Erschienen in:
01.12.2013 | Editorial
SUMOylation in Neuroplasticity and Neurological Disorders
verfasst von:
Marco Feligioni, Mark P. Mattson, Robert Nisticò
Erschienen in:
NeuroMolecular Medicine
|
Ausgabe 4/2013
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Excerpt
Cellular responses to stimuli are mediated by intracellular crosstalk between signaling pathways that, by complex mechanisms, regulate the activities of specific proteins. In particular, post-translational modification (PTM) represents an intriguing molecular system through which a protein, defined as modifier, is able to influence the localization, biological activity, or degradation of a target protein. The most extensively studied PTMs are phosphorylation, acetylation, and ubiquitination. However, protein modification by small ubiquitin-like modifier (SUMO) is increasingly attracting the attention of researchers because of its involvement in many essential physiological processes, and in pathological conditions. …