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European Radiology
Erschienen in: European Radiology 1/2020

23.07.2019 | Nuclear Medicine

The clinical value of F-18 FDG PET/CT in differentiating malignant from benign lesions in pneumoconiosis patients

verfasst von: Eun Kyoung Choi, Hye Lim Park, Ie Ryung Yoo, Seung Joon Kim, Young Kyoon Kim

Erschienen in: European Radiology | Ausgabe 1/2020

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Abstract

Objectives

We reviewed PET/CT findings of pneumoconiosis and determined the ability of PET/CT to differentiate lung cancer from progressive massive fibrosis (PMF), and metastatic lymph nodes (LNs) from underlying reactive LN hyperplasia.

Methods

This was a retrospective study of patients with pneumoconiosis and suspected lung cancer. Maximum standardized uptake value (SUVmax), long- and short-axis diameters (DL and DS), ratio of DL to DS (DL/S), and Hounsfield unit (HU) from the lung mass and mediastinal LNs were measured. The cutoff values of each parameter were obtained by ROC analysis, and we evaluated the diagnostic sensitivity.

Results

Forty-nine pneumoconiosis patients were included. Eighty-three lung masses were detected, of which 42 were confirmed as lung cancer (23 squamous cell carcinomas, 12 adenocarcinomas, and 7 small cell carcinomas) and 41 were PMF. There were significant differences between lung cancer and PMF in terms of SUVmax, DS, DL/S, and HU (all p < 0.05). The sensitivity, specificity, and accuracy for diagnosis of lung cancer were 81.0%, 73.2%, and 77.1%, respectively, with an SUVmax cutoff value of 7.4; and 92.8%, 87.8%, and 90.4%, respectively, with a HU cutoff value of 45.5. Among the 40 LNs with available pathological results, 7 were metastatic. Metastatic LNs showed higher SUVmax, larger DS, and lower HU than benign lesions (all p < 0.05). The sensitivity, specificity, and accuracy for predicting metastatic LNs by PET/CT were 85.7%, 93.9%, and 92.5%, respectively.

Conclusion

By applying PET and CT parameters in combination, the accuracy for differentiating malignant from benign lesions could be increased. PET/CT can play a central role in the discrimination of lung cancer and PMF.

Key Points

• Lung cancer showed significantly higher SUVmax than PMF.
• Lung cancer showed similar D L but longer D S , resulting in a smaller D L/S than PMF.
• SUVmax demonstrated additive value in differentiating lung cancer from PMF, compared with HU alone.
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Metadaten
Titel
The clinical value of F-18 FDG PET/CT in differentiating malignant from benign lesions in pneumoconiosis patients
verfasst von
Eun Kyoung Choi
Hye Lim Park
Ie Ryung Yoo
Seung Joon Kim
Young Kyoon Kim
Publikationsdatum
23.07.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 1/2020
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-019-06342-1

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