Ausgabe 1/2011
Inhalt (152 Artikel)
Targeting canine bladder transitional cell carcinoma with a human bladder cancer-specific ligand
Tzu-yin Lin, Hongyong Zhang, Sisi Wang, Li Xie, Bin Li, Carlos O Rodriguez Jr, Ralph de Vere White, Chong-xian Pan
Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma
Reason Wilken, Mysore S Veena, Marilene B Wang, Eri S Srivatsan
Inhibition of angiogenesis and suppression of colorectal cancer metastatic to the liver using the Sleeping Beauty Transposon System
Lalitha R Belur, Kelly M Podetz-Pedersen, Brent S Sorenson, Alice H Hsu, Josh B Parker, Cathy S Carlson, Daniel A Saltzman, S Ramakrishnan, R Scott McIvor
Identification of early molecular markers for breast cancer
Céline Kretschmer, Anja Sterner-Kock, Friederike Siedentopf, Winfried Schoenegg, Peter M Schlag, Wolfgang Kemmner
Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis
Song Li, Baolu Wang, Yan Xu, Junjie Zhang
Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer
Sampoorna Satheesha, Victoria J Cookson, Louise J Coleman, Nicola Ingram, Brijesh Madhok, Andrew M Hanby, Charlotte AB Suleman, Vicky S Sabine, E Jane Macaskill, John MS Bartlett, J Michael Dixon, Jim N McElwaine, Thomas A Hughes
Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy
Ivan Bièche, Sophie Vacher, François Lallemand, Sengül Tozlu-Kara, Hind Bennani, Michèle Beuzelin, Keltouma Driouch, Etienne Rouleau, Florence Lerebours, Hugues Ripoche, Géraldine Cizeron-Clairac, Frédérique Spyratos, Rosette Lidereau
Short-chain fatty acid level and field cancerization show opposing associations with enteroendocrine cell number and neuropilin expression in patients with colorectal adenoma
Danny CW Yu, Jonathan P Bury, James Tiernan, Jennifer S Waby, Carolyn A Staton, Bernard M Corfe
Overexpression of Aurora-A in primary cells interferes with S-phase entry by diminishing Cyclin D1 dependent activities
Florian Jantscher, Christine Pirker, Christoph-Erik Mayer, Walter Berger, Hedwig Sutterluety
Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer
Mary-Clare Cathcart, Kathy Gately, Robert Cummins, Elaine Kay, Kenneth J O'Byrne, Graham P Pidgeon
Expression ratio of CCND1 to CDKN2A mRNA predicts RB1 status of cultured cancer cell lines and clinical tumor samples
Shinji Mizuarai, Takumitsu Machida, Tsutomu Kobayashi, Hideya Komatani, Hiraku Itadani, Hidehito Kotani
Regulation of β-catenin by t-DARPP in upper gastrointestinal cancer cells
Bhavatarini Vangamudi, Shoumin Zhu, Mohammed Soutto, Abbes Belkhiri, Wael El-Rifai
Inhibition of Oesophageal Squamous Cell Carcinoma Progression by in vivo Targeting of Hyaluronan Synthesis
Sören Twarock, Till Freudenberger, Eva Poscher, Guang Dai, Katharina Jannasch, Christian Dullin, Frauke Alves, Klaus Prenzel, Wolfram T Knoefel, Nikolas H Stoecklein, Rashmin C Savani, Bernhard Homey, Jens W Fischer
Small-cell lung cancer-associated autoantibodies: potential applications to cancer diagnosis, early detection, and therapy
Meleeneh Kazarian, Ite A Laird-Offringa
Targeted expression of tumor necrosis factor-related apoptosis-inducing ligand TRAIL in skin protects mice against chemical carcinogenesis
Valerie Kedinger, Stephanie Muller, Hinrich Gronemeyer
Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer
Hanseul Yang, Chan Kim, Min-Ju Kim, Reto A Schwendener, Kari Alitalo, Warren Heston, Injune Kim, Wun-Jae Kim, Gou Young Koh
Impacting tumor cell-fate by targeting the inhibitor of apoptosis protein survivin
Ronan J Kelly, Ariel Lopez-Chavez, Deborah Citrin, John E Janik, John C Morris
High susceptibility of metastatic cells derived from human prostate and colon cancer cells to TRAIL and sensitization of TRAIL-insensitive primary cells to TRAIL by 4,5-dimethoxy-2-nitrobenzaldehyde
Hak-Bong Kim, Mi-Ju Kim, Dae-Young Kim, Jae-Won Lee, Jae-Ho Bae, Dong-Wan Kim, Chi-Dug Kang, Sun-Hee Kim
MDM2 antagonists boost antitumor effect of androgen withdrawal: implications for therapy of prostate cancer
Christian Tovar, Brian Higgins, Kenneth Kolinsky, Mingxuan Xia, Kathryn Packman, David C Heimbrook, Lyubomir T Vassilev
Hyperactivation of NF-κB via the MEK signaling is indispensable for the inhibitory effect of cAMP on DNA damage-induced cell death
Martine M Kloster, Elin H Naderi, Harald Carlsen, Heidi K Blomhoff, Soheil Naderi
HBx Sensitizes Cells to Oxidative Stress-induced Apoptosis by Accelerating the Loss of Mcl-1 Protein via Caspase-3 Cascade
Liang Hu, Lei Chen, GuangZhen Yang, Liang Li, HanYong Sun, YanXin Chang, QianQian Tu, MengChao Wu, HongYang Wang
Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy
Adam Lister, Taoufik Nedjadi, Neil R Kitteringham, Fiona Campbell, Eithne Costello, Bryony Lloyd, Ian M Copple, Samantha Williams, Andrew Owen, John P Neoptolemos, Chris E Goldring, B Kevin Park
RNA polymerase III transcription in cancer: the BRF2 connection
Stephanie Cabarcas, Laura Schramm
The functional role of long non-coding RNA in human carcinomas
Ewan A Gibb, Carolyn J Brown, Wan L Lam
Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells
Sutapa Mahata, Alok C Bharti, Shirish Shukla, Abhishek Tyagi, Syed A Husain, Bhudev C Das
Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer
Francesco Crea, Elaine M Hurt, Lesley A Mathews, Stephanie M Cabarcas, Lei Sun, Victor E Marquez, Romano Danesi, William L Farrar
Expression patterns of microRNAs associated with CML phases and their disease related targets
Kateřina Machová Poláková, Tereza Lopotová, Hana Klamová, Pavel Burda, Marek Trněný, Tomáš Stopka, Jana Moravcová
Antitumour effects of single or combined monoclonal antibodies directed against membrane antigens expressed by human B cells leukaemia
Séverine Loisel, Pierre-Alain André, Josee Golay, Franz Buchegger, Jean Kadouche, Martine Cérutti, Luca Bologna, Marek Kosinski, David Viertl, Angelika Bischof Delaloye, Christian Berthou, Jean-Pierre Mach, Laurence Boumsell
IκB kinases increase Myc protein stability and enhance progression of breast cancer cells
Pei-Yen Yeh, Yen-Shen Lu, Da-Liang Ou, Ann-Lii Cheng
Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells
Mingmei Liao, Jinfeng Zhao, Ton Wang, Jinghua Duan, Yangde Zhang, Xingming Deng
Regulation of PBX3 expression by androgen and Let-7d in prostate cancer
Håkon Ramberg, Ayham Alshbib, Viktor Berge, Aud Svindland, Kristin Austlid Taskén
Lipid phosphate phosphatase-3 regulates tumor growth via β-catenin and Cyclin-D1 signaling
Ishita Chatterjee, Joseph O Humtsoe, Erin E Kohler, Claudio Sorio, Kishore K Wary
Effects of 1α,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells
Wei-Lin W Wang, Namita Chatterjee, Sridar V Chittur, JoEllen Welsh, Martin P Tenniswood
Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1
Hendrik Ungefroren, Stephanie Groth, Susanne Sebens, Hendrik Lehnert, Frank Gieseler, Fred Fändrich
Epigenetic markers for early detection of nasopharyngeal carcinoma in a high risk population
Susanna H Hutajulu, Sagung R Indrasari, Luh PL Indrawati, Ahmad Harijadi, Sylvia Duin, Sofia M Haryana, Renske DM Steenbergen, Astrid E Greijer, Jaap M Middeldorp
Possible role of death receptor-mediated apoptosis by the E3 ubiquitin ligases Siah2 and POSH
Perry A Christian, Michael V Fiandalo, Steven R Schwarze
Ribosomal Protein S6 Kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein
Qi Ma, Sunny Guin, Snehal S Padhye, Yong-Qing Zhou, Rui-Wen Zhang, Ming-Hai Wang
Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells
Masanao Tabuse, Shigeki Ohta, Yohei Ohashi, Raita Fukaya, Aya Misawa, Kazunari Yoshida, Takeshi Kawase, Hideyuki Saya, Cécile Thirant, Hérve Chneiweiss, Yumi Matsuzaki, Hideyuki Okano, Yutaka Kawakami, Masahiro Toda
A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells
Jean H Overmeyer, Ashley M Young, Haymanti Bhanot, William A Maltese
Micro-RNA expression in cisplatin resistant germ cell tumor cell lines
Matthias Port, Stephanie Glaesener, Christian Ruf, Armin Riecke, Carsten Bokemeyer, Viktor Meineke, Friedemann Honecker, Michael Abend
miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner
Nora Bandi, Erik Vassella
Natriuretic Peptide Receptor A as a Novel Target for Prostate Cancer
Xiaoqin Wang, Payal Raulji, Shyam S Mohapatra, Ronil Patel, Gary Hellermann, Xiaoyuan Kong, Pedro L Vera, Katherine L Meyer-Siegler, Domenico Coppola, Subhra Mohapatra
The HPV-16 E7 oncoprotein induces centriole multiplication through deregulation of Polo-like kinase 4 expression
Nina Korzeniewski, Benjamin Treat, Stefan Duensing
New Topoisomerase I mutations are associated with resistance to camptothecin
Céline Gongora, Nadia Vezzio-Vie, Sandie Tuduri, Vincent Denis, Annick Causse, Céline Auzanneau, Gwenaëlle Collod-Beroud, Arnaud Coquelle, Philippe Pasero, Philippe Pourquier, Pierre Martineau, Maguy Del Rio
The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors
Henning Stehr, Seon-Hi J Jang, José M Duarte, Christoph Wierling, Hans Lehrach, Michael Lappe, Bodo MH Lange
The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells
Brian A Zabel, Susanna Lewén, Robert D Berahovich, Juan C Jaén, Thomas J Schall
Homeobox gene Rhox5 is regulated by epigenetic mechanisms in cancer and stem cells and promotes cancer growth
Qiang Li, Mark E O'Malley, David L Bartlett, Sheng Guo
Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer
Gouji Toyokawa, Ken Masuda, Yataro Daigo, Hyun-Soo Cho, Masanori Yoshimatsu, Masashi Takawa, Shinya Hayami, Kazuhiro Maejima, Makoto Chino, Helen I Field, David E Neal, Eiju Tsuchiya, Bruce AJ Ponder, Yoshihiko Maehara, Yusuke Nakamura, Ryuji Hamamoto
Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4
Hilmar M Warenius, Jeremy D Kilburn, Jon W Essex, Richard I Maurer, Jeremy P Blaydes, Usha Agarwala, Laurence A Seabra
Decreased expression of BRCA1 in SK-BR-3 cells is the result of aberrant activation of the GABP Beta promoter by an NRF-1-containing complex
Crista Thompson, Gwen MacDonald, Christopher R Mueller
Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly
Praveen Rajendran, Barbara Delage, W Mohaiza Dashwood, Tian-Wei Yu, Bradyn Wuth, David E Williams, Emily Ho, Roderick H Dashwood
Targeting oncogenic miR-335 inhibits growth and invasion of malignant astrocytoma cells
Minfeng Shu, Xiaoke Zheng, Sihan Wu, Huimin Lu, Tiandong Leng, Wenbo Zhu, Yuehan Zhou, Yanqiu Ou, Xi Lin, Yuan Lin, Dong Xu, Yuxi Zhou, Guangmei Yan
PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro
Florianne E Henken, N Sanjib Banerjee, Peter JF Snijders, Chris JLM Meijer, Johanna De-Castro Arce, Frank Rösl, Thomas R Broker, Louise T Chow, Renske DM Steenbergen
Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression
Brice V McConnell, Karen Koto, Arthur Gutierrez-Hartmann
Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin
Janna Sand-Dejmek, Guillaume Adelmant, Bijan Sobhian, Anne S Calkins, Jarrod Marto, Dirk J Iglehart, Jean-Bernard Lazaro
Stimulation of neoplastic mouse lung cell proliferation by alveolar macrophage-derived, insulin-like growth factor-1 can be blocked by inhibiting MEK and PI3K activation
Jason M Fritz, Lori D Dwyer-Nield, Alvin M Malkinson
Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression
Sanket Joshi, Antony W Braithwaite, Phillip J Robinson, Megan Chircop
Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells
Masanori Nakashima, Seiji Adachi, Ichiro Yasuda, Takahiro Yamauchi, Junji Kawaguchi, Toshimasa Hanamatsu, Takashi Yoshioka, Yukio Okano, Yoshinobu Hirose, Osamu Kozawa, Hisataka Moriwaki
The monoclonal antibody Zt/f2 targeting RON receptor tyrosine kinase as potential therapeutics against tumor growth-mediated by colon cancer cells
Hang-Ping Yao, Yong-Qing Zhou, Qi Ma, Sunny Guin, Snehal S Padhye, Rui-Wen Zhang, Ming-Hai Wang
Rare human papillomavirus 16 E6 variants reveal significant oncogenic potential
Ingeborg Zehbe, Hava Lichtig, Ashley Westerback, Paul F Lambert, Massimo Tommasino, Levana Sherman
Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells
Agnes Basseville, Laurence Preisser, Sophie de Carné Trécesson, Michèle Boisdron-Celle, Erick Gamelin, Olivier Coqueret, Alain Morel
The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation
Ramiro Mendoza-Maldonado, Valentina Faoro, Sailesh Bajpai, Matteo Berti, Federico Odreman, Marco Vindigni, Tamara Ius, Abdollah Ghasemian, Serena Bonin, Miran Skrap, Giorgio Stanta, Alessandro Vindigni
Role of tissue transglutaminase 2 in the acquisition of a mesenchymal-like phenotype in highly invasive A431 tumor cells
Chun-Yu Lin, Pei-Hsun Tsai, Chithan C Kandaswami, Geen-Dong Chang, Chia-Hsiung Cheng, Chang-Jen Huang, Ping-Ping Lee, Jiuan-Jiuan Hwang, Ming-Ting Lee
A 5'-region polymorphism modulates promoter activity of the tumor suppressor gene MFSD2A
Francesca Colombo, Felicia S Falvella, Antonella Galvan, Elisa Frullanti, Hideo Kunitoh, Toshikazu Ushijima, Tommaso A Dragani
Kinome expression profiling and prognosis of basal breast cancers
Renaud Sabatier, Pascal Finetti, Emilie Mamessier, Stéphane Raynaud, Nathalie Cervera, Eric Lambaudie, Jocelyne Jacquemier, Patrice Viens, Daniel Birnbaum, François Bertucci
Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells
Sarah K Harten, Miguel A Esteban, Deepa Shukla, Margaret Ashcroft, Patrick H Maxwell
Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl
Zhihua Jiang, Ravindra Kamath, Shunquian Jin, Manimalha Balasubramani, Tej K Pandita, Baskaran Rajasekaran
Targeting renal cell carcinoma with NVP-BEZ235, a dual PI3K/mTOR inhibitor, in combination with sorafenib
Didier Roulin, Laurent Waselle, Anne Dormond-Meuwly, Marc Dufour, Nicolas Demartines, Olivier Dormond
A nucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression
Shunsuke Meike, Tohru Yamamori, Hironobu Yasui, Masato Eitaki, Akira Matsuda, Masami Morimatsu, Masakazu Fukushima, Yasundo Yamasaki, Osamu Inanami
Non-cysteine linked MUC1 cytoplasmic dimers are required for Src recruitment and ICAM-1 binding induced cell invasion
Ashlyn J Bernier, Jing Zhang, Erik Lillehoj, Andrew RE Shaw, Nirosha Gunasekara, Judith C Hugh
Regulation of the stem cell marker CD133 is independent of promoter hypermethylation in human epithelial differentiation and cancer
Davide Pellacani, Richard J Packer, Fiona M Frame, Emma E Oldridge, Paul A Berry, Marie-Christine Labarthe, Michael J Stower, Matthew S Simms, Anne T Collins, Norman J Maitland
Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells
Juan Liu, Hiroshi Uematsu, Nobuo Tsuchida, Masa-Aki Ikeda
Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis
Yanfang Wang, Sylvia Shenouda, Somesh Baranwal, Rajamani Rathinam, Prachi Jain, Lili Bao, Siddhartha Hazari, Srikanta Dash, Suresh K Alahari
ZEB1 limits adenoviral infectability by transcriptionally repressing the Coxsackie virus and Adenovirus Receptor
Markus D Lacher, Marisa Shiina, Peter Chang, Debora Keller, Maarit I Tiirikainen, W Michael Korn
Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer
Diego Serrano, Anne-Marie Bleau, Ignacio Fernandez-Garcia, Tamara Fernandez-Marcelo, Pilar Iniesta, Carlos Ortiz-de-Solorzano, Alfonso Calvo
Adeno-associated virus type 2 infection activates caspase dependent and independent apoptosis in multiple breast cancer lines but not in normal mammary epithelial cells
Samina Alam, Brian S Bowser, Michael J Conway, Mohd Israr, Apurva Tandon, Craig Meyers
Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas
Guro E Lind, Stine A Danielsen, Terje Ahlquist, Marianne A Merok, Kim Andresen, Rolf I Skotheim, Merete Hektoen, Torleiv O Rognum, Gunn I Meling, Geir Hoff, Michael Bretthauer, Espen Thiis-Evensen, Arild Nesbakken, Ragnhild A Lothe
The C-terminal region of Bfl-1 sensitizes non-small cell lung cancer to gemcitabine-induced apoptosis by suppressing NF-κB activity and down-regulating Bfl-1
Min-Kyoung Kim, Yoon-Kyung Jeon, Jong-Kyu Woo, Yun Choi, Dae-Han Choi, Yeul-Hong Kim, Chul-Woo Kim
Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?
David P Minde, Zeinab Anvarian, Stefan GD Rüdiger, Madelon M Maurice
Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90
Ming Zhao, Jian Ma, Hai-Yan Zhu, Xu-Hui Zhang, Zhi-Yan Du, Yuan-Ji Xu, Xiao-Dan Yu
MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1
Peixin Dong, Masanori Kaneuchi, Hidemichi Watari, Junichi Hamada, Satoko Sudo, Jingfang Ju, Noriaki Sakuragi
LIP expression is regulated by IGF-1R signaling and participates in suppression of anoikis
Huili Li, Brenda R Baldwin, Cynthia A Zahnow
Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma
Sumalee Obchoei, Sarah M Weakley, Sopit Wongkham, Chaisiri Wongkham, Kanlayanee Sawanyawisuth, Qizhi Yao, Changyi Chen
Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression
Uddalak Bharadwaj, Christian Marin-Muller, Min Li, Changyi Chen, Qizhi Yao
Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4
Kanjoormana Aryan Manu, Muthu K Shanmugam, Peramaiyan Rajendran, Feng Li, Lalitha Ramachandran, Hui Sin Hay, Radhamani Kannaiyan, Shivananju Nanjunda Swamy, Shireen Vali, Shweta Kapoor, Bhargavi Ramesh, Pradeep Bist, Evelyn S Koay, Lina HK Lim, Kwang Seok Ahn, Alan Prem Kumar, Gautam Sethi
c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1
Mario Campone, Bélinda Noël, Cécile Couriaud, Morgan Grau, Yannis Guillemin, Fabien Gautier, Wilfried Gouraud, Catherine Charbonnel, Loïc Campion, Pascal Jézéquel, Frédérique Braun, Benjamin Barré, Olivier Coqueret, Sophie Barillé-Nion, Philippe Juin
Tumor cell-selective apoptosis induction through targeting of KV10.1 via bifunctional TRAIL antibody
Franziska Hartung, Walter Stühmer, Luis A Pardo
Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts
Kristiaan Lenos, Job de Lange, Amina FAS Teunisse, Kirsten Lodder, Matty Verlaan-de Vries, Eliza Wiercinska, Marja JM van der Burg, Karoly Szuhai, Aart G Jochemsen
A fiber-modified adenoviral vector interacts with immunoevasion molecules of the B7 family at the surface of murine leukemia cells derived from dormant tumors
Elodie Grellier, Katia Lécolle, Sophie Rogée, Cyril Couturier, Jean-Claude D'Halluin, Saw-See Hong, Pascal Fender, Pierre Boulanger, Bruno Quesnel, Morvane Colin
Side population rather than CD133+ cells distinguishes enriched tumorigenicity in hTERT-immortalized primary prostate cancer cells
Jianjun Zhou, Honghe Wang, Virginetta Cannon, Karen Marie Wolcott, Hongbin Song, Clayton Yates
A switch in RND3-RHOA signaling is critical for melanoma cell invasion following mutant-BRAF inhibition
R Matthew Klein, Paul J Higgins
Homeobox gene Dlx-2 is implicated in metabolic stress-induced necrosis
Su Yeon Lee, Hyun Min Jeon, Cho Hee Kim, Min Kyung Ju, Hye Sun Bae, Hye Gyeong Park, Sung-Chul Lim, Song Iy Han, Ho Sung Kang
Mapping of ESE-1 subdomains required to initiate mammary epithelial cell transformation via a cytoplasmic mechanism
Jason D Prescott, Joanna M Poczobutt, John J Tentler, Darius M Walker, Arthur Gutierrez-Hartmann
Upregulation of microRNA-125b contributes to leukemogenesis and increases drug resistance in pediatric acute promyelocytic leukemia
Hua Zhang, Xue-Qun Luo, Dan-Dan Feng, Xing-Ju Zhang, Jun Wu, Yu-Sheng Zheng, Xiao Chen, Ling Xu, Yue-Qin Chen
RETRACTED ARTICLE:Differential modulatory effects of GSK-3β and HDM2 on sorafenib-induced AIF nuclear translocation (programmed necrosis) in melanoma
Qingjun Liu, James W Mier, David J Panka
BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study
Eleni Makrodouli, Eftychia Oikonomou, Michal Koc, Ladislav Andera, Takehiko Sasazuki, Senji Shirasawa, Alexander Pintzas
A MCP1 fusokine with CCR2-specific tumoricidal activity
Moutih Rafei, Jiusheng Deng, Marie-Noëlle Boivin, Patrick Williams, Shannon M Matulis, Shala Yuan, Elena Birman, Kathy Forner, Liangping Yuan, Craig Castellino, Lawrence H Boise, Tobey J MacDonald, Jacques Galipeau
Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells
Mei Yang, Jingqi Chen, Fang Su, Bin Yu, Fengxi Su, Ling Lin, Yujie Liu, Jian-Dong Huang, Erwei Song
Downregulation of E-Cadherin enhances proliferation of head and neck cancer through transcriptional regulation of EGFR
Dongsheng Wang, Ling Su, Donghai Huang, Hongzheng Zhang, Dong M Shin, Zhuo G Chen
Downregulation of connective tissue growth factor inhibits the growth and invasion of gastric cancer cells and attenuates peritoneal dissemination
Cheng-Gang Jiang, Ling Lv, Fu-Rong Liu, Zhen-Ning Wang, Fu-Nan Liu, Yan-Shu Li, Chun-Yu Wang, Hong-Yan Zhang, Zhe Sun, Hui-Mian Xu
MiR-185 Targets the DNA Methyltransferases 1 and Regulates Global DNA Methylation in human glioma
Zuping Zhang, Hailin Tang, Zeyou Wang, Baoxin Zhang, Wei Liu, Hongmei Lu, Lan Xiao, Xiaoping Liu, Rong Wang, Xiaoling Li, Minghua Wu, Guiyuan Li
Transglutaminase 2 as an independent prognostic marker for survival of patients with non-adenocarcinoma subtype of non-small cell lung cancer
Chang-Min Choi, Se-Jin Jang, Seong-Yeol Park, Yong-Bock Choi, Jae-Heon Jeong, Dae-Seok Kim, Hyun-Kyoung Kim, Kang-Seo Park, Byung-Ho Nam, Hyeong-Ryul Kim, Soo-Youl Kim, Kyeong-Man Hong
Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation
Yisheng Jiao, Wenbin Ou, Fanguo Meng, Haimeng Zhou, Aiyuan Wang
L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer
Verena Tischler, Marco Pfeifer, Silke Hausladen, Uwe Schirmer, Anne-Katrine Bonde, Glen Kristiansen, Martin L Sos, Walter Weder, Holger Moch, Peter Altevogt, Alex Soltermann
Characterisation and manipulation of docetaxel resistant prostate cancer cell lines
Amanda J O'Neill, Maria Prencipe, Catherine Dowling, Yue Fan, Laoighse Mulrane, William M Gallagher, Darran O'Connor, Robert O'Connor, Aoife Devery, Claire Corcoran, Sweta Rani, Lorraine O'Driscoll, John M Fitzpatrick, R William G Watson
EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartment
Yuanjie Hu, Peter Dion Pioli, Eric Siegel, Qinghua Zhang, Jodi Nelson, Abhishek Chaturbedi, Marlon S Mathews, Daniel I Ro, Selma Alkafeef, Nelson Hsu, Mark Hamamura, Liping Yu, Kenneth R Hess, Bruce J Tromberg, Mark E Linskey, Yi-Hong Zhou
Chemoresistance of glioblastoma cancer stem cells - much more complex than expected
Dagmar Beier, Joerg B Schulz, Christoph P Beier
Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor
Hari Raghu, Christopher S Gondi, Dzung H Dinh, Meena Gujrati, Jasti S Rao
MicroRNAs in rhabdomyosarcoma: pathogenetic implications and translational potentiality
Rossella Rota, Roberta Ciarapica, Antonio Giordano, Lucio Miele, Franco Locatelli
Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation
Ramesh Ummanni, Edgar Jost, Melanie Braig, Frithjof Lohmann, Frederike Mundt, Christine Barett, Thorsten Schlomm, Guido Sauter, Tina Senff, Carsten Bokemeyer, Holger Sültmann, Catherine Meyer-Schwesinger, Tim H Brümmendorf, Stefan Balabanov
Mesenchymal stem cells as carriers and amplifiers in CRAd delivery to tumors
Xi Xia, Teng Ji, Pingbo Chen, Xiao Li, Yong Fang, Qinglei Gao, Shujie Liao, Lanying You, Hongbin Xu, Quanfu Ma, Peng Wu, Wencheng Hu, Mingfu Wu, Li Cao, Kezhen Li, Yanjie Weng, Zhiqiang Han, Junchen Wei, Ronghua Liu, Shixuan Wang, Gang Xu, Daowen Wang, Jianfeng Zhou, Ding Ma
HCCS1-armed, quadruple-regulated oncolytic adenovirus specific for liver cancer as a cancer targeting gene-viro-therapy strategy
Hai-Neng Xu, Wei-Dan Huang, Ying Cai, Miao Ding, Jin-Fa Gu, Na Wei, Lan-Ying Sun, Xin Cao, Hua-Guang Li, Kang-Jian Zhang, Xin-Ran Liu, Xin-Yuan Liu
Long noncoding intronic RNAs are differentially expressed in primary and metastatic pancreatic cancer
Ana C Tahira, Márcia S Kubrusly, Michele F Faria, Bianca Dazzani, Rogério S Fonseca, Vinicius Maracaja-Coutinho, Sergio Verjovski-Almeida, Marcel CC Machado, Eduardo M Reis
Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces
Italia A Asteriti, Maria Giubettini, Patrizia Lavia, Giulia Guarguaglini
SLUG promotes prostate cancer cell migration and invasion via CXCR4/CXCL12 axis
Berna Uygur, Wen-Shu Wu
SOX2-RNAi attenuates S-phase entry and induces RhoA-dependent switch to protease-independent amoeboid migration in human glioma cells
Felix Oppel, Nadja Müller, Gabriele Schackert, Sandy Hendruschk, Daniel Martin, Kathrin D Geiger, Achim Temme
Retinoic acid pathway activity in wilms tumors and characterization of biological responses in vitro
Jenny Wegert, Sabrina Bausenwein, Susanne Kneitz, Sabine Roth, Norbert Graf, Eva Geissinger, Manfred Gessler
Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells
Ramon C Sun, Philip G Board, Anneke C Blackburn
NONO and RALY proteins are required for YB-1 oxaliplatin induced resistance in colon adenocarcinoma cell lines
Serges P Tsofack, Chantal Garand, Chris Sereduk, Donald Chow, Meraj Aziz, David Guay, Hongwei H Yin, Michel Lebel
An integrative genomic analysis revealed the relevance of microRNA and gene expression for drug-resistance in human breast cancer cells
Yusuke Yamamoto, Yusuke Yoshioka, Kaho Minoura, Ryou-u Takahashi, Fumitaka Takeshita, Toshiki Taya, Reiko Horii, Yayoi Fukuoka, Takashi Kato, Nobuyoshi Kosaka, Takahiro Ochiya
Papillomavirus E5: the smallest oncoprotein with many functions
Aldo Venuti, Francesca Paolini, Lubna Nasir, Annunziata Corteggio, Sante Roperto, Maria S Campo, Giuseppe Borzacchiello
β2-adrenoceptor blockage induces G1/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFκB pathway
Dong Zhang, Qingyong Ma, Zheng Wang, Min Zhang, Kun Guo, Fengfei Wang, Erxi Wu
Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation
Kevin Vo, Barushi Amarasinghe, Kay Washington, Adriana Gonzalez, Jordan Berlin, Thao P Dang
Genomic instability influences the transcriptome and proteome in endometrial cancer subtypes
Jens K Habermann, Nana K Bündgen, Timo Gemoll, Sampsa Hautaniemi, Caroline Lundgren, Danny Wangsa, Jana Doering, Hans-Peter Bruch, Britta Nordstroem, Uwe J Roblick, Hans Jörnvall, Gert Auer, Thomas Ried
PAX2 is activated by estradiol in breast cancer cells of the luminal subgroup selectively, to confer a low invasive phenotype
David Beauchemin, Catherine Lacombe, Céline Van Themsche
Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity
Hang Fai Kwok, Richard J Buick, Diana Kuehn, Julie A Gormley, Declan Doherty, Thomas J Jaquin, Angela McClurg, Claire Ward, Teresa Byrne, Jacob Jaworski, Ka Lai Leung, Philip Snoddy, Christine McAnally, Roberta E Burden, Breena Gray, Jenny Lowry, Isabelle Sermadiras, Natalia Gruszka, Nigel Courtenay-Luck, Adrien Kissenpfennig, Christopher J Scott, James A Johnston, Shane A Olwill
Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in ApcMin/+ mice
Kristoffer W Brudvik, Jan E Paulsen, Einar M Aandahl, Borghild Roald, Kjetil Taskén
Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines
Roberta R Alfieri, Maricla Galetti, Stefano Tramonti, Roberta Andreoli, Paola Mozzoni, Andrea Cavazzoni, Mara Bonelli, Claudia Fumarola, Silvia La Monica, Elena Galvani, Giuseppe De Palma, Antonio Mutti, Marco Mor, Marcello Tiseo, Ettore Mari, Andrea Ardizzoni, Pier Giorgio Petronini
Anti-tumor effects of fibroblast growth factor-binding protein (FGF-BP) knockdown in colon carcinoma
Daniel Schulze, Philipp Plohmann, Sabrina Höbel, Achim Aigner
Efficient Blockade of Akt signaling is a determinant factor to overcome resistance to Matuzumab
Debora D Meira, Vitor H Almeida, Jânio S Mororó, Mauricio S Caetano, Isabel P Nóbrega, Delano Batista, Cinthya Sternberg, Carlos G Ferreira
Lymphocyte deficiency limits Epstein-Barr virus latent membrane protein 1 induced chronic inflammation and carcinogenic pathology in vivo
Adele Hannigan, Asif M Qureshi, Colin Nixon, Penelope M Tsimbouri, Sarah Jones, Adrian W Philbey, Joanna B Wilson
Studies on mechanisms of interferon-gamma action in pancreatic cancer using a data-driven and model-based approach
Falko Lange, Katja Rateitschak, Brit Fitzner, Ralf Pöhland, Olaf Wolkenhauer, Robert Jaster
IL-17 induces AKT-dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma
Fang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Kai Zhu, Xiao-Yong Huang, Jin-Feng Pan, Jun Yan, Jin-Hui Hu, Zheng Wang, Zhi Dai, Jia Fan, Jian Zhou
MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation
Yong-Xi Song, Zhen-Yu Yue, Zhen-Ning Wang, Ying-Ying Xu, Yang Luo, Hui-Mian Xu, Xue Zhang, Li Jiang, Cheng-Zhong Xing, Yong Zhang
Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression
Delphine Javelaud, Leon van Kempen, Vasileia I Alexaki, Erwan Le Scolan, Kunxin Luo, Alain Mauviel
Improvement of different vaccine delivery systems for cancer therapy
Azam Bolhassani, Shima Safaiyan, Sima Rafati
Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells
Hideki Tatsukawa, Tetsuro Sano, Yayoi Fukaya, Naoto Ishibashi, Makiko Watanabe, Masataka Okuno, Hisataka Moriwaki, Soichi Kojima
Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability
Yumay Chen, Chi-Fen Chen, Huai-Chin Chiang, Michelle Pena, Rosaria Polci, Randy L Wei, Robert A Edwards, Donna E Hansel, Phang-Lang Chen, Daniel J Riley
LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells
Tenekua Tapia, Richard Ottman, Ratna Chakrabarti
Epigenetic reprogramming of breast cancer cells with oocyte extracts
Cinzia Allegrucci, Michael D Rushton, James E Dixon, Virginie Sottile, Mansi Shah, Rajendra Kumari, Sue Watson, Ramiro Alberio, Andrew D Johnson
Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis
Inamul Haque, Smita Mehta, Monami Majumder, Kakali Dhar, Archana De, Douglas McGregor, Peter J Van Veldhuizen, Sushanta K Banerjee, Snigdha Banerjee
Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer
Bao-Hong Guo, Yan Feng, Rong Zhang, Li-Hua Xu, Man-Zhi Li, Hsiang-Fu Kung, Li-Bing Song, Mu-Sheng Zeng
Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin
Wei Wei, Mei-Sze Chua, Susan Grepper, Samuel K So
Sodium ion channel mutations in glioblastoma patients correlate with shorter survival
Avadhut D Joshi, D Williams Parsons, Victor E Velculescu, Gregory J Riggins
Pro-inflammatory cytokine/chemokine production by reovirus treated melanoma cells is PKR/NF-κB mediated and supports innate and adaptive anti-tumour immune priming
Lynette Steele, Fiona Errington, Robin Prestwich, Elizabeth Ilett, Kevin Harrington, Hardev Pandha, Matt Coffey, Peter Selby, Richard Vile, Alan Melcher
PIAS1 interacts with FLASH and enhances its co-activation of c-Myb
Anne Hege Alm-Kristiansen, Petra I Lorenzo, Ann-Kristin Molværsmyr, Vilborg Matre, Marit Ledsaak, Thomas Sæther, Odd S Gabrielsen
Metastasis: new perspectives on an old problem
Sandra Kraljevic Pavelic, Mirela Sedic, Hrvojka Bosnjak, Sime Spaventi, Kresimir Pavelic
Differential contributory roles of nucleotide excision and homologous recombination repair for enhancing cisplatin sensitivity in human ovarian cancer cells
Qi-En Wang, Keisha Milum, Chunhua Han, Yi-Wen Huang, Gulzar Wani, Jürgen Thomale, Altaf A Wani
EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: A potential mechanism of EGFR-driven antagonism of apoptosis
Xinyu Cao, Hu Zhu, Francis Ali-Osman, Hui-Wen Lo
miR-449 inhibits cell proliferation and is down-regulated in gastric cancer
Tony Bou Kheir, Ewa Futoma-Kazmierczak, Anders Jacobsen, Anders Krogh, Linda Bardram, Christoffer Hother, Kirsten Grønbæk, Birgitte Federspiel, Anders H Lund, Lennart Friis-Hansen