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Journal of Clinical Monitoring and Computing

Erschienen in:

02.11.2017 | Original Research

Toxicity of inhaled agents after prolonged administration

verfasst von: Panumart Manatpon, W. Andrew Kofke

Erschienen in: Journal of Clinical Monitoring and Computing | Ausgabe 4/2018

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Abstract

Inhaled anesthetics have been utilized mostly for general anesthesia in the operating room and oftentimes for sedation and for treatment of refractory status epilepticus and status asthmaticus in the intensive care unit. These contexts in the ICU setting are related to potential for prolonged administration wherein potential organ toxicity is a concern. Over the last decade, several clinical and animal studies of neurotoxicity attributable to inhaled anesthetics have been emerging, particularly in extremes of age. This review overviews potential for and potential mechanisms of neurotoxicity and systemic toxicity of prolonged inhaled anesthesia and clinical scenarios where inhaled anesthesia has been used in order to assess safety of possible prolonged use for sedation. High dose inhaled agents are associated with postoperative cognitive dysfunction (POCD) and other situations. However, thus far no strong indication of problematic neuro or organ toxicity has been demonstrated after prolonged use of low dose volatile anesthesia.

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Titel: Toxicity of inhaled agents after prolonged administration
verfasst von: Panumart Manatpon
W. Andrew Kofke
Publikationsdatum: 02.11.2017
Verlag: Springer Netherlands
Erschienen in: Journal of Clinical Monitoring and Computing / Ausgabe 4/2018
Print ISSN: 1387-1307
Elektronische ISSN: 1573-2614
DOI: https://doi.org/10.1007/s10877-017-0077-0

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Toxicity of inhaled agents after prolonged administration

Abstract

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Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Hinter dieser Appendizitis steckte ein Erreger

Ärztliche Empathie hilft gegen Rückenschmerzen

Mehr Schaden als Nutzen durch präoperatives Aussetzen von GLP-1-Agonisten?

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Springer Medizin

Abstract

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