Erschienen in:
14.02.2021 | Original Article
The updated five-year overall survival and long-term oxaliplatin-related neurotoxicity assessment of the FACOS study
verfasst von:
Emiko Takeshita, Keiichiro Ishibashi, Keiji Koda, Noritaka Oda, Kazuhiko Yoshimatsu, Yu Sato, Masatoshi Oya, Satoru Yamaguchi, Hideo Nakajima, Tomoyuki Momma, Hiroshi Maekawa, Masahiro Tsubaki, Takeshi Yamada, Michiya Kobayashi, Kohji Tanakaya, Hideyuki Ishida
Erschienen in:
Surgery Today
|
Ausgabe 8/2021
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Abstract
Purpose
We previously reported the first evidence of oncological benefits from a Japanese phase II trial of oxaliplatin-based adjuvant chemotherapy in patients with stage III colon cancer (the FACOS study). We herein report the long-term survival and persistent oxaliplatin-related peripheral sensory neuropathy (PSN) for patients enrolled in this trial.
Methods
Patients were scheduled to receive the mFOLFOX6 or CAPOX regimen in the adjuvant setting. The five-year overall survival (OS) rate and persistent PSN were evaluated.
Results
A total of 130 patients (mFOLFOX6, n = 73; CAPOX, n = 57) were eligible. The 5-year OS rate was 91.4%. No significant difference in the OS rate was observed between regimens (mFOLFOX6, 94.4%; CAPOX, 87.4%; P = 0.25). The incidence of PSN during adjuvant treatment was 55.4% in grade 1 (G1), 30.0% in G2, and 4.6% in G3. No patients showed G3 PSN at 12 months, but G1 or G2 residual PSN after 5 years was observed in 21.8% (G1, 20%; G2, 1.8%).
Conclusions
Updated results from the FACOS study support the benefits of oxaliplatin-based adjuvant chemotherapy in terms of the long-term survival among Japanese patients with stage III colon cancer. However, long-term persistent PSN occurs in about 20% of survivors, counterbalancing the favorable OS.