Three factors are implicated in the pathogenesis of cocaine-related myocardial ischemia-infarction: the increased myocardial oxygen demand, the marked vasoconstriction of CA, and the exaggerated platelet aggregation [
3,
4]. Cocaine is a powerful sympathomimetic and dramatically increases oxygen demand by blocking the reuptake of norepinephrine and dopamine at the presynaptic adrenergic terminals. Also, induces significant increase of myocardial oxygen demand due to increased heart rate, systemic arterial pressure and left ventricular contractility. The chronotropic effects of cocaine are intensified in the setting of alcohol use. In addition, cocaine produces a significant coronary vasoconstriction either in normal CA or -more marked- in diseased one [
5]. Factors that are implicated to this coronary vasoconstriction are the increased endothelial production of endothelin and the decreased production of nitric oxide [
6]. There are a lot of reported cardiovascular complications of cocaine users but the incidence of most severe of them is relatively uncommon. According to Hollander J, et al [
7], ventricular arrhythmias occurred in 4 - 17%, congestive heart failure in 5 - 7%, and death in <2%. Therefore, the incidence of cocaine abusers who will need an emergency interventional or surgical reperfusion is low. Interventions should be directed either to treat ischemic complications due to thrombosis [
1‐
3], dissection [
8], or acute/subacute thrombosis of an implanted coronary stent [
9]. Vasoconstrictive and atherosclerotic effects of cocaine, combined with the well documented platelet-activating effect, significantly increase the post-PCI risk of stent thrombosis (ST), in the early and late post implantation phase. Karlsson G et al [
9], reported that among the actively using cocaine patients who underwent PCI, 33% of them presented with ST 51 ± 40 days after the intervention, with an incidence of ST almost 10-fold higher in cocaine users. Similar results reported in a retrospective study by Singh S, et al [
10]. Of their patients with active cocaine use 5% suffered SF with a mean period from stent implantation 28.5 ± 14 days.
Our presentation is one of the rare cases reported in literature referring in AMI due to thrombosis of LM related to cocaine use, in a young patient with normal CA, successfully operated. Drug-abusers seem to have increased mortality and morbidity because of their usually coexistent several problems of general health. Furthermore, a majority of patients that suffer ST continue cocaine and are noncompliant with medical therapy. Improved handling techniques and postoperative long term dual antiplatelet therapy additionally to special consultation services could reduce the incidence of this terrible event. The lack of specific guidelines about treatment of thrombus formation in CA, especially in LM, a catastrophic consequence of cocaine use, leads to a unique and individualized approach to these patients. The small number of reported cases prevents the development of an evidence-based management, but due to high probability of post PCI ST, as mentioned before, we strongly recommend that all these patients should be treated surgically.