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Current Psychiatry Reports

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01.06.2012 | ANXIETY DISORDERS (DJ STEIN, SECTION EDITOR)

Systematic Review of Proinflammatory Cytokines in Obsessive-Compulsive Disorder

verfasst von: Simon M. Gray, Michael H. Bloch

Erschienen in: Current Psychiatry Reports | Ausgabe 3/2012

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Abstract

Several studies have examined levels of proinflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. This meta-analysis was conducted to examine the association between obsessive-compulsive disorder (OCD) and plasma serum levels of proinflammatory cytokines. Twelve studies met inclusion criteria. The meta-analysis demonstrated a significant reduction in IL-1β levels in OCD. No significant difference in plasma levels of IL-6 or TNF-α was demonstrated. Stratified subgroup analysis revealed possible moderating effects of age and medication use on IL-6 levels. Studies including children on psychotropic medication had lower plasma IL-6 levels. Stratified subgroup analysis revealed a moderating effect of comorbid depression on TNF-α levels. Elevated TNF-α levels were reported in studies that included individuals with comorbid depression. Future studies examining immune function in OCD should adjust for potential confounding due to medication use and comorbid depression. Further studies assessing cerebrospinal fluid cytokine levels in OCD are also needed.

Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62:593–602.PubMedCrossRef

Ruscio AM, Stein DJ, Chiu WT, Kessler RC. The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol Psychiatry. 2010;15:53–63.PubMedCrossRef

DuPont RL, Rice DP, Shiraki S, Rowland CR. Economic costs of obsessive-compulsive disorder. Med Interface. 1995;8:102–9.PubMed

First MB. Diagnostic and statistical manual of mental disorders. 4th ed. Washington: American Psychiatric Association; 2000.

• de Oliveira S, Pelajo C. Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection (PANDAS): a controversial diagnosis. Curr Infect Dis Rep. 2010;12:103–9. This review highlights important criticism of the PANDAS hypothesis..PubMedCrossRef

da Rocha FF, Correa H, Teixeira AL. Obsessive-compulsive disorder and immunology: a review. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:1139–46.PubMedCrossRef

Swedo SE, Grant PJ. Annotation: PANDAS: a model for human autoimmune disease. J Child Psychol Psychiatry. 2005;46:227–34.PubMedCrossRef

Swedo SE, Leonard HL, Garvey M, et al. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am J Psychiatry. 1998;155:264–71.PubMed

• Murphy TK, Kurlan R, Leckman J. The immunobiology of Tourette’s disorder, pediatric autoimmune neuropsychiatric disorders associated with streptococcus, and related disorders: a way forward. J Child Adolesc Psychopharmacol. 2010;20:317–31. This review provides an overview of PANDAS, including diagnostic criteria and evidence supporting the PANDAS hypothesis..PubMedCrossRef

10.

Araki K, Turner AP, Shaffer VO, et al. mTOR regulates memory CD8 T-cell differentiation. Nature. 2009;460:108–12.PubMedCrossRef

11.

Shulman ST. Pediatric autoimmune neuropsychiatric disorders associated with streptococci (PANDAS): update. Curr Opin Pediatr. 2009;21:127.PubMedCrossRef

12.

• Dowlati Y, Herrmann N, Swardfager W, et al. A meta-analysis of cytokines in major depression. Biol Psychiatry. 2010;67:446–57. This article demonstrates that cytokine levels are altered by mood disorders, which are highly comorbid in OCD..PubMedCrossRef

13.

Maes M, Bosmans E, De Jongh R, Kenis G, Vandoolaeghe E, Neels H. Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression. Cytokine. 1997;9:853–8.PubMedCrossRef

14.

Penninx BWJH, Kritchevsky SB, Yaffe K, et al. Inflammatory markers and depressed mood in older persons: results from the health, aging and body composition study. Biol Psychiatry. 2003;54:566–72.PubMedCrossRef

15.

Empana JP, Sykes DH, Luc G, et al. Contributions of depressive mood and circulating inflammatory markers to coronary heart disease in healthy European men. Circulation. 2005;111:2299–305.PubMedCrossRef

16.

Kim YK, Suh IB, Kim H, et al. The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs. Mol Psychiatry. 2002;7:1107.PubMedCrossRef

17.

Jones AL, Mowry BJ, Pender MP, Greer JM. Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis? Immunol Cell Biol. 2005;83:9–17.PubMedCrossRef

18.

Strous RD, Shoenfeld Y. Schizophrenia, autoimmunity and immune system dysregulation: a comprehensive model updated and revisited. J Autoimmun. 2006;27:71–80.PubMedCrossRef

19.

Potvin S, Stip E, Sepehry AA, Gendron A, Bah R, Kouassi E. Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review. Biol Psychiatry. 2008;63:801–8.PubMedCrossRef

20.

• Hannestad J, DellaGioia N, Bloch M. The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis. Neuropsychopharmacology. 2011;36:2452–9. This article demonstrates that psychotropic medication alters inflammatory cytokine levels in major depressive disorder..PubMedCrossRef

21.

Murphy K, Travers P, Walport M. Janeway’s immunobiology. 7th ed. New York: Garland Science; 2008.

22.

Steinke JW, Borish L. 3. Cytokines and chemokines. J Allergy Clin Immunol. 2006;117:S441–5.PubMedCrossRef

23.

Brough D, Tyrrell PJ, Allan SM. Regulation of interleukin-1 in acute brain injury. Trends Pharmacol Sci. 2011;32:617–22.PubMedCrossRef

24.

Konuk N, Tek, #x131, et al. Plasma levels of tumor necrosis factor-alpha and interleukin-6 in obsessive compulsive disorder. Mediat Inflamm. 2007;2007.

25.

Pan W, Zadina JE, Harlan RE, Weber JT, Banks WA, Kastin AJ. Tumor necrosis factor-alpha: a neuromodulator in the CNS. Neurosci Biobehav Rev. 1997;21:603–13.PubMedCrossRef

26.

Schöbitz B, de Kloet ER, Sutanto W, Holsboer F. Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain. Eur J Neurosci. 1993;5:1426–35.PubMedCrossRef

27.

Carlson NG, Wieggel WA, Chen J, Bacchi A, Rogers SW, Gahring LC. Inflammatory cytokines IL-1α, IL-1β, IL-6, and TNF-α impart neuroprotection to an excitotoxin through distinct pathways. J Immunol. 1999;163:3963–8.PubMed

28.

Hirano T, Yasukawa K, Harada H, et al. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature. 1986;324:73–6.PubMedCrossRef

29.

Spooren A, Kolmus K, Laureys G, et al. Interleukin-6, a mental cytokine. Brain Res Rev. 2011;67:157–83.PubMedCrossRef

30.

Tadamitsu K. Interleukin-6 and its receptor in autoimmunity. J Autoimmun. 1992;5(Supplement A):123–32.

31.

Xing Z, Gauldie J, Cox G, et al. IL-6 is an anti-inflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest. 1998;101:311–20.PubMedCrossRef

32.

Uyttenhove C, Coulie PG, Van Snick J. T cell growth and differentiation induced by interleukin-HP1/IL-6, the murine hybridoma/plasmacytoma growth factor. J Exp Med. 1988;167:1417–27.PubMedCrossRef

33.

Lotz M, Jirik F, Kabouridis P, et al. B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes. J Exp Med. 1988;167:1253–8.PubMedCrossRef

34.

Zheng H, Fletcher D, Kozak W, et al. Resistance to fever induction and impaired acute-phase response in interleukin-1β-deficient mice. Immunity. 1995;3:9–19.PubMedCrossRef

35.

Tilg H, Trehu E, Atkins MB, Dinarello CA, Mier JW. Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood. 1994;83:113–8.PubMed

36.

Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol. 2009;27:519–50.PubMedCrossRef

37.

Dinarello CA. Biologic basis for interleukin-1 in disease. Blood. 1996;87:2095–147.PubMed

38.

Marlin SD, Springer TA. Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell. 1987;51:813–9.PubMedCrossRef

39.

Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA. Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol. 1986;137:245–54.PubMed

40.

Sironi M, Breviario F, Proserpio P, et al. IL-1 stimulates IL-6 production in endothelial cells. J Immunol. 1989;142:549–53.PubMed

41.

Wang CC, Fu CL, Yang YH, et al. Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma. Gene Ther. 2006;13:1414–21.PubMedCrossRef

42.

Nakae S, Asano M, Horai R, Iwakura Y. Interleukin-1β, but not interleukin-1α, is required for T-cell-dependent antibody production. Immunology. 2001;104:402–9.PubMedCrossRef

43.

Pfeffer K. Biological functions of tumor necrosis factor cytokines and their receptors. Cytokine Growth Factor Rev. 2003;14:185–91.PubMedCrossRef

44.

McCoy M, Tansey M. TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J Neuroinflamm. 2008;5:1–13.CrossRef

45.

Cairns CB, Panacek EA, Harken AH, Banerjee A. Bench to bedside tumor necrosis factor-alpha: from inflammation to resuscitation. Acad Emerg Med. 2000;7:930–41.PubMedCrossRef

46.

Graham AL, Allen JE, Read AF. Evolutionary causes and consequences of immunopathology. Annu Rev Ecol Evol Syst. 2005;36:373–97.CrossRef

47.

Deeks J, Higgins J, Altman D. Cochrane reviewer’s handbook 4.2.2 [Updated March 2004] In: The Cochrane library. Chinchester: Wiley; 2004.

48.

Brambilla F, Perna G, Bellodi L, et al. Plasma interleukin-1β and tumor necrosis factor concentrations in obsessive-compulsive disorders. Biol Psychiatry. 1997;42:976–81.PubMedCrossRef

49.

Maes M, Meltzer HY, Bosmans E. Psychoimmune investigation in obsessive-compulsive disorder: assays of plasma transferrin, IL-2 and IL-6 receptor, and IL-1β and IL-6 concentrations. Neuropsychobiology. 1994;30:57–60.PubMedCrossRef

50.

Monteleone P, Catapano F, Fabrazzo M, Tortorella A, Maj M. Decreased blood levels of tumor necrosis factor-alpha in patients with obsessive-compulsive disorder. Neuropsychobiology. 1998;37:182–5.PubMedCrossRef

51.

Leckman JF, Katsovich L, Kawikova I, et al. Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome. Biol Psychiatry. 2005;57:667–73.PubMedCrossRef

52.

Gabbay V, Coffey BJ, Guttman LE, et al. A cytokine study in children and adolescents with Tourette’s disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:967–71.PubMedCrossRef

53.

Bos-Veneman NGP, Bijzet J, Limburg PC, Minderaa RB, Kallenberg CG, Hoekstra PJ. Cytokines and soluble adhesion molecules in children and adolescents with a tic disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:1390–5.PubMedCrossRef

54.

Weizman R, Laor N, Barber Y, et al. Cytokine production in obsessive-compulsive disorder. Biol Psychiatry. 1996;40:908–12.PubMedCrossRef

55.

Denys D, Fluitman S, Kavelaars A, Heijnen C, Westenberg H. Decreased TNF-α and NK activity in obsessive-compulsive disorder. Psychoneuroendocrinology. 2004;29:945–52.PubMedCrossRef

56.

Denys D, Fluitman S, Kavelaars A, Heijnen C, Westenberg HGM. Effects of paroxetine and venlafaxine on immune parameters in patients with obsessive compulsive disorder. Psychoneuroendocrinology. 2006;31:355–60.PubMedCrossRef

57.

Fluitman S, Denys D, Vulink N, Schutters S, Heijnen C, Westenberg H. Lipopolysaccharide-induced cytokine production in obsessive-compulsive disorder and generalized social anxiety disorder. Psychiatry Res. 2010;178:313–6.PubMedCrossRef

58.

Fluitman SBAHA, Denys DAJP, Heijnen CJ, Westenberg HGM. Disgust affects TNF-alpha, IL-6 and noradrenalin levels in patients with obsessive-compulsive disorder. Psychoneuroendocrinology. 2010;35:906–11.PubMedCrossRef

59.

Carpenter LL, Heninger GR, McDougle CJ, Tyrka AR, Epperson CN, Price LH. Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania. Psychiatry Res. 2002;112:257–62.PubMedCrossRef

60.

Mittleman BB, Castellanos FX, Jacobsen LK, Rapoport JL, Swedo SE, Shearer GM. Cerebrospinal fluid cytokines in pediatric neuropsychiatric disease. J Immunol. 1997;159:2994–9.PubMed

61.

Elenkov IJ, Chrousos GP. Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity. Ann N Y Acad Sci. 2002;966:290–303.PubMedCrossRef

62.

Vgontzas AN, Bixler EO, Lin HM, Prolo P, Trakada G, Chrousos GP. IL-6 and Its Circadian Secretion in Humans. Neuroimmunomodulation. 2005;12:131–40.PubMedCrossRef

Titel: Systematic Review of Proinflammatory Cytokines in Obsessive-Compulsive Disorder
verfasst von: Simon M. Gray
Michael H. Bloch
Publikationsdatum: 01.06.2012
Verlag: Current Science Inc.
Erschienen in: Current Psychiatry Reports / Ausgabe 3/2012
Print ISSN: 1523-3812
Elektronische ISSN: 1535-1645
DOI: https://doi.org/10.1007/s11920-012-0272-0

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