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Intensive Care Medicine
Erschienen in: Intensive Care Medicine 4/2020

01.04.2020 | Conference Reports and Expert Panel

Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine

verfasst von: Alexander P. Vlaar, Simon Oczkowski, Sanne de Bruin, Marije Wijnberge, Massimo Antonelli, Cecile Aubron, Philippe Aries, Jacques Duranteau, Nicole P. Juffermans, Jens Meier, Gavin J. Murphy, Riccardo Abbasciano, Marcella Muller, Akshay Shah, Anders Perner, Sofie Rygaard, Timothy S. Walsh, Gordon Guyatt, J. C. Dionne, Maurizio Cecconi

Erschienen in: Intensive Care Medicine | Ausgabe 4/2020

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Abstract

Objective

To develop evidence-based clinical practice recommendations regarding transfusion practices in non-bleeding, critically ill adults.

Design

A task force involving 13 international experts and three methodologists used the GRADE approach for guideline development.

Methods

The task force identified four main topics: red blood cell transfusion thresholds, red blood cell transfusion avoidance strategies, platelet transfusion, and plasma transfusion. The panel developed structured guideline questions using population, intervention, comparison, and outcomes (PICO) format.

Results

The task force generated 16 clinical practice recommendations (3 strong recommendations, 13 conditional recommendations), and identified five PICOs with insufficient evidence to make any recommendation.

Conclusions

This clinical practice guideline provides evidence-based recommendations and identifies areas where further research is needed regarding transfusion practices and transfusion avoidance in non-bleeding, critically ill adults.
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Literatur
1.
2.
Strauss R et al (2002) Thrombocytopenia in patients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome. Crit Care Med 30:1765–1771PubMed
3.
Walsh TS et al (2010) Prevalence, management, and outcomes of critically ill patients with prothrombin time prolongation in United Kingdom intensive care units. Crit Care Med 38:1939–1946PubMed
4.
Khamiees M, Raju P, DeGirolamo A, Amoateng-Adjepong Y, Manthous CA (2001) Predictors of extubation outcome in patients who have successfully completed a spontaneous breathing trial. Chest 120:1262–1270PubMed
5.
Vanderschueren S et al (2000) Thrombocytopenia and prognosis in intensive care. Crit Care Med 28:1871–1876PubMed
6.
Rasmussen L, Christensen S, Lenler-Petersen P, Johnsen SP (2010) Anaemia and 90-day mortality in COPD patients requiring invasive mechanical ventilation. Clin Epidemiol 3:1–5PubMedPubMedCentral
7.
Bolton-Maggs PHB (2016) SHOT conference report 2016: serious hazards of transfusion—human factors continue to cause most transfusion-related incidents. Transfus Med 26:401–405PubMed
8.
Goldman M et al (2005) Proceedings of a consensus conference: towards an understanding of TRALI. Transfus Med Rev 19:2–31PubMed
9.
Hébert PC et al (1999) A multicentre, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 340:409–417PubMed
10.
11.
Simon GI, Craswell A, Thom O, Fung YL (2017) Outcomes of restrictive versus liberal transfusion strategies in older adults from nine randomised controlled trials: a systematic review and meta-analysis. Lancet Haematol 4:e465–e474PubMed
12.
Carson JL, Stanworth SJ, Roubinian N, Fergusson DA, Triulzi D, Doree C, Hebert PC (2016) Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database of Syst Rev 10:CD002042
13.
Vincent JL et al (2002) Anaemia and blood transfusion in critically ill patients. J Am Med Assoc 288:1499–1507
14.
Schofield WN, Rubin GL, Dean MG (2003) Appropriateness of platelet, fresh frozen plasma and cryoprecipitate transfusion in New South Wales public hospitals. Med J Aust 178:117–121PubMed
15.
Stanworth SJ et al (2011) A national study of plasma use in critical care: clinical indications, dose and effect on prothrombin time. Crit Care 15:R108PubMedPubMedCentral
16.
Yang L, Stanworth S, Hopewell S, Doree C, Murphy M (2012) Is fresh-frozen plasma clinically effective? An update of a systematic review of randomized controlled trials. Transfusion 52:1673–1686PubMed
17.
Napolitano LM, Kurek S, Luchette FA, Corwin HL, Barie PS, Tisherman SA, Hebert PC, Anderson GL, Bard MR, Bromberg W, Chiu WC (2009) Clinical practice guideline: red blood cell transfusion in adult trauma and critical care. Crit Care Med 37(12):3124–3157PubMed
18.
Carson JL, Guyatt G, Heddle NM, Grossman BJ, Cohn CS, Fung MK, Gernsheimer T, Holcomb JB, Kaplan LJ, Katz LM, Peterson N (2016) Clinical practice guidelines from the AABB: red blood cell transfusion thresholds and storage. JAMA 316(19):2025–2035PubMed
19.
Mueller MM, Van Remoortel H, Meybohm P, Aranko K, Aubron C, Burger R, CarsonJL Cichutek K, De Buck E, Devine D, Fergusson D, Folléa G, French C, Frey KP, Gammon R, Levy JH, Murphy MF, Ozier Y, Pavenski K, So-Osman C, Tiberghien P, Volmink J, Waters JH, Wood EM, Seifried E, ICC PBM Frankfurt 2018 Group (2019) Patient blood management: recommendations from the 2018 Frankfurt Consensus Conference. JAMA 321(10):983–997PubMed
20.
Padhi S, Kemmis-Betty S, Rajesh S, Hill J, Murphy MF (2015) Guideline development. Blood transfusion: summary of NICE guidance. BMJ 351:h5832PubMed
21.
Klein AA, Arnold P, Bingham RM, Brohi K, Clark R, Collis R et al (2016) AAGBI guidelines: the use of blood components and their alternatives. Anaesthesia 2016(71):829–842
22.
Vlaar AP, Juffermans NP (2013) Transfusion-related acute lung injury: a clinical review. Lancet 382(9896):984–994PubMed
23.
Valentine SL, Bembea MM, Muszynski JA et al (2018) Consensus recommendations for RBC transfusion practice in critically Ill children from the pediatric critical care transfusion and anemia expertise initiative. Pediatr Crit Care Med 19:884–898PubMedPubMedCentral
24.
25.
De Bruin S, Vlaar AP, Scheeren TW et al (2019) Transfusion practice on the intensive care unit; an international online survey—the TRACE Survey. Crit Care 23:309PubMedPubMedCentral
26.
Guyatt GH, Oxman AD, Kunz R, Atkins D, Brozek J, Vist G, Alderson P, Glasziou P, Falck-Ytter Y, Schünemann HJ (2011) GRADE guidelines: 2. Framing the question and deciding on important outcomes. J Clin Epidermiol 64(4):395–400
27.
28.
Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, Savović J, Schulz KF, Weeks L, Sterne JA (2011) The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 343:d5928PubMedPubMedCentral
29.
Peterson J, Welch V, Losos M, Tugwell P (2011) The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Hospital Research Institute, Ottawa. https://​ca/​programs/​clinical_​epidemiology/​oxford.​asp.​2001
30.
Cornell JE, Mulrow CD, Localio R, Stack CB, Meibohm AR, Guallar E, Goodman SN (2014) Random-effects meta-analysis of inconsistent effects: a time for change. Ann Intern Med 160(4):267–270PubMed
31.
Guyatt GH, Oxman AD, Vist G, Kunz R, Brozek J, Alonso-Coello P, Montori V, Akl EA, Djulbegovic B, Falck-Ytter Y, Norris SL (2011) GRADE guidelines: 4. Rating the quality of evidence—study limitations (risk of bias). J Clin Epidemiol 64(4):407–415PubMed
32.
Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, Alonso-Coello P, Glasziou P, Jaeschke R, Akl EA, Norris S (2011) GRADE guidelines: 7. Rating the quality of evidence—inconsistency. J Clin Epidemiol 64(12):1294–1302PubMed
33.
Guyatt GH, Oxman AD, Kunz R, Woodcock J, Brozek J, Helfand M, Alonso-Coello P, Falck-Ytter Y, Jaeschke R, Vist G, Akl EA (2011) GRADE guidelines: 8. Rating the quality of evidence—indirectness. J Clin Epidemiol 64(12):1303–1310PubMed
34.
Guyatt GH, Oxman AD, Kunz R, Brozek J, Alonso-Coello P, Rind D, Devereaux PJ, Montori VM, Freyschuss B, Vist G, Jaeschke R (2011) GRADE guidelines 6. Rating the quality of evidence—imprecision. J Clin Epidemiol 64(12):1283–1293PubMed
35.
Alonso-Coello P, Oxman AD, Moberg J et al (2016) GRADE Evidence to Decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. 2: clinical practice guidelines. BMJ 353:i2089PubMed
36.
Andrews JC, Schunemann HJ, Oxman AD et al (2013) GRADE guidelines: 15. Going from evidence to recommendation—determinants of a recommendation’s direction and strength. J Clin Epidemiol 66:726–735PubMed
37.
Guyatt GH, Oxman AD, Kunz R, Falck- Ytter Y, Vist GE, Liberati A et al (2008) Going from evidence to recommendations. BMJ 336(7652):1049–1051PubMedPubMedCentral
38.
Hébert PC, Wells G, Marshall J, Martin C, Tweeddale M, Pagliarello G, Blajchman M, Wood G, Hill R, Granton J, Calvin J (1995) Transfusion requirements in critical care: a pilot study. JAMA 273(18):1439–1444PubMed
39.
Walsh TS, Boyd JA, Watson D, Hope D, Lewis S, Krishan A, Forbes JF, Ramsay P, Pearse R, Wallis C, Cairns C (2013) Restrictive versus liberal transfusion strategies for older mechanically ventilated critically ill patients: a randomized pilot trial. Crit Care Med 41(10):2354–2363PubMed
40.
Holst LB, Haase N, Wetterslev J, Wernerman J, Guttormsen AB, Karlsson S, Johansson PI, Åneman A, Vang ML, Winding R, Nebrich L (2014) Lower versus higher haemoglobin threshold for transfusion in septic shock. N Engl J Med 371(15):1381–1391PubMed
41.
Mazza BF, Freitas FG, Barros MM, Azevedo LC, Machado FR (2015) Blood transfusions in septic shock: is 7.0 g/dL really the appropriate threshold? Rev Bras Ter Intensiva 27(1):36–43PubMedPubMedCentral
42.
Cooper HA, Rao SV, Greenberg MD, Rumsey MP, McKenzie M, Alcorn KW, Panza JA (2011) Conservative versus liberal red cell transfusion in acute myocardial infarction (the CRIT Randomized Pilot Study). Am J Cardiol 108(8):1108–1111PubMed
43.
Carson JL, Brooks MM, Abbott JD, Chaitman B, Kelsey SF, Triulzi DJ, Srinivas V, Menegus MA, Marroquin OC, Rao SV, Noveck H (2013) Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease. Am Heart J 165(6):964–971PubMedPubMedCentral
44.
Lenz C, Rebel A, Waschke KF, Koehler RC, Frietsch T (2007) Blood viscosity modulates tissue perfusion—sometimes and somewhere. Transfus Altern Transfus Med 9(4):265–272
45.
Docherty AB, O’Donnell R, Brunskill S, Trivella M, Doree C, Holst LB, Parker M, Gregersen M, de Almeida JP, Walsh TS, Stanworth SJ (2016) Effect of restrictive versus liberal transfusion strategies on outcomes in patients with cardiovascular disease in a non-cardiac surgery setting: systematic review and meta-analysis. BMJ 352:i1351PubMedPubMedCentral
46.
Bergamin FS, Almeida JP, Landoni G, Galas FR, Fukushima JT, Fominskiy E, Park CH, Osawa EA, Diz MP, Oliveira GQ, Franco RA (2017) Liberal versus restrictive transfusion strategy in critically ill oncologic patients: the transfusion requirements in critically ill oncologic patients randomized controlled trial. Crit Care Med 45(5):766–773PubMed
47.
Hébert PC, Blajchman MA, Cook DJ, Yetisir E, Wells G, Marshall J, Schweitzer I (2001) Do blood transfusions improve outcomes related to mechanical ventilation? Chest 119(6):1850–1857PubMed
48.
Johnson RG, Thurer RL, Kruskall MS, Sirois C, Gervino EV, Critchlow J, Weintraub RM (1992) Comparison of two transfusion strategies after elective operations for myocardial revascularization. J Thorac Cardiovasc Surg 104(2):307–314PubMed
49.
Bracey AW, Radovancevic R, Riggs SA, Houston S, Cozart H, Vaughn WK, Radovancevic B, McAllister HA Jr, Cooley DA (1999) Lowering the haemoglobin threshold for transfusion in coronary artery bypass procedures: effect on patient outcome. Transfusion 39(10):1070–1077PubMed
50.
Hajjar LA, Vincent JL, Galas FR, Nakamura RE, Silva CM, Santos MH, Fukushima J, Kalil Filho R, Sierra DB, Lopes NH, Mauad T (2010) Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. JAMA 304(14):1559–1567PubMed
51.
Shehata N, Burns LA, Nathan H, Hebert P, Hare GM, Fergusson D, Mazer CD (2012) A randomized controlled pilot study of adherence to transfusion strategies in cardiac surgery. Transfusion 52(1):91–99PubMed
52.
Murphy GJ, Pike K, Rogers CA, Wordsworth S, Stokes EA, Angelini GD, Reeves BC (2015) Liberal or restrictive transfusion after cardiac surgery. N Engl J Med 372(11):997–1008PubMed
53.
Mazer CD, Whitlock RP, Fergusson DA, Hall J, Belley-Cote E, Connolly K, Khanykin B, Gregory AJ, de Médicis É, McGuinness S, Royse A (2017) Restrictive or liberal red-cell transfusion for cardiac surgery. N Engl J Med 377(22):2133–2144PubMed
54.
Laine A, Niemi T, Schramko A (2018) Transfusion threshold of haemoglobin 80 g/L is comparable to 100 g/L in terms of bleeding in cardiac surgery: a prospective randomized study. J Cardiothorac Vasc Anesth 32(1):131–139PubMed
55.
McIntyre LA, Fergusson DA, Hutchison JS, Pagliarello G, Marshall JC, Yetisir E, Hare GM, Hébert PC (2006) Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury. Neurocrit Care 5(1):4–9PubMed
56.
Naidech AM, Shaibani A, Garg RK, Duran IM, Liebling SM, Bassin SL, Bendok BR, Bernstein RA, Batjer HH, Alberts MJ (2010) Prospective, randomized trial of higher goal haemoglobin after subarachnoid haemorrhage. Neurocrit Care 13(3):313–320PubMed
57.
Robertson CS, Hannay HJ, Yamal JM, Gopinath S, Goodman JC, Tilley BC, Baldwin A, Lara LR, Saucedo-Crespo H, Ahmed O, Sadasivan S (2014) Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial. JAMA 312(1):36–47PubMedPubMedCentral
58.
Gobatto AL, Link MA, Solla DJ, Bassi E, Tierno PF, Paiva W, Taccone FS, Malbouisson LM (2019) Transfusion requirements after head trauma: a randomized feasibility controlled trial. Critl Care 23(1):89
59.
60.
Voelker MT, Busch T, Bercker S, Fichtner F, Kaisers UX, Laudi S (2015) Restrictive transfusion practice during extracorporeal membrane oxygenation therapy for severe acute respiratory distress syndrome. Artif Organs 39(4):374–378PubMed
61.
Panholzer B, Meckelburg K, Huenges K, Hoffmann G, von der Brelie M, Haake N, Pilarczyk K, Cremer J, Haneya A (2017) Extracorporeal membrane oxygenation for acute respiratory distress syndrome in adults: an analysis of differences between survivors and non-survivors. Perfusion 32(6):495–500PubMed
62.
Guttendorf J, Boujoukos AJ, Ren D, Rosenzweig MQ, Hravnak M (2014) Discharge outcome in adults treated with extracorporeal membrane oxygenation. Am J Crit Care 23(5):365–377PubMed
63.
Agerstrand CL, Burkart KM, Abrams DC, Bacchetta MD, Brodie D (2015) Blood conservation in extracorporeal membrane oxygenation for acute respiratory distress syndrome. Ann Thorac Surg 99(2):590–595PubMed
64.
Cahill C, Blumberg N, Schmidt A, Knight P, Melvin A, Massey H, Delehanty J, Zebrak S, Refaai KA, Refaai M (2016) Implementation of a standardized laboratory testing, clinical evaluation and transfusion protocol for cardiac patients receiving extracorporeal membrane oxygenation (ECMO) is associated with decreased blood transfusions and improved survival. Transfusion 56:32
65.
Schmidt M, Tachon G, Devilliers C, Muller G, Hekimian G, Bréchot N, Merceron S, Luyt CE, Trouillet JL, Chastre J, Leprince P (2013) Blood oxygenation and decarboxylation determinants during venovenous ECMO for respiratory failure in adults. Intensive Care Med 39(5):838–846PubMed
66.
Weingart C, Lubnow M, Philipp A, Bein T, Camboni D, Müller T (2015) Comparison of coagulation parameters, anticoagulation, and need for transfusion in patients on interventional lung assist or veno-venous extracorporeal membrane oxygenation. Artif Organs 39(9):765–773PubMed
67.
Elabbassi W, Al Aila F, Chowdhury MA, Najib A, Zaid H, Michelin M, Al Nooryani A (2017) The impact of severity of initial illness, determined by SOFA score, and presence of anaemia on outcomes among patients requiring Extra Corporal Membrane Oxygenation (ECMO) support: a single centre experience. Indian Heart J 69(6):762–766PubMedPubMedCentral
68.
Jenq CC, Tsai FC, Tsai TY, Hsieh SY, Lai YW, Tian YC, Chang MY, Lin CY, Fang JT, Yang CW, Chen YC (2018) Effect of anaemia on prognosis in patients on extracorporeal membrane oxygenation. Artif Organs 42(7):705–713PubMed
69.
De Almeida JP, Vincent JL, Galas FR, de Almeida EP, Fukushima JT, Osawa EA, Bergamin F, Park CL, Nakamura RE, Fonseca SM, Cutait G (2015) Transfusion requirements in surgical oncology patients a prospective, randomized controlled trial. Anaesthesiology 122(1):29–38
70.
DeZern AE, Williams K, Zahurak M, Hand W, Stephens RS, King KE, Frank SM, Ness PM (2016) Red blood cell transfusion triggers in acute leukemia: a randomized pilot study. Transfusion 56(7):1750–1757PubMedPubMedCentral
71.
Webert KE, Cook RJ, Couban S, Carruthers J, Lee KA, Blajchman MA, Lipton JH, Brandwein JM, Heddle NM (2008) A multicentre pilot-randomized controlled trial of the feasibility of an augmented red blood cell transfusion strategy for patients treated with induction chemotherapy for acute leukemia or stem cell transplantation. Transfusion 48(1):81–91PubMed
72.
Bafeta A, Dechartres A, Trinquart L, Yavchitz A, Boutron I, Ravaud P (2012) Impact of single centre status on estimates of intervention effects in trials with continuous outcomes: meta-epidemiological study. BMJ 344:e813PubMedPubMedCentral
73.
Simon GI, Craswell A, Thom O, Fung YL (2017) Outcomes of restrictive versus liberal transfusion strategies in older adults from nine randomised controlled trials: a systematic review and meta-analysis. Lancet Haematol 4(10):e465–e474PubMed
74.
Meier J, Filipescu D, Kozek-Langenecker S, Llau Pitarch J, Mallett S, Martus P, Matot I, ETPOS Collaborators, Accurso G, Adelmann D, Ahrens N (2016) Intraoperative transfusion practices in Europe. Br J Anaesth 116(2):255–261
75.
Adamczyk S, Robin E, Barreau O, Fleyfel M, Tavernier B, Lebuffe G, Vallet B (2009) Apport de la saturation veineuse centrale en oxygène dans la décision transfusionnelle postopératoire. Ann Fr Anesth Reanim 28(6):522–530PubMed
76.
Samarani G, Zeroual N, Saour M, Ruiz R, Gaudard P, Colson P (2015) B41 Don’t let me down: advances in thoracic surgery: central venous oxygen saturation as a potential trigger for blood transfusion in cardiovascular surgery patients: an observational study. Am J Respir Crit Care Med 191:1
77.
Zeroual N, Saour M, Ruiz R, Gaudard P, Colson P, Samarani G (2015) Central venous oxygen saturation as a potential trigger for blood transfusion in cardiovascular surgery patients: an observational study. Am J Respir Crit Care Med 191:A3028
78.
Surve RM, Muthuchellappan R, Rao GS, Philip M (2016) The effect of blood transfusion on central venous oxygen saturation in critically ill patients admitted to a neurointensive care unit. Transfus Med 26(5):343–348PubMed
79.
Sehgal LR, Zebala LP, Takagi I, Curran RD, Votapka TV, Caprini JA (2001) Evaluation of oxygen extraction ratio as a physiologic transfusion trigger in coronary artery bypass graft surgery patients. Transfusion 41(5):591–595PubMed
80.
Orlov D, O’Farrell R, McCluskey SA, Carroll J, Poonawala H, Hozhabri S, Karkouti K (2009) The clinical utility of an index of global oxygenation for guiding red blood cell transfusion in cardiac surgery. Transfusion 49(4):682–688PubMed
81.
Mung’ayi V, Sharif T, Odaba DS (2014) Blood transfusion and oxygen extraction ratio in patients admitted to the general intensive care unit: A quasi experimental study. Afr J Emerg Med 4(2):66–70
82.
Fogagnolo A, Spadaro S, Creteur J, Cavalcante E, Taccone FS, Volta CA (2017) Can arterio-venous-oxygen content difference be a target to guide transfusion in critically ill patients? Intensive Care Med Exp 5(Suppl 2):0041
83.
McCredie VA, Piva S, Santos M, Xiong W, de Oliveira Manoel AL, Rigamonti A, Hare GM, Chapman MG, Baker AJ (2017) The impact of red blood cell transfusion on cerebral tissue oxygen saturation in severe traumatic brain injury. Neurocrit Care 26(2):247–255PubMed
84.
Muthuchellappan R, Shaikh NA, Surve RM, Ganne UR, Philip M (2018) Regional cerebral tissue oxygen saturation changes following blood transfusion in neuro-intensive care unit patients–a pilot observational study. Transfus Med 28(4):304–309PubMed
85.
Rogers CA, Stoica S, Ellis L, Stokes EA, Wordsworth S, Dabner L, Clayton G, Downes R, Nicholson E, Bennett S, Angelini GD (2017) Randomized trial of near-infrared spectroscopy for personalized optimization of cerebral tissue oxygenation during cardiac surgery. Br J Anaesth 119(3):384–393PubMed
86.
Torella F, Cowley RD, Thorniley MS, McCollum CN (2002) Regional tissue oxygenation during haemorrhage: can near infrared spectroscopy be used to monitor blood loss? Shock 18(5):440–444PubMed
87.
Zogheib E, Walczak K, Guinot P, Badoux L, Duwat A, Lorne E, Remadi JP, Caus T, Dupont H (2011) STO2 changes after transfusion of packed red blood cells in critical care patients. Intensive Care Med 37:S155
88.
Loukas A, Matadial C, Yapor J, Martinez-Ruiz R (2011) Tissue oxygen monitoring leads to lower rates of blood transfusions. Crit Care 15(1):P425PubMedCentral
89.
Powell S, Franzen D, Thacker L, Hogan C (2012) 1014: red blood cell transfusion improves microvascular perfusion in surgical critically ill patients in a delayed fashion. Crit Care Med 40(12):1–328
90.
Parimi N, Fontaine MJ, Yang S, Hu PF, Li HC, Mackenzie CF, Kozar RA, Miller C, Scalea TM, Stein DM (2018) Blood transfusion indicators following trauma in the non-massively bleeding patient. Ann Clin Lab Sci 48(3):279–285PubMed
91.
Navarro JL, Sanchez-Calzada A, Gastelum R, Delgado L, Torres O, Romano P, Monares E, Gilberto C, Franco J (2015) Venoarterial carbon dioxide gradient utility as a criterion for blood transfusion at the intensive care unit. Intensive care med Exp 3(S1):A221PubMedCentral
92.
Taha A, Shafie A, Mostafa M, Syed N, Hon H, Marktanner R (2015) Evaluation of the quotient of the venoarterial carbon dioxide gradient and the arteriovenous oxygen content difference as a transfusion trigger parameter in haemodynamically stable patients with significant anaemia. Crit Care 19(1):P331PubMedCentral
93.
Römers LH, Bakker C, Dollée N, Hoeks SE, Lima A, Raat NJ, Johannes T, Stolker RJ, Mik EG (2016) Cutaneous mitochondrial PO2, but not tissue oxygen saturation, is an early indicator of the physiologic limit of haemodilution in the Pig. Anaesthesiology 125(1):124–132
94.
van Iperen CE, Gaillard CA, Kraaijenhagen RJ, Braam BG, Marx JJ, van de Wiel A (2000) Response of erythropoiesis and iron metabolism to recombinant human erythropoietin in intensive care unit patients. Crit Care Med 28(8):2773–2778PubMed
95.
Madi-Jebara SN, Sleilaty GS, Achouh PE, Yazigi AG, Haddad FA, Hayek GM, Antakly MC, Jebara VA (2004) Postoperative intravenous iron used alone or in combination with low-dose erythropoietin is not effective for correction of anaemia after cardiac surgery. J Cardiothorac Vasc Anesth 18(1):59–63PubMed
96.
Pieracci FM, Henderson P, Rodney JR, Holena DN, Genisca A, Ip I, Benkert S, Hydo LJ, Eachempati SR, Shou J, Barie PS (2009) Randomized, double-blind, placebo-controlled trial of effects of enteral iron supplementation on anaemia and risk of infection during surgical critical illness. Surg Infect (Larchmt) 10(1):9–19
97.
Garrido-Martín P, Nassar-Mansur MI, de la Llana-Ducros R, Virgos-Aller TM, Fortunez PM, Ávalos-Pinto R, Jimenez-Sosa A, Martínez-Sanz R (2012) The effect of intravenous and oral iron administration on perioperative anaemia and transfusion requirements in patients undergoing elective cardiac surgery: a randomized clinical trial. Interact Cardiovasc Thorac Surg 15(6):1013–1018PubMedPubMedCentral
98.
Pieracci FM, Stovall RT, Jaouen B, Rodil M, Cappa A, Burlew CC, Holena DN, Maier R, Berry S, Jurkovich J, Moore EE (2014) A multicentre, randomized clinical trial of IV iron supplementation for anaemia of traumatic critical illness. Crit Care Med 42(9):2048–2057PubMed
99.
Litton E, Baker S, Erber WN, Farmer S, Ferrier J, French C, Gummer J, Hawkins D, Higgins A, Hofmann A, De Keulenaer B (2016) Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial. Intensive Care Med 42(11):1715–1722PubMed
100.
Mueller MM, Remoortel HV, Meybohm P et al (2019) Patient blood management: recommendations from the 2018 Frankfurt Consensus Conference. JAMA 321:983–997PubMed
101.
Ratcliffe LE, Thomas W, Glen J et al (2016) Diagnosis and Management of Iron Deficiency in CKD: a Summary of the NICE guideline recommendations and their rationale. Am J Kidney Dis 67:548–558PubMed
102.
Ponikowski P, Voors AA, Anker SD et al (2016) 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Eur Heart J 37:2129–2200PubMed
103.
Corwin HL, Gettinger A, Rodriguez RM, Pearl RG, Gubler KD, Enny C, Colton T, Corwin MJ (2001) Efficacy of recombinant human erythropoietin in the critically ill patient: a randomized, double-blind, placebo-controlled trial. Crit Care Med 29(9):S201–S205
104.
Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy MM, Shapiro MJ, Corwin MJ, Colton T, EPO Critical Care Trials Group (2002) Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial. JAMA 288(22):2827–2835
105.
Georgopoulos D, Matamis D, Routsi C, Michalopoulos A, Maggina N, Dimopoulos G, Zakynthinos E, Nakos G, Thomopoulos G, Mandragos K, Maniatis A (2005) Recombinant human erythropoietin therapy in critically ill patients: a dose-response study. Crit Care 9(5):R508PubMedPubMedCentral
106.
Silver M, Corwin MJ, Bazan A, Gettinger A, Enny C, Corwin HL (2006) Efficacy of recombinant human erythropoietin in critically ill patients admitted to a long-term acute care facility: a randomized, double-blind, placebo-controlled trial. Crit Care Med 34(9):2310–2316PubMed
107.
Vincent JL, Spapen HD, Creteur J, Piagnerelli M, Hubloue I, Diltoer M, Roman A, Stevens E, Vercammen E, Beaver JS (2006) Pharmacokinetics and pharmacodynamics of once-weekly subcutaneous epoetinalfa in critically ill patients: results of a randomized, double-blind, placebo-controlled trial. Crit Care Med 34(6):1661–1667PubMed
108.
Corwin HL, Gettinger A, Fabian TC, May A, Pearl RG, Heard S, An R, Bowers PJ, Burton P, Klausner MA, Corwin MJ (2007) Efficacy and safety of epoetinalfa in critically ill patients. N Engl J Medi 357(10):965–976
109.
Luchette FA, Pasquale MD, Fabian TC, Langholff WK, Wolfson M (2012) A randomized, double-blind, placebo-controlled study to assess the effect of recombinant human erythropoietin on functional outcomes in anemic, critically ill, trauma subjects: the long term trauma outcomes study. Am J Surg 203(4):508–516PubMed
110.
Nichol A, French C, Little L et al (2015) Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial. Lancet 386(10012):2499–2506PubMed
111.
MacLaren R, Sullivan PW (2005) Cost-effectiveness of recombinant human erythropoietin for reducing red blood cells transfusions in critically ill patients. Value Health 8(2):105–116PubMed
112.
Shermock KM et al (2005) Number needed to treat and cost of recombinant human erythropoietin to avoid one transfusion related adverse event in critically ill patients. Crit Care Med 33(3):497–503PubMed
113.
Yoo YC, Shim JK, Kim JC, Jo YY, Lee JH, Kwak YL (2011) Effect of single recombinant human erythropoietin injection on transfusion requirements in preoperatively anemic patients undergoing valvular heart surgery. Anaesthesiology 115(5):929–937
114.
Chui BK et al (2012) Economic analysis of epoetin alfa in critically ill trauma patients. J Trauma Acute Care Surg 3(1):195–201
115.
Vincent JL, Baron JF, Reinhart K, Gattinoni L, Thijs L, Webb A, Meier-Hellmann A, Nollet G, Peres-Bota D, Investigators ABC (2002) Anaemia and blood transfusion in critically ill patients. JAMA 288(12):1499–1507PubMed
116.
Smoller BR, Kruskall MS, Horowitz GL (1989) Reducing adult phlebotomy blood loss with the use of pediatric-sized blood collection tubes. Am J Clin Pathol 91(6):701–703PubMed
117.
Sanchez-Giron F, Alvarez-Mora F (2008) Reduction of blood loss from laboratory testing in hospitalized adult patients using small-volume (pediatric) tubes. Arch Pathol Lab Med 132(12):1916–1919PubMed
118.
Dolman HS, Evans K, Zimmerman LH, Lavery T, Baylor AE, Wilson RF, Tyburski JG (2015) Impact of minimizing diagnostic blood loss in the critically ill. Surgery 158(4):1083–1088PubMed
119.
Peruzzi WT, Parker MA, Lichtenthal PR, Cochran-Zull CA, Toth BR, Blake MI (1993) A clinical evaluation of a blood conservation device in medical intensive care unit patients. Crit Care Med 21(4):501–506PubMed
120.
Moron NJE, Moreno I, Lazaro A (2003) Dispositivo VAMP beneficis para el paciente critico. Rev ROL Enf 26(9):591–594
121.
MacIsaac CM, Presneill JJ, Boyce CA, Byron KL, Cade JF (2003) The influence of a blood conserving device on anaemia in intensive care patients. Anaesth Intensive Care 31(6):653–657PubMed
122.
Harber CR, Sosnowski KJ, Hegde RM (2006) Highly conservative phlebotomy in adult intensive care—a prospective randomized controlled trial. Anaesth Intensive Care 34(4):434–437PubMed
123.
Mahdy S, Khan EI, Attia M, O’Brien BP, Seigne P (2009) Evaluation of a blood conservation strategy in the intensive care unit: a prospective, randomised study. Middle East J Anesthesiol 3:219–223
124.
Woda RP et al (1999) On the dynamic performance of the Abbott Safeset blood-conserving arterial line system. J Clin Monit Comput 15(3-4):215–221PubMed
125.
Rezende E, Ferez MA, Junior JM, Oliveira AM, Viana RA, Mendes CL, Toledo DD, Neto MC, Setoyama TA (2010) Utilização de sistema fechado para coleta de sangue e necessidade de transfusão em pacientes graves. Rev Bras Ter Intensiva 22(1):5–10PubMed
126.
Liu F, Liao T, Wang Q, Tao Y (2018) Evaluation of a novel flushing protocol for a peripherally inserted central catheter (PICC) in the neurological intensive care unit: a prospective randomized study. Natl Med J India 31(1):5PubMed
127.
Page C, Retter A, Wyncoll D (2013) Blood conservation devices in critical care: a narrative review. Ann Intensive Care 3(1):14PubMedPubMedCentral
128.
Salman SS, Fernandez Perez ER, Stubbs JR, Gajic O (2007) The practice of platelet transfusion in the intensive care unit. J Intensive Care Med 22(2):105–110PubMed
129.
Warner MA, Chandran A, Frank RD, Kor DJ (2019) Prophylactic platelet transfusions for critically ill patients with thrombocytopenia: a single-institution propensity-matched cohort study. Anaesth Analg 128(2):288–295
130.
Stanworth SJ, Estcourt LJ, Powter G, Kahan BC, Dyer C, Choo L, Bakrania L, Llewelyn C, Littlewood T, Soutar R, Norfolk D (2013) A no-prophylaxis platelet-transfusion strategy for hematologic cancers. N Engl J Med 368(19):1771–1780PubMed
131.
Veelo DP, Vlaar AP, Dongelmans DA, Binnekade JM, Levi M, Paulus F, Berends F, Schultz MJ (2012) Correction of subclinical coagulation disorders before percutaneous dilatational tracheotomy: a randomised controlled trial. Blood Transfus 10(2):213PubMedPubMedCentral
132.
Warner MA, Woodrum D, Hanson A, Schroeder DR, Wilson G, Kor DJ (2017) Preprocedural platelet transfusion for patients with thrombocytopenia undergoing interventional radiology procedures is not associated with reduced bleeding complications. Transfusion 57(4):890–898PubMedPubMedCentral
133.
Vavricka SR, Walter RB, Irani S, Halter J, Schanz U (2003) Safety of lumbar puncture for adults with acute leukemia and restrictive prophylactic platelet transfusion. Ann Hematol 82(9):570–573PubMed
134.
Zeidler K, Arn K, Senn O, Schanz U, Stussi G (2011) Optimal preprocedural platelet transfusion threshold for central venous catheter insertions in patients with thrombocytopenia. Transfusion 51(11):2269–2276PubMed
135.
Estcourt LJ, Birchall J, Allard S, Bassey SJ, Hersey P, Kerr JP, Mumford AD, Stanworth SJ, Tinegate H, British Committee for Standards in Haematology (2017) Guidelines for the use of platelet transfusions. Br J Haematol 176(3):365–394PubMed
136.
Trimble AS, Osborn JJ, Kerth WJ, Gerbode F (1964) The prophylactic use of fresh frozen plasma after extracorporeal circulation. J Thorac Cardiovasc Surg 48:314PubMed
137.
Boldt J, Kling D, von Bormann B, Zuge M, Hempelmann G (1989) Homologous fresh frozen plasma in heart surgery. Myth or necessity]. [German. Anaesthesist 38:353–359PubMed
138.
Martinowitz U, Goor DA, Ramot B, Mohr R (1990) Is transfusion of fresh plasma after cardiac operations indicated? J Thorac Cardiovasc Surg 100:92–98PubMed
139.
Consten EC, Henny CP, Eijsman L. Dongelmans DA, van Oers MH (1996) The routine use of fresh frozen plasma in operations with cardiopulmonary bypass is not justified. J Thorac Cardiovasc Surg 112:162–167
140.
Wilhelmi M, Franke U, Cohnert T, Weber P, Kaukemüller J, Fischer S, Wahlers T, Haverich A (2001) CABG surgery without the routine application of blood products: Is it feasible. Eur J Thorac Cardiovasc Surg 19:657–661
141.
Kasper SM, Giesecke T, Limpers P, Sabatowski R, Mehlhorn U, Diefenbach C (2001) Failure of autologous fresh frozen plasma to reduce blood loss and transfusion requirements in coronary artery bypass surgery. Anaesthesiol 95:81–86
142.
Dara SI, Rana R, Afessa B, Moore SB, Gajic O (2005) Fresh frozen plasma transfusion in critically ill medical patients with coagulopathy. Crit Care Med 33(11):2667–2671PubMed
143.
Müller MC, Straat M, Meijers JC, Klinkspoor JH, De Jonge E, Arbous MS, Schultz MJ, Vroom MB, Juffermans NP (2015) Fresh frozen plasma transfusion fails to influence the haemostatic balance in critically ill patients with a coagulopathy. J Thromb Haemost 13(6):989–997PubMed
144.
Yang L, Stanworth S, Hopewell S, Doree C, Murphy M (2012) Is fresh-frozen plasma clinically effective? An update of a systematic review of randomized controlled trials (CME). Transfusion 52(8):1673–1686PubMed
145.
Tinmouth A, Thompson T, Arnold DM, Callum JL, Gagliardi K, Lauzon D, Owens W, Pinkerton P (2013) Utilization of frozen plasma in Ontario: a province-wide audit reveals a high rate of inappropriate transfusions. Transfusion 53(10):2222–2229PubMed
146.
Stanworth SJ, Grant-Casey J, Lowe D, Laffan M, New H, Murphy MF, Allard S (2011) The use of fresh-frozen plasma in England: high levels of inappropriate use in adults and children. Transfusion 51(1):62–70PubMed
147.
Müller MC, Arbous MS, Spoelstra-de Man AM, Vink R, Karakus A, Straat M, Binnekade JM, de Jonge E, Vroom MB, Juffermans NP (2015) Transfusion of fresh-frozen plasma in critically ill patients with a coagulopathy before invasive procedures: a randomized clinical trial (CME). Transfusion 55(1):26–35PubMed
148.
Segal JB, Dzik WH, Transfusion Medicine/Haemostasis Clinical Trials Network (2005) Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: an evidence-based review. Transfusion 45(9):1413–1425PubMed
149.
Müller MCA, Stanworth SJ, Coppens M, Juffermans NP (2017) Recognition and management of haemostatic disorders in critically ill patients needing to undergo an invasive procedure. Transfus Med Rev 31(4):223–229PubMed
150.
Watson DM, Stanworth SJ, Wyncoll D, McAuley DF, Perkins GD, Young D, Biggin KJ, Walsh TS (2011) A national clinical scenario-based survey of clinicians’ attitudes towards fresh frozen plasma transfusion for critically ill patients. Transfus Med 21(2):124–129PubMed
Metadaten
Titel
Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine
verfasst von
Alexander P. Vlaar
Simon Oczkowski
Sanne de Bruin
Marije Wijnberge
Massimo Antonelli
Cecile Aubron
Philippe Aries
Jacques Duranteau
Nicole P. Juffermans
Jens Meier
Gavin J. Murphy
Riccardo Abbasciano
Marcella Muller
Akshay Shah
Anders Perner
Sofie Rygaard
Timothy S. Walsh
Gordon Guyatt
J. C. Dionne
Maurizio Cecconi
Publikationsdatum
01.04.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Intensive Care Medicine / Ausgabe 4/2020
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-019-05884-8

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