Erschienen in:
01.12.2007 | Letter to the Editor
Do we need whole brain irradiation in multifocal or multicentric high-grade cerebral gliomas? Review of cases and the literature
verfasst von:
Federico Ampil, Gary V. Burton, Eduardo Gonzalez-Toledo, Anil Nanda
Erschienen in:
Journal of Neuro-Oncology
|
Ausgabe 3/2007
Einloggen, um Zugang zu erhalten
Excerpt
Sir: High-grade cerebral gliomas (HGCG) are known to have a rather poorer prognosis than lower grade neoplasms. In most cases, local relapse connotes an adverse patient prognosis [
1]. Improved brain tumor imaging and failure patterns after radiotherapy (RT) have shown that the most common areas for recurrence in HGCGs are within or closely adjacent to the primary neoplastic site [
1‐
3]. Hence, the radiation treatment has evolved from whole brain irradiation (WBI) to limited field irradiation (LFI, defined as initially encompassing the primary lesion and associated edema with a margin of 2–4 cm as demonstrated on preoperative computed tomography [CT] or magnetic resonance imaging [MRI] scanning and then focusing on the primary lesion with a 2-cm margin) [
4]. …