Background
Methods
Patient selection and diagnosis of distal bile duct cancer
Variables, definitions, and cutoff values
Statistical analysis
Results
Clinicopathological features
Variables | Total (n = 40) | |
---|---|---|
Age (year) | Mean ± SD | 70 (66–77) |
Gender | Male | 33 (82%) |
Female | 7 (18%) | |
Differentiation | Well | 8 (20%) |
Moderately | 30 (77%) | |
Poorly | 2 (3%) | |
T classification | T1 | 4 (10%) |
T2 | 6 (15%) | |
T3 | 29 (73%) | |
T4 | 1 (3%) | |
N classification | N (+) | 19 (48%) |
N (−) | 21 (52%) | |
Resection margin | R0 | 29 (73%) |
R1 | 8 (20%) | |
R2 | 3 (8%) | |
alb (g/dL) | Mean ± SD | 3.7 (3.3–3.9) |
CRP (mg/dL) | Mean ± SD | 0.27 (0.1–1.3) |
CEA (ng/mL) | Mean ± SD | 2.6 (1.9–4.0) |
CA19-9 (U/mL) | Mean ± SD | 53.9 (10.1–173.5) |
WBC (/mm3) | Mean ± SD | 5800 (4200–7000) |
Hb (g/dL) | Mean ± SD | 11.6 (10.5–13.1) |
plt (104/mm3) | Mean ± SD | 22.2 (19.4–26.7) |
NLR | Mean ± SD | 1.98 (1.37–2.54) |
LMR | Mean ± SD | 4.75 (2.93–5.84) |
Cutoff values for the neutrophil-to-lymphocyte ratio, the lymphocyte-to-monocyte ratio, and tumor markers
Collinearity of clinicopathological factors to the neutrophil-to-lymphocyte ratio and lymphocyte-to-monocyte ratio
Factors | NLR | LMR | |||||
---|---|---|---|---|---|---|---|
NLR ≥ 3.14 | NLR < 3.14 | P value | LMR ≥ 4.55 | LMR < 4.55 | P value | ||
Age (years) | ≥ 65 | 5 | 26 | 0.503 | 19 | 12 | 0.135 |
< 65 | 2 | 7 | 3 | 6 | |||
Gender | Male | 6 | 27 | 0.645 | 17 | 16 | 0.297 |
Female | 1 | 6 | 5 | 2 | |||
Differentiation | well differentiated | 0 | 8 | 0.181 | 3 | 5 | 0.237 |
others | 7 | 25 | 19 | 13 | |||
T classification | T1/2 | 2 | 8 | 0.572 | 6 | 4 | 0.503 |
T3/4 | 5 | 25 | 16 | 14 | |||
N classification | N (−) | 4 | 17 | 0.559 | 14 | 7 | 0.203 |
N (+) | 3 | 16 | 8 | 11 | |||
Resection margin | R0 | 6 | 23 | 0.364 | 17 | 12 | 0.347 |
R1 or R2 | 1 | 10 | 5 | 6 | |||
Albumin (g/dL) | ≥ 3.5 | 1 | 23 | 0.011 | 17 | 7 | 0.016 |
< 3.5 | 6 | 10 | 5 | 11 | |||
CRP (mg/dL) | ≥ 0.5 | 4 | 12 | 0.273 | 6 | 10 | 0.068 |
< 0.5 | 3 | 21 | 16 | 8 | |||
CEA (ng/mL) | ≥ 2.5 | 4 | 17 | 0.559 | 12 | 9 | 0.512 |
< 2.5 | 3 | 16 | 10 | 9 | |||
CA19-9 (U/mL) | ≥ 60.2 | 5 | 14 | 0.164 | 7 | 12 | 0.030 |
< 60.2 | 2 | 19 | 15 | 6 |
Association between prognostic indicators and long-term survival on univariate analysis
Factors | No. (%) | Univariate analysis | Multivariate analysis | |||||
---|---|---|---|---|---|---|---|---|
Hazard ratio | 95% CI | P value | Hazard ratio | 95% CI | P value | |||
Age (years) | ≥ 65 | 31 (82%) | 0.508 | 0.2046–1.245 | 0.138 | |||
< 65 | 9 (22%) | (Referent) | ||||||
Gender | Male | 33 (87%) | 0.945 | 0.352–3.282 | 0.920 | |||
Female | 7 (13%) | (Referent) | ||||||
Differentiation | Well differentiated | 8 (20%) | 1.243 | 0.416–3.716 | 0.697 | |||
Others | 32 (80%) | (Referent) | ||||||
T classification | T1/2 | 10 (25%) | (Referent) | 0.6476–5.816 | 0.236 | |||
T3/4 | 30 (75%) | 1.941 | ||||||
N classification | N (−) | 21 (53%) | (Referent) | 1.078–5.772 | 0.033 | |||
N (+) | 19 (48%) | 2.495 | ||||||
Resection margin | R0 | 29 (73%) | (Referent) | 0.9687–5.581 | 0.059 | |||
R1 or R2 | 11 (27%) | 2.325 | ||||||
Albumin (g/dL) | ≥ 3.5 | 24 (60%) | (Referent) | 1.521–8.495 | 0.004 | 1.484 | 0.537–4.107 | 0.447 |
< 3.5 | 16 (40%) | 3.595 | ||||||
CRP (mg/dL) | ≥ 0.5 | 16 (40%) | 1.220 | 0.5223–2.85 | 0.646 | |||
< 0.5 | 24 (60%) | (Referent) | ||||||
CEA (ng/mL) | ≥ 2.5 | 21 (53%) | 1.665 | 0.7226–3.838 | 0.231 | |||
< 2.5 | 19 (48%) | (Referent) | ||||||
CA19-9 (U/mL) | ≥ 60.2 | 19 (48%) | 3.165 | 1.345–7.449 | 0.008 | 2.614 | 0.978–6.993 | 0.056 |
< 60.2 | 21 (53%) | (Referent) | ||||||
NLR | ≥ 3.14 | 8 (20%) | 11.810 | 3.296–42.32 | < 0.001 | 6.133 | 1.453–25.900 | 0.014 |
< 3.14 | 32 (80%) | (Referent) | ||||||
LMR | ≥ 4.55 | 18 (45%) | (Referent) | 1.826–12.81 | 0.002 | 3.16 | 1.024–9.751 | 0.045 |
< 4.55 | 22 (55%) | 4.837 |