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Zeitschrift

Journal of Hematology & Oncology

Journal of Hematology & Oncology 1/2019

Ausgabe 1/2019

Inhaltsverzeichnis ( 144 Artikel )

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia: a single-institution experience

Kamal Chamoun, Hagop Kantarjian, Rami Atallah, Graciela Nogueras Gonzalez, Ghayas C. Issa, Mary Beth Rios, Guillermo Garcia-Manero, Gautam Borthakur, Farhad Ravandi, Nitin Jain, Naval Daver, Marina Konopleva, Courtney D. DiNardo, Tapan Kadia, Naveen Pemmaraju, Elias Jabbour, Jorge Cortes

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis

Stefania Raimondo, Laura Saieva, Emanuela Vicario, Marzia Pucci, Denise Toscani, Mauro Manno, Samuele Raccosta, Nicola Giuliani, Riccardo Alessandro

01.12.2019 | Research | Ausgabe 1/2019 Open Access

lncRNA SNHG6 regulates EZH2 expression by sponging miR-26a/b and miR-214 in colorectal cancer

Mu Xu, Xiaoxiang Chen, Kang Lin, Kaixuan Zeng, Xiangxiang Liu, Xueni Xu, Bei Pan, Tao Xu, Li Sun, Bangshun He, Yuqin Pan, Huiling Sun, Shukui Wang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Prognostic or predictive value of circulating cytokines and angiogenic factors for initial treatment of multiple myeloma in the GIMEMA MM0305 randomized controlled trial

Ilaria Saltarella, Fortunato Morabito, Nicola Giuliani, Carolina Terragna, Paola Omedè, Antonio Palumbo, Sara Bringhen, Lorenzo De Paoli, Enrica Martino, Alessandra Larocca, Massimo Offidani, Francesca Patriarca, Chiara Nozzoli, Tommasina Guglielmelli, Giulia Benevolo, Vincenzo Callea, Luca Baldini, Mariella Grasso, Giovanna Leonardi, Manuela Rizzo, Antonietta Pia Falcone, Daniela Gottardi, Vittorio Montefusco, Pellegrino Musto, Maria Teresa Petrucci, Franco Dammacco, Mario Boccadoro, Angelo Vacca, Roberto Ria

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Selective killing of circulating tumor cells prevents metastasis and extends survival

Yi Rang Kim, Jung Ki Yoo, Chang Wook Jeong, Jin Woo Choi

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Allogeneic hematopoietic cell transplantation provides effective salvage despite refractory disease or failed prior autologous transplant in angioimmunoblastic T-cell lymphoma: a CIBMTR analysis

Narendranath Epperla, Kwang W. Ahn, Carlos Litovich, Sairah Ahmed, Minoo Battiwalla, Jonathon B. Cohen, Parastoo Dahi, Nosha Farhadfar, Umar Farooq, Cesar O. Freytes, Nilanjan Ghosh, Bradley Haverkos, Alex Herrera, Mark Hertzberg, Gerhard Hildebrandt, David Inwards, Mohamed A. Kharfan-Dabaja, Farhad Khimani, Hillard Lazarus, Aleksandr Lazaryan, Lazaros Lekakis, Hemant Murthy, Sunita Nathan, Taiga Nishihori, Attaphol Pawarode, Tim Prestidge, Praveen Ramakrishnan, Andrew R. Rezvani, Rizwan Romee, Nirav N. Shah, Ana Sureda, Timothy S. Fenske, Mehdi Hamadani

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Safety and clinical activity with an anti-PD-1 antibody JS001 in advanced melanoma or urologic cancer patients

Bixia Tang, Xieqiao Yan, Xinan Sheng, Lu Si, Chuanliang Cui, Yan Kong, Lili Mao, Bin Lian, Xue Bai, Xuan Wang, Siming Li, Li Zhou, Jiayi Yu, Jie Dai, Kai Wang, Jinwei Hu, Lihou Dong, Haifeng Song, Hai Wu, Hui Feng, Sheng Yao, Zhihong Chi, Jun Guo

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia

Alva Rani James, Michael P. Schroeder, Martin Neumann, Lorenz Bastian, Cornelia Eckert, Nicola Gökbuget, Jutta Ortiz Tanchez, Cornelia Schlee, Konstandina Isaakidis, Stefan Schwartz, Thomas Burmeister, Arend von Stackelberg, Michael A. Rieger, Stefanie Göllner, Martin Horstman, Martin Schrappe, Renate Kirschner-Schwabe, Monika Brüggemann, Carsten Müller-Tidow, Hubert Serve, Altuna Akalin, Claudia D. Baldus

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Phase I dose-escalation study of chiauranib, a novel angiogenic, mitotic, and chronic inflammation inhibitor, in patients with advanced solid tumors

Yongkun Sun, Lin Yang, Xuezhi Hao, Yutao Liu, Jinwen Zhang, Zhiqiang Ning, Yuankai Shi

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer

Wei-Lun Hwang, Hsin-Yi Lan, Wei-Chung Cheng, Shih-Ching Huang, Muh-Hwa Yang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Identifying and targeting cancer stem cells in leiomyosarcoma: prognostic impact and role to overcome secondary resistance to PI3K/mTOR inhibition

Benjamin Fourneaux, Aurélien Bourdon, Bérengère Dadone, Carlo Lucchesi, Scott R. Daigle, Elodie Richard, Audrey Laroche-Clary, François Le Loarer, Antoine Italiano

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis

Yi-Hua Jan, Tsung-Ching Lai, Chih-Jen Yang, Yuan-Feng Lin, Ming-Shyan Huang, Michael Hsiao

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Strategies of adoptive T -cell transfer to treat refractory viral infections post allogeneic stem cell transplantation

Theresa Kaeuferle, Ramona Krauss, Franziska Blaeschke, Semjon Willier, Tobias Feuchtinger

01.12.2019 | Research | Ausgabe 1/2019 Open Access

SPAG5 upregulation contributes to enhanced c-MYC transcriptional activity via interaction with c-MYC binding protein in triple-negative breast cancer

Ming Li, Anqi Li, Shuling Zhou, Hong Lv, Wentao Yang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Clinical trial update on bispecific antibodies, antibody-drug conjugates, and antibody-containing regimens for acute lymphoblastic leukemia

Delong Liu, Juanjuan Zhao, Yongping Song, Xiaofeng Luo, Ting Yang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Expert consensus on multidisciplinary therapy of colorectal cancer with lung metastases (2019 edition)

Jian Li, Ying Yuan, Fan Yang, Yi Wang, Xu Zhu, Zhenghang Wang, Shu Zheng, Desen Wan, Jie He, Jianping Wang, Yi Ba, Chunmei Bai, Li Bai, Wei Bai, Feng Bi, Kaican Cai, Muyan Cai, Sanjun Cai, Gong Chen, Keneng Chen, Lin Chen, Pengju Chen, Pan Chi, Guanghai Dai, Yanhong Deng, Kefeng Ding, Qingxia Fan, Weijia Fang, Xuedong Fang, Fengyi Feng, Chuangang Fu, Qihan Fu, Yanhong Gu, Yulong He, Baoqing Jia, Kewei Jiang, Maode Lai, Ping Lan, Enxiao Li, Dechuan Li, Jin Li, Leping Li, Ming Li, Shaolei Li, Yexiong Li, Yongheng Li, Zhongwu Li, Xiaobo Liang, Zhiyong Liang, Feng Lin, Guole Lin, Hongjun Liu, Jianzhong Liu, Tianshu Liu, Yunpeng Liu, Hongming Pan, Zhizhong Pan, Haiping Pei, Meng Qiu, Xiujuan Qu, Li Ren, Zhanlong Shen, Weiqi Sheng, Chun Song, Lijie Song, Jianguo Sun, Lingyu Sun, Yingshi Sun, Yuan Tang, Min Tao, Chang Wang, Haijiang Wang, Jun Wang, Shubin Wang, Xicheng Wang, Xishan Wang, Ziqiang Wang, Aiwen Wu, Nan Wu, Lijian Xia, Yi Xiao, Baocai Xing, Bin Xiong, Jianmin Xu, Jianming Xu, Nong Xu, Ruihua Xu, Zhongfa Xu, Yue Yang, Hongwei Yao, Yingjiang Ye, Yonghua Yu, Yueming Yu, Jinbo Yue, Jingdong Zhang, Jun Zhang, Suzhan Zhang, Wei Zhang, Yanqiao Zhang, Zhen Zhang, Zhongtao Zhang, Lin Zhao, Ren Zhao, Fuxiang Zhou, Jian Zhou, Jing Jin, Jin Gu, Lin Shen

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Clinical trials of dual-target CAR T cells, donor-derived CAR T cells, and universal CAR T cells for acute lymphoid leukemia

Juanjuan Zhao, Yongping Song, Delong Liu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer

Jiang Lv, Ruocong Zhao, Di Wu, Diwei Zheng, Zhiping Wu, Jingxuan Shi, Xinru Wei, Qiting Wu, Youguo Long, Simiao Lin, Suna Wang, Zhi Wang, Yang Li, Yantao Chen, Qing He, Suimin Chen, Huihui Yao, Zixia Liu, Zhaoyang Tang, Yao Yao, Duanqing Pei, Pentao Liu, Xuchao Zhang, Zhenfeng Zhang, Shuzhong Cui, Ren Chen, Peng Li

01.12.2019 | Research | Ausgabe 1/2019 Open Access

LincK contributes to breast tumorigenesis by promoting proliferation and epithelial-to-mesenchymal transition

Jing Li, Yajing Hao, Wenzhe Mao, Xiaowei Xue, Pengchao Xu, Lihui Liu, Jiao Yuan, Dongdong Zhang, Na Li, Hua Chen, Lin Zhao, Zhao Sun, Jianjun Luo, Runsheng Chen, Robert Chunhua Zhao

01.12.2019 | Research | Ausgabe 1/2019 Open Access

miR-195-5p/NOTCH2-mediated EMT modulates IL-4 secretion in colorectal cancer to affect M2-like TAM polarization

Xiaobin Lin, Shuyi Wang, Min Sun, Chunxiao Zhang, Chen Wei, Chaogang Yang, Rongzhang Dou, Qing Liu, Bin Xiong

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Downregulation of RNF128 activates Wnt/β-catenin signaling to induce cellular EMT and stemness via CD44 and CTTN ubiquitination in melanoma

Chuan-Yuan Wei, Meng-Xuan Zhu, Yan-Wen Yang, Peng-Fei Zhang, Xuan Yang, Rui Peng, Chao Gao, Jia-Cheng Lu, Lu Wang, Xin-Yi Deng, Nan-Hang Lu, Fa-Zhi Qi, Jian-Ying Gu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Mortality of lymphoma and myeloma in China, 2004–2017: an observational study

Weiping Liu, Jiangmei Liu, Yuqin Song, Xiaopei Wang, Maigeng Zhou, Lijun Wang, Jun Ma, Jun Zhu, Union for China Leukemia Investigators of the Chinese Society of Clinical Oncology, Union for China Lymphoma Investigators of the Chinese Society of Clinical Oncology

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells

Lufeng Zheng, Qianqian Guo, Chenxi Xiang, Shijia Liu, Yuzhang Jiang, Lanlan Gao, Haiwei Ni, Ting Wang, Qiong Zhao, Hai Liu, Yingying Xing, Yaohui Wang, Xiaoman Li, Tao Xi

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Minimal residual disease- and graft-vs.-host disease-guided multiple consolidation chemotherapy and donor lymphocyte infusion prevent second acute leukemia relapse after allotransplant

Chen-Hua Yan, Yu Wang, Jing-Zhi Wang, Yu-Hong Chen, Yao Chen, Feng-rong Wang, Yu-Qian Sun, Xiao-Dong Mo, Wei Han, Huan Chen, Xiao-hui Zhang, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The IAP antagonist birinapant potentiates bortezomib anti-myeloma activity in vitro and in vivo

Liang Zhou, Yu Zhang, Yun Leng, Yun Dai, Maciej Kmieciak, Lora Kramer, Kanika Sharma, Yan Wang, William Craun, Steven Grant

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting

Jiansong Huang, Xia Li, Xiaofeng Shi, Mark Zhu, Jinghan Wang, Shujuan Huang, Xin Huang, Huafeng Wang, Ling Li, Huan Deng, Yulan Zhou, Jianhua Mao, Zhangbiao Long, Zhixin Ma, Wenle Ye, Jiajia Pan, Xiaodong Xi, Jie Jin

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Recent advances on anti-angiogenesis receptor tyrosine kinase inhibitors in cancer therapy

Shuang Qin, Anping Li, Ming Yi, Shengnan Yu, Mingsheng Zhang, Kongming Wu

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Pathogenesis and biomarkers of natural killer T cell lymphoma (NKTL)

Nagavalli Somasundaram, Jing Quan Lim, Choon Kiat Ong, Soon Thye Lim

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Molecular markers and potential therapeutic targets in non-WNT/non-SHH (group 3 and group 4) medulloblastomas

Otília Menyhárt, Felice Giangaspero, Balázs Győrffy

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells

Marion Wobser, Alexandra Weber, Amelie Glunz, Saskia Tauch, Kristina Seitz, Tobias Butelmann, Sonja Hesbacher, Matthias Goebeler, René Bartz, Hella Kohlhof, David Schrama, Roland Houben

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Early myeloid-derived suppressor cells (HLA-DR−/lowCD33+CD16−) expanded by granulocyte colony-stimulating factor prevent acute graft-versus-host disease (GVHD) in humanized mouse and might contribute to lower GVHD in patients post allo-HSCT

Ke Wang, Meng Lv, Ying-Jun Chang, Xiang-Yu Zhao, Xiao-Su Zhao, Yuan-Yuan Zhang, Yu-Qian Sun, Zhi-Dong Wang, Pan Suo, Yang Zhou, Dan Liu, Shu-Zhen Zhai, Yan Hong, Yu Wang, Xiao-Hui Zhang, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Trabectedin triggers direct and NK-mediated cytotoxicity in multiple myeloma

Maria Cucè, Maria Eugenia Gallo Cantafio, Maria Anna Siciliano, Caterina Riillo, Daniele Caracciolo, Francesca Scionti, Nicoletta Staropoli, Valeria Zuccalà, Lorenza Maltese, Anna Di Vito, Katia Grillone, Vito Barbieri, Mariamena Arbitrio, Maria Teresa Di Martino, Marco Rossi, Nicola Amodio, Pierosandro Tagliaferri, Pierfrancesco Tassone, Cirino Botta

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Molecular pathogenic pathways in extranodal NK/T cell lymphoma

Sanjay de Mel, Susan Swee-Shan Hue, Anand D. Jeyasekharan, Wee-Joo Chng, Siok-Bian Ng

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

Yanhua Mou, Jun Wang, Jinchun Wu, Dan He, Chunfang Zhang, Chaojun Duan, Bin Li

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Activating cGAS-STING pathway for the optimal effect of cancer immunotherapy

Anping Li, Ming Yi, Shuang Qin, Yongping Song, Qian Chu, Kongming Wu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Differential roles of STAT1 and STAT2 in the sensitivity of JAK2V617F- vs. BCR-ABL-positive cells to interferon alpha

Claudia Schubert, Manuel Allhoff, Stefan Tillmann, Tiago Maié, Ivan G. Costa, Daniel B. Lipka, Mirle Schemionek, Kristina Feldberg, Julian Baumeister, Tim H. Brümmendorf, Nicolas Chatain, Steffen Koschmieder

01.12.2019 | Research | Ausgabe 1/2019 Open Access

CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis

Xiao-Lu Ma, Min-Na Shen, Bo Hu, Bei-Li Wang, Wen-Jing Yang, Li-Hua Lv, Hao Wang, Yan Zhou, An-Li Jin, Yun-Fan Sun, Chuan-Yan Zhang, Shuang-Jian Qiu, Bai-Shen Pan, Jian Zhou, Jia Fan, Xin-Rong Yang, Wei Guo

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms

Zeinab Safarpour Lima, Mostafa Ghadamzadeh, Farzad Tahmasebi Arashloo, Ghazaleh Amjad, Mohammad Reza Ebadi, Ladan Younesi

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Treatment and monitoring of Philadelphia chromosome-positive leukemia patients: recent advances and remaining challenges

Simona Soverini, Renato Bassan, Thomas Lion

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Downregulation of CD73 associates with T cell exhaustion in AML patients

Yaxian Kong, Bei Jia, Chenchen Zhao, David F. Claxton, Arati Sharma, Charyguly Annageldiyev, Joseph S. Fotos, Hui Zeng, Robert F. Paulson, K. Sandeep Prabhu, Hong Zheng

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Targeting CLL-1 for acute myeloid leukemia therapy

Hongbing Ma, Iyer Swaminathan Padmanabhan, Simrit Parmar, Yuping Gong

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Combination regimens with PD-1/PD-L1 immune checkpoint inhibitors for gastrointestinal malignancies

Dongxu Wang, Jianzhen Lin, Xu Yang, Junyu Long, Yi Bai, Xiaobo Yang, Yilei Mao, Xinting Sang, Samuel Seery, Haitao Zhao

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Ataxia telangiectasia and Rad3-related inhibitors and cancer therapy: where we stand

Lin Mei, Junran Zhang, Kai He, Jingsong Zhang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Fludarabine-treosulfan compared to thiotepa-busulfan-fludarabine or FLAMSA as conditioning regimen for patients with primary refractory or relapsed acute myeloid leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT)

Francesco Saraceni, Myriam Labopin, Arne Brecht, Nicolaus Kröger, Matthias Eder, Johanna Tischer, Hélène Labussière-Wallet, Hermann Einsele, Dietrich Beelen, Donald Bunjes, Dietger Niederwieser, Tilmann Bochtler, Bipin N. Savani, Mohamad Mohty, Arnon Nagler

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Emerging therapies for non-small cell lung cancer

Chao Zhang, Natasha B. Leighl, Yi-Long Wu, Wen-Zhao Zhong

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Bispecific CD3-HAC carried by E1A-engineered mesenchymal stromal cells against metastatic breast cancer by blocking PD-L1 and activating T cells

Yuanyuan Yang, Xiaolong Zhang, Fangzhen Lin, Mengshang Xiong, Dongmei Fan, Xiangfei Yuan, Yang Lu, Yuewen Song, Yizi Zhang, Mu Hao, Zhou Ye, Yanjun Zhang, Jianxiang Wang, Dongsheng Xiong

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Emerging therapies for small cell lung cancer

Sen Yang, Zhe Zhang, Qiming Wang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Technologies for circulating tumor cell separation from whole blood

Petra Bankó, Sun Young Lee, Viola Nagygyörgy, Miklós Zrínyi, Chang Hoon Chae, Dong Hyu Cho, András Telekes

01.12.2019 | Research | Ausgabe 1/2019 Open Access

2B4 costimulatory domain enhancing cytotoxic ability of anti-CD5 chimeric antigen receptor engineered natural killer cells against T cell malignancies

Yingxi Xu, Qian Liu, Mengjun Zhong, Zhenzhen Wang, Zhaoqi Chen, Yu Zhang, Haiyan Xing, Zheng Tian, Kejing Tang, Xiaolong Liao, Qing Rao, Min Wang, Jianxiang Wang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Progress and challenges in HER2-positive gastroesophageal adenocarcinoma

Dan Zhao, Samuel J. Klempner, Joseph Chao

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia

Yan Liu, Zhiheng Cheng, Yifan Pang, Longzhen Cui, Tingting Qian, Liang Quan, Hongyou Zhao, Jinlong Shi, Xiaoyan Ke, Lin Fu

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Immune cell therapy for hepatocellular carcinoma

Eishiro Mizukoshi, Shuichi Kaneko

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Exosome-mediated communication in the tumor microenvironment contributes to hepatocellular carcinoma development and progression

Qin Wu, Lingyun Zhou, Duoduo Lv, Xia Zhu, Hong Tang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy

Pengfei Zhao, Li Li, Xiaoyue Jiang, Qin Li

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Noncoding RNAs in cancer therapy resistance and targeted drug development

Wen-Tao Wang, Cai Han, Yu-Meng Sun, Tian-Qi Chen, Yue-Qin Chen

01.12.2019 | Research | Ausgabe 1/2019 Open Access

High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer

Wenwu Xiao, Weijie Ma, Sixi Wei, Qianping Li, Ruiwu Liu, Randy P. Carney, Kevin Yang, Joyce Lee, Alan Nyugen, Ken Y. Yoneda, Kit S. Lam, Tianhong Li

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Haploidentical CD19/CD22 bispecific CAR-T cells induced MRD-negative remission in a patient with relapsed and refractory adult B-ALL after haploidentical hematopoietic stem cell transplantation

Hejin Jia, Zhenguang Wang, Yao Wang, Yang Liu, Hanren Dai, Chuan Tong, Yelei Guo, Bo Guo, Dongdong Ti, Xiao Han, Qingming Yang, Zhiqiang Wu, Weidong Han

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Immune checkpoint inhibitors in the treatment of virus-associated cancers

Peipei Gao, Cordelle Lazare, Canhui Cao, Yifan Meng, Ping Wu, Wenhua Zhi, Shitong Lin, Juncheng Wei, Xiaoyuan Huang, Ling Xi, Gang Chen, Junbo Hu, Ding Ma, Peng Wu

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies

Hao Wang, Gurbakhash Kaur, Alexander I. Sankin, Fuxiang Chen, Fangxia Guan, Xingxing Zang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Ilamycin C induces apoptosis and inhibits migration and invasion in triple-negative breast cancer by suppressing IL-6/STAT3 pathway

Qing Xie, Zhijie Yang, Xuanmei Huang, Zikang Zhang, Jiangbin Li, Jianhua Ju, Hua Zhang, Junying Ma

01.12.2019 | Review | Ausgabe 1/2019 Open Access

DLL3: an emerging target in small cell lung cancer

Dwight H. Owen, Michael J. Giffin, Julie M. Bailis, Marie-Anne Damiette Smit, David P. Carbone, Kai He

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Target selection for CAR-T therapy

Jianshu Wei, Xiao Han, Jian Bo, Weidong Han

01.12.2019 | Review | Ausgabe 1/2019 Open Access

MET inhibitors for targeted therapy of EGFR TKI-resistant lung cancer

Qiming Wang, Sen Yang, Kai Wang, Shi-Yong Sun

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Inflammasome inhibitors: promising therapeutic approaches against cancer

Shengchao Xu, Xizhe Li, Yuanqi Liu, Yu Xia, Ruimin Chang, Chunfang Zhang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Prospective target assessment and multimodal prediction of survival for personalized and risk-adapted treatment strategies in multiple myeloma in the GMMG-MM5 multicenter trial

Dirk Hose, Susanne Beck, Hans Salwender, Martina Emde, Uta Bertsch, Christina Kunz, Christoph Scheid, Mathias Hänel, Katja Weisel, Thomas Hielscher, Marc S. Raab, Hartmut Goldschmidt, Anna Jauch, Jérôme Moreaux, Anja Seckinger

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia

Krzysztof Brzezinka, Ekaterina Nevedomskaya, Ralf Lesche, Michael Steckel, Ashley L. Eheim, Andrea Haegebarth, Carlo Stresemann

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Potential immune escape mechanisms underlying the distinct clinical outcome of immune checkpoint blockades in small cell lung cancer

Yaru Tian, Xiaoyang Zhai, Anqin Han, Hui Zhu, Jinming Yu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Leukemia relapse following unmanipulated haploidentical transplantation: a risk factor analysis on behalf of the ALWP of the EBMT

Simona Piemontese, Ariane Boumendil, Myriam Labopin, Christoph Schmid, Fabio Ciceri, William Arcese, Yener Koc, Zafar Gulbas, Johanna Tischer, Benedetto Bruno, Depei Wu, Didier Blaise, Dietrich Beelen, Giuseppe Irrera, Annalisa Ruggeri, Mohamed Houhou, Mohamad Mohty, Arnon Nagler, on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT)

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Engineering switchable and programmable universal CARs for CAR T therapy

Delong Liu, Juanjuan Zhao, Yongping Song

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Glyphosate induces benign monoclonal gammopathy and promotes multiple myeloma progression in mice

Lei Wang, Qipan Deng, Hui Hu, Ming Liu, Zhaojian Gong, Shanshan Zhang, Zijun Y. Xu-Monette, Zhongxin Lu, Ken H. Young, Xiaodong Ma, Yong Li

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Targeting mTOR for cancer therapy

Hui Hua, Qingbin Kong, Hongying Zhang, Jiao Wang, Ting Luo, Yangfu Jiang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Nuclear factor of activated T-cells, NFATC1, governs FLT3ITD-driven hematopoietic stem cell transformation and a poor prognosis in AML

Maria Solovey, Ying Wang, Christian Michel, Klaus H. Metzeler, Tobias Herold, Joachim R. Göthert, Volker Ellenrieder, Elisabeth Hessmann, Stefan Gattenlöhner, Andreas Neubauer, Dinko Pavlinic, Vladimir Benes, Oliver Rupp, Andreas Burchert

01.12.2019 | Rapid communication | Ausgabe 1/2019 Open Access

Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors

Weiping Li, Shiv K. Gupta, Weiguo Han, Ryan A. Kundson, Sara Nelson, Darlene Knutson, Patricia T. Greipp, Sherine F. Elsawa, Eduardo M. Sotomayor, Mamta Gupta

01.12.2019 | Review | Ausgabe 1/2019 Open Access

K+-Cl− cotransporter 1 (KCC1): a housekeeping membrane protein that plays key supplemental roles in hematopoietic and cancer cells

A. P. Garneau, S. Slimani, L. E. Tremblay, M. J. Fiola, A. A. Marcoux, P. Isenring

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Genomic landscape and its correlations with tumor mutational burden, PD-L1 expression, and immune cells infiltration in Chinese lung squamous cell carcinoma

Tao Jiang, Jinpeng Shi, Zhengwei Dong, Likun Hou, Chao Zhao, Xuefei Li, Beibei Mao, Wei Zhu, Xianchao Guo, Henghui Zhang, Ji He, Xiaoxia Chen, Chunxia Su, Shengxiang Ren, Chunyan Wu, Caicun Zhou

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications

Yuxin Lin, Jianxin Xu, Huiyin Lan

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Super-enhancers: critical roles and therapeutic targets in hematologic malignancies

Yunlu Jia, Wee-Joo Chng, Jianbiao Zhou

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Emerging trends in immunotherapy for pediatric sarcomas

Kyle A. Dyson, Brian D. Stover, Adam Grippin, Hector R. Mendez-Gomez, Joanne Lagmay, Duane A. Mitchell, Elias J. Sayour

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancer

Ming-Chuan Hsu, Ya-Li Tsai, Chia-Hsien Lin, Mei-Ren Pan, Yan-Shen Shan, Tsung-Yen Cheng, Skye Hung-Chun Cheng, Li-Tzong Chen, Wen-Chun Hung

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Dual inhibition of IGF-IR and ALK as an effective strategy to eradicate NPM-ALK+ T-cell lymphoma

Bhawana George, Suraj Konnath George, Wenyu Shi, Abedul Haque, Ping Shi, Ghazaleh Eskandari, Magnus Axelson, Olle Larsson, Ahmed O. Kaseb, Hesham M. Amin

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The long noncoding RNA H19 promotes tamoxifen resistance in breast cancer via autophagy

Ji Wang, Shuduo Xie, Jingjing Yang, Hanchu Xiong, Yunlu Jia, Yulu Zhou, Yongxia Chen, Xiaogang Ying, Cong Chen, Chenyang Ye, Linbo Wang, Jichun Zhou

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Novel and emerging therapies for B cell lymphoma

Sabarish Ayyappan, Kami Maddocks

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: High-affinity peptide ligand LXY30 for targeting α3β1 integrin in non-small cell lung cancer

Wenwu Xiao, Weijie Ma, Sixi Wei, Qianping Li, Ruiwu Liu, Randy P. Carney, Kevin Yang, Joyce Lee, Alan Nyugen, Ken Y. Yoneda, Kit S. Lam, Tianhong Li

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment

Xinyu Tian, Han Shen, Zhiyang Li, Tingting Wang, Shengjun Wang

01.12.2019 | Letter to the Editor | Ausgabe 1/2019 Open Access

CD33 splice site genotype was not associated with outcomes of patients receiving the anti-CD33 drug conjugate SGN-CD33A

Michele Stanchina, Alessandro Pastore, Sean Devlin, Christopher Famulare, Eytan Stein, Justin Taylor

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

Tongyan Liu, Chencheng Han, Siwei Wang, Panqi Fang, Zhifei Ma, Lin Xu, Rong Yin

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Who is the best haploidentical donor for acquired severe aplastic anemia? Experience from a multicenter study

Lan-Ping Xu, Shun-Qing Wang, Yan-Ru Ma, Su-Jun Gao, Yi-Fei Cheng, Yuan-Yuan Zhang, Wen-Jian Mo, Xiao-Dong Mo, Yu-Ping Zhang, Chen-Hua Yan, Yu-Hong Chen, Ming Zhou, Yu Wang, Xiao-Hui Zhang, Kai-Yan Liu, Xiao-Jun Huang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Low-dose post-transplant cyclophosphamide and anti-thymocyte globulin as an effective strategy for GVHD prevention in haploidentical patients

Yu Wang, De-Pei Wu, Qi-Fa Liu, Lan-Ping Xu, Kai-Yan Liu, Xiao-Hui Zhang, Wen-Jing Yu, Yang Xu, Fen Huang, Xiao-Jun Huang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Emerging therapeutic agents for genitourinary cancers

Kevin Zarrabi, Azzam Paroya, Shenhong Wu

01.12.2019 | Review | Ausgabe 1/2019 Open Access

CircRNAs in cancer metabolism: a review

Tao Yu, Yanfen Wang, Yu Fan, Na Fang, Tongshan Wang, Tongpeng Xu, Yongqian Shu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis

Qian Hua, Mingming Jin, Baoming Mi, Fei Xu, Tian Li, Li Zhao, Jianjun Liu, Gang Huang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Immune checkpoint inhibitors of PD-L1 as cancer therapeutics

Akintunde Akinleye, Zoaib Rasool

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Tumor neoantigens: from basic research to clinical applications

Tao Jiang, Tao Shi, Henghui Zhang, Jie Hu, Yuanlin Song, Jia Wei, Shengxiang Ren, Caicun Zhou

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Antibody-drug conjugates in clinical trials for lymphoid malignancies and multiple myeloma

Bo Yu, Delong Liu

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Cancer-associated adipocytes: key players in breast cancer progression

Qi Wu, Bei Li, Zhiyu Li, Juanjuan Li, Si Sun, Shengrong Sun

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Incidence and death in 29 cancer groups in 2017 and trend analysis from 1990 to 2017 from the Global Burden of Disease Study

Longfei Lin, Lei Yan, Yuling Liu, Fang Yuan, Hui Li, Jian Ni

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Long noncoding RNA GSTM3TV2 upregulates LAT2 and OLR1 by competitively sponging let-7 to promote gemcitabine resistance in pancreatic cancer

Guangbing Xiong, Chang Liu, Gang Yang, Mengyu Feng, Jianwei Xu, Fangyu Zhao, Lei You, Li Zhou, Lianfang Zheng, Ya Hu, Xiaowo Wang, Taiping Zhang, Yupei Zhao

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Prospects for combining immune checkpoint blockade with PARP inhibition

Anping Li, Ming Yi, Shuang Qin, Qian Chu, Suxia Luo, Kongming Wu

01.12.2019 | Review | Ausgabe 1/2019 Open Access

TCR-like antibodies in cancer immunotherapy

Qinghua He, Zhaoyu Liu, Zhihua Liu, Yuxiong Lai, Xinke Zhou, Jinsheng Weng

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Recent drug approvals for acute myeloid leukemia

Catherine Lai, Kimberley Doucette, Kelly Norsworthy

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Heterogeneity of cancer-associated fibroblasts and roles in the progression, prognosis, and therapy of hepatocellular carcinoma

Zeli Yin, Chengyong Dong, Keqiu Jiang, Zhe Xu, Rui Li, Kun Guo, Shujuan Shao, Liming Wang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

APRIL and BAFF: novel biomarkers for central nervous system lymphoma

Matthias Mulazzani, Marion Huber, Sabine Borchard, Sigrid Langer, Barbara Angele, Elisabeth Schuh, Edgar Meinl, Martin Dreyling, Tobias Birnbaum, Andreas Straube, Uwe Koedel, Louisa von Baumgarten

01.12.2019 | Research | Ausgabe 1/2019 Open Access

circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression

Wei Huang, Ke Fang, Tian-Qi Chen, Zhan-Cheng Zeng, Yu-Meng Sun, Cai Han, Lin-Yu Sun, Zhen-Hua Chen, Qian-Qian Yang, Qi Pan, Xue-Qun Luo, Wen-Tao Wang, Yue-Qin Chen

01.12.2019 | Research | Ausgabe 1/2019 Open Access

RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia

Rabindranath Bera, Ming-Chun Chiu, Ying-Jung Huang, Tung-Huei Lin, Ming-Chung Kuo, Lee-Yung Shih

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Myeloid-derived suppressor cells in hematological malignancies: friends or foes

Meng Lv, Ke Wang, Xiao-jun Huang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

MAGE-A1 in lung adenocarcinoma as a promising target of chimeric antigen receptor T cells

Yuan Mao, Weifei Fan, Hao Hu, Louqian Zhang, Jerod Michel, Yaqin Wu, Jun Wang, Lizhou Jia, Xiaojun Tang, Li Xu, Yan Chen, Jin Zhu, Zhenqing Feng, Lin Xu, Rong Yin, Qi Tang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Global, regional, and national burden of Hodgkin lymphoma from 1990 to 2017: estimates from the 2017 Global Burden of Disease study

Linghui Zhou, Yujiao Deng, Na Li, Yi Zheng, Tian Tian, Zhen Zhai, Si Yang, Qian Hao, Ying Wu, Dingli Song, Dai Zhang, Jun Lyu, Zhijun Dai

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Measurable residual disease at myeloablative allogeneic transplantation in adults with acute lymphoblastic leukemia: a retrospective registry study on 2780 patients from the acute leukemia working party of the EBMT

Jiří Pavlů, Myriam Labopin, Riitta Niittyvuopio, Gerard Socié, Ibrahim Yakoub-Agha, Depei Wu, Peter Remenyi, Jakob Passweg, Dietrich W. Beelen, Mahmoud Aljurf, Nicolaus Kröger, Hélène Labussière-Wallet, Zinaida Perić, Sebastian Giebel, Arnon Nagler, Mohamad Mohty

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells

Lufeng Zheng, Qianqian Guo, Chenxi Xiang, Shijia Liu, Yuzhang Jiang, Lanlan Gao, Haiwei Ni, Ting Wang, Qiong Zhao, Hai Liu, Yingying Xing, Yaohui Wang, Xiaoman Li, Tao Xi

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Emerging agents and regimens for hepatocellular carcinoma

Xiao-Dong Zhu, Hui-Chuan Sun

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Immunotherapy in HER2-positive breast cancer: state of the art and future perspectives

E. Krasniqi, G. Barchiesi, L. Pizzuti, M. Mazzotta, A. Venuti, M. Maugeri-Saccà, G. Sanguineti, G. Massimiani, D. Sergi, S. Carpano, P. Marchetti, S. Tomao, T. Gamucci, R. De Maria, F. Tomao, C. Natoli, N. Tinari, G. Ciliberto, M. Barba, P. Vici

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Higher matrix stiffness as an independent initiator triggers epithelial-mesenchymal transition and facilitates HCC metastasis

Yinying Dong, Qiongdan Zheng, Zhiming Wang, Xiahui Lin, Yang You, Sifan Wu, Yaohui Wang, Chao Hu, Xiaoying Xie, Jie Chen, Dongmei Gao, Yan Zhao, Weizhong Wu, Yinkun Liu, Zhenggang Ren, Rongxin Chen, Jiefeng Cui

01.12.2019 | Editorial | Ausgabe 1/2019 Open Access

CAR-T “the living drugs”, immune checkpoint inhibitors, and precision medicine: a new era of cancer therapy

Delong Liu

01.12.2019 | Letter to the Editor | Ausgabe 1/2019 Open Access

Genetic dynamics in untreated CLL patients with either stable or progressive disease: a longitudinal study

Alice Ramassone, Andrea D’Argenio, Angelo Veronese, Alessio Basti, Shimaa Hassan AbdelAziz Soliman, Stefano Volinia, Cristian Bassi, Sara Pagotto, Manuela Ferracin, Laura Lupini, Elena Saccenti, Veronica Balatti, Felice Pepe, Laura Z. Rassenti, Idanna Innocenti, Francesco Autore, Laura Marzetti, Renato Mariani-Costantini, Thomas J. Kipps, Massimo Negrini, Luca Laurenti, Rosa Visone

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Burden of lymphoma in China, 2006–2016: an analysis of the Global Burden of Disease Study 2016

Weiping Liu, Jiangmei Liu, Yuqin Song, Xinying Zeng, Xiaopei Wang, Lan Mi, Cai Cai, Lijun Wang, Jun Ma, Jun Zhu, Union for China Leukemia Investigators of the Chinese Society of Clinical Oncology, Union for China Lymphoma Investigators of the Chinese Society of Clinical Oncology

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Expression of Concern to: Identifying and targeting cancer stem cells in leiomyosarcoma: prognostic impact and role to overcome secondary resistance to PI3K/mTOR inhibition

Benjamin Fourneaux, Aurélien Bourdon, Bérengère Dadone, Carlo Lucchesi, Scott R. Daigle, Elodie Richard, Audrey Laroche-Clary, François Le Loarer, Antoine Italiano

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: A novel generation 1928zT2 CAR T cells induce remission in extramedullary relapse of acute lymphoblastic leukemia

Jianyu Weng, Peilong Lai, Le Qin, Yunxin Lai, Zhiwu Jiang, Chenwei Luo, Xin Huang, Suijing Wu, Dan Shao, Chengxin Deng, Lisi Huang, Zesheng Lu, Maohua Zhou, Lingji Zeng, Dongmei Chen, Yulian Wang, Xiaomei Chen, Suxia Geng, Robert Weinkove, Zhaoyang Tang, Chang He, Peng Li, Xin Du

01.12.2019 | Review | Ausgabe 1/2019 Open Access

EZH2 abnormalities in lymphoid malignancies: underlying mechanisms and therapeutic implications

Boheng Li, Wee-Joo Chng

01.12.2019 | Rapid communication | Ausgabe 1/2019 Open Access

Simultaneous targeting of XPO1 and BCL2 as an effective treatment strategy for double-hit lymphoma

Yuanhui Liu, Nancy G. Azizian, Yaling Dou, Lan V. Pham, Yulin Li

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Chimeric antigen receptor T cell therapies for multiple myeloma

Chao Wu, Lina Zhang, Qierra R. Brockman, Fenghuang Zhan, Lijuan Chen

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The interplay between m6A RNA methylation and noncoding RNA in cancer

Shuai Ma, Chen Chen, Xiang Ji, Jinbo Liu, Quanbo Zhou, Guixian Wang, Weitang Yuan, Quancheng Kan, Zhenqiang Sun

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: miR-195-5p/NOTCH2-mediated EMT modulates IL-4 secretion in colorectal cancer to affect M2-like TAM polarization

Xiaobin Lin, Shuyi Wang, Min Sun, Chunxiao Zhang, Chen Wei, Chaogang Yang, Rongzhang Dou, Qing Liu, Bin Xiong

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The balance between mitotic death and mitotic slippage in acute leukemia: a new therapeutic window?

Andrea Ghelli Luserna di Rorà, Giovanni Martinelli, Giorgia Simonetti

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer

Yu Pan, Fengchun Lu, Qinglin Fei, Xingxing Yu, Ping Xiong, Xunbin Yu, Yuan Dang, Zelin Hou, Wenji Lin, Xianchao Lin, Zheyang Zhang, Minggui Pan, Heguang Huang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment

Li Yang, Aitian Li, Qingyang Lei, Yi Zhang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Delivery strategies of cancer immunotherapy: recent advances and future perspectives

Zhongwei Zhao, Liyun Zheng, Weiqian Chen, Wei Weng, Jingjing Song, Jiansong Ji

01.12.2019 | Letter to the Editor | Ausgabe 1/2019 Open Access

Targeting glycosylation of PD-1 to enhance CAR-T cell cytotoxicity

Xiaojuan Shi, Daiqun Zhang, Feng Li, Zhen Zhang, Shumin Wang, Yujing Xuan, Yu Ping, Yi Zhang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy

Xiao Han, Yao Wang, Jianshu Wei, Weidong Han

01.12.2019 | Review | Ausgabe 1/2019 Open Access

LSD1/KDM1A inhibitors in clinical trials: advances and prospects

Yuan Fang, Guochao Liao, Bin Yu

01.12.2019 | Short report | Ausgabe 1/2019 Open Access

Clinical correlates of blood-derived circulating tumor DNA in pancreatic cancer

Hitendra Patel, Ryosuke Okamura, Paul Fanta, Charmi Patel, Richard B. Lanman, Victoria M. Raymond, Shumei Kato, Razelle Kurzrock

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Next-generation sequencing for BCR-ABL1 kinase domain mutation testing in patients with chronic myeloid leukemia: a position paper

Simona Soverini, Elisabetta Abruzzese, Monica Bocchia, Massimiliano Bonifacio, Sara Galimberti, Antonella Gozzini, Alessandra Iurlo, Luigiana Luciano, Patrizia Pregno, Gianantonio Rosti, Giuseppe Saglio, Fabio Stagno, Mario Tiribelli, Paolo Vigneri, Giovanni Barosi, Massimo Breccia

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Simultaneously inactivating Src and AKT by saracatinib/capivasertib co-delivery nanoparticles to improve the efficacy of anti-Src therapy in head and neck squamous cell carcinoma

Liwei Lang, Chloe Shay, Xiangdong Zhao, Yuanping Xiong, Xuli Wang, Yong Teng

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Tumorigenesis, diagnosis, and therapeutic potential of exosomes in liver cancer

Hongbo Wang, Zaiming Lu, Xiangxuan Zhao

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Emerging insights of tumor heterogeneity and drug resistance mechanisms in lung cancer targeted therapy

Zuan-Fu Lim, Patrick C. Ma

01.12.2019 | Research | Ausgabe 1/2019 Open Access

m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis

Dan Jin, Jiwei Guo, Yan Wu, Jing Du, Lijuan Yang, Xiaohong Wang, Weihua Di, Baoguang Hu, Jiajia An, Lingqun Kong, Lei Pan, Guoming Su

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Incidence and mortality of multiple myeloma in China, 2006–2016: an analysis of the Global Burden of Disease Study 2016

Jiangmei Liu, Weiping Liu, Lan Mi, Xinying Zeng, Cai Cai, Jun Ma, Lijun Wang, Union for China Lymphoma Investigators of the Chinese Society of Clinical Oncology, Union for China Leukemia Investigators of the Chinese Society of Clinical Oncology

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Endothelial-mesenchymal transition harnesses HSP90α-secreting M2-macrophages to exacerbate pancreatic ductal adenocarcinoma

Chi-Shuan Fan, Li-Li Chen, Tsu-An Hsu, Chia-Chi Chen, Kee Voon Chua, Chung-Pin Li, Tze-Sing Huang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Targeting cancers through TCR-peptide/MHC interactions

Qinghua He, Xianhan Jiang, Xinke Zhou, Jinsheng Weng

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Global burden of breast cancer and attributable risk factors in 195 countries and territories, from 1990 to 2017: results from the Global Burden of Disease Study 2017

Na Li, Yujiao Deng, Linghui Zhou, Tian Tian, Si Yang, Ying Wu, Yi Zheng, Zhen Zhai, Qian Hao, Dingli Song, Dai Zhang, Huafeng Kang, Zhijun Dai

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Targeting T cell malignancies using CAR-based immunotherapy: challenges and potential solutions

Lauren C. Fleischer, H. Trent Spencer, Sunil S. Raikar

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Emerging organoid models: leaping forward in cancer research

Han Fan, Utkan Demirci, Pu Chen

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells

Kai Zhao, Yuxin Zhou, Chen Qiao, Ting Ni, Zhiyu Li, Xiaotang Wang, Qinglong Guo, Na Lu, Libin Wei

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway

Kosuke Ogawa, Qiushi Lin, Le Li, Xuewei Bai, Xuesong Chen, Hua Chen, Rui Kong, Yongwei Wang, Hong Zhu, Fuliang He, Qinggang Xu, Lianxin Liu, Min Li, Songhua Zhang, Katsuya Nagaoka, Rolf Carlson, Howard Safran, Kevin Charpentier, Bei Sun, Jack Wands, Xiaoqun Dong

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Long-term overall survival and prognostic score predicting survival: the IMPACT study in precision medicine

Apostolia-Maria Tsimberidou, David S. Hong, Jennifer J. Wheler, Gerald S. Falchook, Filip Janku, Aung Naing, Siqing Fu, Sarina Piha-Paul, Carrie Cartwright, Russell R. Broaddus, Graciela M. Nogueras Gonzalez, Patrick Hwu, Razelle Kurzrock

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