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Erschienen in: European Radiology 5/2014

01.05.2014 | Gastrointestinal

Training readers to improve their accuracy in grading Crohn’s disease activity on MRI

verfasst von: Jeroen A. W. Tielbeek, Shandra Bipat, Thierry N. Boellaard, C. Yung Nio, Jaap Stoker

Erschienen in: European Radiology | Ausgabe 5/2014

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Abstract

Objectives

To prospectively evaluate if training with direct feedback improves grading accuracy of inexperienced readers for Crohn’s disease activity on magnetic resonance imaging (MRI).

Methods

Thirty-one inexperienced readers assessed 25 cases as a baseline set. Subsequently, all readers received training and assessed 100 cases with direct feedback per case, randomly assigned to four sets of 25 cases. The cases in set 4 were identical to the baseline set. Grading accuracy, understaging, overstaging, mean reading times and confidence scores (scale 0-10) were compared between baseline and set 4, and between the four consecutive sets with feedback. Proportions of grading accuracy, understaging and overstaging per set were compared using logistic regression analyses. Mean reading times and confidence scores were compared by t-tests.

Results

Grading accuracy increased from 66 % (95 % CI, 56-74 %) at baseline to 75 % (95 % CI, 66-81 %) in set 4 (P = 0.003). Understaging decreased from 15 % (95 % CI, 9-23 %) to 7 % (95 % CI, 3-14 %) (P < 0.001). Overstaging did not change significantly (20 % vs 19 %). Mean reading time decreased from 6 min 37 s to 4 min 35 s (P < 0.001). Mean confidence increased from 6.90 to 7.65 (P < 0.001). During training, overall grading accuracy, understaging, mean reading times and confidence scores improved gradually.

Conclusions

Inexperienced readers need training with at least 100 cases to achieve the literature reported grading accuracy of 75 %.

Key points

• Most radiologists have limited experience of grading Crohn’s disease activity on MRI.
• Inexperienced readers need training in the MRI assessment of Crohn’s disease.
• Grading accuracy, understaging, reading time and confidence scores improved during training.
• Radiologists and residents show similar accuracy in grading Crohn’s disease.
• After 100 cases, grading accuracy can be reached as reported in the literature.
Literatur
1.
Zurück zum Zitat D’Haens GR, Fedorak R, Lémann M et al (2009) Endpoints for clinical trials evaluating disease modification and structural damage in adults with Crohn’s disease. Inflamm Bowel Dis 15:1599–1604PubMedCrossRef D’Haens GR, Fedorak R, Lémann M et al (2009) Endpoints for clinical trials evaluating disease modification and structural damage in adults with Crohn’s disease. Inflamm Bowel Dis 15:1599–1604PubMedCrossRef
3.
Zurück zum Zitat Dignass A, Van Assche G, Lindsay JO et al (2010) The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Current management. J Crohns Colitis 4:28–62PubMedCrossRef Dignass A, Van Assche G, Lindsay JO et al (2010) The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Current management. J Crohns Colitis 4:28–62PubMedCrossRef
4.
Zurück zum Zitat Vermeire S, Ferrante M, Rutgeerts P (2013) Recent advances: personalised use of current Crohn’s disease therapeutic options. Gut 62:1511–1515PubMedCrossRef Vermeire S, Ferrante M, Rutgeerts P (2013) Recent advances: personalised use of current Crohn’s disease therapeutic options. Gut 62:1511–1515PubMedCrossRef
5.
Zurück zum Zitat Tielbeek JAW, Löwenberg M, Bipat S et al (2013) Serial magnetic resonance imaging for monitoring medical therapy effects in Crohn’s disease. Inflamm Bowel Dis 19:1943–1950PubMed Tielbeek JAW, Löwenberg M, Bipat S et al (2013) Serial magnetic resonance imaging for monitoring medical therapy effects in Crohn’s disease. Inflamm Bowel Dis 19:1943–1950PubMed
6.
Zurück zum Zitat Horsthuis K, Bipat S, Stokkers PCF, Stoker J (2009) Magnetic resonance imaging for evaluation of disease activity in Crohn’s disease: a systematic review. Eur Radiol 19:1450–1460PubMedCrossRef Horsthuis K, Bipat S, Stokkers PCF, Stoker J (2009) Magnetic resonance imaging for evaluation of disease activity in Crohn’s disease: a systematic review. Eur Radiol 19:1450–1460PubMedCrossRef
7.
Zurück zum Zitat Wu L-M, Xu J-R, Gu H-Y, Hua J, Hu J (2013) Is magnetic resonance imaging a reliable diagnostic tool in the evaluation of active Crohn’s disease in the small bowel? J Clin Gastroenterol 47:328–338PubMedCrossRef Wu L-M, Xu J-R, Gu H-Y, Hua J, Hu J (2013) Is magnetic resonance imaging a reliable diagnostic tool in the evaluation of active Crohn’s disease in the small bowel? J Clin Gastroenterol 47:328–338PubMedCrossRef
8.
Zurück zum Zitat Negaard A, Mulahasanovic A, Reisaeter LA, Aasekjaer K, Sandvik L, Klow N-E (2008) Crohn’s disease evaluated with magnetic resonance enteroclysis: diagnostic performance of experienced and inexperienced readers before and after training. Acta Radiol 49:967–974PubMedCrossRef Negaard A, Mulahasanovic A, Reisaeter LA, Aasekjaer K, Sandvik L, Klow N-E (2008) Crohn’s disease evaluated with magnetic resonance enteroclysis: diagnostic performance of experienced and inexperienced readers before and after training. Acta Radiol 49:967–974PubMedCrossRef
9.
Zurück zum Zitat Maccioni F, Bruni A, Viscido A et al (2006) MR imaging in patients with Crohn disease: value of T2- versus T1-weighted gadolinium-enhanced MR sequences with use of an oral superparamagnetic contrast agent. Radiology 238:517–530PubMedCrossRef Maccioni F, Bruni A, Viscido A et al (2006) MR imaging in patients with Crohn disease: value of T2- versus T1-weighted gadolinium-enhanced MR sequences with use of an oral superparamagnetic contrast agent. Radiology 238:517–530PubMedCrossRef
10.
Zurück zum Zitat Negaard A, Paulsen V, Sandvik L et al (2007) A prospective randomized comparison between two MRI studies of the small bowel in Crohn’s disease, the oral contrast method and MR enteroclysis. Eur Radiol 17:2294–2301PubMedCrossRef Negaard A, Paulsen V, Sandvik L et al (2007) A prospective randomized comparison between two MRI studies of the small bowel in Crohn’s disease, the oral contrast method and MR enteroclysis. Eur Radiol 17:2294–2301PubMedCrossRef
11.
Zurück zum Zitat Fiorino G, Bonifacio C, Padrenostro M et al (2013) Comparison between 1.5 and 3.0 tesla magnetic resonance enterography for the assessment of disease activity and complications in ileo-colonic crohn’s disease. Dig Dis Sci 58:3246–3255PubMedCrossRef Fiorino G, Bonifacio C, Padrenostro M et al (2013) Comparison between 1.5 and 3.0 tesla magnetic resonance enterography for the assessment of disease activity and complications in ileo-colonic crohn’s disease. Dig Dis Sci 58:3246–3255PubMedCrossRef
12.
Zurück zum Zitat Steward MJ, Punwani S, Proctor I et al (2012) Non-perforating small bowel Crohn’s disease assessed by MRI enterography: derivation and histopathological validation of an MR-based activity index. Eur J Radiol 81:2080–2088PubMedCrossRef Steward MJ, Punwani S, Proctor I et al (2012) Non-perforating small bowel Crohn’s disease assessed by MRI enterography: derivation and histopathological validation of an MR-based activity index. Eur J Radiol 81:2080–2088PubMedCrossRef
13.
Zurück zum Zitat Tolan DJM, Greenhalgh R, Zealley IA, Halligan S, Taylor SA (2010) MR enterographic manifestations of small bowel Crohn disease. Radiographics 30:367–384PubMedCrossRef Tolan DJM, Greenhalgh R, Zealley IA, Halligan S, Taylor SA (2010) MR enterographic manifestations of small bowel Crohn disease. Radiographics 30:367–384PubMedCrossRef
14.
Zurück zum Zitat Ziech MLW, Bossuyt PMM, Laghi A, Lauenstein TC, Taylor SA, Stoker J (2012) Grading luminal Crohn’s disease: which MRI features are considered as important? Eur J Radiol 81:e467–e472PubMedCrossRef Ziech MLW, Bossuyt PMM, Laghi A, Lauenstein TC, Taylor SA, Stoker J (2012) Grading luminal Crohn’s disease: which MRI features are considered as important? Eur J Radiol 81:e467–e472PubMedCrossRef
15.
Zurück zum Zitat Florie J, Horsthuis K, Hommes DW et al (2005) Magnetic resonance imaging compared with ileocolonoscopy in evaluating disease severity in Crohn’s disease. Clin Gastroenterol Hepatol 3:1221–1228PubMedCrossRef Florie J, Horsthuis K, Hommes DW et al (2005) Magnetic resonance imaging compared with ileocolonoscopy in evaluating disease severity in Crohn’s disease. Clin Gastroenterol Hepatol 3:1221–1228PubMedCrossRef
16.
Zurück zum Zitat Rimola J, Rodriguez S, García-Bosch O et al (2009) Magnetic resonance for assessment of disease activity and severity in ileocolonic Crohn’s disease. Gut 58:1113–1120PubMedCrossRef Rimola J, Rodriguez S, García-Bosch O et al (2009) Magnetic resonance for assessment of disease activity and severity in ileocolonic Crohn’s disease. Gut 58:1113–1120PubMedCrossRef
17.
Zurück zum Zitat Sailer J, Peloschek P, Reinisch W et al (2008) Anastomotic recurrence of Crohn’s disease after ileocolic resection: comparison of MR enteroclysis with endoscopy. Eur Radiol 18:2512–2521PubMedCrossRef Sailer J, Peloschek P, Reinisch W et al (2008) Anastomotic recurrence of Crohn’s disease after ileocolic resection: comparison of MR enteroclysis with endoscopy. Eur Radiol 18:2512–2521PubMedCrossRef
18.
Zurück zum Zitat Zappa M, Stefanescu C, Cazals-Hatem D et al (2011) Which magnetic resonance imaging findings accurately evaluate inflammation in small bowel Crohn’s disease? A retrospective comparison with surgical pathologic analysis. Inflamm Bowel Dis 17:984–993PubMedCrossRef Zappa M, Stefanescu C, Cazals-Hatem D et al (2011) Which magnetic resonance imaging findings accurately evaluate inflammation in small bowel Crohn’s disease? A retrospective comparison with surgical pathologic analysis. Inflamm Bowel Dis 17:984–993PubMedCrossRef
19.
Zurück zum Zitat Tielbeek JAW, Ziech MLW, Li Z et al (2013) Evaluation of conventional, dynamic contrast enhanced and diffusion weighted MRI for quantitative Crohn’s disease assessment with histopathology of surgical specimens. Eur Radiol. doi:10.1007/s00330-013-3015-7 PubMed Tielbeek JAW, Ziech MLW, Li Z et al (2013) Evaluation of conventional, dynamic contrast enhanced and diffusion weighted MRI for quantitative Crohn’s disease assessment with histopathology of surgical specimens. Eur Radiol. doi:10.​1007/​s00330-013-3015-7 PubMed
20.
Zurück zum Zitat Punwani S, Rodriguez-Justo M, Bainbridge A et al (2009) Mural inflammation in Crohn disease: location-matched histologic validation of MR imaging features. Radiology 252:712–720PubMedCrossRef Punwani S, Rodriguez-Justo M, Bainbridge A et al (2009) Mural inflammation in Crohn disease: location-matched histologic validation of MR imaging features. Radiology 252:712–720PubMedCrossRef
21.
Zurück zum Zitat Rimola J, Ordás I, Rodriguez S et al (2011) Magnetic resonance imaging for evaluation of Crohn’s disease: validation of parameters of severity and quantitative index of activity. Inflamm Bowel Dis 17:1759–1768PubMedCrossRef Rimola J, Ordás I, Rodriguez S et al (2011) Magnetic resonance imaging for evaluation of Crohn’s disease: validation of parameters of severity and quantitative index of activity. Inflamm Bowel Dis 17:1759–1768PubMedCrossRef
22.
Zurück zum Zitat Girometti R, Zuiani C, Toso F et al (2008) MRI scoring system including dynamic motility evaluation in assessing the activity of Crohn’s disease of the terminal ileum. Acad Radiol 15:153–164PubMedCrossRef Girometti R, Zuiani C, Toso F et al (2008) MRI scoring system including dynamic motility evaluation in assessing the activity of Crohn’s disease of the terminal ileum. Acad Radiol 15:153–164PubMedCrossRef
23.
Zurück zum Zitat Van Assche G, Herrmann KA, Louis E et al (2013) Effects of infliximab therapy on transmural lesions as assessed by magnetic resonance enteroclysis in patients with ileal Crohn’s disease. J Crohns Colitis 7:950–957PubMedCrossRef Van Assche G, Herrmann KA, Louis E et al (2013) Effects of infliximab therapy on transmural lesions as assessed by magnetic resonance enteroclysis in patients with ileal Crohn’s disease. J Crohns Colitis 7:950–957PubMedCrossRef
24.
Zurück zum Zitat Tielbeek JAW, Makanyanga J, Bipat S et al (2013) Grading Crohn's disease activity with MRI: interobserver variability of MRI features, MRI scoring of severity and correlation with Crohn's Disease Endoscopic Index of Severity. Am J Roentgenol 201:1220–1228CrossRef Tielbeek JAW, Makanyanga J, Bipat S et al (2013) Grading Crohn's disease activity with MRI: interobserver variability of MRI features, MRI scoring of severity and correlation with Crohn's Disease Endoscopic Index of Severity. Am J Roentgenol 201:1220–1228CrossRef
25.
Zurück zum Zitat Leeuwenburgh MMN, Wiarda BM, Bipat S et al (2012) Acute appendicitis on abdominal MR images: training readers to improve diagnostic accuracy. Radiology 264:455–463PubMedCrossRef Leeuwenburgh MMN, Wiarda BM, Bipat S et al (2012) Acute appendicitis on abdominal MR images: training readers to improve diagnostic accuracy. Radiology 264:455–463PubMedCrossRef
26.
Zurück zum Zitat Oussalah A, Laurent V, Bruot O et al (2010) Diffusion-weighted magnetic resonance without bowel preparation for detecting colonic inflammation in inflammatory bowel disease. Gut 59:1056–1065PubMedCrossRef Oussalah A, Laurent V, Bruot O et al (2010) Diffusion-weighted magnetic resonance without bowel preparation for detecting colonic inflammation in inflammatory bowel disease. Gut 59:1056–1065PubMedCrossRef
27.
28.
Zurück zum Zitat Ajaj WM, Lauenstein TC, Pelster G et al (2005) Magnetic resonance colonography for the detection of inflammatory diseases of the large bowel: quantifying the inflammatory activity. Gut 54:257–263PubMedCentralPubMedCrossRef Ajaj WM, Lauenstein TC, Pelster G et al (2005) Magnetic resonance colonography for the detection of inflammatory diseases of the large bowel: quantifying the inflammatory activity. Gut 54:257–263PubMedCentralPubMedCrossRef
29.
Zurück zum Zitat Liedenbaum MH, de Vries AH, Halligan S et al (2009) CT colonography polyp matching: differences between experienced readers. Eur Radiol 19:1723–1730PubMedCentralPubMedCrossRef Liedenbaum MH, de Vries AH, Halligan S et al (2009) CT colonography polyp matching: differences between experienced readers. Eur Radiol 19:1723–1730PubMedCentralPubMedCrossRef
30.
Zurück zum Zitat Bankier AA, Levine D, Halpern EF, Kressel HY (2010) Consensus interpretation in imaging research: is there a better way? Radiology 257:14–17PubMedCrossRef Bankier AA, Levine D, Halpern EF, Kressel HY (2010) Consensus interpretation in imaging research: is there a better way? Radiology 257:14–17PubMedCrossRef
Metadaten
Titel
Training readers to improve their accuracy in grading Crohn’s disease activity on MRI
verfasst von
Jeroen A. W. Tielbeek
Shandra Bipat
Thierry N. Boellaard
C. Yung Nio
Jaap Stoker
Publikationsdatum
01.05.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 5/2014
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3111-3

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