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Erschienen in: Current Addiction Reports 3/2022

01.09.2022 | Cannabis (B Sherman and R Tomko, Section Editors)

Cannabis and Pregnancy: Factors Associated with Cannabis Use Among Pregnant Women and the Consequences for Offspring Neurodevelopment and Early Postpartum Parenting Behavior

verfasst von: Tessa L. Crume, Shannon Powers, Alexander J. Dufford, Pilyoung Kim

Erschienen in: Current Addiction Reports | Ausgabe 3/2022

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Abstract

Purpose of review

To provide a narrative summary of the epidemiology of prenatal cannabis use, the known reasons for use, the effects of in utero cannabis exposure on offspring neurodevelopment and impact on mother-infant attachment.

Recent findings

Compelling evidence from human imaging studies suggest that in utero cannabis exposure disrupts early brain development and has long-term behavioral consequences for the offspring. Maternal postpartum cannabis use may diminish the maternal-infant bonding process and quality of caregiving.

Summary

The combination of increasing trends in prenatal cannabis use, low perceived risk, and increasing potency pose a serious challenge for the clinical and public health communities. Additional research is needed to understand the consequences of in utero exposure as well as postnatal maternal impacts that diminish the quality of caregiving. Most importantly, clinical cessation programs are needed to support women who enter pregnancy with cannabis dependency.
Literatur
1.
Zurück zum Zitat Agrawal A, Rogers CE, Lessov-Schlaggar CN, Carter EB, Lenze SN, Grucza RA. Alcohol, Cigarette, and Cannabis Use Between 2002 and 2016 in pregnant women from a nationally representative sample. JAMA Pediatr. 2019;173(1):95–6.PubMedCrossRef Agrawal A, Rogers CE, Lessov-Schlaggar CN, Carter EB, Lenze SN, Grucza RA. Alcohol, Cigarette, and Cannabis Use Between 2002 and 2016 in pregnant women from a nationally representative sample. JAMA Pediatr. 2019;173(1):95–6.PubMedCrossRef
2.
Zurück zum Zitat Crume TL, Juhl AL, Brooks-Russell A, Hall KE, Wymore E, Borgelt LM. Cannabis use during the perinatal period in a state with legalized recreational and medical marijuana: the association between maternal characteristics, breastfeeding patterns, and neonatal outcomes. J Pediatr. 2018;197:90–6.PubMedCrossRef Crume TL, Juhl AL, Brooks-Russell A, Hall KE, Wymore E, Borgelt LM. Cannabis use during the perinatal period in a state with legalized recreational and medical marijuana: the association between maternal characteristics, breastfeeding patterns, and neonatal outcomes. J Pediatr. 2018;197:90–6.PubMedCrossRef
3.
Zurück zum Zitat Young-Wolff KC, Sarovar V, Tucker LY, Avalos LA, Alexeeff S, Conway A, et al. Trends in marijuana use among pregnant women with and without nausea and vomiting in pregnancy, 2009–2016. Drug Alcohol Depend. 2019;196:66–70.PubMedPubMedCentralCrossRef Young-Wolff KC, Sarovar V, Tucker LY, Avalos LA, Alexeeff S, Conway A, et al. Trends in marijuana use among pregnant women with and without nausea and vomiting in pregnancy, 2009–2016. Drug Alcohol Depend. 2019;196:66–70.PubMedPubMedCentralCrossRef
4.
Zurück zum Zitat Brown QL, Sarvet AL, Shmulewitz D, Martins SS, Wall MM, Hasin DS. Trends in marijuana use among pregnant and nonpregnant reproductive-aged women, 2002–2014. JAMA. 2017;317(2):207–9.PubMedPubMedCentralCrossRef Brown QL, Sarvet AL, Shmulewitz D, Martins SS, Wall MM, Hasin DS. Trends in marijuana use among pregnant and nonpregnant reproductive-aged women, 2002–2014. JAMA. 2017;317(2):207–9.PubMedPubMedCentralCrossRef
5.
Zurück zum Zitat Allen AM, Jung AM, Alexander AC, Allen SS, Ward KD, al’Absi M. Cannabis use and stressful life events during the perinatal period: cross-sectional results from Pregnancy Risk Assessment Monitoring System (PRAMS) data, 2016. Addiction. 2020;115(9):1707–16.PubMedPubMedCentralCrossRef Allen AM, Jung AM, Alexander AC, Allen SS, Ward KD, al’Absi M. Cannabis use and stressful life events during the perinatal period: cross-sectional results from Pregnancy Risk Assessment Monitoring System (PRAMS) data, 2016. Addiction. 2020;115(9):1707–16.PubMedPubMedCentralCrossRef
7.
Zurück zum Zitat Roberson EK, Patrick WK, Hurwitz EL. Marijuana use and maternal experiences of severe nausea during pregnancy in Hawai’i. Hawaii J Med Public Health. 2014;73(9):283–7.PubMedPubMedCentral Roberson EK, Patrick WK, Hurwitz EL. Marijuana use and maternal experiences of severe nausea during pregnancy in Hawai’i. Hawaii J Med Public Health. 2014;73(9):283–7.PubMedPubMedCentral
8.
Zurück zum Zitat van Gelder MM, Reefhuis J, Caton AR, Werler MM, Druschel CM, Roeleveld N, et al. Characteristics of pregnant illicit drug users and associations between cannabis use and perinatal outcome in a population-based study. Drug Alcohol Depend. 2010;109(1–3):243–7.PubMedCrossRef van Gelder MM, Reefhuis J, Caton AR, Werler MM, Druschel CM, Roeleveld N, et al. Characteristics of pregnant illicit drug users and associations between cannabis use and perinatal outcome in a population-based study. Drug Alcohol Depend. 2010;109(1–3):243–7.PubMedCrossRef
9.
Zurück zum Zitat • Tortoriello G, Morris CV, Alpar A, Fuzik J, Shirran SL, Calvigioni D, et al. Miswiring the brain: Delta9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway. EMBO J. 2014;33(7):668–85. This study demonstrated that exogenous THC exposure during fetal development can trigger a endogenous cannabiniod-receptor-driven molecular cascade that disrupts neuronal specification and rewires fetal cortical circuitry. The authors identified a substrate of altered neuronal connectivity due to THC exposure, Superior Cervical Ganglion 10 (SCG10)/stathmin-2, a microtubule-binding protein in axons. SCG10 mRNA and protein was found to be reduced in the hippocampus of midgestational human cannabis-exposed fetuses, defining SCG10 as the first cannabis-driven molecular effector in the developing cerebrum. CB1 cannabinoid receptor activation by exogenous cannabioniods (THC) recruited in c-Jun N-terminal kinases to phosphorylate SCG10, promoting its rapid degradation in situ in motile axons and microtubule stabilization. Thus, THC enables ectopic formation of filopodia and alters axon morphology. • Tortoriello G, Morris CV, Alpar A, Fuzik J, Shirran SL, Calvigioni D, et al. Miswiring the brain: Delta9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway. EMBO J. 2014;33(7):668–85. This study demonstrated that exogenous THC exposure during fetal development can trigger a endogenous cannabiniod-receptor-driven molecular cascade that disrupts neuronal specification and rewires fetal cortical circuitry. The authors identified a substrate of altered neuronal connectivity due to THC exposure, Superior Cervical Ganglion 10 (SCG10)/stathmin-2, a microtubule-binding protein in axons. SCG10 mRNA and protein was found to be reduced in the hippocampus of midgestational human cannabis-exposed fetuses, defining SCG10 as the first cannabis-driven molecular effector in the developing cerebrum. CB1 cannabinoid receptor activation by exogenous cannabioniods (THC) recruited in c-Jun N-terminal kinases to phosphorylate SCG10, promoting its rapid degradation in situ in motile axons and microtubule stabilization. Thus, THC enables ectopic formation of filopodia and alters axon morphology.
10.
Zurück zum Zitat Association AP. Diagnostic and Statistical manual of mental disorders. 1994. Association AP. Diagnostic and Statistical manual of mental disorders. 1994.
11.
Zurück zum Zitat ElSohly MA, Mehmedic Z, Foster S, Gon C, Chandra S, Church JC. Changes in cannabis potency over the last 2 decades (1995–2014): analysis of current data in the United States. Biol Psychiatry. 2016;79(7):613–9.PubMedPubMedCentralCrossRef ElSohly MA, Mehmedic Z, Foster S, Gon C, Chandra S, Church JC. Changes in cannabis potency over the last 2 decades (1995–2014): analysis of current data in the United States. Biol Psychiatry. 2016;79(7):613–9.PubMedPubMedCentralCrossRef
12.
Zurück zum Zitat ElSohly MA, Ross SA, Mehmedic Z, Arafat R, Yi B, Banahan BF 3rd. Potency trends of delta9-THC and other cannabinoids in confiscated marijuana from 1980–1997. J Forensic Sci. 2000;45(1):24–30.PubMedCrossRef ElSohly MA, Ross SA, Mehmedic Z, Arafat R, Yi B, Banahan BF 3rd. Potency trends of delta9-THC and other cannabinoids in confiscated marijuana from 1980–1997. J Forensic Sci. 2000;45(1):24–30.PubMedCrossRef
14.
Zurück zum Zitat Adams IB, Martin BR. Cannabis: pharmacology and toxicology in animals and humans. Addiction. 1996;91(11):1585–614.PubMedCrossRef Adams IB, Martin BR. Cannabis: pharmacology and toxicology in animals and humans. Addiction. 1996;91(11):1585–614.PubMedCrossRef
15.
Zurück zum Zitat Foster BC, Abramovici H, Harris CS. Cannabis and cannabinoids: kinetics and interactions. Am J Med. 2019;132(11):1266–70.PubMedCrossRef Foster BC, Abramovici H, Harris CS. Cannabis and cannabinoids: kinetics and interactions. Am J Med. 2019;132(11):1266–70.PubMedCrossRef
16.
Zurück zum Zitat Lozano J, Garcia-Algar O, Vall O, de la Torre R, Scaravelli G, Pichini S. Biological matrices for the evaluation of in utero exposure to drugs of abuse. Ther Drug Monit. 2007;29(6):711–34.PubMedCrossRef Lozano J, Garcia-Algar O, Vall O, de la Torre R, Scaravelli G, Pichini S. Biological matrices for the evaluation of in utero exposure to drugs of abuse. Ther Drug Monit. 2007;29(6):711–34.PubMedCrossRef
17.
Zurück zum Zitat Koren G, Chan D, Klein J, Karaskov T. Estimation of fetal exposure to drugs of abuse, environmental tobacco smoke, and ethanol. Ther Drug Monit. 2002;24(1):23–5.PubMedCrossRef Koren G, Chan D, Klein J, Karaskov T. Estimation of fetal exposure to drugs of abuse, environmental tobacco smoke, and ethanol. Ther Drug Monit. 2002;24(1):23–5.PubMedCrossRef
18.
Zurück zum Zitat Ostrea EM Jr, Parks PM, Brady MJ. Rapid isolation and detection of drugs in meconium of infants of drug-dependent mothers. Clin Chem. 1988;34(11):2372–3.PubMedCrossRef Ostrea EM Jr, Parks PM, Brady MJ. Rapid isolation and detection of drugs in meconium of infants of drug-dependent mothers. Clin Chem. 1988;34(11):2372–3.PubMedCrossRef
19.
Zurück zum Zitat Moore C, Negrusz A, Lewis D. Determination of drugs of abuse in meconium. J Chromatogr B Biomed Sci Appl. 1998;713(1):137–46.PubMedCrossRef Moore C, Negrusz A, Lewis D. Determination of drugs of abuse in meconium. J Chromatogr B Biomed Sci Appl. 1998;713(1):137–46.PubMedCrossRef
20.
Zurück zum Zitat Russo EB. History of cannabis and its preparations in saga, science, and sobriquet. Chem Biodivers. 2007;4(8):1614–48.PubMedCrossRef Russo EB. History of cannabis and its preparations in saga, science, and sobriquet. Chem Biodivers. 2007;4(8):1614–48.PubMedCrossRef
21.
Zurück zum Zitat Dreher MC, Nugent K, Hudgins R. Prenatal marijuana exposure and neonatal outcomes in Jamaica: an ethnographic study. Pediatrics. 1994;93(2):254–60.PubMedCrossRef Dreher MC, Nugent K, Hudgins R. Prenatal marijuana exposure and neonatal outcomes in Jamaica: an ethnographic study. Pediatrics. 1994;93(2):254–60.PubMedCrossRef
22.
Zurück zum Zitat Committee Opinion No. 722: Marijuana use during pregnancy and lactation. Obstet Gynecol. 2017;130(4):e205–9.CrossRef Committee Opinion No. 722: Marijuana use during pregnancy and lactation. Obstet Gynecol. 2017;130(4):e205–9.CrossRef
23.
Zurück zum Zitat Mark K, Gryczynski J, Axenfeld E, Schwartz RP, Terplan M. Pregnant women’s current and intended cannabis use in relation to their views toward legalization and knowledge of potential harm. J Addict Med. 2017;11(3):211–6.PubMedCrossRef Mark K, Gryczynski J, Axenfeld E, Schwartz RP, Terplan M. Pregnant women’s current and intended cannabis use in relation to their views toward legalization and knowledge of potential harm. J Addict Med. 2017;11(3):211–6.PubMedCrossRef
24.
Zurück zum Zitat Jarlenski M, Tarr JA, Holland CL, Farrell D, Chang JC. Pregnant women’s access to information about perinatal marijuana use: a qualitative study. Womens Health Issues. 2016;26(4):452–9.PubMedPubMedCentralCrossRef Jarlenski M, Tarr JA, Holland CL, Farrell D, Chang JC. Pregnant women’s access to information about perinatal marijuana use: a qualitative study. Womens Health Issues. 2016;26(4):452–9.PubMedPubMedCentralCrossRef
25.
Zurück zum Zitat Weisbeck SJ, Bright KS, Ginn CS, Smith JM, Hayden KA, Ringham C. Perceptions about cannabis use during pregnancy: a rapid best-framework qualitative synthesis. Can J Public Health. 2021;112(1):49–59.PubMedCrossRef Weisbeck SJ, Bright KS, Ginn CS, Smith JM, Hayden KA, Ringham C. Perceptions about cannabis use during pregnancy: a rapid best-framework qualitative synthesis. Can J Public Health. 2021;112(1):49–59.PubMedCrossRef
26.
Zurück zum Zitat Bayrampour H, Zahradnik M, Lisonkova S, Janssen P. Women’s perspectives about cannabis use during pregnancy and the postpartum period: an integrative review. Prev Med. 2019;119:17–23.PubMedCrossRef Bayrampour H, Zahradnik M, Lisonkova S, Janssen P. Women’s perspectives about cannabis use during pregnancy and the postpartum period: an integrative review. Prev Med. 2019;119:17–23.PubMedCrossRef
27.
Zurück zum Zitat Dickson B, Mansfield C, Guiahi M, Allshouse AA, Borgelt LM, Sheeder J, et al. Recommendations from cannabis dispensaries about first-trimester cannabis use. Obstet Gynecol. 2018;131(6):1031–8.PubMedPubMedCentralCrossRef Dickson B, Mansfield C, Guiahi M, Allshouse AA, Borgelt LM, Sheeder J, et al. Recommendations from cannabis dispensaries about first-trimester cannabis use. Obstet Gynecol. 2018;131(6):1031–8.PubMedPubMedCentralCrossRef
28.
Zurück zum Zitat Richards JR. Cannabinoid hyperemesis syndrome: pathophysiology and treatment in the emergency department. J Emerg Med. 2018;54(3):354–63.PubMedCrossRef Richards JR. Cannabinoid hyperemesis syndrome: pathophysiology and treatment in the emergency department. J Emerg Med. 2018;54(3):354–63.PubMedCrossRef
29.
Zurück zum Zitat Committee on Practice B-O. ACOG practice bulletin no. 189: Nausea and vomiting of pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. Committee on Practice B-O. ACOG practice bulletin no. 189: Nausea and vomiting of pregnancy. Obstet Gynecol. 2018;131(1):e15-e30.
30.
Zurück zum Zitat Gaynes BN, Gavin N, Meltzer-Brody S, Lohr KN, Swinson T, Gartlehner G, et al. Perinatal depression: prevalence, screening accuracy, and screening outcomes. Evid Rep Technol Assess (Summ). 2005;119:1–8. Gaynes BN, Gavin N, Meltzer-Brody S, Lohr KN, Swinson T, Gartlehner G, et al. Perinatal depression: prevalence, screening accuracy, and screening outcomes. Evid Rep Technol Assess (Summ). 2005;119:1–8.
31.
Zurück zum Zitat Ko JY, Tong VT, Bombard JM, Hayes DK, Davy J, Perham-Hester KA. Marijuana use during and after pregnancy and association of prenatal use on birth outcomes: a population-based study. Drug Alcohol Depend. 2018;187:72–8.PubMedPubMedCentralCrossRef Ko JY, Tong VT, Bombard JM, Hayes DK, Davy J, Perham-Hester KA. Marijuana use during and after pregnancy and association of prenatal use on birth outcomes: a population-based study. Drug Alcohol Depend. 2018;187:72–8.PubMedPubMedCentralCrossRef
32.
Zurück zum Zitat Goodwin RD, Zhu J, Heisler Z, Metz TD, Wyka K, Wu M, et al. Cannabis use during pregnancy in the United States: the role of depression. Drug Alcohol Depend. 2020;210: 107881.PubMedCrossRef Goodwin RD, Zhu J, Heisler Z, Metz TD, Wyka K, Wu M, et al. Cannabis use during pregnancy in the United States: the role of depression. Drug Alcohol Depend. 2020;210: 107881.PubMedCrossRef
33.
Zurück zum Zitat LeTendre ML, Reed MB. The effect of adverse childhood experience on clinical diagnosis of a substance use disorder: results of a nationally representative study. Subst Use Misuse. 2017;52(6):689–97.PubMedPubMedCentralCrossRef LeTendre ML, Reed MB. The effect of adverse childhood experience on clinical diagnosis of a substance use disorder: results of a nationally representative study. Subst Use Misuse. 2017;52(6):689–97.PubMedPubMedCentralCrossRef
34.
Zurück zum Zitat al'Absi M, Lemieux A, Westra R, Allen S. Early life adversity influences stress response association with smoking relapse. Psychopharmacology (Berl). 2017;234(22):3375–84. al'Absi M, Lemieux A, Westra R, Allen S. Early life adversity influences stress response association with smoking relapse. Psychopharmacology (Berl). 2017;234(22):3375–84.
35.
Zurück zum Zitat Hirschtritt ME, Avalos LA, Sarovar V, Ridout KK, Goler NC, Ansley DR, et al. Association between prenatal cannabis use and psychotropic medication use in pregnant patients with depression and anxiety. J Addict Med. 2022. Hirschtritt ME, Avalos LA, Sarovar V, Ridout KK, Goler NC, Ansley DR, et al. Association between prenatal cannabis use and psychotropic medication use in pregnant patients with depression and anxiety. J Addict Med. 2022.
36.
Zurück zum Zitat Bonari L, Koren G, Einarson TR, Jasper JD, Taddio A, Einarson A. Use of antidepressants by pregnant women: evaluation of perception of risk, efficacy of evidence based counseling and determinants of decision making. Arch Womens Ment Health. 2005;8(4):214–20.PubMedCrossRef Bonari L, Koren G, Einarson TR, Jasper JD, Taddio A, Einarson A. Use of antidepressants by pregnant women: evaluation of perception of risk, efficacy of evidence based counseling and determinants of decision making. Arch Womens Ment Health. 2005;8(4):214–20.PubMedCrossRef
37.
Zurück zum Zitat Kieviet N, Dolman KM, Honig A. The use of psychotropic medication during pregnancy: how about the newborn? Neuropsychiatr Dis Treat. 2013;9:1257–66.PubMedPubMedCentralCrossRef Kieviet N, Dolman KM, Honig A. The use of psychotropic medication during pregnancy: how about the newborn? Neuropsychiatr Dis Treat. 2013;9:1257–66.PubMedPubMedCentralCrossRef
38.
Zurück zum Zitat Bonari L, Pinto N, Ahn E, Einarson A, Steiner M, Koren G. Perinatal risks of untreated depression during pregnancy. Can J Psychiatry. 2004;49(11):726–35.PubMedCrossRef Bonari L, Pinto N, Ahn E, Einarson A, Steiner M, Koren G. Perinatal risks of untreated depression during pregnancy. Can J Psychiatry. 2004;49(11):726–35.PubMedCrossRef
39.
Zurück zum Zitat Davalos DB, Yadon CA, Tregellas HC. Untreated prenatal maternal depression and the potential risks to offspring: a review. Arch Womens Ment Health. 2012;15(1):1–14.PubMedCrossRef Davalos DB, Yadon CA, Tregellas HC. Untreated prenatal maternal depression and the potential risks to offspring: a review. Arch Womens Ment Health. 2012;15(1):1–14.PubMedCrossRef
40.
Zurück zum Zitat Field T, Diego M, Hernandez-Reif M. Prenatal depression effects on the fetus and newborn: a review. Infant Behav Dev. 2006;29(3):445–55.PubMedCrossRef Field T, Diego M, Hernandez-Reif M. Prenatal depression effects on the fetus and newborn: a review. Infant Behav Dev. 2006;29(3):445–55.PubMedCrossRef
41.
Zurück zum Zitat Bara A, Ferland JN, Rompala G, Szutorisz H, Hurd YL. Cannabis and synaptic reprogramming of the developing brain. Nat Rev Neurosci. 2021;22(7):423–38.PubMedPubMedCentralCrossRef Bara A, Ferland JN, Rompala G, Szutorisz H, Hurd YL. Cannabis and synaptic reprogramming of the developing brain. Nat Rev Neurosci. 2021;22(7):423–38.PubMedPubMedCentralCrossRef
42.
Zurück zum Zitat Berghuis P, Rajnicek AM, Morozov YM, Ross RA, Mulder J, Urban GM, et al. Hardwiring the brain: endocannabinoids shape neuronal connectivity. Science. 2007;316(5828):1212–6.PubMedCrossRef Berghuis P, Rajnicek AM, Morozov YM, Ross RA, Mulder J, Urban GM, et al. Hardwiring the brain: endocannabinoids shape neuronal connectivity. Science. 2007;316(5828):1212–6.PubMedCrossRef
43.
Zurück zum Zitat Mulder J, Aguado T, Keimpema E, Barabas K, Ballester Rosado CJ, Nguyen L, et al. Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning. Proc Natl Acad Sci U S A. 2008;105(25):8760–5.PubMedPubMedCentralCrossRef Mulder J, Aguado T, Keimpema E, Barabas K, Ballester Rosado CJ, Nguyen L, et al. Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning. Proc Natl Acad Sci U S A. 2008;105(25):8760–5.PubMedPubMedCentralCrossRef
45.
Zurück zum Zitat Grant KS, Petroff R, Isoherranen N, Stella N, Burbacher TM. Cannabis use during pregnancy: Pharmacokinetics and effects on child development. Pharmacol Ther. 2018;182:133–51.PubMedCrossRef Grant KS, Petroff R, Isoherranen N, Stella N, Burbacher TM. Cannabis use during pregnancy: Pharmacokinetics and effects on child development. Pharmacol Ther. 2018;182:133–51.PubMedCrossRef
46.
Zurück zum Zitat Jutras-Aswad D, DiNieri JA, Harkany T, Hurd YL. Neurobiological consequences of maternal cannabis on human fetal development and its neuropsychiatric outcome. Eur Arch Psychiatry Clin Neurosci. 2009;259(7):395–412.PubMedCrossRef Jutras-Aswad D, DiNieri JA, Harkany T, Hurd YL. Neurobiological consequences of maternal cannabis on human fetal development and its neuropsychiatric outcome. Eur Arch Psychiatry Clin Neurosci. 2009;259(7):395–412.PubMedCrossRef
47.
Zurück zum Zitat Castaldo P, Magi S, Cataldi M, Arcangeli S, Lariccia V, Nasti AA, et al. Altered regulation of glutamate release and decreased functional activity and expression of GLT1 and GLAST glutamate transporters in the hippocampus of adolescent rats perinatally exposed to Delta(9)-THC. Pharmacol Res. 2010;61(4):334–41.PubMedCrossRef Castaldo P, Magi S, Cataldi M, Arcangeli S, Lariccia V, Nasti AA, et al. Altered regulation of glutamate release and decreased functional activity and expression of GLT1 and GLAST glutamate transporters in the hippocampus of adolescent rats perinatally exposed to Delta(9)-THC. Pharmacol Res. 2010;61(4):334–41.PubMedCrossRef
48.
Zurück zum Zitat Shum C, Dutan L, Annuario E, Warre-Cornish K, Taylor SE, Taylor RD, et al. Delta(9)-tetrahydrocannabinol and 2-AG decreases neurite outgrowth and differentially affects ERK1/2 and Akt signaling in hiPSC-derived cortical neurons. Mol Cell Neurosci. 2020;103: 103463.PubMedCrossRef Shum C, Dutan L, Annuario E, Warre-Cornish K, Taylor SE, Taylor RD, et al. Delta(9)-tetrahydrocannabinol and 2-AG decreases neurite outgrowth and differentially affects ERK1/2 and Akt signaling in hiPSC-derived cortical neurons. Mol Cell Neurosci. 2020;103: 103463.PubMedCrossRef
49.
Zurück zum Zitat Saez TM, Aronne MP, Caltana L, Brusco AH. Prenatal exposure to the CB1 and CB2 cannabinoid receptor agonist WIN 55,212–2 alters migration of early-born glutamatergic neurons and GABAergic interneurons in the rat cerebral cortex. J Neurochem. 2014;129(4):637–48.PubMedCrossRef Saez TM, Aronne MP, Caltana L, Brusco AH. Prenatal exposure to the CB1 and CB2 cannabinoid receptor agonist WIN 55,212–2 alters migration of early-born glutamatergic neurons and GABAergic interneurons in the rat cerebral cortex. J Neurochem. 2014;129(4):637–48.PubMedCrossRef
50.
Zurück zum Zitat Grant KS, Conover E, Chambers CD. Update on the developmental consequences of cannabis use during pregnancy and lactation. Birth Defects Res. 2020;112(15):1126–38.PubMedPubMedCentralCrossRef Grant KS, Conover E, Chambers CD. Update on the developmental consequences of cannabis use during pregnancy and lactation. Birth Defects Res. 2020;112(15):1126–38.PubMedPubMedCentralCrossRef
51.
Zurück zum Zitat Huizink AC. Prenatal cannabis exposure and infant outcomes: overview of studies. Prog Neuropsychopharmacol Biol Psychiatry. 2014;52:45–52.PubMedCrossRef Huizink AC. Prenatal cannabis exposure and infant outcomes: overview of studies. Prog Neuropsychopharmacol Biol Psychiatry. 2014;52:45–52.PubMedCrossRef
52.
Zurück zum Zitat Thomason ME, Palopoli AC, Jariwala NN, Werchan DM, Chen A, Adhikari S, et al. Miswiring the brain: Human prenatal Delta9-tetrahydrocannabinol use associated with altered fetal hippocampal brain network connectivity. Dev Cogn Neurosci. 2021;51: 101000.PubMedPubMedCentralCrossRef Thomason ME, Palopoli AC, Jariwala NN, Werchan DM, Chen A, Adhikari S, et al. Miswiring the brain: Human prenatal Delta9-tetrahydrocannabinol use associated with altered fetal hippocampal brain network connectivity. Dev Cogn Neurosci. 2021;51: 101000.PubMedPubMedCentralCrossRef
53.
Zurück zum Zitat •• Grewen K, Salzwedel AP, Gao W. Functional connectivity disruption in neonates with prenatal marijuana exposure. Front Hum Neurosci. 2015;9:601. The authors investigated the effects of prenatal marijuana on development of early brain functional circuitry prior to prolonged postnatal environmental influences by measuring resting state functional connectivity during unsedated sleep in infants at 2–6 weeks. Imaging analyses focused on connectivity of subcortical seed regions with high fetal CB1R expression. Marijuana-specific differences were observed in insula and three striatal connections: anterior insula-cerebellum, right caudate-cerebellum, right caudate-right fusiform gyrus/inferior occipital, left caudate-cerebellum. The marijuana exposed neonates were found to have hypo-connectivity in all clusters compared non-exposed neonates. Altered striatal connectivity to areas involved in visual spatial and motor learning, attention, and in fine-tuning of motor outputs involved in movement and language production may contribute to neurobehavioral deficits. •• Grewen K, Salzwedel AP, Gao W. Functional connectivity disruption in neonates with prenatal marijuana exposure. Front Hum Neurosci. 2015;9:601. The authors investigated the effects of prenatal marijuana on development of early brain functional circuitry prior to prolonged postnatal environmental influences by measuring resting state functional connectivity during unsedated sleep in infants at 2–6 weeks. Imaging analyses focused on connectivity of subcortical seed regions with high fetal CB1R expression. Marijuana-specific differences were observed in insula and three striatal connections: anterior insula-cerebellum, right caudate-cerebellum, right caudate-right fusiform gyrus/inferior occipital, left caudate-cerebellum. The marijuana exposed neonates were found to have hypo-connectivity in all clusters compared non-exposed neonates. Altered striatal connectivity to areas involved in visual spatial and motor learning, attention, and in fine-tuning of motor outputs involved in movement and language production may contribute to neurobehavioral deficits.
54.
Zurück zum Zitat El Marroun H, Tiemeier H, Franken IH, Jaddoe VW, van der Lugt A, Verhulst FC, et al. Prenatal Cannabis and tobacco exposure in relation to brain morphology: a prospective neuroimaging study in young children. Biol Psychiatry. 2016;79(12):971–9.PubMedCrossRef El Marroun H, Tiemeier H, Franken IH, Jaddoe VW, van der Lugt A, Verhulst FC, et al. Prenatal Cannabis and tobacco exposure in relation to brain morphology: a prospective neuroimaging study in young children. Biol Psychiatry. 2016;79(12):971–9.PubMedCrossRef
55.
Zurück zum Zitat Glass M, Dragunow M, Faull RL. Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience. 1997;77(2):299–318.PubMedCrossRef Glass M, Dragunow M, Faull RL. Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience. 1997;77(2):299–318.PubMedCrossRef
56.
Zurück zum Zitat Wang X, Dow-Edwards D, Keller E, Hurd YL. Preferential limbic expression of the cannabinoid receptor mRNA in the human fetal brain. Neuroscience. 2003;118(3):681–94.PubMedCrossRef Wang X, Dow-Edwards D, Keller E, Hurd YL. Preferential limbic expression of the cannabinoid receptor mRNA in the human fetal brain. Neuroscience. 2003;118(3):681–94.PubMedCrossRef
57.
Zurück zum Zitat Antonelli T, Tomasini MC, Tattoli M, Cassano T, Tanganelli S, Finetti S, et al. Prenatal exposure to the CB1 receptor agonist WIN 55,212–2 causes learning disruption associated with impaired cortical NMDA receptor function and emotional reactivity changes in rat offspring. Cereb Cortex. 2005;15(12):2013–20.PubMedCrossRef Antonelli T, Tomasini MC, Tattoli M, Cassano T, Tanganelli S, Finetti S, et al. Prenatal exposure to the CB1 receptor agonist WIN 55,212–2 causes learning disruption associated with impaired cortical NMDA receptor function and emotional reactivity changes in rat offspring. Cereb Cortex. 2005;15(12):2013–20.PubMedCrossRef
58.
Zurück zum Zitat Smith AM, Fried PA, Hogan MJ, Cameron I. Effects of prenatal marijuana on response inhibition: an fMRI study of young adults. Neurotoxicol Teratol. 2004;26(4):533–42.PubMedCrossRef Smith AM, Fried PA, Hogan MJ, Cameron I. Effects of prenatal marijuana on response inhibition: an fMRI study of young adults. Neurotoxicol Teratol. 2004;26(4):533–42.PubMedCrossRef
59.
Zurück zum Zitat Hoekzema E, Barba-Muller E, Pozzobon C, Picado M, Lucco F, Garcia-Garcia D, et al. Pregnancy leads to long-lasting changes in human brain structure. Nat Neurosci. 2017;20(2):287–96.PubMedCrossRef Hoekzema E, Barba-Muller E, Pozzobon C, Picado M, Lucco F, Garcia-Garcia D, et al. Pregnancy leads to long-lasting changes in human brain structure. Nat Neurosci. 2017;20(2):287–96.PubMedCrossRef
60.
Zurück zum Zitat Kim P, Leckman JF, Mayes LC, Feldman R, Wang X, Swain JE. The plasticity of human maternal brain: longitudinal changes in brain anatomy during the early postpartum period. Behav Neurosci. 2010;124(5):695–700.PubMedPubMedCentralCrossRef Kim P, Leckman JF, Mayes LC, Feldman R, Wang X, Swain JE. The plasticity of human maternal brain: longitudinal changes in brain anatomy during the early postpartum period. Behav Neurosci. 2010;124(5):695–700.PubMedPubMedCentralCrossRef
61.
Zurück zum Zitat Strathearn L, Li J, Fonagy P, Montague PR. What’s in a smile? Maternal brain responses to infant facial cues. Pediatrics. 2008;122(1):40–51.PubMedCrossRef Strathearn L, Li J, Fonagy P, Montague PR. What’s in a smile? Maternal brain responses to infant facial cues. Pediatrics. 2008;122(1):40–51.PubMedCrossRef
62.
Zurück zum Zitat Swain JE, Lorberbaum JP, Kose S, Strathearn L. Brain basis of early parent-infant interactions: psychology, physiology, and in vivo functional neuroimaging studies. J Child Psychol Psychiatry. 2007;48(3–4):262–87.PubMedPubMedCentralCrossRef Swain JE, Lorberbaum JP, Kose S, Strathearn L. Brain basis of early parent-infant interactions: psychology, physiology, and in vivo functional neuroimaging studies. J Child Psychol Psychiatry. 2007;48(3–4):262–87.PubMedPubMedCentralCrossRef
63.
Zurück zum Zitat Brunton PJ, Russell JA. The expectant brain: adapting for motherhood. Nat Rev Neurosci. 2008;9(1):11–25.PubMedCrossRef Brunton PJ, Russell JA. The expectant brain: adapting for motherhood. Nat Rev Neurosci. 2008;9(1):11–25.PubMedCrossRef
64.
Zurück zum Zitat Brunton PJ, Russell JA. Endocrine induced changes in brain function during pregnancy. Brain Res. 2010;1364:198–215.PubMedCrossRef Brunton PJ, Russell JA. Endocrine induced changes in brain function during pregnancy. Brain Res. 2010;1364:198–215.PubMedCrossRef
65.
Zurück zum Zitat Russell JA, Douglas AJ, Ingram CD. Brain preparations for maternity–adaptive changes in behavioral and neuroendocrine systems during pregnancy and lactation. An overview. Prog Brain Res. 2001;133:1–38.PubMedCrossRef Russell JA, Douglas AJ, Ingram CD. Brain preparations for maternity–adaptive changes in behavioral and neuroendocrine systems during pregnancy and lactation. An overview. Prog Brain Res. 2001;133:1–38.PubMedCrossRef
66.
Zurück zum Zitat Barba-Muller E, Craddock S, Carmona S, Hoekzema E. Brain plasticity in pregnancy and the postpartum period: links to maternal caregiving and mental health. Arch Womens Ment Health. 2019;22(2):289–99.PubMedCrossRef Barba-Muller E, Craddock S, Carmona S, Hoekzema E. Brain plasticity in pregnancy and the postpartum period: links to maternal caregiving and mental health. Arch Womens Ment Health. 2019;22(2):289–99.PubMedCrossRef
68.
Zurück zum Zitat Bayazit H, Selek S, Karababa IF, Cicek E, Aksoy N. Evaluation of oxidant/antioxidant status and cytokine levels in patients with cannabis use disorder. Clin Psychopharmacol Neurosci. 2017;15(3):237–42.PubMedPubMedCentralCrossRef Bayazit H, Selek S, Karababa IF, Cicek E, Aksoy N. Evaluation of oxidant/antioxidant status and cytokine levels in patients with cannabis use disorder. Clin Psychopharmacol Neurosci. 2017;15(3):237–42.PubMedPubMedCentralCrossRef
69.
Zurück zum Zitat Saroz Y, Kho DT, Glass M, Graham ES, Grimsey NL. Cannabinoid receptor 2 (CB2) signals via G-alpha-s and induces IL-6 and IL-10 cytokine secretion in human primary leukocytes. ACS Pharmacol Transl Sci. 2019;2(6):414–28.PubMedPubMedCentralCrossRef Saroz Y, Kho DT, Glass M, Graham ES, Grimsey NL. Cannabinoid receptor 2 (CB2) signals via G-alpha-s and induces IL-6 and IL-10 cytokine secretion in human primary leukocytes. ACS Pharmacol Transl Sci. 2019;2(6):414–28.PubMedPubMedCentralCrossRef
70.
Zurück zum Zitat Mackie K. Cannabinoid receptors: where they are and what they do. J Neuroendocrinol. 2008;20(Suppl 1):10–4.PubMedCrossRef Mackie K. Cannabinoid receptors: where they are and what they do. J Neuroendocrinol. 2008;20(Suppl 1):10–4.PubMedCrossRef
71.
Zurück zum Zitat Kim P, Feldman R, Mayes LC, Eicher V, Thompson N, Leckman JF, et al. Breastfeeding, brain activation to own infant cry, and maternal sensitivity. J Child Psychol Psychiatry. 2011;52(8):907–15.PubMedPubMedCentralCrossRef Kim P, Feldman R, Mayes LC, Eicher V, Thompson N, Leckman JF, et al. Breastfeeding, brain activation to own infant cry, and maternal sensitivity. J Child Psychol Psychiatry. 2011;52(8):907–15.PubMedPubMedCentralCrossRef
72.
73.
Zurück zum Zitat Rutherford HJ, Gerig G, Gouttard S, Potenza MN, Mayes LC. Investigating maternal brain structure and its relationship to substance use and motivational systems. Yale J Biol Med. 2015;88(3):211–7.PubMedPubMedCentral Rutherford HJ, Gerig G, Gouttard S, Potenza MN, Mayes LC. Investigating maternal brain structure and its relationship to substance use and motivational systems. Yale J Biol Med. 2015;88(3):211–7.PubMedPubMedCentral
74.
Zurück zum Zitat Eiden RD, Schuetze P, Shisler S, Huestis MA. Prenatal exposure to tobacco and cannabis: effects on autonomic and emotion regulation. Neurotoxicol Teratol. 2018;68:47–56.PubMedPubMedCentralCrossRef Eiden RD, Schuetze P, Shisler S, Huestis MA. Prenatal exposure to tobacco and cannabis: effects on autonomic and emotion regulation. Neurotoxicol Teratol. 2018;68:47–56.PubMedPubMedCentralCrossRef
75.
76.
Zurück zum Zitat Schuler ME, Nair P, Black MM. Ongoing maternal drug use, parenting attitudes, and a home intervention: effects on mother-child interaction at 18 months. J Dev Behav Pediatr. 2002;23(2):87–94.PubMedPubMedCentralCrossRef Schuler ME, Nair P, Black MM. Ongoing maternal drug use, parenting attitudes, and a home intervention: effects on mother-child interaction at 18 months. J Dev Behav Pediatr. 2002;23(2):87–94.PubMedPubMedCentralCrossRef
77.
Zurück zum Zitat Abel EL, Tan SE, Subramanian M. Effects of delta 9-tetrahydrocannabinol, phenobarbital, and their combination on pregnancy and offspring in rats. Teratology. 1987;36(2):193–8.PubMedCrossRef Abel EL, Tan SE, Subramanian M. Effects of delta 9-tetrahydrocannabinol, phenobarbital, and their combination on pregnancy and offspring in rats. Teratology. 1987;36(2):193–8.PubMedCrossRef
78.
Zurück zum Zitat •• Hill M, Sternberg A, Suk HW, Meier MH, Chassin L. The intergenerational transmission of cannabis use: associations between parental history of cannabis use and cannabis use disorder, low positive parenting, and offspring cannabis use. Psychol Addict Behav. 2018;32(1):93–103. The authors prospectively evaluated a metric of low positive parenting as a mediator of the relation between parental cannabis use and adolescent cannabis use at the family level and individual level. They found that parental cannabis use disorder was associated with adolescent cannabis use predicted low positive parenting. Average levels of low positive parenting within a family partially mediated the association between parental cannabis use disorder and offspring cannabis use. Results suggest that average levels of positive parenting in families may be a mechanism underlying the intergenerational transmission of cannabis use. •• Hill M, Sternberg A, Suk HW, Meier MH, Chassin L. The intergenerational transmission of cannabis use: associations between parental history of cannabis use and cannabis use disorder, low positive parenting, and offspring cannabis use. Psychol Addict Behav. 2018;32(1):93–103. The authors prospectively evaluated a metric of low positive parenting as a mediator of the relation between parental cannabis use and adolescent cannabis use at the family level and individual level. They found that parental cannabis use disorder was associated with adolescent cannabis use predicted low positive parenting. Average levels of low positive parenting within a family partially mediated the association between parental cannabis use disorder and offspring cannabis use. Results suggest that average levels of positive parenting in families may be a mechanism underlying the intergenerational transmission of cannabis use.
79.
Zurück zum Zitat Chamberlain C, O'Mara-Eves A, Porter J, Coleman T, Perlen SM, Thomas J, et al. Psychosocial interventions for supporting women to stop smoking in pregnancy. Cochrane Database Syst Rev. 2017;2:CD001055. Chamberlain C, O'Mara-Eves A, Porter J, Coleman T, Perlen SM, Thomas J, et al. Psychosocial interventions for supporting women to stop smoking in pregnancy. Cochrane Database Syst Rev. 2017;2:CD001055.
Metadaten
Titel
Cannabis and Pregnancy: Factors Associated with Cannabis Use Among Pregnant Women and the Consequences for Offspring Neurodevelopment and Early Postpartum Parenting Behavior
verfasst von
Tessa L. Crume
Shannon Powers
Alexander J. Dufford
Pilyoung Kim
Publikationsdatum
01.09.2022
Verlag
Springer International Publishing
Erschienen in
Current Addiction Reports / Ausgabe 3/2022
Elektronische ISSN: 2196-2952
DOI
https://doi.org/10.1007/s40429-022-00419-6

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