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Cellular Oncology

Erschienen in:

16.11.2018 | Review

Therapeutic targeting potential of chromatin-associated proteins in MLL-rearranged acute leukemia

verfasst von: Xin Xu, Björn Schneider

Erschienen in: Cellular Oncology | Ausgabe 2/2019

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Abstract

Background

Acute leukemias (AL) with a Mixed Lineage Leukemia (MLL) gene rearrangement (MLLr) represent a group of leukemic entities conferring intermediate to adverse prognoses. Multiple chromatin-associated proteins have been shown to play essential roles during the genesis of MLLr AL. Some chromatin-associated proteins function as negative regulators of MLLr AL whereas others are required for leukemic initiation or maintenance - the latter group constituting potential therapeutic targets. Most of the identified proteins have been functionally analyzed using experimental models with human/murine normal cells transformed by MLL-AF9 or other MLL fusion products, which may recapitulate most but not all aspects of human AML, such as immune system interactions – features of which the importance is rapidly emerging.

Conclusions

Here, we review chromatin-associated proteins fundamental to MLLr AL development, highlighting those with targeting potential by small molecule inhibitors. In particular, we focus on synthetic targeting of multiple chromatin-associated proteins, a strategy that shows superior therapeutic efficacy and offers hope for overcoming drug resistance.

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Titel: Therapeutic targeting potential of chromatin-associated proteins in MLL-rearranged acute leukemia
verfasst von: Xin Xu
Björn Schneider
Publikationsdatum: 16.11.2018
Verlag: Springer Netherlands
Erschienen in: Cellular Oncology / Ausgabe 2/2019
Print ISSN: 2211-3428
Elektronische ISSN: 2211-3436
DOI: https://doi.org/10.1007/s13402-018-0414-4

Springer Medizin

Therapeutic targeting potential of chromatin-associated proteins in MLL-rearranged acute leukemia

Abstract

Background

Conclusions

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

Background

Conclusions

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