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Erschienen in:
01.10.2014 | Magnetic Resonance
Can magnetic resonance spectroscopy differentiate endometrial cancer?
Erschienen in: European Radiology | Ausgabe 10/2014
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Objectives
To investigate whether the choline-containing compounds (Cho) obtained from three-dimensional 1H magnetic resonance (MR) spectroscopy can differentiate endometrial cancer (ECa) from benign lesions in endometria or in submucosa (BLs-ESm) and is associated with the aggressiveness of ECa.
Methods
Fifty-seven patients (ECa, 38; BLs-ESm, 19) underwent preoperative multi-voxel MR spectroscopy at 3.0 T. The ratio of the sum of the Cho peak integral to the sum of the unsuppressed water peak integral (Cho/water) and the coefficient of variation (CV) used to describe the variability of Cho/water in one lesion were calculated.
Results
Mean Cho/water (±standard deviation [SD]) was (3.02 ± 1.43) × 10−3 for ECa and (1.68 ± 0.33) × 10−3 for BLs-ESm (p < 0.001). Mean Cho/water was (4.42 ± 1.53) × 10−3 for type II ECa and (2.65 ± 1.17) × 10−3 for type I ECa (p = 0.001). There were no significant differences among different stages of ECa (p = 0.107) or different grades of ECa (p = 0.142). The Cho/water was positively correlated with tumour stage (r = 0.386, p = 0.017) and size (r = 0.333, p = 0.041). The CV was also positively correlated with tumour stage (r = 0.537, p = 0.001) and size (r = 0.34, p = 0.037).
Conclusion
The Cho/water can differentiate ECa from BLs-ESm and differentiate type II from type I ECa, but cannot differentiate different stages of ECa or different grades of ECa. Cho/water increased with the increase of tumour stage and size.
Key Points
• First report to attempt to assess ECa aggressiveness with magnetic resonance spectroscopy (MRS).
• MRS can differentiate type I from type II ECa.
• MRS can differentiate ECa from BLs-ESm.
• MRS cannot differentiate different stages of ECa or different grades of ECa.
• Cho/water increased with the increase of tumour stage and size.