Skip to main content
Erschienen in: Der Nervenarzt 8/2017

08.05.2017 | Demenz | Übersichten

Nichtmotorische Symptome beim Morbus Parkinson

verfasst von: Prof. Dr. W. H. Jost

Erschienen in: Der Nervenarzt | Ausgabe 8/2017

Einloggen, um Zugang zu erhalten

Zusammenfassung

Der Morbus Parkinson ist eine neurodegenerative Erkrankung, die das periphere und zentrale Nervensystem betrifft. Neben den motorischen Symptomen tritt in allen Krankheitsphasen eine Vielzahl nichtmotorischer Störungen auf, die von hoher klinischer Relevanz sind. Besondere Beachtung finden in den letzten Jahren neuropsychiatrische und autonome Störungen. Unter den neuropsychiatrischen sind besonders die Depression, die kognitiven Einbußen sowie Psychosen und Impulskontrollstörungen zu nennen. Bezüglich der autonomen Funktion können alle Bereiche betroffen sein, wobei vor allem kardiovaskuläre, gastrointestinale und urogenitale Funktionsstörungen und Symptome zu nennen sind. Die Therapie ist schwierig und erfordert eine interdisziplinäre Herangehensweise. Auf dem Gebiet der nichtmotorischen Störungen besteht ein erheblicher diagnostischer und therapeutischer Bedarf.
Literatur
1.
Zurück zum Zitat Duncan GW, Khoo TK, Yarnall AJ et al (2014) Health-related quality of life in early Parkinson’s disease: the impact of nonmotor symptoms. Mov Disord 29:195–202CrossRefPubMed Duncan GW, Khoo TK, Yarnall AJ et al (2014) Health-related quality of life in early Parkinson’s disease: the impact of nonmotor symptoms. Mov Disord 29:195–202CrossRefPubMed
2.
Zurück zum Zitat Havlikova E, van Dijk JP, Nagyova I et al (2011) The impact of sleep and mood disorders on quality of life in Parkinson’s disease patients. J Neurol 258:2222–2229CrossRefPubMed Havlikova E, van Dijk JP, Nagyova I et al (2011) The impact of sleep and mood disorders on quality of life in Parkinson’s disease patients. J Neurol 258:2222–2229CrossRefPubMed
3.
Zurück zum Zitat Schaller S, Anderer P, Dorffner G et al (2012) Autonomic dysfunction in PD during sleep. Mov Disord 27:454CrossRefPubMed Schaller S, Anderer P, Dorffner G et al (2012) Autonomic dysfunction in PD during sleep. Mov Disord 27:454CrossRefPubMed
4.
Zurück zum Zitat Abbott RD, Ross GW, Tanner CM et al (2005) Excessive daytime sleepiness and subsequent development of Parkinson disease. Neurology 65:1442–1446CrossRefPubMed Abbott RD, Ross GW, Tanner CM et al (2005) Excessive daytime sleepiness and subsequent development of Parkinson disease. Neurology 65:1442–1446CrossRefPubMed
5.
Zurück zum Zitat Arnulf I, Konofal E, Merino-Andreu M et al (2002) Parkinson’s disease and sleepiness. Neurology 58:1019–1024CrossRefPubMed Arnulf I, Konofal E, Merino-Andreu M et al (2002) Parkinson’s disease and sleepiness. Neurology 58:1019–1024CrossRefPubMed
6.
Zurück zum Zitat Monaca C, Duhamel A, Jacquesson JM et al (2006) Vigilance troubles in Parkinson’s disease: a subjective and objective polysomnographic study. Sleep Med 7:448–453CrossRefPubMed Monaca C, Duhamel A, Jacquesson JM et al (2006) Vigilance troubles in Parkinson’s disease: a subjective and objective polysomnographic study. Sleep Med 7:448–453CrossRefPubMed
7.
Zurück zum Zitat Ondo WG, Dat Vuong K, Khan H et al (2001) Daytime sleepiness and other sleep disorders in Parkinson’s disease. Neurology 57:1392–1396CrossRefPubMed Ondo WG, Dat Vuong K, Khan H et al (2001) Daytime sleepiness and other sleep disorders in Parkinson’s disease. Neurology 57:1392–1396CrossRefPubMed
8.
Zurück zum Zitat Zesiewicz TA, Sullivan KL, Arnulf I et al (2010) Practice parameter: treatment of nonmotor symptoms of Parkinson disease: report of the quality standards subcommittee of the American Academy of Neurology. Neurology 74:924–931CrossRefPubMed Zesiewicz TA, Sullivan KL, Arnulf I et al (2010) Practice parameter: treatment of nonmotor symptoms of Parkinson disease: report of the quality standards subcommittee of the American Academy of Neurology. Neurology 74:924–931CrossRefPubMed
9.
Zurück zum Zitat Barone P, Antonini A, Colosimo C et al (2009) The PRIAMO study. A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson’s disease. Mov Disord 24:1641–1649CrossRefPubMed Barone P, Antonini A, Colosimo C et al (2009) The PRIAMO study. A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson’s disease. Mov Disord 24:1641–1649CrossRefPubMed
10.
Zurück zum Zitat Zambito-Marsala S, Erro R, Bacchin R et al (2017) Abnormal nociceptive processing occurs centrally and not peripherally in pain-free Parkinson disease patients: a study with laser-evoked potentials. Parkinsonism Relat Disord 34:43–48CrossRefPubMed Zambito-Marsala S, Erro R, Bacchin R et al (2017) Abnormal nociceptive processing occurs centrally and not peripherally in pain-free Parkinson disease patients: a study with laser-evoked potentials. Parkinsonism Relat Disord 34:43–48CrossRefPubMed
11.
Zurück zum Zitat Nègre-Pagès L, Regragui W, Bouhassira D et al (2008) Chronic pain in Parkinson’s disease: the cross-sectional French DoPaMIP survey. Mov Disord 23:1361–1369CrossRefPubMed Nègre-Pagès L, Regragui W, Bouhassira D et al (2008) Chronic pain in Parkinson’s disease: the cross-sectional French DoPaMIP survey. Mov Disord 23:1361–1369CrossRefPubMed
12.
Zurück zum Zitat Perez-Lloret S, Rey MV, Dellapina E et al (2012) Emerging analgesic drugs for Parkinson’s disease. Expert Opin Emerg Drugs 17:157–171CrossRefPubMed Perez-Lloret S, Rey MV, Dellapina E et al (2012) Emerging analgesic drugs for Parkinson’s disease. Expert Opin Emerg Drugs 17:157–171CrossRefPubMed
13.
Zurück zum Zitat Storch A, Schneider CB, Wolz M et al (2013) Nonmotor fluctuations in Parkinson disease: severity and correlation with motor complications. Neurology 80:800–809CrossRefPubMed Storch A, Schneider CB, Wolz M et al (2013) Nonmotor fluctuations in Parkinson disease: severity and correlation with motor complications. Neurology 80:800–809CrossRefPubMed
14.
Zurück zum Zitat Storch A, Ebersbach G, Fuchs G et al (2008) Depression bei Morbus Parkinson – Epidemiologie, Klinik, Pathophysiologie und Diagnostik. Fortschr Neurol Psychiatr 76:715–724CrossRefPubMed Storch A, Ebersbach G, Fuchs G et al (2008) Depression bei Morbus Parkinson – Epidemiologie, Klinik, Pathophysiologie und Diagnostik. Fortschr Neurol Psychiatr 76:715–724CrossRefPubMed
15.
Zurück zum Zitat Storch A, Schneider C, Ebersbach G et al (2010) Depression beim idiopathischen Parkinson – Syndrom – Teil 2: Therapie und Management. Fortschr Neurol Psychiatr 78:456–467CrossRefPubMed Storch A, Schneider C, Ebersbach G et al (2010) Depression beim idiopathischen Parkinson – Syndrom – Teil 2: Therapie und Management. Fortschr Neurol Psychiatr 78:456–467CrossRefPubMed
16.
Zurück zum Zitat Seppi K, Weintraub D, Coelho M et al (2011) The Movement Disorder Society evidence-based medicine review update: treatments for the non-motor symptoms of Parkinson’s disease. Mov Disord 26(S3):S42–S80CrossRefPubMedPubMedCentral Seppi K, Weintraub D, Coelho M et al (2011) The Movement Disorder Society evidence-based medicine review update: treatments for the non-motor symptoms of Parkinson’s disease. Mov Disord 26(S3):S42–S80CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Parkinson J (1817) An essay on the shaking palsy. Sherwood, Neely, and Jones, London Parkinson J (1817) An essay on the shaking palsy. Sherwood, Neely, and Jones, London
18.
Zurück zum Zitat Emre M (2004) Dementia in Parkinson’s disease: cause and treatment. Curr Opin Neurol 17:399–404CrossRefPubMed Emre M (2004) Dementia in Parkinson’s disease: cause and treatment. Curr Opin Neurol 17:399–404CrossRefPubMed
19.
Zurück zum Zitat Kalbe E, Rehberg SP, Heber I et al (2016) Subtypes of mild cognitive impairment in patients with Parkinson’s disease: evidence from the LANDSCAPE study. J Neurol Neurosurg Psychiatr 87:1099–1105CrossRefPubMed Kalbe E, Rehberg SP, Heber I et al (2016) Subtypes of mild cognitive impairment in patients with Parkinson’s disease: evidence from the LANDSCAPE study. J Neurol Neurosurg Psychiatr 87:1099–1105CrossRefPubMed
20.
Zurück zum Zitat Postuma RB, Berg D, Stern M et al (2015) MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 30:1591–1601CrossRefPubMed Postuma RB, Berg D, Stern M et al (2015) MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 30:1591–1601CrossRefPubMed
21.
Zurück zum Zitat Kempster PA, O’Sullivan SS, Holton JL et al (2010) Relationships between age and late progression of Parkinson’s disease: a clinic-pathological study. Brain 133:1755–1762CrossRefPubMed Kempster PA, O’Sullivan SS, Holton JL et al (2010) Relationships between age and late progression of Parkinson’s disease: a clinic-pathological study. Brain 133:1755–1762CrossRefPubMed
22.
Zurück zum Zitat Aarsland D, Brønnick K, Ehrt U et al (2007) Neuropsychiatric symptoms in patients with Parkinson’s disease and dementia: frequency, profile and associated care giver stress. J Neurol Neurosurg Psychiatr 78:36–42CrossRefPubMed Aarsland D, Brønnick K, Ehrt U et al (2007) Neuropsychiatric symptoms in patients with Parkinson’s disease and dementia: frequency, profile and associated care giver stress. J Neurol Neurosurg Psychiatr 78:36–42CrossRefPubMed
23.
Zurück zum Zitat Emre M, Aarsland D, Albanese A et al (2004) Rivastigmine for dementia associated with Parkinson’s disease. N Engl J Med 351:2509–2518CrossRefPubMed Emre M, Aarsland D, Albanese A et al (2004) Rivastigmine for dementia associated with Parkinson’s disease. N Engl J Med 351:2509–2518CrossRefPubMed
24.
Zurück zum Zitat Wood LD, Neumiller JJ, Setter SM, Dobbins EK (2010) Clinical review of treatment options for select nonmotor symptoms of Parkinson’s disease. Am J Geriatr Pharmacother 8:294–315CrossRefPubMed Wood LD, Neumiller JJ, Setter SM, Dobbins EK (2010) Clinical review of treatment options for select nonmotor symptoms of Parkinson’s disease. Am J Geriatr Pharmacother 8:294–315CrossRefPubMed
25.
Zurück zum Zitat Leung IH, Walton CC, Hallock H et al (2015) Cognitive training in Parkinson disease: a systematic review and meta-analysis. Neurology 85:1843–1851CrossRefPubMedPubMedCentral Leung IH, Walton CC, Hallock H et al (2015) Cognitive training in Parkinson disease: a systematic review and meta-analysis. Neurology 85:1843–1851CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Fénelon G, Alves G (2010) Epidemiology of psychosis in Parkinson’s disease. J Neurol Sci 289:12–17CrossRefPubMed Fénelon G, Alves G (2010) Epidemiology of psychosis in Parkinson’s disease. J Neurol Sci 289:12–17CrossRefPubMed
27.
Zurück zum Zitat Fenelon G, Mahieux F, Huon R, Ziegler M (2000) Hallucinations in Parkinson’s disease: prevalence, phenomenology and risk factors. Brain 123:733–745CrossRefPubMed Fenelon G, Mahieux F, Huon R, Ziegler M (2000) Hallucinations in Parkinson’s disease: prevalence, phenomenology and risk factors. Brain 123:733–745CrossRefPubMed
28.
Zurück zum Zitat Reiff J, Jost WH (2011) Drug-induced impulse control disorders in Parkinson’s disease. J Neurol 258(Suppl.2):S323–S327CrossRefPubMed Reiff J, Jost WH (2011) Drug-induced impulse control disorders in Parkinson’s disease. J Neurol 258(Suppl.2):S323–S327CrossRefPubMed
29.
Zurück zum Zitat Garcia-Ruiz PJ, Martinez Castrillo JC, Alonso-Canovas A et al (2014) Impulse control disorder in patients with Parkinson’s diesase under dopamine agonist therapy: a multicentre study. J Neurol Neurosurg Psychiatr 85:840–844CrossRefPubMed Garcia-Ruiz PJ, Martinez Castrillo JC, Alonso-Canovas A et al (2014) Impulse control disorder in patients with Parkinson’s diesase under dopamine agonist therapy: a multicentre study. J Neurol Neurosurg Psychiatr 85:840–844CrossRefPubMed
31.
Zurück zum Zitat Jost WH (1995) Autonome Regulationsstörungen beim Parkinson Syndrom. Fortschr Neurol Psychiatr 63:194–205CrossRefPubMed Jost WH (1995) Autonome Regulationsstörungen beim Parkinson Syndrom. Fortschr Neurol Psychiatr 63:194–205CrossRefPubMed
32.
Zurück zum Zitat Oka H, Yoshioka M, Onouchi K et al (2007) Characteristics of orthostatic hypotension in Parkinson’s disease. Brain 130:2425–2432CrossRefPubMed Oka H, Yoshioka M, Onouchi K et al (2007) Characteristics of orthostatic hypotension in Parkinson’s disease. Brain 130:2425–2432CrossRefPubMed
33.
Zurück zum Zitat Jost WH, Del Tredici K, Landvogt C, Braune S (2010) Importance of 123I-metaiodobenzylguanidin (MIBG) scintigraphy/SPECT for diagnosis and differential diagnostics of Parkinson syndromes. Neurodegener Dis 7:341–347CrossRefPubMed Jost WH, Del Tredici K, Landvogt C, Braune S (2010) Importance of 123I-metaiodobenzylguanidin (MIBG) scintigraphy/SPECT for diagnosis and differential diagnostics of Parkinson syndromes. Neurodegener Dis 7:341–347CrossRefPubMed
34.
Zurück zum Zitat Strano S, Fanciulli A, Rizzo M et al (2016) Cardiovascular dysfunction in untreated Parkinson’s disease: a multi-modality assessment. J Neurol Sci 370:251–255CrossRefPubMed Strano S, Fanciulli A, Rizzo M et al (2016) Cardiovascular dysfunction in untreated Parkinson’s disease: a multi-modality assessment. J Neurol Sci 370:251–255CrossRefPubMed
35.
Zurück zum Zitat Korczyn AD (1990) Autonomic nervous system disturbances in Parkinson’s disease. Adv Neurol 53:463–468PubMed Korczyn AD (1990) Autonomic nervous system disturbances in Parkinson’s disease. Adv Neurol 53:463–468PubMed
36.
Zurück zum Zitat Allcock LM, Ullyart K, Kenny RA, Burn DJ (2004) Frequency of orthostatic hypotension in a community based cohort of patients with Parkinson’s disease. J Neurol Neurosurg Psychiatr 75:1470–1471CrossRefPubMedPubMedCentral Allcock LM, Ullyart K, Kenny RA, Burn DJ (2004) Frequency of orthostatic hypotension in a community based cohort of patients with Parkinson’s disease. J Neurol Neurosurg Psychiatr 75:1470–1471CrossRefPubMedPubMedCentral
37.
Zurück zum Zitat Umehara T, Nakahara A, Matsuno H et al (2016) Predictors of postprandial hypotension in elderly patients with de novo Parkinson’s disease. J Neural Transm (Vienna) 123:1331–1339CrossRef Umehara T, Nakahara A, Matsuno H et al (2016) Predictors of postprandial hypotension in elderly patients with de novo Parkinson’s disease. J Neural Transm (Vienna) 123:1331–1339CrossRef
38.
Zurück zum Zitat Oh YS, Kim JS, Chung YA et al (2013) Orthostatic hypotension, non-dipping and striatal dopamine in Parkinson disease. Neurol Sci 34:557–560CrossRefPubMed Oh YS, Kim JS, Chung YA et al (2013) Orthostatic hypotension, non-dipping and striatal dopamine in Parkinson disease. Neurol Sci 34:557–560CrossRefPubMed
40.
Zurück zum Zitat Chaudhuri KR, Ellis C, Love-Jones S et al (1997) Postprandial hypotension and parkinsonian state in Parkinson’s disease. Mov Disord 12:877–884CrossRefPubMed Chaudhuri KR, Ellis C, Love-Jones S et al (1997) Postprandial hypotension and parkinsonian state in Parkinson’s disease. Mov Disord 12:877–884CrossRefPubMed
41.
Zurück zum Zitat Thomaides T, Karapanayiotides T, Zoukos Y et al (2005) Gastric emptying after semi-solid food in multiple system atrophy and Parkinson’s disease. J Neurol 252:1055–1059CrossRefPubMed Thomaides T, Karapanayiotides T, Zoukos Y et al (2005) Gastric emptying after semi-solid food in multiple system atrophy and Parkinson’s disease. J Neurol 252:1055–1059CrossRefPubMed
42.
Zurück zum Zitat Jost WH, Augustis S (2015) Severity of orthostatic hypotension in the course of Parkinson’s disease: no correlation with the duration of the disease. Parkinsonism Rel Disord 21:314–316CrossRef Jost WH, Augustis S (2015) Severity of orthostatic hypotension in the course of Parkinson’s disease: no correlation with the duration of the disease. Parkinsonism Rel Disord 21:314–316CrossRef
43.
Zurück zum Zitat Goldstein DS (2006) Orthostatic hypotension as an early finding in Parkinson’s disease. Clin Auton Res 16:46–54CrossRefPubMed Goldstein DS (2006) Orthostatic hypotension as an early finding in Parkinson’s disease. Clin Auton Res 16:46–54CrossRefPubMed
44.
Zurück zum Zitat Braak H, Del Tredici K, Bratzke H et al (2002) Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson’s disease. J Neurol 249(S3):1–5CrossRef Braak H, Del Tredici K, Bratzke H et al (2002) Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson’s disease. J Neurol 249(S3):1–5CrossRef
45.
Zurück zum Zitat Goldstein DS, Holmes CS, Dendi R et al (2002) Orthostatic hypotension from sympathetic denervation in Parkinson’s disease. Neurology 58:1247–1255CrossRefPubMed Goldstein DS, Holmes CS, Dendi R et al (2002) Orthostatic hypotension from sympathetic denervation in Parkinson’s disease. Neurology 58:1247–1255CrossRefPubMed
47.
Zurück zum Zitat Schoffer KL, Henderson RD, O’Maley K, O’Sullivan JD (2007) Nonpharmocological treamtent, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson’s disease. Mov Disord 22:1543–1549CrossRefPubMed Schoffer KL, Henderson RD, O’Maley K, O’Sullivan JD (2007) Nonpharmocological treamtent, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson’s disease. Mov Disord 22:1543–1549CrossRefPubMed
48.
Zurück zum Zitat Hauser RA, Isaacson S, Lisk JP et al (2015) Droxidopa for the short-term treatment of symptomatic neurogenic orthostatic hypotension in Parkinson’s disease (nOH306B). Mov Disord 30:646–654CrossRefPubMed Hauser RA, Isaacson S, Lisk JP et al (2015) Droxidopa for the short-term treatment of symptomatic neurogenic orthostatic hypotension in Parkinson’s disease (nOH306B). Mov Disord 30:646–654CrossRefPubMed
49.
50.
Zurück zum Zitat Braak H, de Vos RAI, Bohl J, Del Tredici K (2006) Gastric a‑synuclein immunoreactive inclusions in Meissner’s and Auerbach’s plexuses in cases staged for Parkinson’s disease related brain pathology. Neurosci Lett 396:67–72CrossRefPubMed Braak H, de Vos RAI, Bohl J, Del Tredici K (2006) Gastric a‑synuclein immunoreactive inclusions in Meissner’s and Auerbach’s plexuses in cases staged for Parkinson’s disease related brain pathology. Neurosci Lett 396:67–72CrossRefPubMed
51.
Zurück zum Zitat Den Hartog Jager WA, Bethlem J (1960) The distribution of Lewy bodies in the central and autonomic nervous system in idiopathic paralysis agitans. J Neurol Neurosurg Psychiatr 23:283–290CrossRef Den Hartog Jager WA, Bethlem J (1960) The distribution of Lewy bodies in the central and autonomic nervous system in idiopathic paralysis agitans. J Neurol Neurosurg Psychiatr 23:283–290CrossRef
52.
Zurück zum Zitat Chou KL, Evatt M, Hinson V, Kompoliti K (2007) Sialorrhea in Parkinson’s disease: a review. Mov Disord 16:2306–2313CrossRef Chou KL, Evatt M, Hinson V, Kompoliti K (2007) Sialorrhea in Parkinson’s disease: a review. Mov Disord 16:2306–2313CrossRef
53.
Zurück zum Zitat Adler CH, Dugger PN, Hinni ML et al (2014) Submandibular gland needle biopsy for the diagnosis of Parkinson’s disease. Neurology 82:858–864CrossRefPubMedPubMedCentral Adler CH, Dugger PN, Hinni ML et al (2014) Submandibular gland needle biopsy for the diagnosis of Parkinson’s disease. Neurology 82:858–864CrossRefPubMedPubMedCentral
54.
Zurück zum Zitat Del Tredici K, Hawkes CH, Ghebremedhin E, Braak H (2010) Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson’s diseases. Acta Neuropathol 119:703–713CrossRefPubMed Del Tredici K, Hawkes CH, Ghebremedhin E, Braak H (2010) Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson’s diseases. Acta Neuropathol 119:703–713CrossRefPubMed
55.
Zurück zum Zitat Molloy L (2007) Treatment of sialorroea in patients with Parkinson’s disease: best current evidence. Curr Opin Neurol 20:493–498CrossRefPubMed Molloy L (2007) Treatment of sialorroea in patients with Parkinson’s disease: best current evidence. Curr Opin Neurol 20:493–498CrossRefPubMed
56.
Zurück zum Zitat Arbouw ME, Movig KL, Koopmann M et al (2010) Glycopyrrolate for sialorrhea in Parkinson disease: a randomized, double-blind, crossover trial. Neurology 74:1203–1207CrossRefPubMed Arbouw ME, Movig KL, Koopmann M et al (2010) Glycopyrrolate for sialorrhea in Parkinson disease: a randomized, double-blind, crossover trial. Neurology 74:1203–1207CrossRefPubMed
57.
Zurück zum Zitat Jost WH (1999) Treatment of drooling in Parkinson’s disease with botulinum toxin. Mov Disord 14:1057CrossRefPubMed Jost WH (1999) Treatment of drooling in Parkinson’s disease with botulinum toxin. Mov Disord 14:1057CrossRefPubMed
58.
Zurück zum Zitat Jost WH (2015) The option of sonographic guidance in botulinum toxin injection for drooling in Parkinson’s disease. J Neural Transm 123:51–55CrossRefPubMed Jost WH (2015) The option of sonographic guidance in botulinum toxin injection for drooling in Parkinson’s disease. J Neural Transm 123:51–55CrossRefPubMed
59.
Zurück zum Zitat Bushmann M, Dobmeyer SM, Leeker L et al (1989) Swallowing abnormalities and their response to treatment in Parkinson’s Disease. Neurology 39:1309–1314CrossRefPubMed Bushmann M, Dobmeyer SM, Leeker L et al (1989) Swallowing abnormalities and their response to treatment in Parkinson’s Disease. Neurology 39:1309–1314CrossRefPubMed
60.
Zurück zum Zitat Edwards L, Quigley EMM, Hofman R et al (1993) Gastrointestinal symptoms in Parkinson disease: 18-month follow-up study. Mov Disord 8:83–86CrossRefPubMed Edwards L, Quigley EMM, Hofman R et al (1993) Gastrointestinal symptoms in Parkinson disease: 18-month follow-up study. Mov Disord 8:83–86CrossRefPubMed
61.
62.
Zurück zum Zitat Ertekin C, Tarlaci S, Aydogdu I et al (2002) Electrophysiological evaluation of pharyngeal phase of swallowing in patients with Parkinson’s disease. Mov Disord 17:942–949CrossRefPubMed Ertekin C, Tarlaci S, Aydogdu I et al (2002) Electrophysiological evaluation of pharyngeal phase of swallowing in patients with Parkinson’s disease. Mov Disord 17:942–949CrossRefPubMed
64.
Zurück zum Zitat Kurlan R, Rubin AJ, Miller C et al (1985) Continuous intraduodenal infusion of levodopa for resistant on-off fluctuations in parkinsonism. Ann Neurol 18:139 Kurlan R, Rubin AJ, Miller C et al (1985) Continuous intraduodenal infusion of levodopa for resistant on-off fluctuations in parkinsonism. Ann Neurol 18:139
65.
66.
Zurück zum Zitat Abbott RD, Petrovitch H, White LR et al (2001) Frequency of bowel movements and the future risk of Parkinson’s disease. Neurology 57:456–464CrossRefPubMed Abbott RD, Petrovitch H, White LR et al (2001) Frequency of bowel movements and the future risk of Parkinson’s disease. Neurology 57:456–464CrossRefPubMed
67.
Zurück zum Zitat Svensson E, Henderson VW, Borghammer P et al (2016) Constipation and risk of Parkinson’s disease: a Danish population-based cohort study. Parkinsonism Relat Disord 28:18–22CrossRefPubMed Svensson E, Henderson VW, Borghammer P et al (2016) Constipation and risk of Parkinson’s disease: a Danish population-based cohort study. Parkinsonism Relat Disord 28:18–22CrossRefPubMed
68.
Zurück zum Zitat Kaye J, Gage H, Kimber A et al (2006) Excess burden of constipation in Parkinson’s disease: a pilot study. Mov Disord 21:1270–1273CrossRefPubMed Kaye J, Gage H, Kimber A et al (2006) Excess burden of constipation in Parkinson’s disease: a pilot study. Mov Disord 21:1270–1273CrossRefPubMed
69.
Zurück zum Zitat Zangaglia R, Martignoni E, Glorioso M et al (2007) Macrogol for the treatment of constipation in Parkinson’s disease. A randomized placebo-controlled study. Mov Disord 22:1239–1244CrossRefPubMed Zangaglia R, Martignoni E, Glorioso M et al (2007) Macrogol for the treatment of constipation in Parkinson’s disease. A randomized placebo-controlled study. Mov Disord 22:1239–1244CrossRefPubMed
70.
Zurück zum Zitat Jost WH (2013) Urological problems in Parkinson’s disease: clinical aspects. J Neural Transm 120:587–591CrossRefPubMed Jost WH (2013) Urological problems in Parkinson’s disease: clinical aspects. J Neural Transm 120:587–591CrossRefPubMed
71.
Zurück zum Zitat Sakakibara R, Uchiyama T, Yamanishi T, Kishi M (2010) Genitourinary dysfunction in Parkinson’s disease. Mov Disord 25:2–12CrossRefPubMed Sakakibara R, Uchiyama T, Yamanishi T, Kishi M (2010) Genitourinary dysfunction in Parkinson’s disease. Mov Disord 25:2–12CrossRefPubMed
72.
Zurück zum Zitat Andersen JT, Hebjørn S, Frimodt-Møller C et al (1976) Disturbances of micturition in Parkinson’s disease. Acta Neurol Scand 53:161–170CrossRefPubMed Andersen JT, Hebjørn S, Frimodt-Møller C et al (1976) Disturbances of micturition in Parkinson’s disease. Acta Neurol Scand 53:161–170CrossRefPubMed
73.
Zurück zum Zitat Raz S (1976) Parkinsonism and neurogenic bladder. Urol Res 4:133–138PubMed Raz S (1976) Parkinsonism and neurogenic bladder. Urol Res 4:133–138PubMed
74.
Zurück zum Zitat Winge K, Werdelin LM, Nielsen KK, Stimpel H (2004) Effects of dopaminergic treatment on bladder function in Parkinson’s disease. Neurourol Urodyn 23:689–696CrossRefPubMed Winge K, Werdelin LM, Nielsen KK, Stimpel H (2004) Effects of dopaminergic treatment on bladder function in Parkinson’s disease. Neurourol Urodyn 23:689–696CrossRefPubMed
75.
Zurück zum Zitat Lemack GE, Dewey RB, Roehrborn CR et al (2000) Questionnaire-based assessment of bladder dysfunction in patients with mild to moderate Parkinson’s disease. Urology 56:250–254CrossRefPubMed Lemack GE, Dewey RB, Roehrborn CR et al (2000) Questionnaire-based assessment of bladder dysfunction in patients with mild to moderate Parkinson’s disease. Urology 56:250–254CrossRefPubMed
76.
Zurück zum Zitat Mock S, Osborn DJ, Brown ET et al (2016) The impact of pallidal and subthalamic deep brain stimulation on urologic function in Parkinson’s disease. Neuromodulation 19:717–723CrossRefPubMedPubMedCentral Mock S, Osborn DJ, Brown ET et al (2016) The impact of pallidal and subthalamic deep brain stimulation on urologic function in Parkinson’s disease. Neuromodulation 19:717–723CrossRefPubMedPubMedCentral
77.
Zurück zum Zitat Brusa L, Petta F, Pisani A et al (2007) Acute vs chronic effects of L‑dopa on bladder function in patients with mild Parkinson disease. Neurology 68:1455–1459CrossRefPubMed Brusa L, Petta F, Pisani A et al (2007) Acute vs chronic effects of L‑dopa on bladder function in patients with mild Parkinson disease. Neurology 68:1455–1459CrossRefPubMed
78.
Zurück zum Zitat Singer C, Weiner WJ, Sanchez-Ramos JR et al (1989) Sexual dysfunction in men with Parkinson’s disease. J Neuroeng Rehabil 3:199–204 Singer C, Weiner WJ, Sanchez-Ramos JR et al (1989) Sexual dysfunction in men with Parkinson’s disease. J Neuroeng Rehabil 3:199–204
79.
Zurück zum Zitat Varanda S, Ribeiro da Silva J, Costa AS et al (2016) Sexual dysfunction in women with Parkinson’s disease. Mov Disord 31:1685–1693CrossRefPubMed Varanda S, Ribeiro da Silva J, Costa AS et al (2016) Sexual dysfunction in women with Parkinson’s disease. Mov Disord 31:1685–1693CrossRefPubMed
80.
Zurück zum Zitat Magerkurth C, Schnitzer R, Braune S (2005) Symptoms of autonomic failure in Parkinson’s disease: prevalence and impact on daily life. Clin Auton Res 15:76–82CrossRefPubMed Magerkurth C, Schnitzer R, Braune S (2005) Symptoms of autonomic failure in Parkinson’s disease: prevalence and impact on daily life. Clin Auton Res 15:76–82CrossRefPubMed
Metadaten
Titel
Nichtmotorische Symptome beim Morbus Parkinson
verfasst von
Prof. Dr. W. H. Jost
Publikationsdatum
08.05.2017
Verlag
Springer Medizin
Erschienen in
Der Nervenarzt / Ausgabe 8/2017
Print ISSN: 0028-2804
Elektronische ISSN: 1433-0407
DOI
https://doi.org/10.1007/s00115-017-0346-7

Weitere Artikel der Ausgabe 8/2017

Der Nervenarzt 8/2017 Zur Ausgabe

Mitteilungen der DGN

Mitteilungen der DGN

Passend zum Thema

ANZEIGE

Mittelgradige Depressionen & Johanniskraut: Das hat sich geändert

Die Behandlungsempfehlungen bei mittelgradiger Depression wurden erneuert und der Einsatz von Johanniskraut entscheidend präzisiert – welche zwei Empfehlungen Sie aus der aktualisierten Depressions-Leitlinie jetzt kennen sollten.

ANZEIGE

3 Kernaussagen: Cochrane-Analyse untersucht Johanniskrautextrakte

Johanniskraut gehört zu den am besten untersuchten pflanzlichen Arzneimitteln. Die Ergebnisse zur Wirksamkeit bei Depressionen wurden u. a. in einem Cochrane-Review analysiert [1]. Wie das pflanzliche Antidepressivum dabei abschnitt und welche drei Kernaussagen Sie für die Praxis kennen sollten, lesen Sie hier.

ANZEIGE

Depression behandeln. Natürlich.

Content Hub

Aktuelle Ergebnisse aus in-vitro- und in-vivo-Untersuchungen liefern detaillierte Erklärungen zum Wirkmechanismus von hochdosiertem Johanniskraut-Extrakt: Neu ist die Erkenntnis, dass der Johanniskraut-Extrakt bei chronischem Stress die deregulierte Stressantwort der überaktiven HPA-Achse sowie die Expression des Stressgens FKBP5 normalisieren kann. Mehr zum aktuellen Stand der Wissenschaft bei der Therapie von Depressionen erfahren Sie hier. 

Bayer Vital GmbH