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Medical Microbiology and Immunology

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01.12.2007 | Review

The threat of avian influenza a (H5N1): part II: Clues to pathogenicity and pathology

verfasst von: Jindrich Cinatl Jr, Martin Michaelis, Hans W. Doerr

Erschienen in: Medical Microbiology and Immunology | Ausgabe 4/2007

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Abstract

Among emerging and re-emerging infectious diseases, influenza constitutes one of the major threats to mankind. In this review series epidemiologic, virologic and pathologic concerns raised by infections of humans with avian influenza virus A/H5N1 are discussed. The second part focuses on experimental and clinical results, which give insights in the pathogenic mechanisms of H5N1 infection in humans. H5N1 is poorly transmitted to humans. However, H5N1-induced disease is very severe. More information on the role entry barriers, H5N1 target cells and on H5N1-induced modulation of the host immune response is needed to learn more about the determinants of H5N1 pathogenicity.

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Titel: The threat of avian influenza a (H5N1): part II: Clues to pathogenicity and pathology
verfasst von: Jindrich Cinatl Jr
Martin Michaelis
Hans W. Doerr
Publikationsdatum: 01.12.2007
Verlag: Springer-Verlag
Erschienen in: Medical Microbiology and Immunology / Ausgabe 4/2007
Print ISSN: 0300-8584
Elektronische ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-007-0045-2

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