Background
Methods
Study population
Database
Nested cohort
Statistics
STROBE statement
Results
All N = 5814 (100%) | One-year survivors N = 2401 (41%) | One-year non-survivors N = 3413 (59%) | P value1 | |
---|---|---|---|---|
Age (years) | 65 (56–74) | 63 (54–71) | 67 (57–76) | < 0.01 |
Gender (male) | 71% | 72% | 69% | < 0.01 |
Physical status (independent)2 | 84% | 92% | 79% | < 0.01 |
24h-EC-SOFA | 7 (5–9) | 6 (5–8) | 7 (5–10) | < 0.01 |
24 h-SOFA | 9 (7–12) | 8 (6–10) | 10 (8–13) | < 0.01 |
One-year costs (€1000) | 23 (10–50) | 47 (28–75) | 12 (6.6–25) | < 0.01 |
Cost per day alive (€) | 880 (150–2500) | 130 (77–200) | 2200 (1300–3400) | < 0.01 |
Outcome
Full data | Nested cohort | ||||||||
---|---|---|---|---|---|---|---|---|---|
One-year mortality | One-year mortality | Poor neurologic outcome1 | |||||||
OR | 95% CI |
P
| OR | 95% CI |
P
| OR | 95% CI |
P
| |
Age (year) | 1.02 | 1.01 - 1.02 | < 0.01 | 1.03 | 1.02 - 1.04 | < 0.01 | 1.03 | 1.02 - 1.04 | < 0.01 |
Physical status (dependent)2 | 2.60 | 2.18 - 3.09 | < 0.01 | 2.76 | 1.60 - 4.74 | < 0.01 | 3.72 | 2.01 - 6.88 | < 0.01 |
Not shockable3 | 3.55 | 2.61 - 4.82 | < 0.01 | 3.89 | 2.82 - 5.37 | < 0.01 | |||
ROSC delay (min)4 | 1.05 | 1.03 - 1.06 | < 0.01 | 1.05 | 1.03 - 1.06 | < 0.01 | |||
Not witnessed5 | 1.87 | 1.19 - 2.93 | < 0.01 | 2.05 | 1.26 - 3.32 | < 0.01 | |||
24h-EC-SOFA (point) | 1.16 | 1.14 - 1.18 | < 0.01 | 1.19 | 1.12 - 1.25 | < 0.01 | 1.15 | 1.09 - 1.21 | < 0.01 |
Healthcare-associated costs
Cost per day alive (€) | ||||||
---|---|---|---|---|---|---|
Full data | Nested cohort | |||||
B
| 95% CI |
P
|
B
| 95% CI |
P
| |
Age (year) | − 3.8 | − 8.4 - 0.80 | NS | 3.8 | − 5.1 - 13 | NS |
Physical status (dependent)1 | 110 | − 67 - 284 | NS | 220 | − 240 - 680 | NS |
Not shockable2 | 780 | 510 - 1,100 | < 0.01 | |||
ROSC (min)3 | 37 | 25 - 49 | < 0.01 | |||
Not witnessed4 | 200 | − 200 - 610 | NS | |||
24h-EC-SOFA (point) | 170 | 150 - 190 | < 0.01 | 210 | 170 - 260 | < 0.01 |
Total costs in 1-year survivors (€1000) | ||||||
---|---|---|---|---|---|---|
Full data | Nested cohort | |||||
B
| 95% CI |
P
|
B
| 95% CI |
P
| |
Age (year) | − 0.85 | − 1.1 - -0.64 | < 0.01 | − 0.48 | − 0.85 - –0.10 | 0.01 |
Physical status (dependent)1 | 15 | 5.1 - 25 | < 0.01 | 28 | 2.4 - 54 | 0.03 |
Not shockable2 | 15 | 3.2 - 27 | 0.01 | |||
ROSC (min)3 | 0.047 | − 0.45 - 0.55 | NS | |||
Not witnessed4 | − 20 | − 39 - -0.91 | 0.04 | |||
24h-EC-SOFA (point) | 4.4 | 3.3 - 5.5 | < 0.01 | 7.2 | 5.0 - 9.4 | < 0.01 |