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Zeitschrift

Journal of Hematology & Oncology

Journal of Hematology & Oncology 1/2016

Ausgabe 1/2016

Inhaltsverzeichnis ( 137 Artikel )

01.12.2016 | Research | Ausgabe 1/2016 Open Access

MicroRNA-26a suppresses epithelial-mesenchymal transition in human hepatocellular carcinoma by repressing enhancer of zeste homolog 2

De-Ning Ma, Zong-Tao Chai, Xiao-Dong Zhu, Ning Zhang, Di-Hua Zhan, Bo-Gen Ye, Cheng-Hao Wang, Cheng-Dong Qin, Yi-Ming Zhao, Wei-Ping Zhu, Man-Qing Cao, Dong-Mei Gao, Hui-Chuan Sun, Zhao-You Tang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity

Zhangguo Chen, Mihret T. Elos, Sawanee S. Viboolsittiseri, Katherine Gowan, Sonia M. Leach, Michael Rice, Maxwell D. Eder, Kenneth Jones, Jing H. Wang

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

Hypoacetylation, hypomethylation, and dephosphorylation of H2B histones and excessive histone deacetylase activity in DU-145 prostate cancer cells

Shundong Cang, Xiaobin Xu, Yuehua Ma, Delong Liu, J. W. Chiao

01.12.2016 | Research | Ausgabe 1/2016 Open Access

An engineered multicomponent bone marrow niche for the recapitulation of hematopoiesis at ectopic transplantation sites

Mónica S. Ventura Ferreira, Christian Bergmann, Isabelle Bodensiek, Kristina Peukert, Jessica Abert, Rafael Kramann, Paul Kachel, Björn Rath, Stephan Rütten, Ruth Knuchel, Benjamin L. Ebert, Horst Fischer, Tim H. Brümmendorf, Rebekka K. Schneider

01.12.2016 | Research | Ausgabe 1/2016 Open Access

GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways

Laura Guerenne, Stéphanie Beurlet, Mohamed Said, Petra Gorombei, Carole Le Pogam, Fabien Guidez, Pierre de la Grange, Nader Omidvar, Valérie Vanneaux, Ken Mills, Ghulam J Mufti, Laure Sarda-Mantel, Maria Elena Noguera, Marika Pla, Pierre Fenaux, Rose Ann Padua, Christine Chomienne, Patricia Krief

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Autologous cytokine-induced killer cell transfusion increases overall survival in advanced pancreatic cancer

Zibing Wang, Yuqing Liu, Rui’e Li, Yiman Shang, Yong Zhang, Lingdi Zhao, Wei Li, Yonghao Yang, Xiaojie Zhang, Tiejun Yang, Changfu Nie, Feng Han, Ying Liu, Suxia Luo, Quanli Gao, Yongping Song

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence

Sung-Hyun Park, Steve Xie, Chinthalapally V. Rao, Wei Dai

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Cancer-associated fibroblasts promote the progression of endometrial cancer via the SDF-1/CXCR4 axis

Fei Teng, Wen-Yan Tian, Ying-Mei Wang, Yan-Fang Zhang, Fei Guo, Jing Zhao, Chao Gao, Feng-Xia Xue

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Allogeneic stem cell transplantation for X-linked agammaglobulinemia using reduced intensity conditioning as a model of the reconstitution of humoral immunity

Kazuhiro Ikegame, Kohsuke Imai, Motoi Yamashita, Akihiro Hoshino, Hirokazu Kanegane, Tomohiro Morio, Katsuji Kaida, Takayuki Inoue, Toshihiro Soma, Hiroya Tamaki, Masaya Okada, Hiroyasu Ogawa

01.12.2016 | Review | Ausgabe 1/2016 Open Access

CCR9 in cancer: oncogenic role and therapeutic targeting

Zhenbo Tu, Ruijing Xiao, Jie Xiong, Kingsley M. Tembo, Xinzhou Deng, Meng Xiong, Pan Liu, Meng Wang, Qiuping Zhang

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: NLK functions to maintain proliferation and stemness of NSCLC and is a target of metformin

Dong Suwei, Zeng Liang, Liu Zhimin, Li Ruilei, Zou Yingying, Li Zhen, Ge Chunlei, Lai Zhangchao, Xue Yuanbo, Yang Jinyan, Li Gaofeng, Song Xin

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Synergism between the mTOR inhibitor rapamycin and FAK down-regulation in the treatment of acute lymphoblastic leukemia

Pei-Jie Shi, Lu-Hong Xu, Kang-Yu Lin, Wen-jun Weng, Jian-Pei Fang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets

Huan-Di Liu, Ai-Jie Zhang, Jing-Jing Xu, Ying Chen, Yi-Chun Zhu

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Emerging roles of Nrf2 signal in non-small cell lung cancer

Yijun Tian, Qian Liu, Xuelian He, Xun Yuan, Yuan Chen, Qian Chu, Kongming Wu

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

Systematic analysis of overall survival and interactions between tumor mutations and drug treatment

Francesco Gatto, Jens Nielsen

01.12.2016 | Reviewer acknowledgement | Ausgabe 1/2016 Open Access

Journal of Hematology & Oncology reviewer acknowledgement 2015

Delong Liu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Targeting of BMI-1 with PTC-209 shows potent anti-myeloma activity and impairs the tumour microenvironment

Arnold Bolomsky, Karin Schlangen, Wolfgang Schreiner, Niklas Zojer, Heinz Ludwig

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Bleeding, thrombosis, and anticoagulation in myeloproliferative neoplasms (MPN): analysis from the German SAL-MPN-registry

A. Kaifie, M. Kirschner, D. Wolf, C. Maintz, M. Hänel, N. Gattermann, E. Gökkurt, U. Platzbecker, W. Hollburg, J. R. Göthert, S. Parmentier, F. Lang, R. Hansen, S. Isfort, K. Schmitt, E. Jost, H. Serve, G. Ehninger, W. E. Berdel, T. H. Brümmendorf, S. Koschmieder, for the Study Alliance Leukemia (SAL)

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Second- and third-generation ALK inhibitors for non-small cell lung cancer

Jingjing Wu, John Savooji, Delong Liu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models

Abin You, Manqing Cao, Zhigui Guo, Bingfeng Zuo, Junrong Gao, Hongyuan Zhou, Huikai Li, Yunlong Cui, Feng Fang, Wei Zhang, Tianqiang Song, Qiang Li, Xiaolin Zhu, Haifang Yin, Huichuan Sun, Ti Zhang

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Acalabrutinib (ACP-196): a selective second-generation BTK inhibitor

Jingjing Wu, Mingzhi Zhang, Delong Liu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Romidepsin for the treatment of relapsed/refractory peripheral T cell lymphoma: prolonged stable disease provides clinical benefits for patients in the pivotal trial

Francine Foss, Steven Horwitz, Barbara Pro, H. Miles Prince, Lubomir Sokol, Barbara Balser, Julie Wolfson, Bertrand Coiffier

01.12.2016 | Research | Ausgabe 1/2016 Open Access

First-in-human, open-label dose-escalation and dose-expansion study of the safety, pharmacokinetics, and antitumor effects of an oral ALK inhibitor ASP3026 in patients with advanced solid tumors

Tianhong Li, Patricia LoRusso, Michael L. Maitland, Sai-Hong Ignatius Ou, Erkut Bahceci, Howard A. Ball, Jung Wook Park, Geoffrey Yuen, Anthony Tolcher

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia

Zizhen Feng, Yuan Yao, Chao Zhou, Fengju Chen, Fangrui Wu, Liping Wei, Wei Liu, Shuo Dong, Michele Redell, Qianxing Mo, Yongcheng Song

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Impact of conditioning intensity in T-replete haplo-identical stem cell transplantation for acute leukemia: a report from the acute leukemia working party of the EBMT

Marie T. Rubio, Bipin N. Savani, Myriam Labopin, Simona Piemontese, Emmanuelle Polge, Fabio Ciceri, Andrea Bacigalupo, William Arcese, Yener Koc, Dietrich Beelen, Zafer Gülbas, Depei Wu, Stella Santarone, Johanna Tischer, Boris Afanasyev, Christoph Schmid, Sebastian Giebel, Mohamad Mohty, Arnon Nagler

01.12.2016 | Rapid communication | Ausgabe 1/2016 Open Access

The favorable role of homozygosity for killer immunoglobulin-like receptor (KIR) A haplotype in patients with advanced-stage classic Hodgkin lymphoma

Giorgio La Nasa, Marianna Greco, Roberto Littera, Sara Oppi, Ivana Celeghini, Rossella Caria, Sara Lai, Rita Porcella, Massimo Martino, Alessandra Romano, Francesco Di Raimondo, Andrea Gallamini, Carlo Carcassi, Giovanni Caocci

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Anti-proliferative effects of T cells expressing a ligand-based chimeric antigen receptor against CD116 on CD34+ cells of juvenile myelomonocytic leukemia

Yozo Nakazawa, Kazuyuki Matsuda, Takashi Kurata, Akane Sueki, Miyuki Tanaka, Kazuo Sakashita, Chihaya Imai, Matthew H. Wilson, Kenichi Koike

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Trends in survival of chronic lymphocytic leukemia patients in Germany and the USA in the first decade of the twenty-first century

Dianne Pulte, Felipe A. Castro, Lina Jansen, Sabine Luttmann, Bernd Holleczek, Alice Nennecke, Meike Ressing, Alexander Katalinic, Hermann Brenner, GEKID Cancer Survival Working Group

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Case report: mismatch repair proficiency and microsatellite stability in gastric cancer may not predict programmed death-1 blockade resistance

Kuo-Hsing Chen, Chang-Tsu Yuan, Li-Hui Tseng, Chia-Tung Shun, Kun-Huei Yeh

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

Discovery and characterization of a novel CCND1/MRCK gene fusion in mantle cell lymphoma

Chioniso Patience Masamha, Todd R. Albrecht, Eric J. Wagner

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Functional and genetic screening of acute myeloid leukemia associated with mediastinal germ cell tumor identifies MEK inhibitor as an active clinical agent

Jessica T. Leonard, Philipp W. Raess, Jennifer Dunlap, Brandon Hayes-Lattin, Jeffrey W. Tyner, Elie Traer

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Molecular alterations in the TCR signaling pathway in patients with aplastic anemia

Bo Li, Lixing Guo, Yuping Zhang, Yankai Xiao, Mingjuan Wu, Lingling Zhou, Shaohua Chen, Lijian Yang, Xiang Lu, Yangqiu Li

01.12.2016 | Research | Ausgabe 1/2016 Open Access

PML-RAR alpha induces the downmodulation of HHEX: a key event responsible for the induction of an angiogenetic response

Ernestina Saulle, Alessia Petronelli, Elvira Pelosi, Elena Coppotelli, Luca Pasquini, Ramona Ilari, Francesco Lo-Coco, Ugo Testa

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Third-generation inhibitors targeting EGFR T790M mutation in advanced non-small cell lung cancer

Shuhang Wang, Shundong Cang, Delong Liu

01.12.2016 | Review | Ausgabe 1/2016 Open Access

How do we choose the best donor for T-cell-replete, HLA-haploidentical transplantation?

Ying-Jun Chang, Leo Luznik, Ephraim J. Fuchs, Xiao-Jun Huang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine acute myeloid leukemia

Yanan Gao, Juan Gao, Minghao Li, Yawei Zheng, Yajie Wang, Hongyan Zhang, Weili Wang, Yajing Chu, Xiaomin Wang, Mingjiang Xu, Tao Cheng, Zhenyu Ju, Weiping Yuan

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Therapeutic options in peripheral T cell lymphoma

Yaping Zhang, Wei Xu, Hong Liu, Jianyong Li

01.12.2016 | Research | Ausgabe 1/2016 Open Access

A phase II study on the role of gemcitabine plus romidepsin (GEMRO regimen) in the treatment of relapsed/refractory peripheral T-cell lymphoma patients

Cinzia Pellegrini, Anna Dodero, Annalisa Chiappella, Federico Monaco, Debora Degl’Innocenti, Flavia Salvi, Umberto Vitolo, Lisa Argnani, Paolo Corradini, Pier Luigi Zinzani, On behalf of the Italian Lymphoma Foundation (Fondazione Italiana Linfomi Onlus, FIL)

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Azacitidine front-line in 339 patients with myelodysplastic syndromes and acute myeloid leukaemia: comparison of French-American-British and World Health Organization classifications

Lisa Pleyer, Sonja Burgstaller, Reinhard Stauder, Michael Girschikofsky, Heinz Sill, Konstantin Schlick, Josef Thaler, Britta Halter, Sigrid Machherndl-Spandl, Armin Zebisch, Angelika Pichler, Michael Pfeilstöcker, Eva-Maria Autzinger, Alois Lang, Klaus Geissler, Daniela Voskova, Dietmar Geissler, Wolfgang R. Sperr, Sabine Hojas, Inga M. Rogulj, Johannes Andel, Richard Greil

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Correlation between deletion of the CDKN2 gene and tyrosine kinase inhibitor resistance in adult Philadelphia chromosome-positive acute lymphoblastic leukemia

Na Xu, Yu-ling Li, Xuan Li, Xuan Zhou, Rui Cao, Huan Li, Lin Li, Zi-yuan Lu, Ji-xian Huang, Zhi-ping Fan, Fen Huang, Hong-sheng Zhou, Song Zhang, Zhi Liu, Hong-qian Zhu, Qi-fa Liu, Xiao-li Liu

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

l-asparaginase-based regimens followed by allogeneic hematopoietic stem cell transplantation improve outcomes in aggressive natural killer cell leukemia

Ki Sun Jung, Su-Hee Cho, Seok Jin Kim, Young Hyeh Ko, Eun-Suk Kang, Won Seog Kim

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway

Xiaoxia Li, Shihua Wang, Rongjia Zhu, Hongling Li, Qin Han, Robert Chunhua Zhao

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

iPSC-derived mesenchymal stromal cells are less supportive than primary MSCs for co-culture of hematopoietic progenitor cells

Theresa Vasko, Joana Frobel, Richard Lubberich, Tamme W. Goecke, Wolfgang Wagner

01.12.2016 | Rapid communication | Ausgabe 1/2016 Open Access

PU.1 controls the expression of long noncoding RNA HOTAIRM1 during granulocytic differentiation

Shuyong Wei, Ming Zhao, Xiaoling Wang, Yizhen Li, Kankan Wang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Calreticulin-mutant proteins induce megakaryocytic signaling to transform hematopoietic cells and undergo accelerated degradation and Golgi-mediated secretion

Lijuan Han, Claudia Schubert, Johanna Köhler, Mirle Schemionek, Susanne Isfort, Tim H. Brümmendorf, Steffen Koschmieder, Nicolas Chatain

01.12.2016 | Review | Ausgabe 1/2016 Open Access

The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation

Ke Zhao, Qifa Liu

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy

Weijie Ma, Barbara M. Gilligan, Jianda Yuan, Tianhong Li

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Programmed cell death-1 blockade in recurrent disseminated Ewing sarcoma

Georgia J. B. McCaughan, Michael J. Fulham, Annabelle Mahar, Judy Soper, Angela M. Hong, Paul D. Stalley, Martin H. N. Tattersall, Vivek A. Bhadri

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives

Yongcheng Song, Fangrui Wu, Jingyu Wu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Superior anti-tumor activity of the MDM2 antagonist idasanutlin and the Bcl-2 inhibitor venetoclax in p53 wild-type acute myeloid leukemia models

Christian Lehmann, Thomas Friess, Fabian Birzele, Anna Kiialainen, Markus Dangl

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Daratumumab: a first-in-class CD38 monoclonal antibody for the treatment of multiple myeloma

Larysa Sanchez, Yucai Wang, David S. Siegel, Michael L. Wang

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Novel agents in the treatment of multiple myeloma: a review about the future

Leonard Naymagon, Maher Abdul-Hay

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Azacytidine mitigates experimental sclerodermic chronic graft-versus-host disease

Gilles Fransolet, Grégory Ehx, Joan Somja, Loïc Delens, Muriel Hannon, Joséphine Muller, Sophie Dubois, Pierre Drion, Jo Caers, Stéphanie Humblet-Baron, Philippe Delvenne, Yves Beguin, Giuseppina Conteduca, Frédéric Baron

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

Pooled analysis of the reports of carfilzomib, panobinostat, and elotuzumab combinations in patients with refractory/relapsed multiple myeloma

Liping Liu, Ningning Zhao, Wenjun Xu, Zhixin Sheng, Lida Wang

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Elotuzumab for the treatment of multiple myeloma

Yucai Wang, Larysa Sanchez, David S. Siegel, Michael L. Wang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Effective adoptive immunotherapy of triple-negative breast cancer by folate receptor-alpha redirected CAR T cells is influenced by surface antigen expression level

De-Gang Song, Qunrui Ye, Mathilde Poussin, Jessica A. Chacon, Mariangela Figini, Daniel J. Powell Jr.

01.12.2016 | Research | Ausgabe 1/2016 Open Access

RETRACTED ARTICLE: Decreased expression of the long noncoding RNA LINC00261 indicate poor prognosis in gastric cancer and suppress gastric cancer metastasis by affecting the epithelial–mesenchymal transition

Yu Fan, Yan-fen Wang, Hua-fang Su, Na Fang, Chen Zou, Wen-feng Li, Zheng-hua Fei

01.12.2016 | Research highlight | Ausgabe 1/2016 Open Access

Chasing the precursor of functional hematopoietic stem cells at the single cell levels in mouse embryos

Xiaochen Wang, Yuemin Gong, Hideo Ema

01.12.2016 | Review | Ausgabe 1/2016 Open Access

EGFR C797S mutation mediates resistance to third-generation inhibitors in T790M-positive non-small cell lung cancer

Shuhang Wang, Stella T. Tsui, Christina Liu, Yongping Song, Delong Liu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Risk of venous thromboembolism in hospitalised cancer patients in England—a cohort study

Sonia Ratib, Alex J. Walker, Tim R. Card, Matthew J. Grainge

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Immunoprofiling of leukemic stem cells CD34+/CD38−/CD123+ delineate FLT3/ITD-positive clones

Adhra Al-Mawali, David Gillis, Ian Lewis

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Short telomere length and its correlation with gene mutations in myelodysplastic syndrome

Sang Mee Hwang, Seon Young Kim, Jung Ah Kim, Hee-Sue Park, Si Nae Park, Kyongok Im, Kwantae Kim, Sung-Min Kim, Dong Soon Lee

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

Telomere length shortening is associated with treatment-free remission in chronic myeloid leukemia patients

Giovanni Caocci, Marianna Greco, Giuseppe Delogu, Christian Secchi, Bruno Martino, Claudia Labate, Elisabetta Abruzzese, Malgorzata Monika Trawinska, Sara Galimberti, Federica Orru, Claudio Fozza, Carlo Gambacorti Passerini, Francesco Galimi, Giorgio La Nasa

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

Epidermal growth factor receptor is expressed and active in a subset of acute myeloid leukemia

Hasan Mahmud, Steven M. Kornblau, Arja ter Elst, Frank J. G. Scherpen, Yi Hua Qiu, Kevin R. Coombes, Eveline S. J. M. de Bont

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The impact of HLA-matching on reduced intensity conditioning regimen unrelated donor allogeneic stem cell transplantation for acute myeloid leukemia in patients above 50 years—a report from the EBMT acute leukemia working party

Marie T. Rubio, Bipin N. Savani, Myriam Labopin, Emmanuelle Polge, Dietger Niederwieser, Arnold Ganser, Rainer Schwerdtfeger, Gerhard Ehninger, Jürgen Finke, Arnold Renate, Charles Craddock, Nicolaus Kröger, Michael Hallek, Pavel Jindra, Mohamad Mohty, Arnon Nagler

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

Lung adenocarcinoma harboring concomitant SPTBN1-ALK fusion, c-Met overexpression, and HER-2 amplification with inherent resistance to crizotinib, chemotherapy, and radiotherapy

Fei-fei Gu, Yong Zhang, Yang-yang Liu, Xiao-hua Hong, Jin-yan Liang, Fan Tong, Jing-song Yang, Li Liu

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Ruxolitinib in steroid refractory graft-vs.-host disease: a case report

Enrico Maffini, Luisa Giaccone, Moreno Festuccia, Lucia Brunello, Ilaria Buondonno, Dario Ferrero, Mario Boccadoro, Chiara Dellacasa, Alessandro Busca, Domenico Novero, Benedetto Bruno

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Phase II trial of utidelone as monotherapy or in combination with capecitabine in heavily pretreated metastatic breast cancer patients

Pin Zhang, Zhongsheng Tong, Fuguo Tian, Yongsheng Wang, Junlan Yang, Weilian Li, Lijun Di, Wei Liu, Li Tang, Rongguo Qiu, Binghe Xu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

MiR-124-3p/B4GALT1 axis plays an important role in SOCS3-regulated growth and chemo-sensitivity of CML

Yu-xiao Liu, Li Wang, Wen-jia Liu, Hai-tao Zhang, Jing-hui Xue, Zhi-wen Zhang, Chun-ji Gao

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

Predominant cerebral cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T cell therapy

Yongxian Hu, Jie Sun, Zhao Wu, Jian Yu, Qu Cui, Chengfei Pu, Bin Liang, Yi Luo, Jimin Shi, Aiyun Jin, Lei Xiao, He Huang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery

Michael M. B. Green, Nelson Chao, Saurabh Chhabra, Kelly Corbet, Cristina Gasparetto, Ari Horwitz, Zhiguo Li, Jagadish Kummetha Venkata, Gwynn Long, Alice Mims, David Rizzieri, Stefanie Sarantopoulos, Robert Stuart, Anthony D. Sung, Keith M. Sullivan, Luciano Costa, Mitchell Horwitz, Yubin Kang

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma

Kai Qing, Zhen Jin, Wanbin Fu, Wenfang Wang, Zhao Liu, Xiaoyang Li, Zizhen Xu, Junmin Li

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Treatment of acquired drug resistance in multiple myeloma by combination therapy with XPO1 and topoisomerase II inhibitors

Joel G. Turner, Jana L. Dawson, Steven Grant, Kenneth H. Shain, William S. Dalton, Yun Dai, Mark Meads, Rachid Baz, Michael Kauffman, Sharon Shacham, Daniel M. Sullivan

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Epithelial-to-mesenchymal plasticity of cancer stem cells: therapeutic targets in hepatocellular carcinoma

Aparna Jayachandran, Bijay Dhungel, Jason C. Steel

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Erythropoietin (EPO)-receptor signaling induces cell death of primary myeloma cells in vitro

Thea Kristin Våtsveen, Anne-Marit Sponaas, Erming Tian, Qing Zhang, Kristine Misund, Anders Sundan, Magne Børset, Anders Waage, Gaute Brede

01.12.2016 | Research | Ausgabe 1/2016 Open Access

A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway

Jing Liu, Changqie Pan, Lihong Guo, Mengwan Wu, Jing Guo, Sheng Peng, Qianying Wu, Qiang Zuo

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Immune phenotypes predict survival in patients with glioblastoma multiforme

Haouraa Mostafa, Andrej Pala, Josef Högel, Michal Hlavac, Elvira Dietrich, M. Andrew Westhoff, Lisa Nonnenmacher, Timo Burster, Michael Georgieff, C. Rainer Wirtz, E. Marion Schneider

01.12.2016 | Research | Ausgabe 1/2016 Open Access

A three-gene expression-based risk score can refine the European LeukemiaNet AML classification

Stefan Wilop, Wen-Chien Chou, Edgar Jost, Martina Crysandt, Jens Panse, Ming-Kai Chuang, Tim H. Brümmendorf, Wolfgang Wagner, Hwei-Fang Tien, Behzad Kharabi Masouleh

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Matched and mismatched unrelated donor compared to autologous stem cell transplantation for acute myeloid leukemia in first complete remission: a retrospective, propensity score-weighted analysis from the ALWP of the EBMT

Francesco Saraceni, Myriam Labopin, Norbert-Claude Gorin, Didier Blaise, Reza Tabrizi, Liisa Volin, Jan Cornelissen, Jean-Yves Cahn, Patrice Chevallier, Charles Craddock, Depei Wu, Anne Huynh, William Arcese, Mohamad Mohty, Arnon Nagler, Acute Leukemia Working Party (ALWP) of the European society for Blood and Marrow Transplantation (EBMT)

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Second-generation inhibitors of Bruton tyrosine kinase

Jingjing Wu, Christina Liu, Stella T. Tsui, Delong Liu

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Selective inhibition of autoimmune exacerbation while preserving the anti-tumor clinical benefit using IL-6 blockade in a patient with advanced melanoma and Crohn’s disease: a case report

Marc Uemura, Van A. Trinh, Cara Haymaker, Natalie Jackson, Dae Won Kim, James P. Allison, Padmanee Sharma, Luis Vence, Chantale Bernatchez, Patrick Hwu, Adi Diab

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Proteasome subunit expression analysis and chemosensitivity in relapsed paediatric acute leukaemia patients receiving bortezomib-containing chemotherapy

Denise Niewerth, Gertjan J. L. Kaspers, Gerrit Jansen, Johan van Meerloo, Sonja Zweegman, Gaye Jenkins, James A. Whitlock, Stephen P. Hunger, Xiaomin Lu, Todd A. Alonzo, Peter M. van de Ven, Terzah M. Horton, Jacqueline Cloos

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer

Yijun Tian, Kongming Wu, Qian Liu, Na Han, Li Zhang, Qian Chu, Yuan Chen

01.12.2016 | Research | Ausgabe 1/2016 Open Access

PEG-aspargase and DEP regimen combination therapy for refractory Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis

Jingshi Wang, Yini Wang, Lin Wu, Jia Zhang, Wenyuan Lai, Zhao Wang

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Aberrant splicing and drug resistance in AML

Rosalia de Necochea-Campion, Geoffrey P. Shouse, Qi Zhou, Saied Mirshahidi, Chien-Shing Chen

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Serial cfDNA assessment of response and resistance to EGFR-TKI for patients with EGFR-L858R mutant lung cancer from a prospective clinical trial

Qing Zhou, Jin-Ji Yang, Zhi-Hong Chen, Xu-Chao Zhang, Hong-Hong Yan, Chong-Rui Xu, Jian Su, Hua-Jun Chen, Hai-Yan Tu, Wen-Zhao Zhong, Xue-Ning Yang, Yi-Long Wu

01.12.2016 | Rapid communication | Ausgabe 1/2016 Open Access

Minimal residual disease- and graft-vs.-host disease-guided multiple consolidation chemotherapy and donor lymphocyte infusion prevent second acute leukemia relapse after allotransplant

Chen-Hua Yan, Yu Wang, Jing-Zhi Wang, Yu-Hong Chen, Yao Chen, Feng-rong Wang, Yu-Qian Sun, Xiao-Dong Mo, Wei Han, Huan Chen, Xiao-hui Zhang, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Extensive next-generation sequencing analysis in chronic lymphocytic leukemia at diagnosis: clinical and biological correlations

Gian Matteo Rigolin, Elena Saccenti, Cristian Bassi, Laura Lupini, Francesca Maria Quaglia, Maurizio Cavallari, Sara Martinelli, Luca Formigaro, Enrico Lista, Maria Antonella Bardi, Eleonora Volta, Elisa Tammiso, Aurora Melandri, Antonio Urso, Francesco Cavazzini, Massimo Negrini, Antonio Cuneo

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Unrelated donor versus matched sibling donor in adults with acute myeloid leukemia in first relapse: an ALWP-EBMT study

Annalisa Ruggeri, Giorgia Battipaglia, Myriam Labopin, Gerhard Ehninger, Dietrich Beelen, Johanna Tischer, Arnold Ganser, Rainer Schwerdtfeger, Bertram Glass, Jurgen Finke, Mauricette Michallet, Matthias Stelljes, Pavel Jindra, Renate Arnold, Nicolaus Kröger, Mohamad Mohty, Arnon Nagler

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Bmi-1 regulates stem cell-like properties of gastric cancer cells via modulating miRNAs

Xiaofeng Wang, Chang Wang, Xiaowei Zhang, Ruixi Hua, Lu Gan, Mingzhu Huang, Liqin Zhao, Sujie Ni, Weijian Guo

01.12.2016 | Research | Ausgabe 1/2016 Open Access

NT1014, a novel biguanide, inhibits ovarian cancer growth in vitro and in vivo

Lu Zhang, Jianjun Han, Amanda L. Jackson, Leslie N. Clark, Joshua Kilgore, Hui Guo, Nick Livingston, Kenneth Batchelor, Yajie Yin, Timothy P. Gilliam, Paola A. Gehrig, Xiugui Sheng, Chunxiao Zhou, Victoria L. Bae-Jump

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Histologic and molecular analysis of patient derived xenografts of high-grade serous ovarian carcinoma

Ruifen Dong, Wenan Qiang, Haiyang Guo, Xiaofei Xu, J. Julie Kim, Andrew Mazar, Beihua Kong, Jian-Jun Wei

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Alantolactone selectively ablates acute myeloid leukemia stem and progenitor cells

Yahui Ding, Huier Gao, Yu Zhang, Ye Li, Neil Vasdev, Yingdai Gao, Yue Chen, Quan Zhang

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized

Zhiwu Jiang, Manman Deng, Xinru Wei, Wei Ye, Yiren Xiao, Simiao Lin, Suna Wang, Baiheng Li, Xin Liu, Gong Zhang, Peilong Lai, Jianyu Weng, Donghai Wu, Haijia Chen, Wei Wei, Yuguo Ma, Yangqiu Li, Pentao Liu, Xin Du, Duanqing Pei, Yao Yao, Bing Xu, Peng Li

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Silencing of GATA3 defines a novel stem cell-like subgroup of ETP-ALL

L. Fransecky, M. Neumann, S. Heesch, C. Schlee, J. Ortiz-Tanchez, S. Heller, M. Mossner, S. Schwartz, L. H. Mochmann, K. Isaakidis, L. Bastian, U. R. Kees, T. Herold, K. Spiekermann, N. Gökbuget, C. D. Baldus

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Immune biomarkers of treatment failure for a patient on a phase I clinical trial of pembrolizumab plus radiotherapy

Gregory S. Alexander, Joshua D. Palmer, Madalina Tuluc, Jianqing Lin, Adam P. Dicker, Voichita Bar-Ad, Larry A Harshyne, Jennifer Louie, Colette M. Shaw, D. Craig Hooper, Bo Lu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Antifungal prophylaxis of patients undergoing allogenetic hematopoietic stem cell transplantation in China: a multicenter prospective observational study

Lei Gao, Yuqian Sun, Fanyi Meng, Mingzhe Han, He Huang, Depei Wu, Li Yu, Hanyun Ren, Xiaojun Huang, Xi Zhang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms

Zhu-Ling Guo, Des R. Richardson, Danuta S. Kalinowski, Zaklina Kovacevic, Kian Cheng Tan-Un, Godfrey Chi-Fung Chan

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Long non-coding RNAs in the regulation of myeloid cells

Xinyu Tian, Jie Tian, Xinyi Tang, Jie Ma, Shengjun Wang

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Protein glycosylation in cancers and its potential therapeutic applications in neuroblastoma

Wan-Ling Ho, Wen-Ming Hsu, Min-Chuan Huang, Kenji Kadomatsu, Akira Nakagawara

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Interleukin-15 enhances the proliferation, stimulatory phenotype, and antitumor effector functions of human gamma delta T cells

Heleen H. Van Acker, Sébastien Anguille, Yannick Willemen, Johan M. Van den Bergh, Zwi N. Berneman, Eva Lion, Evelien L. Smits, Viggo F. Van Tendeloo

01.12.2016 | Research | Ausgabe 1/2016 Open Access

A synthetic three-dimensional niche system facilitates generation of functional hematopoietic cells from human-induced pluripotent stem cells

Yulin Xu, Wei Shan, Xia Li, Binsheng Wang, Senquan Liu, Yebo Wang, Yan Long, Ruxiu Tie, Limengmeng Wang, Shuyang Cai, Hao Zhang, Yu Lin, Mingming Zhang, Weiyan Zheng, Yi Luo, Xiaohong Yu, Jiing-Kuan Yee, Junfeng Ji, He Huang

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Extensive next-generation sequencing analysis in chronic lymphocytic leukemia at diagnosis: clinical and biological correlations

Gian Matteo Rigolin, Elena Saccenti, Cristian Bassi, Laura Lupini, Francesca Maria Quaglia, Maurizio Cavallari, Sara Martinelli, Luca Formigaro, Enrico Lista, Maria Antonella Bardi, Eleonora Volta, Elisa Tammiso, Aurora Melandri, Antonio Urso, Francesco Cavazzini, Massimo Negrini, Antonio Cuneo

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Safety, pharmacokinetics, and antitumor properties of anlotinib, an oral multi-target tyrosine kinase inhibitor, in patients with advanced refractory solid tumors

Yongkun Sun, Wei Niu, Feng Du, Chunxia Du, Shuting Li, Jinwan Wang, Li Li, Fengqing Wang, Yu Hao, Chuan Li, Yihebali Chi

01.12.2016 | Research | Ausgabe 1/2016 Open Access

DNMT3A mutation leads to leukemic extramedullary infiltration mediated by TWIST1

Jie Xu, Wu Zhang, Xiao-Jing Yan, Xue-Qiu Lin, Wei Li, Jian-Qing Mi, Jun-Min Li, Jiang Zhu, Zhu Chen, Sai-Juan Chen

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

High applicability of ASO-RQPCR for detection of minimal residual disease in multiple myeloma by entirely patient-specific primers/probes

Yinlei Bai, Kwan Yeung Wong, Tsz Kin Fung, Chor Sang Chim

01.12.2016 | Research | Ausgabe 1/2016 Open Access

CRM1/XPO1 is associated with clinical outcome in glioma and represents a therapeutic target by perturbing multiple core pathways

Xuejiao Liu, Yulong Chong, Yiming Tu, Ning Liu, Chenglong Yue, Zhenglei Qi, Huize Liu, Yao Yao, Hongmei Liu, Shangfeng Gao, Mingshan Niu, Rutong Yu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

PD-L1 is upregulated by EBV-driven LMP1 through NF-κB pathway and correlates with poor prognosis in natural killer/T-cell lymphoma

Xi-wen Bi, Hua Wang, Wen-wen Zhang, Jing-hua Wang, Wen-jian Liu, Zhong-jun Xia, Hui-qiang Huang, Wen-qi Jiang, Yu-jing Zhang, Liang Wang

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Targeting MET kinase with the small-molecule inhibitor amuvatinib induces cytotoxicity in primary myeloma cells and cell lines

Cornel Joseph Phillip, Shadia Zaman, Shujun Shentu, Kumudha Balakrishnan, Jiexin Zhang, Veera Baladandayuthapani, Pietro Taverna, Sanjeev Redkar, Michael Wang, Christine Marie Stellrecht, Varsha Gandhi

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Efficacy and safety of angiogenesis inhibitors in advanced gastric cancer: a systematic review and meta-analysis

Jing Yu, Yue Zhang, Lai-Han Leung, Lian Liu, Fan Yang, Xiaojun Yao

01.12.2016 | Research | Ausgabe 1/2016 Open Access

MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis

Yingmei Wang, Limei Hu, Ping Ji, Fei Teng, Wenyan Tian, Yuexin Liu, David Cogdell, Jinsong Liu, Anil K. Sood, Russell Broaddus, Fengxia Xue, Wei Zhang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Targeting of PI3K/AKT/mTOR pathway to inhibit T cell activation and prevent graft-versus-host disease development

Mª Carmen Herrero-Sánchez, Concepción Rodríguez-Serrano, Julia Almeida, Laura San Segundo, Susana Inogés, Ángel Santos-Briz, Jesús García-Briñón, Luis Antonio Corchete, Jesús F. San Miguel, Consuelo del Cañizo, Belén Blanco

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway

Annalisa Lonetti, Alessandra Cappellini, Alice Bertaina, Franco Locatelli, Andrea Pession, Francesca Buontempo, Camilla Evangelisti, Cecilia Evangelisti, Ester Orsini, Laura Zambonin, Luca Maria Neri, Alberto Maria Martelli, Francesca Chiarini

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

Integrating a prospective pilot trial and patient-derived xenografts to trace metabolic changes associated with acute myeloid leukemia

Matteo G. Carrabba, Laurette Tavel, Giacomo Oliveira, Alessandra Forcina, Giacomo Quilici, Francesca Nardelli, Cristina Tresoldi, Alessandro Ambrosi, Fabio Ciceri, Massimo Bernardi, Luca Vago, Giovanna Musco

01.12.2016 | Research | Ausgabe 1/2016 Open Access

T cells in multiple myeloma display features of exhaustion and senescence at the tumor site

Claudia Zelle-Rieser, Shanmugapriya Thangavadivel, Rainer Biedermann, Andrea Brunner, Patrizia Stoitzner, Ella Willenbacher, Richard Greil, Karin Jöhrer

01.12.2016 | Research | Ausgabe 1/2016 Open Access

LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner

Wen-Tao Wang, Hua Ye, Pan-Pan Wei, Bo-Wei Han, Bo He, Zhen- Hua Chen, Yue-Qin Chen

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Long-term survival and late events after allogeneic stem cell transplantation from HLA-matched siblings for acute myeloid leukemia with myeloablative compared to reduced-intensity conditioning: a report on behalf of the acute leukemia working party of European group for blood and marrow transplantation

Avichai Shimoni, Myriam Labopin, Bipin Savani, Liisa Volin, Gerhard Ehninger, Jurgen Kuball, Donald Bunjes, Nicolaas Schaap, Stephane Vigouroux, Andrea Bacigalupo, Hendrik Veelken, Jorge Sierra, Matthias Eder, Dietger Niederwieser, Mohamad Mohty, Arnon Nagler

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The expression profile and clinic significance of the SIX family in non-small cell lung cancer

Qian Liu, Anping Li, Yijun Tian, Yu Liu, Tengfei Li, Cuntai Zhang, Jennifer D. Wu, Xinwei Han, Kongming Wu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

A positive feedback loop involving the Wnt/β-catenin/MYC/Sox2 axis defines a highly tumorigenic cell subpopulation in ALK-positive anaplastic large cell lymphoma

Chengsheng Wu, Hai-Feng Zhang, Nidhi Gupta, Abdulraheem Alshareef, Qian Wang, Yung-Hsing Huang, Jamie T. Lewis, Donna N. Douglas, Norman M. Kneteman, Raymond Lai

01.12.2016 | Research | Ausgabe 1/2016 Open Access

WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells

R. Moles, X. T. Bai, H. Chaib-Mezrag, C. Nicot

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study

Luqiao Wang, Hangfei Fu, Gayani Nanayakkara, Yafeng Li, Ying Shao, Candice Johnson, Jiali Cheng, William Y. Yang, Fan Yang, Muriel Lavallee, Yanjie Xu, Xiaoshu Cheng, Hang Xi, Jonathan Yi, Jun Yu, Eric T. Choi, Hong Wang, Xiaofeng Yang

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

High IKZF1/3 protein expression is a favorable prognostic factor for survival of relapsed/refractory multiple myeloma patients treated with lenalidomide

Maryam Pourabdollah, Mohammad Bahmanyar, Eshetu G. Atenafu, Donna Reece, Jian Hou, Hong Chang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

CD274 promotes cell cycle entry of leukemia-initiating cells through JNK/Cyclin D2 signaling

Xia Fang, Chiqi Chen, Fangzhen Xia, Zhuo Yu, Yaping Zhang, Feifei Zhang, Hao Gu, Jiangbo Wan, Xiaocui Zhang, Wei Weng, Cheng Cheng Zhang, Guo-Qiang Chen, Aibing Liang, Li Xie, Junke Zheng

01.12.2016 | Short report | Ausgabe 1/2016 Open Access

Microarray-based analysis and clinical validation identify ubiquitin-conjugating enzyme E2E1 (UBE2E1) as a prognostic factor in acute myeloid leukemia

Hongmei Luo, Yu Qin, Frederic Reu, Sujuan Ye, Yang Dai, Jingcao Huang, Fangfang Wang, Dan Zhang, Ling Pan, Huanling Zhu, Yu Wu, Ting Niu, Zhijian Xiao, Yuhuan Zheng, Ting Liu

01.12.2016 | Rapid communication | Ausgabe 1/2016 Open Access

Oligoclonal expansion of TCR Vδ T cells may be a potential immune biomarker for clinical outcome of acute myeloid leukemia

Zhenyi Jin, Qiang Luo, Shuai Lu, Xinyu Wang, Zifan He, Jing Lai, Shaohua Chen, Lijian Yang, Xiuli Wu, Yangqiu Li

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Monoacylglycerol lipase promotes progression of hepatocellular carcinoma via NF-κB-mediated epithelial-mesenchymal transition

Weiping Zhu, Yiming Zhao, Jiamin Zhou, Xin Wang, Qi Pan, Ning Zhang, Longrong Wang, Miao Wang, Dihua Zhan, Zeyang Liu, Xigan He, Dening Ma, Shuang Liu, Lu Wang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia

Sixuan Qian, Jianyong Li, Ming Hong, Yu Zhu, Huihui Zhao, Yue Xie, Jiayu Huang, Yun Lian, Yanru Li, Shuai Wang, Jianping Mao, Yaoyu Chen

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms

Xiaoying Lan, Chong Zhao, Xin Chen, Peiquan Zhang, Dan Zang, Jinjie Wu, Jinghong Chen, Huidan Long, Li Yang, Hongbiao Huang, Bing Z. Carter, Xuejun Wang, Xianping Shi, Jinbao Liu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells

Zeyou Wang, Qin Guo, Rong Wang, Gang Xu, Peiyao Li, Yingnan Sun, Xiaoling She, Qiang Liu, Qiong Chen, Zhibin Yu, Changhong Liu, Jing Xiong, Guiyuan Li, Minghua Wu

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Co-infusion of haplo-identical CD19-chimeric antigen receptor T cells and stem cells achieved full donor engraftment in refractory acute lymphoblastic leukemia

Bo Cai, Mei Guo, Yao Wang, Yajing Zhang, Jun Yang, Yelei Guo, Hanren Dai, Changlin Yu, Qiyun Sun, Jianhui Qiao, Kaixun Hu, Hongli Zuo, Zheng Dong, Zechuan Zhang, Mingxing Feng, Bingxia Li, Yujing Sun, Tieqiang Liu, Zhiqing Liu, Yi Wang, Yajing Huang, Bo Yao, Weidong Han, Huisheng Ai

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

High rate of complete responses to immune checkpoint inhibitors in patients with relapsed or refractory Hodgkin lymphoma previously exposed to epigenetic therapy

Lorenzo Falchi, Ahmed Sawas, Changchun Deng, Jennifer E. Amengual, Donald S. Colbourn, Emily A. Lichtenstein, Karen A. Khan, Lawrence H. Schwartz, Owen A. O’Connor

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: High expression of myocyte enhancer factor 2C (MEF2C) is associated with adverse-risk features and poor outcome in pediatric acute myeloid leukemia: a report from the Children’s Oncology Group

George S. Laszlo, Todd A. Alonzo, Chelsea J. Gudgeon, Kimberly H. Harrington, Alex Kentsis, Robert B. Gerbing, Yi-Cheng Wang, Rhonda E. Ries, Susana C. Raimondi, Betsy A. Hirsch, Alan S. Gamis, Soheil Meshinchi, Roland B. Walter

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay

Maria Pia Abruzzese, Maria Teresa Bilotta, Cinzia Fionda, Alessandra Zingoni, Alessandra Soriani, Elisabetta Vulpis, Cristiana Borrelli, Beatrice Zitti, Maria Teresa Petrucci, Maria Rosaria Ricciardi, Rosa Molfetta, Rossella Paolini, Angela Santoni, Marco Cippitelli

01.12.2016 | Review | Ausgabe 1/2016 Open Access

The role of HGF/c-MET signaling pathway in lymphoma

Bao Quoc Lam, Lu Dai, Zhiqiang Qin

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Identification of a potent small molecule capable of regulating polyploidization, megakaryocyte maturation, and platelet production

Nick Huang, Mabel Lou, Hua Liu, Cecilia Avila, Yupo Ma

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Phase 1/2 study of pacritinib, a next generation JAK2/FLT3 inhibitor, in myelofibrosis or other myeloid malignancies

Srdan Verstovsek, Olatoyosi Odenike, Jack W. Singer, Tanya Granston, Suliman Al-Fayoumi, H. Joachim Deeg

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Emerging therapeutic agents for lung cancer

Bhagirathbhai Dholaria, William Hammond, Amanda Shreders, Yanyan Lou

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