Skip to main content
main-content

29.11.2018 | PRECLINICAL STUDIES Open Access

The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines

Zeitschrift:
Investigational New Drugs
Autoren:
Malgorzata Kucinska, Helena Mieszczak, Hanna Piotrowska-Kempisty, Mariusz Kaczmarek, Walter Granig, Marek Murias, Thomas Erker
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s10637-018-0704-8) contains supplementary material, which is available to authorized users.
Chemical compound studied in this article: 63T, 3,4,5-trifluoro-N-[2-[(3,4,5-trifluorobenzenecarbothioyl)amino]phenyl]benzenecarbothioamide (PubChem CID: 51346886)

Summary

It has been shown previously that molecules built on benzanilide and thiobenzanilide scaffolds possess differential biological properties including selective anticancer activity. In our previous study, we examined the cytotoxic activity and mechanism of action of the thiobenzanilide derivative N,N′-(1,2-phenylene)bis3,4,5–trifluorobenzothioamide (63 T) as a potential chemotherapeutic compound in an experimental model employing A549 lung adenocarcinoma cells and CCD39Lu non-tumorigenic lung fibroblasts. Since the results suggested oxidative stress as a co-existing mechanism of the cytotoxic effect exerted by 63 T on tested cells, studies involving the analysis of reactive oxygen species (ROS) generation and markers of oxidative stress in cells incubated with 63 T were carried out. It may be concluded that the selective activity of 63 T against cancer cells shown in our experiments is caused, at least in part, by the response of the tested cells to 63 T mediated oxidative stress in both tested cell lines.

Unsere Produktempfehlungen

e.Med Interdisziplinär

Kombi-Abonnement

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Zusatzmaterial
High resolution image (TIF 1801 kb)
10637_2018_704_MOESM1_ESM.tif
High resolution image (TIF 863 kb)
10637_2018_704_MOESM2_ESM.tif
High resolution image (TIF 945 kb)
10637_2018_704_MOESM3_ESM.tif
Literatur
Über diesen Artikel

Neu im Fachgebiet Onkologie

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Onkologie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise