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01.04.2014 | Bekanntmachungen - Amtliche Mitteilungen

Stoffmonographie Ochratoxin A

Stellungnahme der Kommission Human-Biomonitoring des Umweltbundesamtes

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Erschienen in: Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz | Ausgabe 4/2014

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Ochratoxin A (OTA) ist ein Mykotoxin und gehört damit zu einer strukturell extrem heterogenen Gruppe von Substanzen, die alle Metabolite des Sekundärstoffwechsels von Schimmelpilzen sind. OTA wurde erstmalig 1965 aus einer Kultur von Aspergillus ochraceus isoliert. Auch in anderen Aspergillen, z. B. Aspergillus carbonarius, findet sich OTA. Daneben produziert Penicillium verrucosum als einziger Vertreter der Schimmelpilzgattung Penicillium OTA. …

Greim H (Hrsg) (2003) Ochratoxin A. Gesundheitsschädliche Arbeitsstoffe: Toxikologisch-arbeitsmedizinische Begründung von MAK-Werten. 37. Lieferung. Wiley-VCH, Weinheim. http://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb30347d0037/pdf

NTP (National Toxicology Program, U.S. Department of Health and Human Services) (2011) 12th Report on Carcinogens. http://ntp.niehs.nih.gov/ntp/roc/twelfth/roc12.pdf, http://ntp.niehs.nih.gov/

IARC (1976) Ochratoxin A. IARC monographs on the evaluation of the carcinogenic risk of chemicals to man: some naturally occurring substances. 10:191–197. http://monographs.iarc.fr/ENG/Monographs/vol1-42/mono10.pdf

Domijan AM, Peraica M, Cvjetković B et al (2005) Mould contamination and co-occurrence of mycotoxins in maize grain in Croatia. Acta Pharm 55:349–356. http://www.ncbi.nlm.nih.gov/pubmed/16375824

Sangare-Tigori B, Moukha S, Kouadio HJ et al (2006) Co-occurrence of aflatoxin B1, fumonisin B1, ochratoxin A and zearalenone in cereals and peanuts from Côte d’Ivoire. Food Addit Contam 23:1000–1007. http://www.tandfonline.com/doi/full/10.1080/02652030500415686#.UtU0Jydsvp8

Peraica M, Domijan AM, Miletić-Medved M, Fuchs R (2008) The involvement of mycotoxins in the development of endemic nephropathy. Wien Klin Wochenschr 120(13–14):402–407. http://link.springer.com/article/10.1007%2Fs00508-008-0981-x

Klarić MS, Cvetnić Z, Pepeljnjak S, Kosalec I (2009) Co-occurrence of aflatoxins, ochratoxin A, fumonisins, and zearalenone in cereals and feed, determined by competitive direct enzyme-linked immunosorbent assay and thin-layer chromatography. Arh Hig Rada Toksikol 60:427–434. http://www.degruyter.com/view/j/aiht.2009.60.issue-4/10004-1254-60-2009-1975/10004-1254-60-2009-1975.xml

Peraica M, Flajs D, Domijan AM et al (2010) Ochratoxin A contamination of food from Croatia. Toxins 2:2098–2105. http://www.mdpi.com/2072-6651/2/8/2098

IARC (1993) Ochratoxin A. IARC monographs on the evaluation of carcinogenic risks to humas. Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. 56:489–521. http://monographs.iarc.fr/ENG/Monographs/vol56/mono56.pdf

10.

WHO (World Health Organisation) (2001) Safety evaluation of certain mycotoxins in food. IPCS-FAO food and nutrition paper WHO, Genf. 74:281–387. http://www.inchem.org/documents/jecfa/jecmono/v47je01.htm

11.

Jørgensen K (2005) Occurrence of ochratoxin A in commodities and processed food – a review of EU occurrence data. Food Add Contam 22:26–30. http://www.tandfonline.com/doi/pdf/10.1080/02652030500344811

12.

EU (2006) Amtsblatt der Europäischen Union, Verordnung (EG) Nr.1881/2006 der Kommission zur Festsetzung der Höchstgehalte für bestimmte Kontaminanten in Lebensmitteln (Text with EEA relevance). 576(49)(L364):05-24. http://eur-lex.europa.eu/JOHtml.do?uri=OJ:L:2006:364:SOM:DE:HTML, http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2006:364:0005:0024:DE:PDF

13.

EU (2010) Amtsblatt der Europäischen Union, VERORDNUNG (EU) Nr.105/2010 DER KOMMISSION zur Änderung der Verordnung (EG) Nr.1881/2006 zur Festsetzung der Höchstgehalte für bestimmte Kontaminanten in Lebensmitteln hinsichtlich Ochratoxin A.35(53)(L35):7–8. http://eur-lex.europa.eu/JOHtml.do?uri=OJ:L:2010:035:SOM:DE:HTML, http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2010:035:FULL:DE:PDF

14.

EU (2006) Commission of the European Communities, Commission Recommendation on the presence of deoxynivalenol, zearalenone, ochratoxin A, T-2 and HT-2 and fumonisins in products intended for animal feeding (Text with EEA relevance). 576(49)(L229):7–9. http://eur-lex.europa.eu/JOHtml.do?uri=OJ:L:2006:229:SOM:EN:HTML, http://irmm.jrc.ec.europa.eu/EURLs/eurl_mycotoxins/legislation/Pages/index.aspx, http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2006:229:0007:0009:EN:PDF

15.

EU (2009) Amtsblatt der Europäischen Union, Verordnung (EG) Nr.386/2009 der Kommission vom 12. Mai 2009 zur Änderung der Verordnung (EG) Nr.1831/2003 des Europäischen Parlaments und des Rates hinsichtlich der Festlegung einer neuen Funktionsgruppe für Futtermittelzusatzstoffe. 52(L118):66. http://eur-lex.europa.eu/JOHtml.do?uri=OJ:L:2009:118:SOM:DE:HTML, http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2009:118:FULL:DE:PDF

16.

Walker R, Larsen JC (2005) Ochratoxin A: previous risk assessments and issues arising. Food Addit Contam 22(Suppl 1):6–9. http://www.ncbi.nlm.nih.gov/pubmed/16332615

17.

Duarte SC, Lino CM, Pena A (2010) Mycotoxin food and feed regulation and the specific case of ochratoxin A: a review of the worldwide status. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 27:1440–1450. http://www.ncbi.nlm.nih.gov/pubmed/20658402

18.

Duarte SC, Lino CM, Pena A (2011) Ochratoxin A in feed of food-producing animals: an undesirable mycotoxin with health and performance effects. Vet Microbiol 154(1–2):1–13. http://www.sciencedirect.com/science/article/pii/S0378113511002707

19.

Duarte SC, Pena A, Lino CM (2009) Ochratoxin A non-conventional exposure sources – a review. Microchem J 93:115–120. http://www.sciencedirect.com/science/article/pii/S0026265X09000885

20.

SCOOP (Scientific Cooperation Task Reports) (2002) Assessment of dietary intake of Ochratoxin A by the population of EU Member States. http://ec.europa.eu/food/fs/scoop/3.2.7_en.pdf, http://ec.europa.eu/food/fs/scoop/index_en.html

21.

Di Giuseppe R, Bertuzzi T, Rossi F et al (2012) Plasma ochratoxin A levels, food consumption, and risk biomarkers of a representative sample of men and women from the Molise region in Italy. Eur J Nutr 51:851–860. http://link.springer.com/article/10.1007%2Fs00394-011-0265-5

22.

Mateo R, Medina A, Mateo EM et al (2007) An overview of ochratoxin A in beer and wine. Int J Food Microbiol 119:79–83. http://www.sciencedirect.com/science/article/pii/S016816050700390X

23.

EC SCF (European Commission’s Scientific Committee on Food) (1998) Opinion of the European Commission’s Scientific Committee on food on ochratoxin A. Expressed 17.09.98 – SCF. http://ec.europa.eu/food/fs/sc/scf/out14_en.html

24.

Kuiper-Goodman T, Hilts C, Billiard SM et al (2010) Health risk assessment of ochratoxin A for all age-sex strata in a market economy. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 27:212–240. http://www.tandfonline.com/doi/abs/10.1080/02652030903013278?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed#.UtQUGydsvp8

25.

JECFA (Joint FAO/WHO Expert Committee on Food Additives) (2001) WHO food additives series: 47. Safety evaluation of certain mycotoxins in food. Ochratoxin A. http://www.inchem.org/documents/jecfa/jecmono/v47je04.htm

26.

EFSA (European Food Safety Authority) (2006) Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to Ochratoxin A in food. Question N° EFSA-Q-2005-154. EFSA J 365:1–56. http://www.efsa.europa.eu/en/scdocs/doc/contam_op_ej365_ochratoxin_a_food_en.pdf

27.

EFSA (European Food Safety Authority) (2010) Scientific opinion. Statement on recent scientific information on the toxicity of Ochratoxin A.EFSA panel on contaminants in the food chain. EFSA J 8:1626. http://www.efsa.europa.eu/it/search/doc/1626.pdf

28.

Kasel U, Wichmann G, Bleck M (1999) Ochratoxin im Hausstaub. Umweltmed Forsch Prax 4(5):301–303. http://www.ecomed-medizin.de/sj/ufp/Pdf/aId/979

29.

Degen GH, Meifort J, Blaszkewicz M (2005) Pilotstudie zum Biomonitoring für Ochratoxin A bei Beschäftigten im Getreide- und Rohkaffee-Umschlag. Mycotoxin Res 21:168–171. http://link.springer.com/article/10.1007%2FBF02959256#page-1

30.

Mayer S, Gareis M, Degen GH et al (2007) Belastung durch luftgetragene Mykotoxine in Getreidelägern und Mykotoxinkonzentrationen im Blut von Getreidelagerarbeitern. Gefahrst Reinhalt Luft 67:119–125. http://www.gefahrstoffe.de/gest/article.php?data[article_id]=34784

31.

Tarin A, Rosell MG, Guardino X (2004) Use of high-performance liquid chromato-graphy to assess airborne mycotoxins: Aflatoxins and ochratoxin A. J Chromatogr A 1047:235–240. http://www.sciencedirect.com/science/article/pii/S0021967304010623

32.

DFG (Deutsche Forschungsgemeinschaft) (2013) MAK- und BAT-Werte-Liste 2013. Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe. Mitteilung 49. Wiley-VCH, Weinheim

33.

Pfohl-Leszkowicz A, Manderville RA (2007) Ochratoxin A: an overview on toxicity and carcinogenicity in animals and humans. Mol Nutr Food Res 51:61–99. http://onlinelibrary.wiley.com/doi/10.1002/mnfr.200600137/abstract

34.

Boonen J, Malysheva SV, Taevernier L et al (2012) Human skin penetration of selected model mycotoxins. Toxicology 301:21–32. http://www.sciencedirect.com/science/article/pii/S0300483X12002429#

35.

Pfohl-Leszkowicz A, Manderville RA (2012) An update on direct genotoxicity as a molecular mechanism of ochratoxin A carcinogenicity. Chem Res Toxicol 25:252–262. http://pubs.acs.org/doi/abs/10.1021/tx200430f

36.

Mantle PG, Faucet-Marquis V, Manderville RA et al (2010) Structures of covalent adducts between DNA and ochratoxin A: a new factor in debate about genotoxicity and human risk assessment. Chem Res Toxicol 23:89–98. http://pubs.acs.org/doi/abs/10.1021/tx900295a

37.

Al-Anati L, Petzinger E (2006) Immunotoxic activity of ochratoxin A. J Vet Pharmacol Ther 29:79–90. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.2006.00718.x/abstract

38.

Wangikar PB, Dwivedi P, Sinha N (2004) Effect in rats of simultaneous prenatal exposure to ochratoxin A and aflatoxin B1. I. Maternal toxicity and fetal malformations. Birth Defects Res B Dev Reprod Toxicol 71:343–351. http://onlinelibrary.wiley.com/doi/10.1002/bdrb.20021/pdf

39.

Hsuuw YD, Chan WH, Yu JS (2013) Ochratoxin A inhibits mouse embryonic development by activating a mitochondrion-dependent apoptotic signaling pathway. Int J Mol Sci 14:935–953. http://www.mdpi.com/1422-0067/14/1/935

40.

Patil RD, Dwivedi P, Sharma AK (2006) Critical period and minimum single oral dose of ochratoxin A for inducing developmental toxicity in pregnant Wistar rats. Reprod Toxicol 22:679–687. http://www.sciencedirect.com/science/article/pii/S0890623806001067

41.

Abid S, Hassan W, Achour A et al (2003) Ochratoxin A and human chronic nephropathy in Tunesia: is the situation endemic? Hum Exp Toxicol 22:77–84. http://het.sagepub.com/content/22/2/77.full.pdf+html

42.

Vrabcheva T, Petkova-Bocharova T, Grosso F et al (2004) Analysis of ochratoxin A in foods consumed by inhabitants from an area with balkan endemic nephropathy: a 1 month follow-up study. J Agric Food Chem 52:2404–2410. http://pubs.acs.org/doi/abs/10.1021/jf030498z

43.

Fuchs R, Peraica M (2005) Ochratoxin A in human kidney diseases. Food Addit Contam 22(s1):53–57. http://www.tandfonline.com/doi/pdf/10.1080/02652030500309368

44.

Yordanova P, Wilfried K, Tsolova S, Dimitrov P (2010) Ochratoxin A and β2-microglobulin in BEN patients and controls. Toxins 2:780–792. http://www.mdpi.com/2072-6651/2/4/780

45.

Petkova-Bocharova T, Castegnaro M, Michelon J, Maru V (1991) Ochratoxin A and other mycotoxins in cereals from an area of Balkan endemic nephropathy and urinary tract tumours in Bulgaria. IARC Sci Publ 115:83–87. http://www.ncbi.nlm.nih.gov/pubmed/1820357

46.

Castegnaro M, Canadas D, Vrabcheva T et al (2006) Balkan endemic nephropathy: role of ochratoxins A through biomarkers. Mol Nutr Food Res 50:519–529. http://onlinelibrary.wiley.com/doi/10.1002/mnfr.200500182/abstract

47.

Chernozemsky IN, Stoyanov IS, Petkova-Bocharova TK et al (1977) Geographic correlation between the occurrence of endemic nephropathy and urinary tract tumours in Vratza district Bulgaria. Int J Cancer 19:1–11. http://onlinelibrary.wiley.com/doi/10.1002/ijc.2910190102/pdf

48.

Wafa EW, Yahya RS, Sobh MA et al (1998) Human ochratoxicosis and nephropathy in Egypt: a preliminary study. Hum Exp Toxicol 17:124–129. http://het.sagepub.com/content/17/2/124.full.pdf+html

49.

Grollman AP, Shibutani S, Moriya M et al (2007) Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc Natl Acad Sci U S A 104(29):12129–12134. http://www.pnas.org/content/104/29/12129.long

50.

Pepeljnjak S, Klarić MŠ (2010) „Suspects“ in etiology of endemic nephropathy: aristolochic acid versus mycotoxins. Toxins 2:1414–1427. http://www.mdpi.com/2072-6651/2/6/1414

51.

Haighton LA, Lynch BS, Magnuson BA, Nestmann ER (2012) A reassessment of risk associated with dietary intake of ochratoxin A based on a lifetime exposure model. Crit Rev Toxicol 42:147–168. http://informahealthcare.com/doi/pdfplus/10.3109/10408444.2011.636342

52.

Coronel MB, Sanchis V, Ramos AJ, Marin S (2010) Review. Ochratoxin A: presence in human plasma and intake estimation. Food Sci Technol Int 16:5–18. http://fst.sagepub.com/content/16/1/5.long

53.

Studer-Rohr I, Schlatter J, Dietrich DR (2000) Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans. Arch Toxicol 74:499–510. http://kops.ub.uni-konstanz.de/bitstream/handle/urn:nbn:de:bsz:352-opus-49607/Kinetic_parameters_and_intraindividual_fluctuations_of_ochratoxin_A_plasma_levels_in_humans.pdf?sequence=1

54.

Stojkovic R, Hult K, Gamulin S, Plestina R (1984) High affinity binding of ochratoxin A to plasma constituents. Biochem Int 9:33–38. http://www.ncbi.nlm.nih.gov/pubmed/6477636

55.

Hagelberg S, Hult K, Fuchs R (1989) Toxicokinetics of ochratoxin A in several species and its plasma-binding properties. J Appl Toxicol 9:91–96. http://onlinelibrary.wiley.com/doi/10.1002/jat.2550090204/pdf

56.

Ringot D, Chango A, Schneider Y, Larondelle Y (2006) Toxicokinetics and toxicodynamics of ochratoxin A, an update. Chem Biol Interact 159:18–46. http://www.sciencedirect.com/science/article/pii/S0009279705003479

57.

Fuchs R, Hult K (1992) Ochratoxin A in blood and its pharmacokinetic properties. Food Chem Toxicol 30:201–204. http://www.sciencedirect.com/science/article/pii/027869159290034I

58.

Corcuera LA, Vettorazzi A, Arbillaga L et al (2012) An approach to the toxicity and toxicokinetics of aflatoxin B1 and ochratoxin A after simultaneous oral administration to fasted F344 rats. Food Chem Toxicol 50:3440–3446. http://www.sciencedirect.com/science/article/pii/S0278691512004620

59.

Gaou I, Dubois M, Pfohl-Leszkowicz A et al (2005) Safety of Oxygreen®, an ozone treatment on wheat grains. Part 1. A four-week toxicity study in rats by dietary administration of treated wheat. Food Addit Contam 22:1113–1119. http://www.tandfonline.com/doi/abs/10.1080/02652030500307156?journalCode=tfac19#.UtP1iidsvp8

60.

Miraglia M, Brera C, Corneli S et al (1998) Occurrence of ochratoxin A in maternal blood serum, placenta and funiculum. In: Miraglia M, Egmond HP van, Brera C, Gilbert J (Hrsg) Mycotoxins and phycotoxins: developments in chemistry, toxicology and food safety. Alaken Inc, Fort Collins, S 165–179. http://www.alaken.com/myco_phyco.html

61.

Zimmerli B, Dick R (1995) Determination of ochratoxin A at the ppt level in human blood, serum, milk and some foodstuffs by high-performance liquid chromatography with enhanced fluorescence detection and immune affinity column cleanup: methodology and Swiss data. J Chromatogr B Biomed Appl 666:85–99. http://www.sciencedirect.com/science/article/pii/037843479400569Q#

62.

Gekle M, Sauvant C, Schwerdt G (2005) Ochratoxin A at nanomolar concentrations: a signal modulator in renal cells. Mol Nutr Food Res 49:118–130. http://onlinelibrary.wiley.com/doi/10.1002/mnfr.200400062/pdf

63.

Li S, Marquardt RR, Frohlich AA et al (1997) Pharmacokinetics of ochratoxin A and its metabolites in rats. Toxicol Appl Pharmacol 145:82–90. http://www.sciencedirect.com/science/article/pii/S0041008X97981552

64.

Wu Q, Dohnal V, Huang L et al (2011) Metabolic pathways of ochratoxin A. Curr Drug Metab12:1–10. http://www.eurekaselect.com/73315/article

65.

Grenier B, Applegate TJ (2013) Modulation of intestinal functions following mycotoxin ingestion: meta-analysis of published experiments in animals. Toxins 5:396–430. http://www.mdpi.com/2072-6651/5/2/396

66.

Størmer FC, Hansen CE, Pedersen JI et al (1981) Formation of 4R- and 4S- 4-hydroxyochratoxin A from ochratoxin A by liver microsomes from various species. Appl Environ Microbiol 42:1051–1056. http://aem.asm.org/content/42/6/1051.abstract

67.

Gautier JC, Richoz J, Welti DH et al (2001) Metabolism of ochratoxin A: absence of formation of genotoxic derivatives by human and rat enzymes. Chem Res Toxicol 14:34–45. http://pubs.acs.org/doi/abs/10.1021/tx000070j

68.

Gross-Steinmeyer KG, Weymann J, Hege HG, Metzler M (2002) Metabolism and lack of DNA reactivity of the mycotoxin ochratoxin A in cultured rat and human primary hepatocytes. J Agric Food Chem 50:938–945. http://pubs.acs.org/doi/abs/10.1021/jf0111817

69.

Pinelli E, Adlouni CE, Pipy B et al (1999) Roles of cyclooxygenase and lipoxygenases in ochratoxin A genotoxicity in human epithelial lung cells. Environ Toxicol Pharmacol 7:95–107. http://www.sciencedirect.com/science/article/pii/S1382668999000083

70.

Mally A, Dekant W (2009) Mycotoxins and the kidney: modes of action for renal tumor formation by ochratoxin A in rodents. Mol Nutr Food Res 53:467–478. http://onlinelibrary.wiley.com/doi/10.1002/mnfr.200800149/abstract;jsessionid=A8835A4A189F4BF3EE03655233CC8B42.f01t01

71.

Mally A (2012) Ochratoxin A and mitotic disruption: mode of action analysis of renal tumor formation by ochratoxin A. Toxicol Sci127:315–330. http://toxsci.oxfordjournals.org/content/127/2/315.full

72.

Mally A, Pepe G, Ravoori S et al (2005) Ochratoxin A causes DNA damage and cytogenetic effects but no DNA adducts in rats. Chem Res Toxicol18:1253–1261. http://pubs.acs.org/doi/abs/10.1021/tx049650x

73.

Kamp HG, Eisenbrand G, Janzowski C et al (2005) Ochratoxin A induces oxidative DNA damage in liver and kidney after oral dosing to rats. Mol Nutr Food Res 49:1160–1167. http://onlinelibrary.wiley.com/doi/10.1002/mnfr.200500124/pdf

74.

Scott PM (2005) Biomarkers of human exposure to ochratoxin A. Food Addit Contam 22(s1):99–107. http://www.tandfonline.com/doi/pdf/10.1080/02652030500410315

75.

Duarte SC, Pena A, Lino CM (2011) Human ochratoxin A biomarkers – from exposure to effect. Crit Rev Toxicol 41:187–212. http://informahealthcare.com/doi/abs/10.3109/10408444.2010.529103

76.

Coronel MB, Marin S, Tarragó M et al (2011) Ochratoxin A and its metabolite ochratoxin alpha in urine and assessment of the exposure of inhabitants of Lleida. Spain. Food Chem Toxicol 49:1436–1442. http://www.sciencedirect.com/science/article/pii/S0278691511001220

77.

Breitholtz-Emanuelsson A, Olsen M, Oskarsson A et al (1993) Ochratoxin A in cow’s milk and in human milk with corresponding human blood samples. J AOAC Int 76:842–846. http://www.ncbi.nlm.nih.gov/pubmed/8374329

78.

Munoz K, Wollin K-M, Kalhoff H, Degen GH (2013) Zum Vorkommen des Mykotoxins Ochratoxin A in Muttermilchproben aus Deutschland. Gesundheitswesen 75:194–191. https://www.thieme-connect.com/ejournals/html/10.1055/s-0033-1341442

79.

Blaszkewicz M, Baumhoer G, Butte W (2010) Ochratoxin A. In: Angerer J, Hartwig A (Hrsg) Analytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe. Analysen in biologischem Material. 19. Lieferung. Wiley-VCH, Weinheim. http://onlinelibrary.wiley.com/doi/10.1002/3527600418.bi30347d0019/pdf

80.

Meulenberg EP (2012) Immunochemical methods for ochratoxin A detection: a review. Toxins 4:244–266. http://www.mdpi.com/2072-6651/4/4/244

81.

Märtlbauer E, Usleber E, Dietrich R, Schneider E (2009) Ochratoxin A in human blood serum – retrospective long-term data. Mycotoxin Res 25:175–186. http://link.springer.com/article/10.1007%2Fs12550-009-0025-z

82.

Köller G, Rolle-Kampczyk U, Lehmann I et al (2004) Determination of ochratoxin A in small volumes of human blood serum. J Chromatogr B Analyt Technol Biomed Life Sci 804:313–317. http://www.sciencedirect.com/science/article/pii/S1570023204000649

83.

Erkekoğlu P, Sabuncuoğlu S, Aydin S et al (2010) Determination of seasonal variations in serum ochratoxin A levels in healthy population living in some regions of Turkey by enzyme-linked immunosorbent assay. Toxicon 55:507–513. http://www.sciencedirect.com/science/article/pii/S0041010109004760

84.

Ruprich J, Ostrý V (1993) Health risk assessment of the mycotoxin ochratoxin A to humans: Czech Republic – Brno – 1991/92. Cent Eur J Public Health 1:86–93. http://apps.szu.cz/svi/cejph/archiv/1993-2-05.pdf

85.

Märtlbauer E, Usleber E, Straka M (1996) Ochratoxin A im Serum eines Lehrstuhlkollektivs: 1990–1995. Proceedings, 18. Mykotoxin Workshop, 10–12 June 1996, Kulmbach, Germany: 97–101. http://d-nb.info/953992012/04

86.

Gilbert J, Brereton P, MacDonald S (2001) Assessment of dietary exposure to ochratoxin A in the UK using a duplicate diet approach and analysis of urine and plasma samples. Food Addit Contam 18(12):1088–1093. http://www.tandfonline.com/doi/abs/10.1080/02652030110070030?journalCode=tfac19#.UtP3bSdsvp8

87.

Palli D, Miraglia M, Saieva C et al (1999) Serum Levels of ochratoxin A in healthy adults in Tuscany: correlation with individual characteristics and between repeat measurements. Cancer Epidemiol Biomarkers Prev 8:265–269. http://cebp.aacrjournals.org/content/8/3/265.full

88.

Breitholtz A, Olsen M, Dahlback A, Hult K (1991) Plasma ochratoxin A levels in three Swedish populations surveyed using an ion-pair HPLC technique. Food Addit Contam 8:183–192. http://www.tandfonline.com/doi/abs/10.1080/02652039109373968?journalCode=tfac19#.UtAJZSdsvp8

89.

Peraica M, Domijan AM (2001) Mycotoxins in food and human health. Arh Hig Rada Toksikol 52:23–35PubMed

90.

Gareis M, Rosner H, Ehrhardt S (2000) Blood serum levels of ochratoxin A and nutrition habits. Arch Lebensmittelhygiene 51:108–110. http://www.zbmed.de/ccmedimages/2000/11897.pdf

91.

Rosner H, Rohrmann B, Peiker G (2000) Ochratoxin A in human serum. Arch Lebensmittelhygiene 51(4–5):104–107. http://www.zbmed.de/ccmedimages/2000/11897.pdf

92.

Miraglia M, Brera C, Colatosti M (1996) Application of biomarkers to assessment of risk to human health from exposure to mycotoxins. Microchem J 54:472–477. http://www.sciencedirect.com/science/article/pii/S0026265X96901241

93.

Studer-Rohr I (1995) Ochratoxin A in humans: exposure, kinetics and risk assessment. Dissertation ETH Zürich (DissETHNo. 11071). doi:10.3929/ethz-a-001455649. Available via ETH Institutional Repository. http://e-collection.ethbib.ethz.ch/view/eth:22417, http://e-collection.library.ethz.ch/eserv/eth:22417/eth-22417-02.pdf

94.

Thuvander A, Paulsen JE, Axberg K et al (2001) Levels of ochratoxin A in blood from Norwegian and Swedish blood donors and their possible correlation with food consumption. Food Chem Toxicol 39:1145–1151. http://www.sciencedirect.com/science/article/pii/S0278691501000801

95.

Munoz K, Vega M, Rios G et al (2006) Preliminary study of ochratoxin A in human plasma in agricultural zones of Chile and its relation to food consumption. Food Chem Toxicol 44:1884–1889. http://www.sciencedirect.com/science/article/pii/S027869150600158X

96.

Coronel MB, Sanchis V, Ramos AJ, Marin S (2009) Assessment of the exposure to ochratoxin A in the province of Lleida, Spain. Food Chem Toxicol 47:2847–2852. http://www.sciencedirect.com/science/article/pii/S027869150900413X

97.

Kommission Human-Biomonitoring des Umweltbundesamtes (1996) Konzept der Referenz und Human-Biomonitoring-Werte (HBM) in der Umweltmedizin. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 39(6):221–224

98.

Kommission Human-Biomonitoring des Umweltbundesamtes (2009) Addendum zum Konzept der Referenz- und Human-Biomonitoring-Werte (HBM) in der Umweltmedizin. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 52(8): 874–877. https://www.umweltbundesamt.de/sites/default/files/medien/pdfs/addendum_ref_werte_2009.pdf

Titel: Stoffmonographie Ochratoxin A
Stellungnahme der Kommission Human-Biomonitoring des Umweltbundesamtes
verfasst von: -
Publikationsdatum: 01.04.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz / Ausgabe 4/2014
Print ISSN: 1436-9990
Elektronische ISSN: 1437-1588
DOI: https://doi.org/10.1007/s00103-014-1939-y

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