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01.03.2018 | Allergies and the Environment (M Hernandez, Section Editor) | Ausgabe 3/2018

Current Allergy and Asthma Reports 3/2018

Do Glutathione S-Transferase Genes Modify the Link between Indoor Air Pollution and Asthma, Allergies, and Lung Function? A Systematic Review

Zeitschrift:
Current Allergy and Asthma Reports > Ausgabe 3/2018
Autoren:
Xin Dai, Gayan Bowatte, Adrian J. Lowe, Melanie C. Matheson, Lyle C. Gurrin, John A. Burgess, Shyamali C. Dharmage, Caroline J. Lodge
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s11882-018-0771-0) contains supplementary material, which is available to authorized users.

Prior presentation

This work was presented in Cleaner Air, Better Health: CAR Annual Symposium 2016 in Sydney, Australia, by Xin Dai in 05/05/2016.
This article is part of the Topical Collection on Allergies and the Environment

Abstract

Purpose of Review

Glutathione S-transferase (GST) genes are involved in oxidative stress management and may modify the impact of indoor air pollution. We aimed to assess the influence of GST genes on the relationship between indoor air pollution and allergy/lung function.

Recent Findings

Our systematic review identified 22 eligible studies, with 15 supporting a gene-environment interaction. Carriers of GSTM1/T1 null and GSTP1 val genotypes were more susceptible to indoor air pollution exposures, having a higher risk of asthma and lung function deficits. However, findings differed in terms of risk alleles and specific exposures. High-exposure heterogeneity precluded meta-analysis.

Summary

We found evidence that respiratory effects of indoor air pollution depend on the individual’s GST profile. This may help explain the inconsistent associations found when gene-environment interactions are not considered. Future studies should aim to improve the accuracy of pollution assessment and investigate this finding in different populations.

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Zusatzmaterial
ESM 1 (DOCX 17 kb)
11882_2018_771_MOESM1_ESM.docx
Literatur
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