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The Cerebellum
Erschienen in: The Cerebellum 3/2009

01.09.2009

The Role of Kv3-type Potassium Channels in Cerebellar Physiology and Behavior

verfasst von: Rolf H. Joho, Edward C. Hurlock

Erschienen in: The Cerebellum | Ausgabe 3/2009

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Abstract

Different subunits of the Kv3 subfamily of voltage-gated potassium (Kv) channels (Kv3.1–Kv3.4) are expressed in distinct neuronal subpopulations in the cerebellum. Behavioral phenotypes in Kv3-null mutant mice such as ataxia with prominent hypermetria and heightened alcohol sensitivity are characteristic of cerebellar dysfunction. Here, we review how the unique biophysical properties of Kv3-type potassium channels, fast activation and fast deactivation that enable cerebellar neurons to generate brief action potentials at high frequencies, affect firing patterns and influence cerebellum-mediated behavior.
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Metadaten
Titel
The Role of Kv3-type Potassium Channels in Cerebellar Physiology and Behavior
verfasst von
Rolf H. Joho
Edward C. Hurlock
Publikationsdatum
01.09.2009
Verlag
Springer-Verlag
Erschienen in
The Cerebellum / Ausgabe 3/2009
Print ISSN: 1473-4222
Elektronische ISSN: 1473-4230
DOI
https://doi.org/10.1007/s12311-009-0098-4

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