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Erschienen in: Medizinische Klinik - Intensivmedizin und Notfallmedizin 5/2017

29.05.2017 | ECMO | Leitthema

Extrakorporale Verfahren zur Lungenunterstützung

verfasst von: S. Braune, A. Sieweke, D. Jarczak, Prof. Dr. S. Kluge

Erschienen in: Medizinische Klinik - Intensivmedizin und Notfallmedizin | Ausgabe 5/2017

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Zusammenfassung

Verfahren zur extrakorporalen Lungenunterstützung haben in den letzten Jahren eine rapide technologische Weiterentwicklung mit Verbesserung von Effektivität und Sicherheit erfahren. Trotz der derzeit noch sehr begrenzten wissenschaftlichen Evidenz kommen diese Systeme in der Intensivmedizin zunehmend zur Therapie unterschiedlicher Arten akuter respiratorischer Insuffizienzen zum Einsatz. Die Systeme lassen sich in Verfahren zur extrakorporalen Kohlendioxid (CO2-)Eliminierung (ECCO2R) bei ventilatorischer Insuffizienz und Verfahren zur extrakorporalen Membranoxygenierung (ECMO) bei schwerer hypoxämischer Insuffizienz unterteilen. Trotz der technologischen Fortentwicklung bleiben extrakorporale Lungenunterstützungsverfahren invasive und potenziell komplikationsträchtige Therapieformen mit Blutungen und Gefäßverletzungen als die beiden Hauptkomplikationen. Daher sollten Indikation und Kontraindikationen stets kritisch abgewogen werden und ihr Einsatz nur in Zentren mit entsprechender Erfahrung und Expertise erfolgen.
Literatur
1.
Zurück zum Zitat Abrams DC, Brenner K, Burkart KM et al (2013) Pilot study of extracorporeal carbon dioxide removal to facilitate extubation and ambulation in exacerbation of chronic obstructive pulmonary disease. Ann Am Thorac Soc 10(4):307–314CrossRefPubMed Abrams DC, Brenner K, Burkart KM et al (2013) Pilot study of extracorporeal carbon dioxide removal to facilitate extubation and ambulation in exacerbation of chronic obstructive pulmonary disease. Ann Am Thorac Soc 10(4):307–314CrossRefPubMed
2.
Zurück zum Zitat Abrams D, Javidfar J, Farrand E et al (2014) Early mobilization of patients receiving extracorporeal membrane oxygenation: a retrospective cohort study. Crit Care 18:R38CrossRefPubMedPubMedCentral Abrams D, Javidfar J, Farrand E et al (2014) Early mobilization of patients receiving extracorporeal membrane oxygenation: a retrospective cohort study. Crit Care 18:R38CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat Abrams DC, Prager K, Blinderman CD (2014) Ethical dilemmas encountered with the use of extracorporeal membrane oxygenation in adults. Chest 145:876–882CrossRefPubMed Abrams DC, Prager K, Blinderman CD (2014) Ethical dilemmas encountered with the use of extracorporeal membrane oxygenation in adults. Chest 145:876–882CrossRefPubMed
4.
Zurück zum Zitat Allardet-Servent J, Castanier M, Signouret T et al (2015) Safety and efficacy of combined extracorporeal CO2 removal and renal replacement therapy in patients with acute respiratory distress syndrome and acute kidney injury: the pulmonary and renal support in acute respiratory distress syndrome study. Crit Care Med 43:2570–2581CrossRefPubMedPubMedCentral Allardet-Servent J, Castanier M, Signouret T et al (2015) Safety and efficacy of combined extracorporeal CO2 removal and renal replacement therapy in patients with acute respiratory distress syndrome and acute kidney injury: the pulmonary and renal support in acute respiratory distress syndrome study. Crit Care Med 43:2570–2581CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Banfi C, Pozzi M, Siegenthaler N et al (2016) Veno-venous extracorporeal membrane oxygenation: cannulation techniques. J Thorac Dis 8(12):3762–3773CrossRefPubMedPubMedCentral Banfi C, Pozzi M, Siegenthaler N et al (2016) Veno-venous extracorporeal membrane oxygenation: cannulation techniques. J Thorac Dis 8(12):3762–3773CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Barbaro RP, Odetola FO, Kidwell KM et al (2015) Association of hospital-level volume of extracorporeal membrane oxygenation cases and mortality. Analysis of the extracorporeal life support organization registry. Am J Respir Crit Care Med 191:894–901CrossRefPubMedPubMedCentral Barbaro RP, Odetola FO, Kidwell KM et al (2015) Association of hospital-level volume of extracorporeal membrane oxygenation cases and mortality. Analysis of the extracorporeal life support organization registry. Am J Respir Crit Care Med 191:894–901CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Bein T, Weber-Carstens S, Goldmann A (2013) Lower tidal volume strategy (≈3 ml/kg) combined with extracorporeal CO2 removal versus „conventional“ protective ventilation (6 ml/kg) in severe ARDS. The prospective randomized Xtravent-study. Intensive Care Med 39:847–856CrossRefPubMedPubMedCentral Bein T, Weber-Carstens S, Goldmann A (2013) Lower tidal volume strategy (≈3 ml/kg) combined with extracorporeal CO2 removal versus „conventional“ protective ventilation (6 ml/kg) in severe ARDS. The prospective randomized Xtravent-study. Intensive Care Med 39:847–856CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Braune S, Kluge S (2013) Extracorporeal lung support in patients with chronic obstructive pulmonary disease. Minerva Anestesiol 79:934–943PubMed Braune S, Kluge S (2013) Extracorporeal lung support in patients with chronic obstructive pulmonary disease. Minerva Anestesiol 79:934–943PubMed
11.
Zurück zum Zitat Braune S, Sieweke A, Brettner F et al (2016) The feasibility and safety of extracorporeal carbon dioxide removal to avoid intubation in patients with COPD unresponsive to noninvasive ventilation for acute hypercapnic respiratory failure (ECLAIR study): multicentre case-control study. Intensive Care Med 42:1437–1444CrossRefPubMed Braune S, Sieweke A, Brettner F et al (2016) The feasibility and safety of extracorporeal carbon dioxide removal to avoid intubation in patients with COPD unresponsive to noninvasive ventilation for acute hypercapnic respiratory failure (ECLAIR study): multicentre case-control study. Intensive Care Med 42:1437–1444CrossRefPubMed
12.
Zurück zum Zitat Brenner K, Abrams DC, Agerstrand CL et al (2014) Extracorporeal carbon dioxide removal for refractory status asthmaticus: experience in distinct exacerbation phenotypes. Perfusion 29(1):26–28CrossRefPubMed Brenner K, Abrams DC, Agerstrand CL et al (2014) Extracorporeal carbon dioxide removal for refractory status asthmaticus: experience in distinct exacerbation phenotypes. Perfusion 29(1):26–28CrossRefPubMed
13.
14.
Zurück zum Zitat Burki NK, Mani RK, Herth FJF et al (2013) A novel extracorporeal CO2 removal system. Results of a pilot study of hypercapnic respiratory failure in patients with COPD. Chest 143(3):678–686CrossRefPubMed Burki NK, Mani RK, Herth FJF et al (2013) A novel extracorporeal CO2 removal system. Results of a pilot study of hypercapnic respiratory failure in patients with COPD. Chest 143(3):678–686CrossRefPubMed
15.
Zurück zum Zitat Combes A, Brodie D, Bartlett R (2014) Position paper for the organization of extracorporeal membrane oxygenation programs for akute respiratory failure in adult patients. Am J Respir Crit Care Med 190(5):488–496CrossRefPubMed Combes A, Brodie D, Bartlett R (2014) Position paper for the organization of extracorporeal membrane oxygenation programs for akute respiratory failure in adult patients. Am J Respir Crit Care Med 190(5):488–496CrossRefPubMed
16.
Zurück zum Zitat Cove ME, MacLaren G, Federspiel WJ et al (2012) Bench to bedside review: extracorporeal carbon dioxide removal, past present and future. Crit Care 16:232CrossRefPubMedPubMedCentral Cove ME, MacLaren G, Federspiel WJ et al (2012) Bench to bedside review: extracorporeal carbon dioxide removal, past present and future. Crit Care 16:232CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Davies A, Jones D, Beca J et al (2009) Extracorporeal membrane oxygenation for 2009 influenza A (H1N1) acute respiratory distress syndrome. JAMA 302(17):1888–1895CrossRefPubMed Davies A, Jones D, Beca J et al (2009) Extracorporeal membrane oxygenation for 2009 influenza A (H1N1) acute respiratory distress syndrome. JAMA 302(17):1888–1895CrossRefPubMed
18.
Zurück zum Zitat Del Sorbo L, Boffini M, Rinaldi M (2012) Bridging to lung transplantation by extracorporeal support. Minerva Anestesiol 78(2):243–250PubMed Del Sorbo L, Boffini M, Rinaldi M (2012) Bridging to lung transplantation by extracorporeal support. Minerva Anestesiol 78(2):243–250PubMed
19.
Zurück zum Zitat Del Sorbo L, Fan E, Nava S et al (2016) ECCO2R in COPD exacerbation only for the right patients and with the right strategy. Intensive Care Med 42:1830–1833CrossRefPubMed Del Sorbo L, Fan E, Nava S et al (2016) ECCO2R in COPD exacerbation only for the right patients and with the right strategy. Intensive Care Med 42:1830–1833CrossRefPubMed
20.
Zurück zum Zitat Del Sorbo L, Pisani L, Filippini C (2015) Extracorporeal CO2 removal in hypercapnic patients at risk of noninvasive ventilation failure: a matched cohort study with historical control. Crit Care Med 43:120–127CrossRefPubMed Del Sorbo L, Pisani L, Filippini C (2015) Extracorporeal CO2 removal in hypercapnic patients at risk of noninvasive ventilation failure: a matched cohort study with historical control. Crit Care Med 43:120–127CrossRefPubMed
21.
Zurück zum Zitat Enger TB, Philipp A, Videm V et al (2014) Prediction of mortality in adult patients with severe acute lung failure receiving veno-venous extracorporeal membrane oxygenation: a prospective observational study. Crit Care 18(2):R27CrossRef Enger TB, Philipp A, Videm V et al (2014) Prediction of mortality in adult patients with severe acute lung failure receiving veno-venous extracorporeal membrane oxygenation: a prospective observational study. Crit Care 18(2):R27CrossRef
24.
Zurück zum Zitat Fan E, Gattinoni L, Combes A et al (2016) Venonenous extracorporeal membrane oxygenation for acute respiratory failure. A clinical review from an international group of experts. Intensive Care Med 42:712–724CrossRefPubMed Fan E, Gattinoni L, Combes A et al (2016) Venonenous extracorporeal membrane oxygenation for acute respiratory failure. A clinical review from an international group of experts. Intensive Care Med 42:712–724CrossRefPubMed
25.
Zurück zum Zitat Fitzgerald M, Millar J, Blackwood B et al (2014) Extracorporeal carbon dioxide removal for patients with acute respiratory failure secondary to the acute respiratory distress syndrome: a systematic review. Crit Care 18(3):222CrossRefPubMedPubMedCentral Fitzgerald M, Millar J, Blackwood B et al (2014) Extracorporeal carbon dioxide removal for patients with acute respiratory failure secondary to the acute respiratory distress syndrome: a systematic review. Crit Care 18(3):222CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Forster C, Schriewer J, John S et al (2013) Low-flow CO2 removal integrated into a renal replacement circuit can reduce acidosis and decrease vasopressor requirements. Crit Care 17(4):R154CrossRefPubMedPubMedCentral Forster C, Schriewer J, John S et al (2013) Low-flow CO2 removal integrated into a renal replacement circuit can reduce acidosis and decrease vasopressor requirements. Crit Care 17(4):R154CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Fuehner T, Kuehn C, Hadem J et al (2012) Extracorporeal membrane oxygenation in awake patients as bridge to lung transplantation. Am J Respir Crit Care Med 185(7):763–768CrossRefPubMed Fuehner T, Kuehn C, Hadem J et al (2012) Extracorporeal membrane oxygenation in awake patients as bridge to lung transplantation. Am J Respir Crit Care Med 185(7):763–768CrossRefPubMed
28.
Zurück zum Zitat Gattinoni L, Tonetti T, Quintel M (2017) How best to set the ventilator on extracorporeal membrane lung oxygenation. Curr Opin Crit Care 23:66–72CrossRefPubMed Gattinoni L, Tonetti T, Quintel M (2017) How best to set the ventilator on extracorporeal membrane lung oxygenation. Curr Opin Crit Care 23:66–72CrossRefPubMed
29.
Zurück zum Zitat Gattinoni L, Marini JJ, Pesenti A et al (2016) The „baby lung“ became an adult. Intensive Care Med 42(5):663–673CrossRefPubMed Gattinoni L, Marini JJ, Pesenti A et al (2016) The „baby lung“ became an adult. Intensive Care Med 42(5):663–673CrossRefPubMed
30.
Zurück zum Zitat Gottschalk A, Bräuning J, Brause D (2016) Early goal directed physiotherapy in patients undergoing extracorporeal cardiac life support. Int J Sci Eng Res 7(1):1589–1600 Gottschalk A, Bräuning J, Brause D (2016) Early goal directed physiotherapy in patients undergoing extracorporeal cardiac life support. Int J Sci Eng Res 7(1):1589–1600
33.
Zurück zum Zitat Hoeper MM, Wiesner O, Hadem J (2013) Extracorporeal membrane oxygenation instead of invasive mechanical ventilation in patients with acute respiratory distress syndrome. Intensive Care Med 39(11):2056–2057CrossRefPubMed Hoeper MM, Wiesner O, Hadem J (2013) Extracorporeal membrane oxygenation instead of invasive mechanical ventilation in patients with acute respiratory distress syndrome. Intensive Care Med 39(11):2056–2057CrossRefPubMed
34.
Zurück zum Zitat Kalbhenn J, Wittau N, Schmutz A et al (2015) Identification of acquired coagulation disorders and effects of target-controlled coagulation factor substitution on the incidence and severity of spontaneous intracranial bleeding during veno-venous ECMO therapy. Perfusion 30(8):675–682CrossRefPubMed Kalbhenn J, Wittau N, Schmutz A et al (2015) Identification of acquired coagulation disorders and effects of target-controlled coagulation factor substitution on the incidence and severity of spontaneous intracranial bleeding during veno-venous ECMO therapy. Perfusion 30(8):675–682CrossRefPubMed
35.
36.
Zurück zum Zitat Karagiannidis C, Auf’m Kampe K, Sipmann FS (2014) Veno-venous extracorporeal CO2 removal for the treatment of severe respiratory acidosis. Pathphysiologic and technical considerations. Crit Care 18(3):R124CrossRefPubMedPubMedCentral Karagiannidis C, Auf’m Kampe K, Sipmann FS (2014) Veno-venous extracorporeal CO2 removal for the treatment of severe respiratory acidosis. Pathphysiologic and technical considerations. Crit Care 18(3):R124CrossRefPubMedPubMedCentral
38.
Zurück zum Zitat Kluge S, Braune S, Engel M (2012) Avoiding invasive mechanical ventilation by extracorporeal carbon dioxide removal in patients failing noninvasive ventilation. Intensive Care Med 38:1632–1639CrossRefPubMed Kluge S, Braune S, Engel M (2012) Avoiding invasive mechanical ventilation by extracorporeal carbon dioxide removal in patients failing noninvasive ventilation. Intensive Care Med 38:1632–1639CrossRefPubMed
39.
Zurück zum Zitat Kluge S, Sensen B, Braune S (2017) Extrakorporale Lungenunterstützung bei Patienten mit ARDS. Dtsch Med Wochenschr 142:88–95CrossRefPubMed Kluge S, Sensen B, Braune S (2017) Extrakorporale Lungenunterstützung bei Patienten mit ARDS. Dtsch Med Wochenschr 142:88–95CrossRefPubMed
40.
Zurück zum Zitat Kolobow T, Gattinoni L, Tomlinson TA et al (1977) Control of breathing using an extracorporeal membrane lung. Anesthesiology 46(2):138–141CrossRefPubMed Kolobow T, Gattinoni L, Tomlinson TA et al (1977) Control of breathing using an extracorporeal membrane lung. Anesthesiology 46(2):138–141CrossRefPubMed
41.
Zurück zum Zitat Kumar A, Zarynchanski R, Pinto R et al (2009) Critically ill patients with 2009 influenza A (H1N1) infection in Canada. JAMA 302(17):1872–1879CrossRefPubMed Kumar A, Zarynchanski R, Pinto R et al (2009) Critically ill patients with 2009 influenza A (H1N1) infection in Canada. JAMA 302(17):1872–1879CrossRefPubMed
42.
Zurück zum Zitat Langer T, Santini A, Bottino N (2016) „Awake“ extracorporeal membrane oxygenation (ECMO): pathphysiology, technical considerations, and clinical peoneering. Crit Care 20:150CrossRefPubMedPubMedCentral Langer T, Santini A, Bottino N (2016) „Awake“ extracorporeal membrane oxygenation (ECMO): pathphysiology, technical considerations, and clinical peoneering. Crit Care 20:150CrossRefPubMedPubMedCentral
44.
Zurück zum Zitat Luyt CE, Bréchot N, Demondion P et al (2016) Brain injury during venovenous extracorporeal membrane oxygenation. Intensive Care Med 42(5):897–907CrossRefPubMed Luyt CE, Bréchot N, Demondion P et al (2016) Brain injury during venovenous extracorporeal membrane oxygenation. Intensive Care Med 42(5):897–907CrossRefPubMed
45.
Zurück zum Zitat Morelli A, Del Sorbo L, Pesenti A et al (2017) Extracorporeal carbon dioxide removal (ECCO2R) in patients with acute respiratory failure. Intensive Care Med. doi:10.1007/s00134-016-4673-0 Morelli A, Del Sorbo L, Pesenti A et al (2017) Extracorporeal carbon dioxide removal (ECCO2R) in patients with acute respiratory failure. Intensive Care Med. doi:10.​1007/​s00134-016-4673-0
46.
Zurück zum Zitat Muellenbach R, Kredel M, Kunze E et al (2012) Prolonged heparin-free extracorporeal membrane oxygenation in multiple injured acute respiratory distress syndrome patients with traumatic brain injury. J Trauma 72(5):1444–1447 Muellenbach R, Kredel M, Kunze E et al (2012) Prolonged heparin-free extracorporeal membrane oxygenation in multiple injured acute respiratory distress syndrome patients with traumatic brain injury. J Trauma 72(5):1444–1447
47.
Zurück zum Zitat Müller T, Bein T, Philipp A et al (2013) Extracorporeal pulmonary support in severe pulmonary failure in adult. Dtsch Arztebl Int 110(10):159–166PubMedPubMedCentral Müller T, Bein T, Philipp A et al (2013) Extracorporeal pulmonary support in severe pulmonary failure in adult. Dtsch Arztebl Int 110(10):159–166PubMedPubMedCentral
49.
Zurück zum Zitat Nierhaus A, Frings DP, Braune S et al (2011) Interventional lung assist enables lung protective mechanical ventilation in acute respiratory distress syndrome. Minerva Anestesiol 77:797–801PubMed Nierhaus A, Frings DP, Braune S et al (2011) Interventional lung assist enables lung protective mechanical ventilation in acute respiratory distress syndrome. Minerva Anestesiol 77:797–801PubMed
50.
Zurück zum Zitat Peek GJ, Mugford M, Tiruvoipati R et al (2009) Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR), a multicentre randomised controlled trial. Lancet 374:1351–1363CrossRefPubMed Peek GJ, Mugford M, Tiruvoipati R et al (2009) Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR), a multicentre randomised controlled trial. Lancet 374:1351–1363CrossRefPubMed
51.
Zurück zum Zitat Pesenti A, Patroniti N, Fumagalli R (2010) Carbon dioxide dialysis will save the lung. Crit Care Med 38:549–554CrossRef Pesenti A, Patroniti N, Fumagalli R (2010) Carbon dioxide dialysis will save the lung. Crit Care Med 38:549–554CrossRef
52.
Zurück zum Zitat Petzoldt M, Braune S, Bittmann I et al (2012) Rescue therapy with a pumpless extracorporeal lung assist device in a patient with acute interstitial lung disease and severe refractory hypercapnia. Respir Care 57(2):293–297PubMed Petzoldt M, Braune S, Bittmann I et al (2012) Rescue therapy with a pumpless extracorporeal lung assist device in a patient with acute interstitial lung disease and severe refractory hypercapnia. Respir Care 57(2):293–297PubMed
53.
Zurück zum Zitat Rozencwajg S, Pilcher D, Combes A et al (2016) Outcomes and survival prediction models for severe adult acute respiratory distress syndrome treated with ECMO. Crit Care 20:392CrossRefPubMedPubMedCentral Rozencwajg S, Pilcher D, Combes A et al (2016) Outcomes and survival prediction models for severe adult acute respiratory distress syndrome treated with ECMO. Crit Care 20:392CrossRefPubMedPubMedCentral
54.
Zurück zum Zitat Schmidt M, Pilcher D (2014) Mortality prediction models in ARF treated with extracorporeal membrane oxygenation: it must be firstly designed for clinicians and bedside use. Crit Care 18(4):445CrossRefPubMedPubMedCentral Schmidt M, Pilcher D (2014) Mortality prediction models in ARF treated with extracorporeal membrane oxygenation: it must be firstly designed for clinicians and bedside use. Crit Care 18(4):445CrossRefPubMedPubMedCentral
55.
Zurück zum Zitat Schmidt M, Tachon G, Devillier C et al (2013) Blood oxygenation and decarboxylation determinants during venovenous ECMO for respiratory failure in adults. Intensive Care Med 39:838–846CrossRefPubMed Schmidt M, Tachon G, Devillier C et al (2013) Blood oxygenation and decarboxylation determinants during venovenous ECMO for respiratory failure in adults. Intensive Care Med 39:838–846CrossRefPubMed
56.
Zurück zum Zitat Schmidt M, Zogheib E, Rozè H et al (2013) The PRESERVE mortality risc score and analysis of long term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. Intensive Care Med 39(10):1704–1713CrossRefPubMed Schmidt M, Zogheib E, Rozè H et al (2013) The PRESERVE mortality risc score and analysis of long term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. Intensive Care Med 39(10):1704–1713CrossRefPubMed
57.
Zurück zum Zitat Serpa Neto A, Schmidt M, Azevedo LC et al (2016) Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis: mechanical ventilation during ECMO. Intensive Care Med 42:1672–1684CrossRefPubMed Serpa Neto A, Schmidt M, Azevedo LC et al (2016) Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis: mechanical ventilation during ECMO. Intensive Care Med 42:1672–1684CrossRefPubMed
58.
Zurück zum Zitat Sklar MC, Beloncle F, Katsios CM (2015) Extracorporeal carbon dioxide removal in patients with chronic obstructive pulmonary disease: a systematic review. Intensive Care Med. doi:10.1007/s00134-015-3921-z PubMed Sklar MC, Beloncle F, Katsios CM (2015) Extracorporeal carbon dioxide removal in patients with chronic obstructive pulmonary disease: a systematic review. Intensive Care Med. doi:10.​1007/​s00134-015-3921-z PubMed
61.
Zurück zum Zitat Thiagarajan RR, Barbaros RP, Rycus PT (2017) ELSO Registry international report 2016. ASAIO J 63:60–67CrossRefPubMed Thiagarajan RR, Barbaros RP, Rycus PT (2017) ELSO Registry international report 2016. ASAIO J 63:60–67CrossRefPubMed
62.
Zurück zum Zitat Trudzinski FC, Minko P, Rapp D (2016) Runtime and aPTT predict venous thrombosis and thromboembolism in patients on extracorporeal membrane oxygenation: a retrospective analysis. Ann Intensive Care 6:66CrossRefPubMedPubMedCentral Trudzinski FC, Minko P, Rapp D (2016) Runtime and aPTT predict venous thrombosis and thromboembolism in patients on extracorporeal membrane oxygenation: a retrospective analysis. Ann Intensive Care 6:66CrossRefPubMedPubMedCentral
63.
Zurück zum Zitat Welterer S, Schmidt K, Deininger M (2016) Komplexe Fokussanierung in der Sepsis. Extrakorporale Membranoxygenierung (ECMO) als Bridging-Konzept zur trachealen Fistelsanierung bei sepsisassoziiertem ARDS. Anaesthesist 65:696–702CrossRef Welterer S, Schmidt K, Deininger M (2016) Komplexe Fokussanierung in der Sepsis. Extrakorporale Membranoxygenierung (ECMO) als Bridging-Konzept zur trachealen Fistelsanierung bei sepsisassoziiertem ARDS. Anaesthesist 65:696–702CrossRef
64.
Zurück zum Zitat Westermaier T, Stetter C, Kunze E et al (2016) Controlled hypercapnia enhances cerebral blood flow and brain tissue oxygenation after aneurysmal subarachnoid hemmorrhage: results of a phase I study. Neurocrit Care 25:205–214CrossRefPubMed Westermaier T, Stetter C, Kunze E et al (2016) Controlled hypercapnia enhances cerebral blood flow and brain tissue oxygenation after aneurysmal subarachnoid hemmorrhage: results of a phase I study. Neurocrit Care 25:205–214CrossRefPubMed
65.
Zurück zum Zitat Westhoff M, Bachmann M, Braune S et al (2016) Schweres hyperkapnisches Atemversagen bei akuter COPD-Exazerbation: Stellenwert von Beatmung und ECCO2R. Dtsch Med Wochenschr 141:1758–1717CrossRefPubMed Westhoff M, Bachmann M, Braune S et al (2016) Schweres hyperkapnisches Atemversagen bei akuter COPD-Exazerbation: Stellenwert von Beatmung und ECCO2R. Dtsch Med Wochenschr 141:1758–1717CrossRefPubMed
Metadaten
Titel
Extrakorporale Verfahren zur Lungenunterstützung
verfasst von
S. Braune
A. Sieweke
D. Jarczak
Prof. Dr. S. Kluge
Publikationsdatum
29.05.2017
Verlag
Springer Medizin
Schlagwörter
ECMO
ECMO
Erschienen in
Medizinische Klinik - Intensivmedizin und Notfallmedizin / Ausgabe 5/2017
Print ISSN: 2193-6218
Elektronische ISSN: 2193-6226
DOI
https://doi.org/10.1007/s00063-017-0304-y

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