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04.05.2017 | Original Article

Uncertainty of cosmetic evaluation after accelerated partial breast irradiation: interim analysis of a Japanese prospective multi-institutional feasibility study

verfasst von: Eisaku Yoden, Takayuki Nose, Yuki Otani, Shuuji Asahi, Iwao Tsukiyama, Takushi Dokiya, Toshiaki Saeki, Ichirou Fukuda, Hiroshi Sekine, Naoto Shikama, Yu Kumazaki, Takao Takahashi, Ken Yoshida, Tadayuki Kotsuma, Norikazu Masuda, Kazutaka Nakashima, Taisei Matsumura, Shino Nakagawa, Seiji Tachiiri, Yoshio Moriguchi, Jun Itami, Masahiko Oguchi

Erschienen in: Japanese Journal of Radiology | Ausgabe 7/2017

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Abstract

Purpose

We conducted a multi-institutional prospective study on accelerated partial breast irradiation (APBI) using interstitial brachytherapy. The clinical results over a minimum follow-up period of 30 months are presented here.

Materials and methods

Forty-six patients with breast cancer were treated with breast-conserving surgery and postoperative APBI. After confirmation of negative surgical margins and negative lymph nodes, a high-dose-rate brachytherapy protocol of 36 Gy/6 fractions was carried out. All clinical data were prospectively collected using the Common Terminology Criteria for Adverse Events ver. 3.0.

Results

No recurrence was observed. Cumulative rates of grade 2 or higher late sequelae were 25% for fibrosis, 2% for fractures, 9% for pain, and 9% for soft tissue necrosis. Rates of excellent or good cosmetic results as assessed by the physician and patient were 93 and 89% at the 12-month follow-up and 76 and 74% at the 30-month follow-up, respectively. Large volumes of resected tissue in small breasts were associated with fibrosis of grade 2 or higher.

Conclusion

APBI in Japanese women provides satisfactory clinical results except for cosmetic outcomes. There is some difficulty with the assessment of fibrosis and cosmetic outcomes, especially in patients with small breasts.

Clinical Trial Registration Number

UMIN000001677.

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Titel: Uncertainty of cosmetic evaluation after accelerated partial breast irradiation: interim analysis of a Japanese prospective multi-institutional feasibility study
verfasst von: Eisaku Yoden
Takayuki Nose
Yuki Otani
Shuuji Asahi
Iwao Tsukiyama
Takushi Dokiya
Toshiaki Saeki
Ichirou Fukuda
Hiroshi Sekine
Naoto Shikama
Yu Kumazaki
Takao Takahashi
Ken Yoshida
Tadayuki Kotsuma
Norikazu Masuda
Kazutaka Nakashima
Taisei Matsumura
Shino Nakagawa
Seiji Tachiiri
Yoshio Moriguchi
Jun Itami
Masahiko Oguchi
Publikationsdatum: 04.05.2017
Verlag: Springer Japan
Erschienen in: Japanese Journal of Radiology / Ausgabe 7/2017
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-017-0640-0

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Uncertainty of cosmetic evaluation after accelerated partial breast irradiation: interim analysis of a Japanese prospective multi-institutional feasibility study