Janice L. Holton, Zane Jaunmuktane, Christos Proukakis

Brain tumor with an ATXN1-NUTM1 fusion gene expands the histologic spectrum of NUTM1-rearranged neoplasia

Aurore Siegfried, Julien Masliah-Planchon, Franck-Emmanuel Roux, Delphine Larrieu-Ciron, Gaelle Pierron, Yvan Nicaise, Marion Gambart, Isabelle Catalaa, Sarah Péricart, Charlotte Dubucs, Badreddine Mohand-Oumoussa, Franck Tirode, Franck Bourdeaut, Emmanuelle Uro-Coste

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

Nolwen L. Rey, Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki, Patrik Brundin

Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis

Gemma Gomez-Giro, Jonathan Arias-Fuenzalida, Javier Jarazo, Dagmar Zeuschner, Muhammad Ali, Nina Possemis, Silvia Bolognin, Rashi Halder, Christian Jäger, Willemijn F. E. Kuper, Peter M. van Hasselt, Holm Zaehres, Antonio del Sol, Herman van der Putten, Hans R. Schöler, Jens C. Schwamborn