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Intensive Care Medicine

Erschienen in:

17.10.2016 | Editorial

Statins in patients with sepsis and ARDS: is it over? We are not sure

verfasst von: Danny McAuley, Pierre-Emmanuel Charles, Laurent Papazian

Erschienen in: Intensive Care Medicine | Ausgabe 5/2017

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Excerpt

Statins are lipid-lowering agents which act by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase and are generally used for cardiovascular prevention. Statins, however, also present anti-inflammatory and immunomodulating effects which could be of interest in sepsis and acute respiratory distress syndrome (ARDS). Many experimental investigations and some epidemiological studies support this theoretical beneficial effect. However, recent interventional studies which showed no benefit have been discouraging and do not support the use of statins in septic and/or ARDS patients. …

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Titel: Statins in patients with sepsis and ARDS: is it over? We are not sure
verfasst von: Danny McAuley
Pierre-Emmanuel Charles
Laurent Papazian
Publikationsdatum: 17.10.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Intensive Care Medicine / Ausgabe 5/2017
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-016-4454-9

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