nach oben

Current Addiction Reports

Erschienen in:

01.12.2015 | Transgenerational Considerations in Addictions (LC Mayes and E McCrory, Section Editors)

DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective

verfasst von: Charlotte A. M. Cecil, Esther Walton, Essi Viding

Erschienen in: Current Addiction Reports | Ausgabe 4/2015

Einloggen, um Zugang zu erhalten

Abstract

Growing evidence points to the role of epigenetic mechanisms, including DNA methylation, in substance use and addiction. We conducted a systematic review of 47 recent (2012–2015) animal and human studies that investigate DNA methylation and substance use/exposure, spanning preconception to adulthood. The majority of extant studies (i) focused on exposure during adulthood, (ii) examined the effects of alcohol use, (iii) employed a candidate gene approach, and (iv) were cross-sectional. While studies generally support an association between substance use/exposure and DNA methylation and also suggest that developmental context and timing matter, a dearth of longitudinal data and low comparability across studies currently limits the conclusions that can be drawn. Future challenges and directions for the field are discussed.

McQuown SC, Wood MA. Epigenetic regulation in substance use disorders. Curr psychiatry rep. 2010;12(2):145–53. doi:10.1007/s11920-010-0099-5.PubMedCentralCrossRefPubMed

2.•

Kendler KS, Chen X, Dick D, Maes H, Gillespie N, Neale MC, et al. Recent advances in the genetic epidemiology and molecular genetics of substance use disorders. Nat Neurosci. 2012;15(2):181–9. doi:10.1038/nn.3018. Provides a comprehensive overview of genetic influences on substance use disorders.PubMedCentralCrossRefPubMed

Tsankova N, Renthal W, Kumar A, Nestler EJ. Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci. 2007;8(5):355–67. doi:10.1038/nrn2132.CrossRefPubMed

4.••

Nestler EJ. Epigenetic mechanisms of drug addiction. Neuropharmacology. 2014;76(Pt B):259–68. doi:10.1016/j.neuropharm.2013.04.004. Important for conveying a mechanistic understanding of the role of epigenetics in drug addiction.CrossRefPubMed

Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet. 2003;33(Suppl):245–54. doi:10.1038/ng1089.CrossRefPubMed

Eckhardt F, Lewin J, Cortese R, Rakyan VK, Attwood J, Burger M, et al. DNA methylation profiling of human chromosomes 6, 20, and 22. Nat Genet. 2006;38(12):1378–85. doi:10.1038/ng1909.PubMedCentralCrossRefPubMed

7.•

Jones PA. Functions of DNA methylation: islands, start sites, gene bodies, and beyond. Nat Rev Genet. 2012;13(7):484–92. doi:10.1038/nrg3230. Comprehensive overview of the epigenetic process of DNA methylation, including physical properties, functions, and role in development and disease.CrossRefPubMed

Alabert C, Groth A. Chromatin replication and epigenome maintenance. Nat Rev Mol Cell Biol. 2012;13(3):153–67. doi:10.1038/nrm3288.CrossRefPubMed

Wong CC, Mill J, Fernandes C. Drugs and addiction: an introduction to epigenetics. Addiction (Abingdon, England). 2011;106(3):480–9. doi:10.1111/j.1360-0443.2010.03321.x.CrossRef

10.

Kaminen-Ahola N, Ahola A, Maga M, Mallitt KA, Fahey P, Cox TC, et al. Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model. PLoS Genet. 2010;6(1), e1000811. doi:10.1371/journal.pgen.1000811.PubMedCentralCrossRefPubMed

11.••

Harlaar N, Hutchison KE. Alcohol and the methylome: design and analysis considerations for research using human samples. Drug Alcohol Depend. 2013;133(2):305–16. doi:10.1016/j.drugalcdep.2013.07.026. Systematic review of existing human studies examining DNA methylation and alcohol use, including current challenges and considerations for future research.CrossRefPubMed

12.

Finegersh A, Homanics GE. Paternal alcohol exposure reduces alcohol drinking and increases behavioral sensitivity to alcohol selectively in male offspring. PLoS One. 2014;9(6), e99078. doi:10.1371/journal.pone.0099078.PubMedCentralCrossRefPubMed

13.

Govorko D, Bekdash RA, Zhang C, Sarkar DK. Male germline transmits fetal alcohol adverse effect on hypothalamic proopiomelanocortin gene across generations. Biol Psychiatry. 2012;72(5):378–88. doi:10.1016/j.biopsych.2012.04.006.PubMedCentralCrossRefPubMed

14.

Knezovich JG, Ramsay M. The effect of preconception paternal alcohol exposure on epigenetic remodeling of the h19 and rasgrf1 imprinting control regions in mouse offspring. Front Genet. 2012;3:10. doi:10.3389/fgene.2012.00010.PubMedCentralCrossRefPubMed

15.

Bekdash RA, Zhang C, Sarkar DK. Gestational choline supplementation normalized fetal alcohol-induced alterations in histone modifications, DNA methylation, and proopiomelanocortin (POMC) gene expression in beta-endorphin-producing POMC neurons of the hypothalamus. Alcohol Clin Exp Res. 2013;37(7):1133–42. doi:10.1111/acer.12082.PubMedCentralCrossRefPubMed

16.

Gangisetty O, Bekdash R, Maglakelidze G, Sarkar DK. Fetal alcohol exposure alters proopiomelanocortin gene expression and hypothalamic-pituitary-adrenal axis function via increasing MeCP2 expression in the hypothalamus. PLoS One. 2014;9(11), e113228. doi:10.1371/journal.pone.0113228.PubMedCentralCrossRefPubMed

17.

Laufer BI, Mantha K, Kleiber ML, Diehl EJ, Addison SM, Singh SM. Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice. Dis Model Mech. 2013;6(4):977–92. doi:10.1242/dmm.010975.PubMedCentralCrossRefPubMed

18.

Itzhak Y, Ergui I, Young JI. Long-term parental methamphetamine exposure of mice influences behavior and hippocampal DNA methylation of the offspring. Mol Psychiatry. 2015;20(2):232–9. doi:10.1038/mp.2014.7.CrossRefPubMed

19.

Nagre NN, Subbanna S, Shivakumar M, Psychoyos D, Basavarajappa BS. CB1-receptor knockout neonatal mice are protected against ethanol-induced impairments of DNMT1, DNMT3A, and DNA methylation. J Neurochem. 2015;132(4):429–42. doi:10.1111/jnc.13006.CrossRefPubMed

20.

Otero NK, Thomas JD, Saski CA, Xia X, Kelly SJ. Choline supplementation and DNA methylation in the hippocampus and prefrontal cortex of rats exposed to alcohol during development. Alcohol Clin Exp Res. 2012;36(10):1701–9. doi:10.1111/j.1530-0277.2012.01784.x.PubMedCentralCrossRefPubMed

21.

Fowler AK, Hewetson A, Agrawal RG, Dagda M, Dagda R, Moaddel R, et al. Alcohol-induced one-carbon metabolism impairment promotes dysfunction of DNA base excision repair in adult brain. J Biol Chem. 2012;287(52):43533–42. doi:10.1074/jbc.M112.401497.PubMedCentralCrossRefPubMed

22.

Tammen SA, Dolnikowski GG, Ausman LM, Liu Z, Sauer J, Friso S, et al. Aging and alcohol interact to alter hepatic DNA hydroxymethylation. Alcohol Clin Exp Res. 2014;38(8):2178–85. doi:10.1111/acer.12477.PubMedCentralCrossRefPubMed

23.

Barker JM, Zhang Y, Wang F, Taylor JR, Zhang H. Ethanol-induced Htr3a promoter methylation changes in mouse blood and brain. Alcohol Clin Exp Res. 2013;37 Suppl 1:E101–7. doi:10.1111/j.1530-0277.2012.01906.x.PubMedCentralCrossRefPubMed

24.

Srinivasan P, Kapadia R, Biswas A, Said HM. Chronic alcohol exposure inhibits biotin uptake by pancreatic acinar cells: possible involvement of epigenetic mechanisms. Am J Physiol Gastrointest Liver Physiol. 2014;307(9):G941–9. doi:10.1152/ajpgi.00278.2014.CrossRefPubMed

25.

Khachatoorian R, Dawson D, Maloney EM, Wang J, French BA, French SW, et al. SAMe treatment prevents the ethanol-induced epigenetic alterations of genes in the Toll-like receptor pathway. Exp Mol Pathol. 2013;94(1):243–6. doi:10.1016/j.yexmp.2012.09.024.PubMedCentralCrossRefPubMed

26.

Qiang M, Li JG, Denny AD, Yao JM, Lieu M, Zhang K et al. Epigenetic mechanisms are involved in the regulation of ethanol consumption in mice. Int J Neuropsychopharmacol. 2014;18(2). doi:10.1093/ijnp/pyu072.

27.

Wani NA, Hamid A, Kaur J. Alcohol-associated folate disturbances result in altered methylation of folate-regulating genes. Mol Cell Biochem. 2012;363(1–2):157–66. doi:10.1007/s11010-011-1168-8.CrossRefPubMed

28.

D’Addario C, Caputi FF, Ekstrom TJ, Di Benedetto M, Maccarrone M, Romualdi P, et al. Ethanol induces epigenetic modulation of prodynorphin and pronociceptin gene expression in the rat amygdala complex. J Mol Neurosci. 2013;49(2):312–9. doi:10.1007/s12031-012-9829-y.CrossRefPubMed

29.

Nielsen DA, Huang W, Hamon SC, Maili L, Witkin BM, Fox RG, et al. Forced abstinence from cocaine self-administration is associated with DNA methylation changes in myelin genes in the corpus callosum: a preliminary study. Front Psychiatry. 2012;3:60. doi:10.3389/fpsyt.2012.00060.PubMedCentralCrossRefPubMed

30.

Fragou D, Zanos P, Kouidou S, Njau S, Kitchen I, Bailey A, et al. Effect of chronic heroin and cocaine administration on global DNA methylation in brain and liver. Toxicol Lett. 2013;218(3):260–5. doi:10.1016/j.toxlet.2013.01.022.CrossRefPubMed

31.

Chao MR, Fragou D, Zanos P, Hu CW, Bailey A, Kouidou S, et al. Epigenetically modified nucleotides in chronic heroin and cocaine treated mice. Toxicol Lett. 2014;229(3):451–7. doi:10.1016/j.toxlet.2014.07.023.CrossRefPubMed

32.

Tian W, Zhao M, Li M, Song T, Zhang M, Quan L, et al. Reversal of cocaine-conditioned place preference through methyl supplementation in mice: altering global DNA methylation in the prefrontal cortex. PLoS One. 2012;7(3), e33435. doi:10.1371/journal.pone.0033435.PubMedCentralCrossRefPubMed

33.

Rodrigues AJ, Leao P, Pego JM, Cardona D, Carvalho MM, Oliveira M, et al. Mechanisms of initiation and reversal of drug-seeking behavior induced by prenatal exposure to glucocorticoids. Mol Psychiatry. 2012;17(12):1295–305. doi:10.1038/mp.2011.126.CrossRefPubMed

34.

Anier K, Malinovskaja K, Pruus K, Aonurm-Helm A, Zharkovsky A, Kalda A. Maternal separation is associated with DNA methylation and behavioural changes in adult rats. Eur Neuropsychopharmacol J Eur College Neuropsychopharmacol. 2014;24(3):459–68. doi:10.1016/j.euroneuro.2013.07.012.CrossRef

35.

Pol Bodetto S, Carouge D, Fonteneau M, Dietrich JB, Zwiller J, Anglard P. Cocaine represses protein phosphatase-1Cbeta through DNA methylation and methyl-CpG binding protein-2 recruitment in adult rat brain. Neuropharmacology. 2013;73:31–40. doi:10.1016/j.neuropharm.2013.05.005.CrossRefPubMed

36.

Wilhelm-Benartzi CS, Houseman EA, Maccani MA, Poage GM, Koestler DC, Langevin SM, et al. In utero exposures, infant growth, and DNA methylation of repetitive elements and developmentally related genes in human placenta. Environ Health Perspect. 2012;120(2):296–302. doi:10.1289/ehp.1103927.PubMedCentralCrossRefPubMed

37.

Azzi S, Sas TC, Koudou Y, Le Bouc Y, Souberbielle JC, Dargent-Molina P, et al. Degree of methylation of ZAC1 (PLAGL1) is associated with prenatal and post-natal growth in healthy infants of the EDEN mother child cohort. Epigenetics Off J DNA Methylation Soc. 2014;9(3):338–45. doi:10.4161/epi.27387.CrossRef

38.

van der Knaap LJ, Schaefer JM, Franken IH, Verhulst FC, van Oort FV, Riese H. Catechol-O-methyltransferase gene methylation and substance use in adolescents: the TRAILS study. Genes Brain Behav. 2014;13(7):618–25. doi:10.1111/gbb.12147.CrossRefPubMed

39.

Zhu ZZ, Hou L, Bollati V, Tarantini L, Marinelli B, Cantone L, et al. Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis. Int J Epidemiol. 2012;41(1):126–39. doi:10.1093/ije/dyq154.PubMedCentralCrossRefPubMed

40.

Desplats P, Dumaop W, Cronin P, Gianella S, Woods S, Letendre S, et al. Epigenetic alterations in the brain associated with HIV-1 infection and methamphetamine dependence. PLoS One. 2014;9(7), e102555. doi:10.1371/journal.pone.0102555.PubMedCentralCrossRefPubMed

41.

Doehring A, Oertel BG, Sittl R, Lotsch J. Chronic opioid use is associated with increased DNA methylation correlating with increased clinical pain. Pain. 2013;154(1):15–23. doi:10.1016/j.pain.2012.06.011.CrossRefPubMed

42.

Zhang H, Herman AI, Kranzler HR, Anton RF, Zhao H, Zheng W, et al. Array-based profiling of DNA methylation changes associated with alcohol dependence. Alcohol Clin Exp Res. 2013;37 Suppl 1:E108–15. doi:10.1111/j.1530-0277.2012.01928.x.PubMedCentralCrossRefPubMed

43.

Zhang H, Herman AI, Kranzler HR, Anton RF, Simen AA, Gelernter J. Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence. J Hum Genet. 2012;57(10):670–5. doi:10.1038/jhg.2012.98.PubMedCentralCrossRefPubMed

44.

Hillemacher T, Weinland C, Lenz B, Kraus T, Heberlein A, Glahn A, et al. DNA methylation of the LEP gene is associated with craving during alcohol withdrawal. Psychoneuroendocrinology. 2015;51:371–7. doi:10.1016/j.psyneuen.2014.10.014.CrossRefPubMed

45.

Beach SR, Brody GH, Lei MK, Gibbons FX, Gerrard M, Simons RL, et al. Impact of child sex abuse on adult psychopathology: a genetically and epigenetically informed investigation. J Fam Psychol JFP J Div Fam Psychol Am Psychol Assoc (Div 43). 2013;27(1):3–11. doi:10.1037/a0031459.

46.

Nieratschker V, Grosshans M, Frank J, Strohmaier J, von der Goltz C, El-Maarri O, et al. Epigenetic alteration of the dopamine transporter gene in alcohol-dependent patients is associated with age. Addict Biol. 2014;19(2):305–11. doi:10.1111/j.1369-1600.2012.00459.x.CrossRefPubMed

47.

Yasar U, Greenblatt DJ, Guillemette C, Court MH. Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers. J Pharm Pharmacol. 2013;65(6):874–83. doi:10.1111/jphp.12053.CrossRefPubMed

48.

Glahn A, Riera Knorrenschild R, Rhein M, Haschemi Nassab M, Groschl M, Heberlein A, et al. Alcohol-induced changes in methylation status of individual CpG sites, and serum levels of vasopressin and atrial natriuretic peptide in alcohol-dependent patients during detoxification treatment. Eur Addict Res. 2014;20(3):143–50. doi:10.1159/000357473.CrossRefPubMed

49.

Heberlein A, Muschler M, Frieling H, Behr M, Eberlein C, Wilhelm J, et al. Epigenetic down regulation of nerve growth factor during alcohol withdrawal. Addict Biol. 2013;18(3):508–10. doi:10.1111/j.1369-1600.2010.00307.x.CrossRefPubMed

50.

Harlaar N, Bryan AD, Thayer RE, Karoly HC, Oien N, Hutchison KE. Methylation of a CpG site near the ALDH1A2 gene is associated with loss of control over drinking and related phenotypes. Alcohol Clin Exp Res. 2014;38(3):713–21. doi:10.1111/acer.12312.CrossRefPubMed

51.

Zhang R, Miao Q, Wang C, Zhao R, Li W, Haile CN, et al. Genome-wide DNA methylation analysis in alcohol dependence. Addict Biol. 2013;18(2):392–403. doi:10.1111/adb.12037.CrossRefPubMed

52.

Philibert RA, Plume JM, Gibbons FX, Brody GH, Beach SR. The impact of recent alcohol use on genome wide DNA methylation signatures. Front Genet. 2012;3:54. doi:10.3389/fgene.2012.00054.PubMedCentralCrossRefPubMed

53.

Zhao R, Zhang R, Li W, Liao Y, Tang J, Miao Q, et al. Genome-wide DNA methylation patterns in discordant sib pairs with alcohol dependence. Asia-Pacific Psychiatry Off J Pac Rim Coll Psychiatrists. 2013;5(1):39–50. doi:10.1111/appy.12010.CrossRef

54.

Philibert RA, Penaluna B, White T, Shires S, Gunter T, Liesveld J, et al. A pilot examination of the genome-wide DNA methylation signatures of subjects entering and exiting short-term alcohol dependence treatment programs. Epigenetics Off J DNA Methylation Soc. 2014;9(9):1212–9. doi:10.4161/epi.32252.CrossRef

55.

Weng JT, Wu LS, Lee CS, Hsu PW, Cheng AT. Integrative epigenetic profiling analysis identifies DNA methylation changes associated with chronic alcohol consumption. Comput Biol Med. 2014. doi:10.1016/j.compbiomed.2014.12.003.PubMed

56.

Ponomarev I, Wang S, Zhang L, Harris RA, Mayfield RD. Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence. J Neurosci Off J Soc Neurosci. 2012;32(5):1884–97. doi:10.1523/jneurosci.3136-11.2012.CrossRef

57.

Crews F, He J, Hodge C. Adolescent cortical development: a critical period of vulnerability for addiction. Pharmacol Biochem Behav. 2007;86(2):189–99. doi:10.1016/j.pbb.2006.12.001.CrossRefPubMed

58.••

Mill J, Heijmans BT. From promises to practical strategies in epigenetic epidemiology. Nat Rev Genet. 2013;14(8):585–94. doi:10.1038/nrg3405. An overview of current methods used in epigenetic epidemiology, challenges for the field and future directions.CrossRefPubMed

59.•

Liang L, Cookson WOC. Grasping nettles: cellular heterogeneity and other confounders in epigenome-wide association studies. Human Mol Genet. 2014;23(R1):R83–8. doi:10.1093/hmg/ddu284. An overview of important confounds that need to be accounted for in epigenetic research.CrossRef

60.

Bell JT, Pai AA, Pickrell JK, Gaffney DJ, Pique-Regi R, Degner JF, et al. DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines. Genome Biol. 2011;12(1):R10-R. doi:10.1186/gb-2011-12-1-r10.CrossRef

61.

Bell JT, Saffery R. The value of twins in epigenetic epidemiology. Int J Epidemiol. 2012. doi:10.1093/ije/dyr179.PubMed

62.•

Morris TJ, Beck S. Analysis pipelines and packages for Infinium HumanMethylation450 BeadChip (450k) data. Methods (San Diego, Calif). 2015;72:3–8. doi:10.1016/j.ymeth.2014.08.011. An overview of currently available pipelines and packages for the preparation and analysis of DNA methylation data quantified using the Illumina 450k platform.CrossRef

63.

Tsai P-C, Bell JT. Power and sample size estimation for epigenome-wide association scans to detect differential DNA methylation. Int J Epidemiol. 2015. doi:10.1093/ije/dyv041.PubMedCentralPubMed

64.

Relton CL, Gaunt T, McArdle W, Ho K, Duggirala A, Shihab H, et al. Data resource profile: Accessible Resource for Integrated Epigenomic Studies (ARIES). Int J Epidemiol. 2015. doi:10.1093/ije/dyv072.

65.

Cecil CA, Lysenko LJ, Jaffee SR, Pingault JB, Smith RG, Relton CL, et al. Environmental risk, oxytocin receptor gene (OXTR) methylation and youth callous-unemotional traits: a 13-year longitudinal study. Mol Psychiatry. 2014;19(10):1071–7. doi:10.1038/mp.2014.95.PubMedCentralCrossRefPubMed

66.

Relton CL, Davey SG. Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease. Int J Epidemiol. 2012;41(1):161–76. doi:10.1093/ije/dyr233.PubMedCentralCrossRefPubMed

67.

Pingault JB, Cecil CAM, Murray J, Munafò MR, Viding E. Causal inference in psychopathology: a systematic review of Mendelian randomisation studies aiming to identify environmental risk factors for psychopathology. Psychopathol Rev. In Press.

68.

Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinf. 2008;9:559. doi:10.1186/1471-2105-9-559.CrossRef

Titel: DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective
verfasst von: Charlotte A. M. Cecil
Esther Walton
Essi Viding
Publikationsdatum: 01.12.2015
Verlag: Springer International Publishing
Erschienen in: Current Addiction Reports / Ausgabe 4/2015
Elektronische ISSN: 2196-2952
DOI: https://doi.org/10.1007/s40429-015-0072-9

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective

Abstract

Neu im Fachgebiet Psychiatrie

Hörschwäche erhöht Demenzrisiko unabhängig von Beta-Amyloid

So wirken verschiedene Alkoholika auf den Blutdruck

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

ADHS-Medikation erhöht das kardiovaskuläre Risiko

Update Psychiatrie

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2015

Pathological Video Gaming and Its Relationship to Substance Use Disorders

Understanding Addiction as a Developmental Disorder: An Argument for a Developmentally Informed Multilevel Approach

Adolescent Substance Use and Comorbid Psychopathology: Emotion Regulation Deficits as a Transdiagnostic Risk Factor

Understanding the Relationship Between Amphetamines and Psychosis

Dual Diagnosis of Traumatic Brain Injury and Alcohol Use Disorder: Characterizing Clinical and Neurobiological Underpinnings

Designing Interventions Informed by Scientific Knowledge About Effects of Early Adversity: a Translational Neuroscience Agenda for Next-Generation Addictions Research

Neu im Fachgebiet Psychiatrie

Hörschwäche erhöht Demenzrisiko unabhängig von Beta-Amyloid

So wirken verschiedene Alkoholika auf den Blutdruck

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

ADHS-Medikation erhöht das kardiovaskuläre Risiko

Update Psychiatrie