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European Radiology
Erschienen in: European Radiology 7/2012

01.07.2012 | Computed Tomography

Current status and guidelines for the assessment of tumour vascular support with dynamic contrast-enhanced computed tomography

Erschienen in: European Radiology | Ausgabe 7/2012

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Abstract

Dynamic contrast-enhanced computed tomography (DCE-CT) assesses the vascular support of tumours through analysis of temporal changes in attenuation in blood vessels and tissues during a rapid series of images acquired with intravenous administration of iodinated contrast material. Commercial software for DCE-CT analysis allows pixel-by-pixel calculation of a range of validated physiological parameters and depiction as parametric maps. Clinical studies support the use of DCE-CT parameters as surrogates for physiological and molecular processes underlying tumour angiogenesis. DCE-CT has been used to provide biomarkers of drug action in early phase trials for the treatment of a range of cancers. DCE-CT can be appended to current imaging assessments of tumour response with the benefits of wide availability and low cost. This paper sets out guidelines for the use of DCE-CT in assessing tumour vascular support that were developed using a Delphi process. Recommendations encompass CT system requirements and quality assurance, radiation dosimetry, patient preparation, administration of contrast material, CT acquisition parameters, terminology and units, data processing and reporting. DCE-CT has reached technical maturity for use in therapeutic trials in oncology. The development of these consensus guidelines may promote broader application of DCE-CT for the evaluation of tumour vascularity.
Key Points
• DCE-CT can robustly assess tumour vascular support
• DCE-CT has reached technical maturity for use in therapeutic trials in oncology
• This paper presents consensus guidelines for using DCE-CT in assessing tumour vascularity
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Metadaten
Titel
Current status and guidelines for the assessment of tumour vascular support with dynamic contrast-enhanced computed tomography
Publikationsdatum
01.07.2012
Erschienen in
European Radiology / Ausgabe 7/2012
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-012-2379-4

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