Skip to main content
Erschienen in: Neurological Sciences 9/2020

05.08.2020 | COVID-19 | COVID-19 Zur Zeit gratis

Challenges and management of neurological and psychiatric manifestations in SARS-CoV-2 (COVID-19) patients

verfasst von: Alessandro Orsini, Martina Corsi, Andrea Santangelo, Antonella Riva, Diego Peroni, Thomas Foiadelli, Salvatore Savasta, Pasquale Striano

Erschienen in: Neurological Sciences | Ausgabe 9/2020

Einloggen, um Zugang zu erhalten

Abstract

COVID-19 is a pandemic caused by human coronavirus (HCoV) SARS-CoV-2, which originated in Wuhan, China, at the end of 2019 and spread globally during 2020. Due to the difficulty of clinical decision-making during this period, our study group reviewed current literature focusing on the neurological and psychiatric aspects of COVID-19. Despite the knowledge on this newly discovered virus which is constantly evolving, different pieces of evidence reported an association between COVID-19 and neurological symptoms like headache, dizziness, taste and smell disorders and complications involving the nervous system eventually triggered by the pathologic processes elicited by SARS-CoV-2. It seems that younger patients are less prone to develop severe forms of COVID-19. However, neurological signs have been reported in paediatric patients as well, and in some cases, the infection presented neurological sequelae. Furthermore, children with particular neurological diseases or treated with specific drugs (e.g. immune-suppressant therapies) must be carefully monitored during this pandemic. Neurologists should be aware of the main drug–drug interactions and the neurological side effects of COVID-19 treatments. Notably, adverse mental health impact has been reported in patients with SARS-CoV-2, which could be related either to the social strain or to the eventual neurotropic effects of the virus, which in other infections have been proven to promote the onset of psychiatric symptoms. Further, psychiatric population may be more vulnerable to the infection and at higher risk for adverse outcomes.
Literatur
1.
Zurück zum Zitat Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F, Ma X, Wang D, Xu W, Wu G, Gao GF, Tan W, China Novel Coronavirus Investigating and Research Team (2020) A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 382(8):727–733CrossRefPubMedPubMedCentral Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F, Ma X, Wang D, Xu W, Wu G, Gao GF, Tan W, China Novel Coronavirus Investigating and Research Team (2020) A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 382(8):727–733CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL (2020) A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 579(7798):270–273PubMedPubMedCentral Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL (2020) A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 579(7798):270–273PubMedPubMedCentral
4.
Zurück zum Zitat WHO: Coronavirus disease (COVID-19) Situation Report 138. June 6, 2020 WHO: Coronavirus disease (COVID-19) Situation Report 138. June 6, 2020
5.
Zurück zum Zitat Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, Tong S (2020) Epidemiology of COVID-19 among children in China. Pediatrics 145:e20200702CrossRefPubMed Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, Tong S (2020) Epidemiology of COVID-19 among children in China. Pediatrics 145:e20200702CrossRefPubMed
8.
Zurück zum Zitat Holmes EA, O'Connor RC, Perry VH, Tracey I, Wessely S, Arseneault L, Ballard C, Christensen H, Cohen Silver R, Everall I, Ford T, John A, Kabir T, King K, Madan I, Michie S, Przybylski AK, Shafran R, Sweeney A, Worthman CM, Yardley L, Cowan K, Cope C, Hotopf M, Bullmore E (2020) Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science. Lancet Psychiatry 7:547–560PubMedPubMedCentral Holmes EA, O'Connor RC, Perry VH, Tracey I, Wessely S, Arseneault L, Ballard C, Christensen H, Cohen Silver R, Everall I, Ford T, John A, Kabir T, King K, Madan I, Michie S, Przybylski AK, Shafran R, Sweeney A, Worthman CM, Yardley L, Cowan K, Cope C, Hotopf M, Bullmore E (2020) Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science. Lancet Psychiatry 7:547–560PubMedPubMedCentral
10.
Zurück zum Zitat Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J et al (2020) SARS-CoV-2 infection in children. N Engl J Med 382(17):1663–1665PubMed Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J et al (2020) SARS-CoV-2 infection in children. N Engl J Med 382(17):1663–1665PubMed
12.
Zurück zum Zitat Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Xia J', Yu T, Zhang X, Zhang L (2020) Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 395(10223):507–513PubMedPubMedCentral Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Xia J', Yu T, Zhang X, Zhang L (2020) Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 395(10223):507–513PubMedPubMedCentral
13.
Zurück zum Zitat To KF, Lo AW (2004) Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2). J Pathol 203(3):740–743PubMedPubMedCentral To KF, Lo AW (2004) Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2). J Pathol 203(3):740–743PubMedPubMedCentral
15.
Zurück zum Zitat Netland J, Meyerholz DK, Moore S, Cassell M, Perlman S (2008) Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. J Virol 82(15):7264–7275PubMedPubMedCentral Netland J, Meyerholz DK, Moore S, Cassell M, Perlman S (2008) Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. J Virol 82(15):7264–7275PubMedPubMedCentral
16.
Zurück zum Zitat Andries K, Pensaert MB (1980) Immunofluorescence studies on the pathogenesis of hemagglutinating encephalomyelitis virus infection in pigs after oronasal inoculation. Am J Vet Res 41(9):1372–1378PubMed Andries K, Pensaert MB (1980) Immunofluorescence studies on the pathogenesis of hemagglutinating encephalomyelitis virus infection in pigs after oronasal inoculation. Am J Vet Res 41(9):1372–1378PubMed
17.
Zurück zum Zitat Baig AM, Khaleeq A, Ali U, Syeda H (2020) Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci 11(7):995–998PubMed Baig AM, Khaleeq A, Ali U, Syeda H (2020) Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci 11(7):995–998PubMed
19.
21.
Zurück zum Zitat Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395(10223):497–506PubMedPubMedCentral Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395(10223):497–506PubMedPubMedCentral
23.
Zurück zum Zitat Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ (2020) COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 395(10229):1033–1034PubMedPubMedCentral Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ (2020) COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 395(10229):1033–1034PubMedPubMedCentral
24.
Zurück zum Zitat Bohmwald K, Galvez NMS, Rios M, Kalergis AM (2018) Neurologic alterations due to respiratory virus infections. Front Cell Neurosci 12:386PubMedPubMedCentral Bohmwald K, Galvez NMS, Rios M, Kalergis AM (2018) Neurologic alterations due to respiratory virus infections. Front Cell Neurosci 12:386PubMedPubMedCentral
25.
Zurück zum Zitat Asadi-Pooya AA, Simani L (2020) Central nervous system manifestations of COVID-19: a systematic review. J Neurol Sci 413:116832PubMedPubMedCentral Asadi-Pooya AA, Simani L (2020) Central nervous system manifestations of COVID-19: a systematic review. J Neurol Sci 413:116832PubMedPubMedCentral
26.
Zurück zum Zitat Lechien JR, Chiesa-Estomba CM, De Siati DR, et al (2020) Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol 277(8):2251–2261. https://doi.org/10.1007/s00405-020-05965-1 Lechien JR, Chiesa-Estomba CM, De Siati DR, et al (2020) Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol 277(8):2251–2261. https://​doi.​org/​10.​1007/​s00405-020-05965-1
28.
Zurück zum Zitat Xiang P, Xu XM, Gao LL, Wang HZ, Xiong HF, Li RH (2020) First case of 2019 novel coronavirus disease with encephalitis. ChinaXiv 202003:00015 Xiang P, Xu XM, Gao LL, Wang HZ, Xiong HF, Li RH (2020) First case of 2019 novel coronavirus disease with encephalitis. ChinaXiv 202003:00015
29.
Zurück zum Zitat Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J, Ueno M, Sakata H, Kondo K, Myose N, Nakao A, Takeda M, Haro H, Inoue O, Suzuki-Inoue K, Kubokawa K, Ogihara S, Sasaki T, Kinouchi H, Kojin H, Ito M, Onishi H, Shimizu T, Sasaki Y, Enomoto N, Ishihara H, Furuya S, Yamamoto T, Shimada S (2020) A first case of meningitis/encephalitis associated with SARS-coronavirus-2. Int J Infect Dis 94:55–58PubMedPubMedCentral Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J, Ueno M, Sakata H, Kondo K, Myose N, Nakao A, Takeda M, Haro H, Inoue O, Suzuki-Inoue K, Kubokawa K, Ogihara S, Sasaki T, Kinouchi H, Kojin H, Ito M, Onishi H, Shimizu T, Sasaki Y, Enomoto N, Ishihara H, Furuya S, Yamamoto T, Shimada S (2020) A first case of meningitis/encephalitis associated with SARS-coronavirus-2. Int J Infect Dis 94:55–58PubMedPubMedCentral
31.
Zurück zum Zitat Wu X, Wu W, Pan W, Wu L, Liu K, Zhang HL (2015) Acute necrotizing encephalopathy: an underrecognized clinicoradiologic disorder. Mediat Inflamm 2015:792578 Wu X, Wu W, Pan W, Wu L, Liu K, Zhang HL (2015) Acute necrotizing encephalopathy: an underrecognized clinicoradiologic disorder. Mediat Inflamm 2015:792578
32.
Zurück zum Zitat Wang H, Ma S (2008) The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome. Am J Emerg Med 26(6):711–715PubMed Wang H, Ma S (2008) The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome. Am J Emerg Med 26(6):711–715PubMed
33.
Zurück zum Zitat Avula A, Nalleballe K, Narula N, Sapozhnikov S, Dandu V, Toom S, Glaser A, Elsayegh D (2020) COVID-19 presenting as stroke. Brain Behav Immun 87:115–119PubMedPubMedCentral Avula A, Nalleballe K, Narula N, Sapozhnikov S, Dandu V, Toom S, Glaser A, Elsayegh D (2020) COVID-19 presenting as stroke. Brain Behav Immun 87:115–119PubMedPubMedCentral
34.
Zurück zum Zitat Oxley TJ, Mocco J, Majidi S, Kellner CP, Shoirah H, Singh IP et alLarge-vessel stroke as a presenting feature of Covid-19 in the young. N Engl J Med 3822020:e60 Oxley TJ, Mocco J, Majidi S, Kellner CP, Shoirah H, Singh IP et alLarge-vessel stroke as a presenting feature of Covid-19 in the young. N Engl J Med 3822020:e60
35.
Zurück zum Zitat Klok FA, Kruip M, van der Meer NJM, Arbous MS, Gommers D, Kant KM et al (2020) Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res 191:145–147PubMedPubMedCentral Klok FA, Kruip M, van der Meer NJM, Arbous MS, Gommers D, Kant KM et al (2020) Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res 191:145–147PubMedPubMedCentral
36.
Zurück zum Zitat Lippi G, Plebani M, Henry BM (2020) Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis. Clin Chim Acta 506:145–148PubMedPubMedCentral Lippi G, Plebani M, Henry BM (2020) Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis. Clin Chim Acta 506:145–148PubMedPubMedCentral
37.
38.
Zurück zum Zitat Doobay MF, Talman LS, Obr TD, Tian X, Davisson RL, Lazartigues E (2007) Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol 292(1):R373–R381PubMed Doobay MF, Talman LS, Obr TD, Tian X, Davisson RL, Lazartigues E (2007) Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol 292(1):R373–R381PubMed
39.
Zurück zum Zitat Zhao H, Shen D, Zhou H, Liu J, Chen S (2020) Guillain-Barre syndrome associated with SARS-CoV-2 infection: causality or coincidence? Lancet Neurol 19(5):383–384PubMedPubMedCentral Zhao H, Shen D, Zhou H, Liu J, Chen S (2020) Guillain-Barre syndrome associated with SARS-CoV-2 infection: causality or coincidence? Lancet Neurol 19(5):383–384PubMedPubMedCentral
43.
Zurück zum Zitat Camdessanche JP, Morel J, Pozzetto B, Paul S, Tholance Y, Botelho-Nevers E (2020) COVID-19 may induce Guillain-Barré syndrome. Rev Neurol (Paris) 176(6):516–518 Camdessanche JP, Morel J, Pozzetto B, Paul S, Tholance Y, Botelho-Nevers E (2020) COVID-19 may induce Guillain-Barré syndrome. Rev Neurol (Paris) 176(6):516–518
45.
Zurück zum Zitat Brownlee W, Bourdette D, Broadley S, Killestein J, Ciccarelli O (2020) Treating multiple sclerosis and neuromyelitis optica spectrum disorder during the COVID-19 pandemic. Neurology. 94:949–952PubMed Brownlee W, Bourdette D, Broadley S, Killestein J, Ciccarelli O (2020) Treating multiple sclerosis and neuromyelitis optica spectrum disorder during the COVID-19 pandemic. Neurology. 94:949–952PubMed
46.
Zurück zum Zitat Amor S, Baker D, Khoury SJ, Schmierer K, Giovanonni G (2020) SARS-CoV-2 and multiple sclerosis: not all immune depleting DMTs are equal or bad. Ann Neurol n/a(n/a) Amor S, Baker D, Khoury SJ, Schmierer K, Giovanonni G (2020) SARS-CoV-2 and multiple sclerosis: not all immune depleting DMTs are equal or bad. Ann Neurol n/a(n/a)
47.
Zurück zum Zitat Winkelmann A, Loebermann M, Reisinger EC, Hartung HP, Zettl UK (2016) Disease-modifying therapies and infectious risks in multiple sclerosis. Nat Rev Neurol 12(4):217–233PubMed Winkelmann A, Loebermann M, Reisinger EC, Hartung HP, Zettl UK (2016) Disease-modifying therapies and infectious risks in multiple sclerosis. Nat Rev Neurol 12(4):217–233PubMed
48.
Zurück zum Zitat Guidon AC, Amato AA (2020) COVID-19 and neuromuscular disorders. Neurology 94:959–969PubMed Guidon AC, Amato AA (2020) COVID-19 and neuromuscular disorders. Neurology 94:959–969PubMed
49.
Zurück zum Zitat Gummi RR, Kukulka NA, Deroche CB, Govindarajan R (2019) Factors associated with acute exacerbations of myasthenia gravis. Muscle Nerve 60(6):693–699PubMed Gummi RR, Kukulka NA, Deroche CB, Govindarajan R (2019) Factors associated with acute exacerbations of myasthenia gravis. Muscle Nerve 60(6):693–699PubMed
50.
Zurück zum Zitat Szperka CL, Ailani J, Barmherzig R, Klein BC, Minen MT, Halker Singh RB, Shapiro RE (2020) Migraine care in the era of COVID-19: clinical pearls and plea to insurers. Headache. 60(5):833–842PubMedPubMedCentral Szperka CL, Ailani J, Barmherzig R, Klein BC, Minen MT, Halker Singh RB, Shapiro RE (2020) Migraine care in the era of COVID-19: clinical pearls and plea to insurers. Headache. 60(5):833–842PubMedPubMedCentral
51.
Zurück zum Zitat EMA gives advice on the use of non-steroidal anti-inflammatories for COVID-19 EMA gives advice on the use of non-steroidal anti-inflammatories for COVID-19
52.
Zurück zum Zitat Muller KI, Alstadhaug KB, Bekkelund SI (2017) A randomized trial of telemedicine efficacy and safety for nonacute headaches. Neurology. 89(2):153–162PubMedPubMedCentral Muller KI, Alstadhaug KB, Bekkelund SI (2017) A randomized trial of telemedicine efficacy and safety for nonacute headaches. Neurology. 89(2):153–162PubMedPubMedCentral
53.
Zurück zum Zitat Qubty W, Patniyot I, Gelfand A (2018) Telemedicine in a pediatric headache clinic: a prospective survey. Neurology 90(19):e1702–e17e5PubMed Qubty W, Patniyot I, Gelfand A (2018) Telemedicine in a pediatric headache clinic: a prospective survey. Neurology 90(19):e1702–e17e5PubMed
54.
Zurück zum Zitat Bove R, Bevan C, Crabtree E, Zhao C, Gomez R, Garcha P, Morrissey J, Dierkhising J, Green AJ, Hauser SL, Cree BAC, Wallin MT, Gelfand JM (2019) Toward a low-cost, in-home, telemedicine-enabled assessment of disability in multiple sclerosis. Mult Scler 25(11):1526–1534PubMed Bove R, Bevan C, Crabtree E, Zhao C, Gomez R, Garcha P, Morrissey J, Dierkhising J, Green AJ, Hauser SL, Cree BAC, Wallin MT, Gelfand JM (2019) Toward a low-cost, in-home, telemedicine-enabled assessment of disability in multiple sclerosis. Mult Scler 25(11):1526–1534PubMed
55.
Zurück zum Zitat Carlotti APdCP, Carvalho WBd, Johnston C, Rodriguez IS, Delgado AF (2020) COVID-19 diagnostic and management protocol for pediatric patients. Clinics 75 Carlotti APdCP, Carvalho WBd, Johnston C, Rodriguez IS, Delgado AF (2020) COVID-19 diagnostic and management protocol for pediatric patients. Clinics 75
56.
Zurück zum Zitat Cortegiani A, Ingoglia G, Ippolito M, Giarratano A, Einav S (2020) A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19. J Crit Care 57:279–283PubMedPubMedCentral Cortegiani A, Ingoglia G, Ippolito M, Giarratano A, Einav S (2020) A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19. J Crit Care 57:279–283PubMedPubMedCentral
59.
Zurück zum Zitat Chen J, Liu D, Liu L, Liu P, Xu Q, Xia L, Ling Y, Huang D, Song S, Zhang D, Qian Z, Li T, Shen Y, Lu H (2020) A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19. Zhejiang Da Xue Xue Bao Yi Xue Ban 49(2):215–219PubMedPubMedCentral Chen J, Liu D, Liu L, Liu P, Xu Q, Xia L, Ling Y, Huang D, Song S, Zhang D, Qian Z, Li T, Shen Y, Lu H (2020) A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19. Zhejiang Da Xue Xue Bao Yi Xue Ban 49(2):215–219PubMedPubMedCentral
60.
Zurück zum Zitat Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A, du B, Aboodi M, Wunsch H, Cecconi M, Koh Y, Chertow DS, Maitland K, Alshamsi F, Belley-Cote E, Greco M, Laundy M, Morgan JS, Kesecioglu J, McGeer A, Mermel L, Mammen MJ, Alexander PE, Arrington A, Centofanti JE, Citerio G, Baw B, Memish ZA, Hammond N, Hayden FG, Evans L, Rhodes A (2020) Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19). Intensive Care Med 46(5):854–887PubMedPubMedCentral Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A, du B, Aboodi M, Wunsch H, Cecconi M, Koh Y, Chertow DS, Maitland K, Alshamsi F, Belley-Cote E, Greco M, Laundy M, Morgan JS, Kesecioglu J, McGeer A, Mermel L, Mammen MJ, Alexander PE, Arrington A, Centofanti JE, Citerio G, Baw B, Memish ZA, Hammond N, Hayden FG, Evans L, Rhodes A (2020) Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19). Intensive Care Med 46(5):854–887PubMedPubMedCentral
61.
Zurück zum Zitat Agenzia Italiana del Farmaco (AIFA): AIFA sospende l’autorizzazione all’utilizzo di idrossiclorochina per il trattamento del COVID-19 al di fuori degli studi clinici Agenzia Italiana del Farmaco (AIFA): AIFA sospende l’autorizzazione all’utilizzo di idrossiclorochina per il trattamento del COVID-19 al di fuori degli studi clinici
62.
Zurück zum Zitat Mulhauser P, Allemann Y, Regamey C (1995) Chloroquine and nonconvulsive status epilepticus. Ann Intern Med 123(1):76–77PubMed Mulhauser P, Allemann Y, Regamey C (1995) Chloroquine and nonconvulsive status epilepticus. Ann Intern Med 123(1):76–77PubMed
63.
Zurück zum Zitat Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M et al (2020) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 30. England:269–271PubMedPubMedCentral Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M et al (2020) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 30. England:269–271PubMedPubMedCentral
64.
Zurück zum Zitat Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, Spitters C, Ericson K, Wilkerson S, Tural A, Diaz G, Cohn A, Fox L, Patel A, Gerber SI, Kim L, Tong S, Lu X, Lindstrom S, Pallansch MA, Weldon WC, Biggs HM, Uyeki TM, Pillai SK, Washington State 2019-nCoV Case Investigation Team (2020) First case of 2019 novel coronavirus in the United States. N Engl J Med 382(10):929–936PubMedPubMedCentral Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, Spitters C, Ericson K, Wilkerson S, Tural A, Diaz G, Cohn A, Fox L, Patel A, Gerber SI, Kim L, Tong S, Lu X, Lindstrom S, Pallansch MA, Weldon WC, Biggs HM, Uyeki TM, Pillai SK, Washington State 2019-nCoV Case Investigation Team (2020) First case of 2019 novel coronavirus in the United States. N Engl J Med 382(10):929–936PubMedPubMedCentral
65.
Zurück zum Zitat Russo EILClinically relevant drug-drug interaction between AEDs and medications used in the treatment of COVID-19 patients. Italian League Against Epilepsy Russo EILClinically relevant drug-drug interaction between AEDs and medications used in the treatment of COVID-19 patients. Italian League Against Epilepsy
67.
Zurück zum Zitat Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, Ruan L, Song B, Cai Y, Wei M, Li X, Xia J, Chen N, Xiang J, Yu T, Bai T, Xie X, Zhang L, Li C, Yuan Y, Chen H, Li H, Huang H, Tu S, Gong F, Liu Y, Wei Y, Dong C, Zhou F, Gu X, Xu J, Liu Z, Zhang Y, Li H, Shang L, Wang K, Li K, Zhou X, Dong X, Qu Z, Lu S, Hu X, Ruan S, Luo S, Wu J, Peng L, Cheng F, Pan L, Zou J, Jia C, Wang J, Liu X, Wang S, Wu X, Ge Q, He J, Zhan H, Qiu F, Guo L, Huang C, Jaki T, Hayden FG, Horby PW, Zhang D, Wang C (2020) A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19. N Engl J Med 382(19):1787–1799PubMed Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, Ruan L, Song B, Cai Y, Wei M, Li X, Xia J, Chen N, Xiang J, Yu T, Bai T, Xie X, Zhang L, Li C, Yuan Y, Chen H, Li H, Huang H, Tu S, Gong F, Liu Y, Wei Y, Dong C, Zhou F, Gu X, Xu J, Liu Z, Zhang Y, Li H, Shang L, Wang K, Li K, Zhou X, Dong X, Qu Z, Lu S, Hu X, Ruan S, Luo S, Wu J, Peng L, Cheng F, Pan L, Zou J, Jia C, Wang J, Liu X, Wang S, Wu X, Ge Q, He J, Zhan H, Qiu F, Guo L, Huang C, Jaki T, Hayden FG, Horby PW, Zhang D, Wang C (2020) A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19. N Engl J Med 382(19):1787–1799PubMed
68.
Zurück zum Zitat Brooks J, Daily J, Schwamm L (1997) Protease inhibitors and anticonvulsants. AIDS Clin Care 9(11):87–90PubMed Brooks J, Daily J, Schwamm L (1997) Protease inhibitors and anticonvulsants. AIDS Clin Care 9(11):87–90PubMed
69.
Zurück zum Zitat May EF, Calvert PC (1990) Aggravation of myasthenia gravis by erythromycin. Ann Neurol 28(4):577–579PubMed May EF, Calvert PC (1990) Aggravation of myasthenia gravis by erythromycin. Ann Neurol 28(4):577–579PubMed
72.
Zurück zum Zitat WHO. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) WHO. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19)
73.
Zurück zum Zitat Task force COVID-19 del Dipartimento Malattie Infettive e Servizio di Informatica, Istituto Superiore di Sanità. Epidemia COVID-19, Aggiornamento nazionale: 23 aprile 2020 Task force COVID-19 del Dipartimento Malattie Infettive e Servizio di Informatica, Istituto Superiore di Sanità. Epidemia COVID-19, Aggiornamento nazionale: 23 aprile 2020
75.
Zurück zum Zitat Xu Y, Li X, Zhu B, Liang H, Fang C, Gong Y, Guo Q, Sun X, Zhao D, Shen J, Zhang H, Liu H, Xia H, Tang J, Zhang K, Gong S (2020) Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med 26(4):502–505PubMed Xu Y, Li X, Zhu B, Liang H, Fang C, Gong Y, Guo Q, Sun X, Zhao D, Shen J, Zhang H, Liu H, Xia H, Tang J, Zhang K, Gong S (2020) Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med 26(4):502–505PubMed
77.
Zurück zum Zitat Sun D, Li H, Lu XX, Xiao H, Ren J, Zhang FR, Liu ZS (2020) Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World J Pediatr 16:251–259PubMed Sun D, Li H, Lu XX, Xiao H, Ren J, Zhang FR, Liu ZS (2020) Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World J Pediatr 16:251–259PubMed
78.
Zurück zum Zitat Tan X, Huang J, Zhao F, Zhou Y, Li JQ, Wang XY (2020) Clinical features of children with SARS-CoV-2 infection: an analysis of 13 cases from Changsha, China. Zhongguo Dang Dai Er Ke Za Zhi 22(4):294–298PubMed Tan X, Huang J, Zhao F, Zhou Y, Li JQ, Wang XY (2020) Clinical features of children with SARS-CoV-2 infection: an analysis of 13 cases from Changsha, China. Zhongguo Dang Dai Er Ke Za Zhi 22(4):294–298PubMed
79.
Zurück zum Zitat Streng A, Hartmann K, Armann J, Berner R, Liese JG (2020) COVID-19 bei hospitalisierten Kindern und Jugendlichen: Ein systematischer Review zu publizierten Fallserien (Stand 31.03.2020) und erste Daten aus Deutschland. [COVID-19 in hospitalized children and adolescents]. Monatsschr Kinderheilkd 1–12. https://doi.org/10.1007/s00112-020-00919-7 Streng A, Hartmann K, Armann J, Berner R, Liese JG (2020) COVID-19 bei hospitalisierten Kindern und Jugendlichen: Ein systematischer Review zu publizierten Fallserien (Stand 31.03.2020) und erste Daten aus Deutschland. [COVID-19 in hospitalized children and adolescents]. Monatsschr Kinderheilkd 1–12. https://​doi.​org/​10.​1007/​s00112-020-00919-7
80.
Zurück zum Zitat Galea S, Merchant RM, Lurie N (2020) The mental health consequences of COVID-19 and physical distancing: the need for prevention and early intervention. JAMA Intern Med 180:817PubMed Galea S, Merchant RM, Lurie N (2020) The mental health consequences of COVID-19 and physical distancing: the need for prevention and early intervention. JAMA Intern Med 180:817PubMed
81.
Zurück zum Zitat Gunnell D, Appleby L, Arensman E, Hawton K, John A, Kapur N, Khan M, O’Connor RC, Pirkis J, Appleby L, Arensman E, Caine ED, Chan LF, Chang SS, Chen YY, Christensen H, Dandona R, Eddleston M, Erlangsen A, Gunnell D, Harkavy-Friedman J, Hawton K, John A, Kapur N, Khan M, Kirtley OJ, Knipe D, Konradsen F, Liu S, McManus S, Mehlum L, Miller M, Moran P, Morrissey J, Moutier C, Niederkrotenthaler T, Nordentoft M, O’Connor RC, O’Neill S, Page A, Phillips MR, Pirkis J, Platt S, Pompili M, Qin P, Rezaeian M, Silverman M, Sinyor M, Stack S, Townsend E, Turecki G, Vijayakumar L, Yip PSF (2020) Suicide risk and prevention during the COVID-19 pandemic. Lancet Psychiatry 7:468–471PubMedPubMedCentral Gunnell D, Appleby L, Arensman E, Hawton K, John A, Kapur N, Khan M, O’Connor RC, Pirkis J, Appleby L, Arensman E, Caine ED, Chan LF, Chang SS, Chen YY, Christensen H, Dandona R, Eddleston M, Erlangsen A, Gunnell D, Harkavy-Friedman J, Hawton K, John A, Kapur N, Khan M, Kirtley OJ, Knipe D, Konradsen F, Liu S, McManus S, Mehlum L, Miller M, Moran P, Morrissey J, Moutier C, Niederkrotenthaler T, Nordentoft M, O’Connor RC, O’Neill S, Page A, Phillips MR, Pirkis J, Platt S, Pompili M, Qin P, Rezaeian M, Silverman M, Sinyor M, Stack S, Townsend E, Turecki G, Vijayakumar L, Yip PSF (2020) Suicide risk and prevention during the COVID-19 pandemic. Lancet Psychiatry 7:468–471PubMedPubMedCentral
82.
Zurück zum Zitat Severance EG, Dickerson FB, Viscidi RP, Bossis I, Stallings CR, Origoni AE, Sullens A, Yolken RH (2009) Coronavirus immunoreactivity in individuals with a recent onset of psychotic symptoms. Schizophr Bull 37(1):101–107PubMedPubMedCentral Severance EG, Dickerson FB, Viscidi RP, Bossis I, Stallings CR, Origoni AE, Sullens A, Yolken RH (2009) Coronavirus immunoreactivity in individuals with a recent onset of psychotic symptoms. Schizophr Bull 37(1):101–107PubMedPubMedCentral
83.
Zurück zum Zitat Okusaga O, Yolken RH, Langenberg P, Lapidus M, Arling TA, Dickerson FB, Scrandis DA, Severance E, Cabassa JA, Balis T, Postolache TT (2011) Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts. J Affect Disord 130(1–2):220–225PubMed Okusaga O, Yolken RH, Langenberg P, Lapidus M, Arling TA, Dickerson FB, Scrandis DA, Severance E, Cabassa JA, Balis T, Postolache TT (2011) Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts. J Affect Disord 130(1–2):220–225PubMed
84.
Zurück zum Zitat Liu N, Zhang F, Wei C, Jia Y, Shang Z, Sun L, Wu L, Sun Z, Zhou Y, Wang Y, Liu W (2020) Prevalence and predictors of PTSS during COVID-19 outbreak in China hardest-hit areas: gender differences matter. Psychiatry Res 287:112921PubMedPubMedCentral Liu N, Zhang F, Wei C, Jia Y, Shang Z, Sun L, Wu L, Sun Z, Zhou Y, Wang Y, Liu W (2020) Prevalence and predictors of PTSS during COVID-19 outbreak in China hardest-hit areas: gender differences matter. Psychiatry Res 287:112921PubMedPubMedCentral
85.
Zurück zum Zitat Tang W, Hu T, Hu B, Jin C, Wang G, Xie C, Chen S, Xu J (2020) Prevalence and correlates of PTSD and depressive symptoms one month after the outbreak of the COVID-19 epidemic in a sample of home-quarantined Chinese university students. J Affect Disord 274:1–7PubMedPubMedCentral Tang W, Hu T, Hu B, Jin C, Wang G, Xie C, Chen S, Xu J (2020) Prevalence and correlates of PTSD and depressive symptoms one month after the outbreak of the COVID-19 epidemic in a sample of home-quarantined Chinese university students. J Affect Disord 274:1–7PubMedPubMedCentral
88.
Zurück zum Zitat Zambrelli E, Canevini M, Gambini O, D’Agostino A (2020) Delirium and sleep disturbances in COVID-19: a possible role for melatonin in hospitalized patients? Sleep Med 70:111PubMedPubMedCentral Zambrelli E, Canevini M, Gambini O, D’Agostino A (2020) Delirium and sleep disturbances in COVID-19: a possible role for melatonin in hospitalized patients? Sleep Med 70:111PubMedPubMedCentral
Metadaten
Titel
Challenges and management of neurological and psychiatric manifestations in SARS-CoV-2 (COVID-19) patients
verfasst von
Alessandro Orsini
Martina Corsi
Andrea Santangelo
Antonella Riva
Diego Peroni
Thomas Foiadelli
Salvatore Savasta
Pasquale Striano
Publikationsdatum
05.08.2020
Verlag
Springer International Publishing
Erschienen in
Neurological Sciences / Ausgabe 9/2020
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-020-04544-w

Weitere Artikel der Ausgabe 9/2020

Neurological Sciences 9/2020 Zur Ausgabe

Passend zum Thema

ANZEIGE

IPD-Fallzahlen & Pneumokokken-Impfung bei Kindern in Deutschland

Das Niveau der postpandemischen Fallzahlen für invasive Pneumokokken-Erkrankungen (IPD) ist aus Sicht des Referenz-Zentrums für Streptokokken in Aachen alarmierend [1]. Wie sich die monatlichen IPD-Fallzahlen bei Kindern und Jugendlichen von Juli 2015 bis März 2023 entwickelt haben, lesen Sie hier.

ANZEIGE

HPV-Impfung: Auch für junge Erwachsene sinnvoll und wichtig

Auch nach dem 18. Lebensjahr kann eine HPV-Impfung sinnvoll und wichtig sein. Viele gesetzliche Krankenkassen übernehmen die Kosten auch zu einem späteren Zeitpunkt noch.

ANZEIGE

Impfstoffe – Krankheiten vorbeugen, bevor sie entstehen

Seit mehr als 130 Jahren entwickelt und produziert MSD Impfstoffe für alle Altersgruppen. Hier finden Sie nützliche Informationen und Praxismaterialien rund um das Thema Impfen.

MSD Sharp & Dohme GmbH

Passend zum Thema

ANZEIGE

Mittelgradige Depressionen & Johanniskraut: Das hat sich geändert

Die Behandlungsempfehlungen bei mittelgradiger Depression wurden erneuert und der Einsatz von Johanniskraut entscheidend präzisiert – welche zwei Empfehlungen Sie aus der aktualisierten Depressions-Leitlinie jetzt kennen sollten.

ANZEIGE

3 Kernaussagen: Cochrane-Analyse untersucht Johanniskrautextrakte

Johanniskraut gehört zu den am besten untersuchten pflanzlichen Arzneimitteln. Die Ergebnisse zur Wirksamkeit bei Depressionen wurden u. a. in einem Cochrane-Review analysiert [1]. Wie das pflanzliche Antidepressivum dabei abschnitt und welche drei Kernaussagen Sie für die Praxis kennen sollten, lesen Sie hier.

ANZEIGE

Depression behandeln. Natürlich.

Content Hub

Aktuelle Ergebnisse aus in-vitro- und in-vivo-Untersuchungen liefern detaillierte Erklärungen zum Wirkmechanismus von hochdosiertem Johanniskraut-Extrakt: Neu ist die Erkenntnis, dass der Johanniskraut-Extrakt bei chronischem Stress die deregulierte Stressantwort der überaktiven HPA-Achse sowie die Expression des Stressgens FKBP5 normalisieren kann. Mehr zum aktuellen Stand der Wissenschaft bei der Therapie von Depressionen erfahren Sie hier. 

Bayer Vital GmbH