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Erschienen in: CardioVascular and Interventional Radiology 5/2009

01.09.2009 | Clinical Investigation

Whole-Body Magnetic Resonance Angiography at 3 Tesla Using a Hybrid Protocol in Patients with Peripheral Arterial Disease

verfasst von: Yousef W. Nielsen, Jonas P. Eiberg, Vibeke B. Logager, Torben V. Schroeder, Sven Just, Henrik S. Thomsen

Erschienen in: CardioVascular and Interventional Radiology | Ausgabe 5/2009

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Abstract

The purpose of this study was to determine the diagnostic performance of 3T whole-body magnetic resonance angiography (WB-MRA) using a hybrid protocol in comparison with a standard protocol in patients with peripheral arterial disease (PAD). In 26 consecutive patients with PAD two different protocols were used for WB-MRA: a standard sequential protocol (n = 13) and a hybrid protocol (n = 13). WB-MRA was performed using a gradient echo sequence, body coil for signal reception, and gadoterate meglumine as contrast agent (0.3 mmol/kg body weight). Two blinded observers evaluated all WB-MRA examinations with regard to presence of stenoses, as well as diagnostic quality and degree of venous contamination in each of the four stations used in WB-MRA. Digital subtraction angiography served as the method of reference. Sensitivity for detecting significant arterial disease (luminal narrowing ≥ 50%) using standard-protocol WB-MRA for the two observers was 0.63 (95%CI: 0.51–0.73) and 0.66 (0.58–0.78). Specificities were 0.94 (0.91–0.97) and 0.96 (0.92–0.98), respectively. In the hybrid protocol WB-MRA sensitivities were 0.75 (0.64–0.84) and 0.70 (0.58–0.8), respectively. Specificities were 0.93 (0.88–0.96) and 0.95 (0.91–0.97). Interobserver agreement was good using both the standard and the hybrid protocol, with κ = 0.62 (0.44–0.67) and κ = 0.70 (0.59–0.79), respectively. WB-MRA quality scores were significantly higher in the lower leg using the hybrid protocol compared to standard protocol (p = 0.003 and p = 0.03, observers 1 and 2). Distal venous contamination scores were significantly lower with the hybrid protocol (p = 0.02 and p = 0.01, observers 1 and 2). In conclusion, hybrid-protocol WB-MRA shows a better diagnostic performance than standard protocol WB-MRA at 3 T in patients with PAD.
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Metadaten
Titel
Whole-Body Magnetic Resonance Angiography at 3 Tesla Using a Hybrid Protocol in Patients with Peripheral Arterial Disease
verfasst von
Yousef W. Nielsen
Jonas P. Eiberg
Vibeke B. Logager
Torben V. Schroeder
Sven Just
Henrik S. Thomsen
Publikationsdatum
01.09.2009
Verlag
Springer-Verlag
Erschienen in
CardioVascular and Interventional Radiology / Ausgabe 5/2009
Print ISSN: 0174-1551
Elektronische ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-009-9549-z

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