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01.12.2012 | Research | Ausgabe 1/2012 Open Access

Journal of Inflammation 1/2012

Higher IL-6 and IL6:IGF Ratio in Patients with Barth Syndrome

Zeitschrift:
Journal of Inflammation > Ausgabe 1/2012
Autoren:
Lori D Wilson, Sadeeka Al-Majid, Cyril S Rakovski, Christina D Schwindt MD
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1476-9255-9-25) contains supplementary material, which is available to authorized users.

Competing interest

The authors declare that they have no competing interests.

Authors’ contributions

LDW and CS developed the research hypothesis and study methodologies, LDW carried out the laboratory analyses, CR conducted the statistical analyses, and SA assisted in the interpretation of findings. All authors contributed toward the writing of the final manuscript.

Abstract

Background

Barth Syndrome (BTHS) is a serious X-linked genetic disorder associated with mutations in the tafazzin gene (TAZ, also called G4.5). The multi-system disorder is primarily characterized by the following pathologies: cardiac and skeletal myopathies, neutropenia, growth delay, and exercise intolerance. Although growth anomalies have been widely reported in BTHS, there is a paucity of research on the role of inflammation and the potential link to alterations in growth factors levels in BTHS patients.

Methods

Plasma from 36 subjects, 22 patients with Barth Syndrome (0.5 - 24 yrs) and 14 healthy control males (8 - 21 yrs) was analyzed for two growth factors: IGF-1 (bound and free) and Growth Hormone (GH); and two inflammatory cytokines IL-6 and TNF-α using high-sensitivity enzyme-linked immunosorbent assays.

Results

The average IL-6 and IL6:IGF ratio levels were significantly higher in the BTHS (p = 0.046 and 0.02 respectively). As for GH, there was a significant group by age interaction (p = 0.01), such that GH was lower for BTHS patients under the age of 14.4 years and higher than controls after age 14.4 years. TNF-α levels were not significantly different, however, the TNF-α:GH was lower in BTHS patients than controls (p = 0.01).

Conclusions

Comparison of two anabolic growth mediators, IGF and GH, and two catabolic cytokines, IL-6 and TNF-α, in BTHS patients and healthy age-matched controls demonstrated a potential imbalance in inflammatory cytokines and anabolic growth factors. Higher rates of IL-6 (all ages) and lower GH levels were observed in BTHS patients (under age 14.5) compared to controls. These findings may implicate inflammatory processes in the catabolic nature of Barth Syndrome pathology as well as provide a link to mitochondrial function. Furthermore, interactions between growth factors, testosterone and inflammatory mediators may explain some of the variability in cardiac and skeletal myopathies seen in Barth Syndrome.
Zusatzmaterial
Authors’ original file for figure 1
12950_2011_238_MOESM1_ESM.pdf
Authors’ original file for figure 2
12950_2011_238_MOESM2_ESM.pdf
Authors’ original file for figure 3
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Authors’ original file for figure 4
12950_2011_238_MOESM4_ESM.pdf
Authors’ original file for figure 5
12950_2011_238_MOESM5_ESM.pdf
Literatur
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