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Zeitschrift

Journal of Translational Medicine

Journal of Translational Medicine 1/2017

Ausgabe 1/2017

Inhaltsverzeichnis ( 265 Artikel )

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response

Darin K. Edwards, Edith Jasny, Heesik Yoon, Nigel Horscroft, Brian Schanen, Tanya Geter, Mariola Fotin-Mleczek, Benjamin Petsch, Vaughan Wittman

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers—results of a dose escalation trial

Darja Karpova, Susanne Bräuninger, Eliza Wiercinska, Ariane Krämer, Belinda Stock, Jochen Graff, Hans Martin, Achim Wach, Christophe Escot, Garry Douglas, Barbara Romagnoli, Eric Chevalier, Klaus Dembowski, Leon Hooftman, Halvard Bonig

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Two differentially structured collagen scaffolds for potential urinary bladder augmentation: proof of concept study in a Göttingen minipig model

Dorothea Leonhäuser, Katja Stollenwerk, Volker Seifarth, Isabella M. Zraik, Michael Vogt, Pramod K. Srinivasan, Rene H. Tolba, Joachim O. Grosse

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Endothelial microparticles are increased in congenital heart diseases and contribute to endothelial dysfunction

Ze-Bang Lin, Hong-Bo Ci, Yan Li, Tian-Pu Cheng, Dong-Hong Liu, Yan-Sheng Wang, Jun Xu, Hao-Xiang Yuan, Hua-Ming Li, Jing Chen, Li Zhou, Zhi-Ping Wang, Xi Zhang, Zhi-Jun Ou, Jing-Song Ou

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Placental mitochondrial DNA and CYP1A1 gene methylation as molecular signatures for tobacco smoke exposure in pregnant women and the relevance for birth weight

Bram G. Janssen, Wilfried Gyselaers, Hyang-Min Byun, Harry A. Roels, Ann Cuypers, Andrea A. Baccarelli, Tim S. Nawrot

01.12.2017 | Methodology | Ausgabe 1/2017 Open Access

Advances in rare cell isolation: an optimization and evaluation study

Stefan Schreier, Piamsiri Sawaisorn, Rachanee Udomsangpetch, Wannapong Triampo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Prediction of anti-inflammatory proteins/peptides: an insilico approach

Sudheer Gupta, Ashok K. Sharma, Vibhuti Shastri, Midhun K. Madhu, Vineet K. Sharma

01.12.2017 | Research | Ausgabe 1/2017 Open Access

B cell repertoires in HLA-sensitized kidney transplant candidates undergoing desensitization therapy

John F. Beausang, H. Christina Fan, Rene Sit, Maria U. Hutchins, Kshama Jirage, Rachael Curtis, Edward Hutchins, Stephen R. Quake, Julie M. Yabu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Study of the microRNA expression profile of foreskin derived mesenchymal stromal cells following inflammation priming

Hussein Fayyad-Kazan, Mohammad Fayyad-Kazan, Bassam Badran, Dominique Bron, Laurence Lagneaux, Mehdi Najar

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Inhibitory effects of serum from sepsis patients on epithelial cell migration in vitro: a case control study

Henna Jaurila, Vesa Koivukangas, Marjo Koskela, Fiia Gäddnäs, Sirpa Salo, Johanna Korvala, Maija Risteli, Toni Karhu, Karl-Heinz Herzig, Tuula Salo, Tero I. Ala-Kokko

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Effects of the intradiscal implantation of stromal vascular fraction plus platelet rich plasma in patients with degenerative disc disease

Kristin Comella, Robert Silbert, Michelle Parlo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Antibiotics-induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility

Xiaolong Ge, Chao Ding, Wei Zhao, Lizhi Xu, Hongliang Tian, Jianfeng Gong, Minsheng Zhu, Jieshou Li, Ning Li

01.12.2017 | Methodology | Ausgabe 1/2017 Open Access

Lymph node pooling: a feasible and efficient method of lymph node molecular staging in colorectal carcinoma

Natalia Rakislova, Carla Montironi, Iban Aldecoa, Eva Fernandez, Josep Antoni Bombi, Mireya Jimeno, Francesc Balaguer, Maria Pellise, Antoni Castells, Miriam Cuatrecasas

01.12.2017 | Methodology | Ausgabe 1/2017 Open Access

Realising stratified psychiatry using multidimensional signatures and trajectories

Dan W. Joyce, Angie A. Kehagia, Derek K. Tracy, Jessica Proctor, Sukhwinder S. Shergill

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Neuroregenerative potential of intravenous G-CSF and autologous peripheral blood stem cells in children with cerebral palsy: a randomized, double-blind, cross-over study

Wee-Jin Rah, Young-Ho Lee, Jin-Hwa Moon, Hyun-Ju Jun, Hye-Ryeong Kang, Hani Koh, Hye Jung Eom, Ji Young Lee, Young Jun Lee, Ji Young Kim, Yun-Young Choi, Kyeongil Park, Mi Jung Kim, Seung-Hyun Kim

01.12.2017 | Commentary | Ausgabe 1/2017 Open Access

Genetic instability and increased mutational load: which diagnostic tool best direct patients with cancer to immunotherapy?

Giuseppe Palmieri, Maria Colombino, Antonio Cossu, Antonio Marchetti, Gerardo Botti, Paolo A. Ascierto

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Near infrared fluorescent imaging of brain tumor with IR780 dye incorporated phospholipid nanoparticles

Shihong Li, Jennifer Johnson, Anderson Peck, Qian Xie

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Inhibitory effect of a novel peptide, H-RN, on keratitis induced by LPS or poly(I:C) in vitro and in vivo via suppressing NF-κB and MAPK activation

Shaopin Zhu, Xun Xu, Lili Wang, Li Su, Qing Gu, Fang Wei, Kun Liu

01.12.2017 | Protocol | Ausgabe 1/2017 Open Access

A phase II trial of stereotactic body radiotherapy with concurrent anti-PD1 treatment in metastatic melanoma: evaluation of clinical and immunologic response

Katrien De Wolf, Vibeke Kruse, Nora Sundahl, Mireille van Gele, Ines Chevolet, Reinhart Speeckaert, Lieve Brochez, Piet Ost

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Towards standardization of next-generation sequencing of FFPE samples for clinical oncology: intrinsic obstacles and possible solutions

Maxim Ivanov, Konstantin Laktionov, Valery Breder, Polina Chernenko, Ekaterina Novikova, Ekaterina Telysheva, Sergey Musienko, Ancha Baranova, Vladislav Mileyko

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Microwave ablation combined with OK-432 induces Th1-type response and specific antitumor immunity in a murine model of breast cancer

Li Li, Wei Wang, Hong Pan, Ge Ma, Xinyi Shi, Hui Xie, Xiaoan Liu, Qiang Ding, Wenbin Zhou, Shui Wang

01.12.2017 | Editorial | Ausgabe 1/2017 Open Access

Opening editorial

Seah H. Lim

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Novel neuro-audiological findings and further evidence for TWNK involvement in Perrault syndrome

Monika Ołdak, Dominika Oziębło, Agnieszka Pollak, Iwona Stępniak, Michal Lazniewski, Urszula Lechowicz, Krzysztof Kochanek, Mariusz Furmanek, Grażyna Tacikowska, Dariusz Plewczynski, Tomasz Wolak, Rafał Płoski, Henryk Skarżyński

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Individualized analysis reveals CpG sites with methylation aberrations in almost all lung adenocarcinoma tissues

Haidan Yan, Qingzhou Guan, Jun He, Yunqing Lin, Juan Zhang, Hongdong Li, Huaping Liu, Yunyan Gu, Zheng Guo, Fei He

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Optimized creation of glioblastoma patient derived xenografts for use in preclinical studies

Doreen William, Christina Susanne Mullins, Björn Schneider, Andrea Orthmann, Nora Lamp, Mathias Krohn, Annika Hoffmann, Carl-Friedrich Classen, Michael Linnebacher

01.12.2017 | Research | Ausgabe 1/2017 Open Access

HIF-1α inhibitor echinomycin reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect

Yushi Yao, Lei Wang, Jihao Zhou, Xinyou Zhang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis

Fulvio Santacatterina, María Sánchez-Aragó, Marc Catalán-García, Glòria Garrabou, Cristina Nuñez de Arenas, Josep M. Grau, Francesc Cardellach, José M. Cuezva

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Association of osteopontin with specific prognostic factors and survival in adjuvant breast cancer trials of the Hellenic Cooperative Oncology Group

Amanda Psyrri, Konstantine T. Kalogeras, Ralph M. Wirtz, George Kouvatseas, Georgia Karayannopoulou, Anna Goussia, Flora Zagouri, Elke Veltrup, Eleni Timotheadou, Helen Gogas, Angelos Koutras, Georgios Lazaridis, Christos Christodoulou, George Pentheroudakis, Panagiota Economopoulou, Apostolos Laskarakis, Petroula Arapantoni-Dadioti, Anna Batistatou, Maria Sotiropoulou, Gerasimos Aravantinos, Pavlos Papakostas, Paris Kosmidis, Dimitrios Pectasides, George Fountzilas

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1

Su-Jin Moon, Eun-Kyung Kim, Joo Yeon Jhun, Hee Jin Lee, Weon Sun Lee, Sang-Hi Park, Mi-La Cho, Jun-Ki Min

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Tacrolimus in the prevention of adverse pregnancy outcomes and diabetes-associated embryopathies in obese and diabetic mice

Ahmad J. H. Albaghdadi, Melanie A. Hewitt, Samantha M. Putos, Michael Wells, Terence R. S. Ozolinš, Frederick W. K. Kan

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A novel cytoprotective peptide protects mesenchymal stem cells against mitochondrial dysfunction and apoptosis induced by starvation via Nrf2/Sirt3/FoxO3a pathway

Shuo Wang, Chao Zhang, Sidikejiang Niyazi, Long Zheng, Jiawei Li, Weitao Zhang, Ming Xu, Ruiming Rong, Cheng Yang, Tongyu Zhu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Bone Morphogenetic Proteins and myostatin pathways: key mediator of human sarcopenia

Manuel Scimeca, Eleonora Piccirilli, Francesca Mastrangeli, Cecilia Rao, Maurizio Feola, Augusto Orlandi, Elena Gasbarra, Elena Bonanno, Umberto Tarantino

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Exendin-4 in combination with adipose-derived stem cells promotes angiogenesis and improves diabetic wound healing

Eunhui Seo, Jae Soo Lim, Jin-Bum Jun, Woohyuk Choi, In-Sun Hong, Hee-Sook Jun

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity

Kely Campos Navegantes, Rafaelli de Souza Gomes, Priscilla Aparecida Tártari Pereira, Paula Giselle Czaikoski, Carolina Heitmann Mares Azevedo, Marta Chagas Monteiro

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Distinct patterns and prognostic values of tumor-infiltrating macrophages in hepatocellular carcinoma and gastric cancer

Jin-Qing Li, Xing-Juan Yu, Yong-Chun Wang, Li-Yun Huang, Chao-Qun Liu, Limin Zheng, Yu-jing Fang, Jing Xu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

TCD4pos lymphocytosis in rheumatoid and psoriatic arthritis patients following TNFα blocking agents

Andrea Picchianti Diamanti, Bruno Laganà, Maria Christina Cox, Emanuela Pilozzi, Rachele Amodeo, Maurizio Bove, Milica Markovic, Roberta Di Rosa, Simonetta Salemi, Maria Laura Sorgi, Maria Manuela Rosado, Raffaele D’Amelio

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Melanoma antigen-specific effector T cell cytokine secretion patterns in patients treated with ipilimumab

Yana G. Najjar, Fei Ding, Yan Lin, Robert VanderWeele, Lisa H. Butterfield, Ahmad A. Tarhini

01.12.2017 | Methodology | Ausgabe 1/2017 Open Access

Generation of donor-specific Tr1 cells to be used after kidney transplantation and definition of the timing of their in vivo infusion in the presence of immunosuppression

Bechara Mfarrej, Eleonora Tresoldi, Angela Stabilini, Alessia Paganelli, Rossana Caldara, Antonio Secchi, Manuela Battaglia

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Identification of miRNA-mRNA crosstalk in CD4+ T cells during HIV-1 infection by integrating transcriptome analyses

Qibin Liao, Jin Wang, Zenglin Pei, Jianqing Xu, Xiaoyan Zhang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

IRE1α-XBP1 pathway promotes melanoma progression by regulating IL-6/STAT3 signaling

Cheng Chen, Xuejun Zhang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Assessment of plasma chitotriosidase activity, CCL18/PARC concentration and NP-C suspicion index in the diagnosis of Niemann-Pick disease type C: a prospective observational study

Isabel De Castro-Orós, Pilar Irún, Jorge Javier Cebolla, Victor Rodriguez-Sureda, Miguel Mallén, María Jesús Pueyo, Pilar Mozas, Carmen Dominguez, Miguel Pocoví, on behalf of the Spanish NP-C Group

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Circulating tumor cells capture disease evolution in advanced prostate cancer

Justin Lack, Marc Gillard, Maggie Cam, Gladell P. Paner, David J. VanderWeele

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study

Sarah H. White, Mary M. McDermott, Robert L. Sufit, Kate Kosmac, Alex W. Bugg, Marta Gonzalez-Freire, Luigi Ferrucci, Lu Tian, Lihui Zhao, Ying Gao, Melina R. Kibbe, Michael H. Criqui, Christiaan Leeuwenburgh, Charlotte A. Peterson

01.12.2017 | Research | Ausgabe 1/2017 Open Access

COX-2 expression positively correlates with PD-L1 expression in human melanoma cells

Gerardo Botti, Federica Fratangelo, Margherita Cerrone, Giuseppina Liguori, Monica Cantile, Anna Maria Anniciello, Stefania Scala, Crescenzo D’Alterio, Chiara Trimarco, Angela Ianaro, Giuseppe Cirino, Corrado Caracò, Maria Colombino, Giuseppe Palmieri, Stefano Pepe, Paolo Antonio Ascierto, Francesco Sabbatino, Giosuè Scognamiglio

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Imatinib increases oxygen delivery in extracellular matrix-rich but not in matrix-poor experimental carcinoma

Mikhail Burmakin, Tijs van Wieringen, P. Olof Olsson, Linda Stuhr, Aive Åhgren, Carl-Henrik Heldin, Rolf K. Reed, Kristofer Rubin, Carina Hellberg

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Comparative analysis of curative effect of bone marrow mesenchymal stem cell and bone marrow mononuclear cell transplantation for spastic cerebral palsy

Xuebin Liu, Xiaojun Fu, Guanghui Dai, Xiaodong Wang, Zan Zhang, Hongbin Cheng, Pei Zheng, Yihua An

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Therapeutic strategies for cell-based neovascularization in critical limb ischemia

Makoto Samura, Tohru Hosoyama, Yuriko Takeuchi, Koji Ueno, Noriyasu Morikage, Kimikazu Hamano

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A rabbit model for experimental alveolar cleft grafting

Mohammad Kamal, Lars Andersson, Rene Tolba, Alexander Bartella, Felix Gremse, Frank Hölzle, Peter Kessler, Bernd Lethaus

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Heterogeneity of Toll-like receptor 9 signaling in B cell malignancies and its potential therapeutic application

Ling Bai, Wei Chen, Jingtao Chen, Wei Li, Lei Zhou, Chao Niu, Wei Han, Jiuwei Cui

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Luteolin suppresses gastric cancer progression by reversing epithelial-mesenchymal transition via suppression of the Notch signaling pathway

Ming-de Zang, Lei Hu, Zhi-yuan Fan, He-xiao Wang, Zheng-lun Zhu, Shu Cao, Xiong-yan Wu, Jian-fang Li, Li-ping Su, Chen Li, Zheng-gang Zhu, Min Yan, Bing-ya Liu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Stability of pro- and anti-inflammatory immune biomarkers for human cohort studies

C. Graham, R. Chooniedass, W. P. Stefura, L. Lotoski, P. Lopez, A. D. Befus, A. B. Becker, K. T. HayGlass

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Endothelial and smooth muscle cells derived from human cardiac explants demonstrate angiogenic potential and suitable for design of cell-containing vascular grafts

I. S. Zakharova, M. K. Zhiven’, Sh. B. Saaya, A. I. Shevchenko, A. M. Smirnova, A. Strunov, A. A. Karpenko, E. A. Pokushalov, L. N. Ivanova, P. I. Makarevich, Y. V. Parfyonova, E. Aboian, S. M. Zakian

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Hyperglycemia enhances arsenic-induced platelet and megakaryocyte activation

Jonathan D. Newman, Christina T. Echagarruga, Yoscar M. Ogando, Emilie Montenont, Yu Chen, Edward A. Fisher, Jeffrey S. Berger

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Non-invasive in vivo imaging of cardiac stem/progenitor cell biodistribution and retention after intracoronary and intramyocardial delivery in a swine model of chronic ischemia reperfusion injury

María Collantes, Beatriz Pelacho, María José García-Velloso, Juán José Gavira, Gloria Abizanda, Itziar Palacios, Luis Rodriguez-Borlado, Virginia Álvarez, Elena Prieto, Margarita Ecay, Eduardo Larequi, Iván Peñuelas, Felipe Prósper

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Aberrant T cell responses in the bone marrow microenvironment of patients with poor graft function after allogeneic hematopoietic stem cell transplantation

Yuan Kong, Yu-Tong Wang, Xie-Na Cao, Yang Song, Yu-Hong Chen, Yu-Qian Sun, Yu Wang, Xiao-Hui Zhang, Lan-Ping Xu, Xiao-Jun Huang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model

Agata Szymiczek, Sandra Pastorino, David Larson, Mika Tanji, Laura Pellegrini, Jiaming Xue, Shuangjing Li, Carlotta Giorgi, Paolo Pinton, Yasutaka Takinishi, Harvey I. Pass, Hideki Furuya, Giovanni Gaudino, Andrea Napolitano, Michele Carbone, Haining Yang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells

David F. Stroncek, Daniel W. Lee, Jiaqiang Ren, Marianna Sabatino, Steven Highfill, Hanh Khuu, Nirali N. Shah, Rosandra N. Kaplan, Terry J. Fry, Crystal L. Mackall

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: a cross sectional study

Brett A. Lidbury, Badia Kita, Donald P. Lewis, Susan Hayward, Helen Ludlow, Mark P. Hedger, David M. de Kretser

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Veliparib in combination with radiotherapy for the treatment of MGMT unmethylated glioblastoma

Toni Rose Jue, Kyoko Nozue, Ashleigh J. Lester, Swapna Joshi, Lisette B. W. Schroder, Shane P. Whittaker, Sheri Nixdorf, Robert W. Rapkins, Mustafa Khasraw, Kerrie L. McDonald

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Epidermal growth factor receptor and epididymis invasion as prognostic biomarkers in clinical stage I testicular germ cell tumours

Miguel F. Sanmamed, E. Esteban, E. Uriol, R. Zarate, M. Capelan, C. Muriel, G. Crespo, J. P. Berros, P. Pardo-Coto, Q. Perez, C. Alvarez-Fernández, P. Jiménez Fonseca, M. Luque, A. Astudillo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Urinary collagen degradation products as early markers of progressive renal fibrosis

Ryanne S. Hijmans, Daniel Guldager Kring Rasmussen, Saleh Yazdani, Gerjan Navis, Harry van Goor, Morten Asser Karsdal, Federica Genovese, Jacob van den Born

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Dynamic and specific immune responses against multiple tumor antigens were elicited in patients with hepatocellular carcinoma after cell-based immunotherapy

Yanyan Han, Yeting Wu, Chou Yang, Jing Huang, Yabing Guo, Li Liu, Ping Chen, Dongyun Wu, Junyun Liu, Jin Li, Xiangjun Zhou, Jinlin Hou

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Myocyte enhancer factor 2D provides a cross-talk between chronic inflammation and lung cancer

Hai-xing Zhu, Lin Shi, Yong Zhang, Yi-chun Zhu, Chun-xue Bai, Xiang-dong Wang, Jie-bai Zhou

01.12.2017 | Research | Ausgabe 1/2017 Open Access

24h-gene variation effect of combined bevacizumab/erlotinib in advanced non-squamous non-small cell lung cancer using exon array blood profiling

Florent Baty, Markus Joerger, Martin Früh, Dirk Klingbiel, Francesco Zappa, Martin Brutsche

01.12.2017 | Research | Ausgabe 1/2017 Open Access

In vivo MRI and ex vivo histological assessment of the cardioprotection induced by ischemic preconditioning, postconditioning and remote conditioning in a closed-chest porcine model of reperfused acute myocardial infarction: importance of microvasculature

Tamás Baranyai, Zoltán Giricz, Zoltán V. Varga, Gábor Koncsos, Dominika Lukovic, András Makkos, Márta Sárközy, Noémi Pávó, András Jakab, Csilla Czimbalmos, Hajnalka Vágó, Zoltán Ruzsa, Levente Tóth, Rita Garamvölgyi, Béla Merkely, Rainer Schulz, Mariann Gyöngyösi, Péter Ferdinandy

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Proteomic analysis of protein purified derivative of Mycobacterium bovis

Sante Roperto, Mariaconcetta Varano, Valeria Russo, Roberta Lucà, Monica Cagiola, Marco Gaspari, Dora Maria Ceccarelli, Giovanni Cuda, Franco Roperto

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Multiple gene variations contributed to congenital heart disease via GATA family transcriptional regulation

Yanyan Qian, Deyong Xiao, Xiao Guo, Hongbo Chen, Lili Hao, Xiaojing Ma, Guoying Huang, Duan Ma, Huijun Wang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Detection of newly produced T and B lymphocytes by digital PCR in blood stored dry on nylon flocked swabs

Marion Vaglio Tessitore, Alessandra Sottini, Aldo M. Roccaro, Claudia Ghidini, Simona Bernardi, Giovanni Martellosio, Federico Serana, Luisa Imberti

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Association of atrial fibrillation susceptibility genes, atrial fibrillation phenotypes and response to catheter ablation: a gene-based analysis of GWAS data

Daniela Husser, Petra Büttner, Laura Ueberham, Borislav Dinov, Philipp Sommer, Arash Arya, Gerhard Hindricks, Andreas Bollmann

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Combination of serum histidine and plasma tryptophan as a potential biomarker to detect clear cell renal cell carcinoma

Hyung-Ok Lee, Robert G. Uzzo, Debra Kister, Warren D. Kruger

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Influence of diet on the gut microbiome and implications for human health

Rasnik K. Singh, Hsin-Wen Chang, Di Yan, Kristina M. Lee, Derya Ucmak, Kirsten Wong, Michael Abrouk, Benjamin Farahnik, Mio Nakamura, Tian Hao Zhu, Tina Bhutani, Wilson Liao

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Partnering with patients in translational oncology research: ethical approach

Marie-France Mamzer, Nathalie Duchange, Sylviane Darquy, Patrice Marvanne, Claude Rambaud, Giovanna Marsico, Catherine Cerisey, Florian Scotté, Anita Burgun, Cécile Badoual, Pierre Laurent-Puig, Christian Hervé

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Levels of hepatic Th17 cells and regulatory T cells upregulated by hepatic stellate cells in advanced HBV-related liver fibrosis

Xiaoyan Li, Yujie Su, Xuefeng Hua, Chan Xie, Jing Liu, Yuehua Huang, Liang Zhou, Min Zhang, Xu Li, Zhiliang Gao

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Specific circulating microRNA signature of bicuspid aortic valve disease

Neus Martínez-Micaelo, Raúl Beltrán-Debón, Isabel Baiges, Marta Faiges, Josep M. Alegret

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The role of vitamin C in the treatment of pain: new insights

Anitra C. Carr, Cate McCall

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Novel trigenic CACNA1C/DES/MYPN mutations in a family of hypertrophic cardiomyopathy with early repolarization and short QT syndrome

Yanhong Chen, Hector Barajas-Martinez, Dongxiao Zhu, Xihui Wang, Chonghao Chen, Ruijuan Zhuang, Jingjing Shi, Xueming Wu, Yijia Tao, Weidong Jin, Xiaoyan Wang, Dan Hu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

A. Schiza, J. Wenthe, S. Mangsbo, E. Eriksson, Anders Nilsson, T. H. Tötterman, A. Loskog, G. Ullenhag

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Partnering with patients in translational oncology research: ethical approach

Marie-France Mamzer, Nathalie Duchange, Sylviane Darquy, Patrice Marvanne, Claude Rambaud, Giovanna Marsico, Catherine Cerisey, Florian Scotté, Anita Burgun, Cécile Badoual, Pierre Laurent-Puig, Christian Hervé

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Preliminary results demonstrating the impact of Mediterranean diet on bone health

Maria Cristina Savanelli, Luigi Barrea, Paolo Emidio Macchia, Silvia Savastano, Andrea Falco, Andrea Renzullo, Elisabetta Scarano, Immacolata Cristina Nettore, Annamaria Colao, Carolina Di Somma

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Electrochemotherapy efficacy evaluation for treatment of locally advanced stage III cutaneous squamous cell carcinoma: a 22-cases retrospective analysis

Gianluca Di Monta, Corrado Caracò, Ester Simeone, Antonio Maria Grimaldi, Ugo Marone, Massimiliano Di Marzo, Vito Vanella, Lucia Festino, Marco Palla, Stefano Mori, Nicola Mozzillo, Paolo Antonio Ascierto

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Longitudinal analysis of serum oxylipin profile as a novel descriptor of the inflammatory response to surgery

Arnaud M. Wolfer, Alasdair J. Scott, Claudia Rueb, Mathieu Gaudin, Ara Darzi, Jeremy K. Nicholson, Elaine Holmes, James M. Kinross

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Cystic fibrosis: current therapeutic targets and future approaches

Misbahuddin M. Rafeeq, Hussam Aly Sayed Murad

01.12.2017 | Research | Ausgabe 1/2017 Open Access

RETRACTED ARTICLE: TREM-1 associated macrophage polarization plays a significant role in inducing insulin resistance in obese population

Saravanan Subramanian, Pradeep K. Pallati, Poonam Sharma, Devendra K. Agrawal, Kalyana C. Nandipati

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Analysis of necroptotic proteins in failing human hearts

Adrián Szobi, Eva Gonçalvesová, Zoltán V. Varga, Przemyslaw Leszek, Mariusz Kuśmierczyk, Michal Hulman, Ján Kyselovič, Péter Ferdinandy, Adriana Adameová

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Apoptosis in ischemic heart disease

Elena Teringova, Petr Tousek

01.12.2017 | Commentary | Ausgabe 1/2017 Open Access

On the brink of extinction: the future of translational physician-scientists in the United States

Hideki Furuya, Dean Brenner, Charles J. Rosser

01.12.2017 | Research | Ausgabe 1/2017 Open Access

MicroRNA-223 demonstrated experimentally in exosome-like vesicles is associated with decreased risk of persistent pain after lumbar disc herniation

Aurora Moen, Daniel Jacobsen, Santosh Phuyal, Anna Legfeldt, Fred Haugen, Cecilie Røe, Johannes Gjerstad

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The production method affects the efficacy of platelet derivatives to expand mesenchymal stromal cells in vitro

Martina Bernardi, Francesco Agostini, Katia Chieregato, Eliana Amati, Cristina Durante, Mario Rassu, Marco Ruggeri, Sabrina Sella, Elisabetta Lombardi, Mario Mazzucato, Giuseppe Astori

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Her2 assessment using quantitative reverse transcriptase polymerase chain reaction reliably identifies Her2 overexpression without amplification in breast cancer cases

Gabriele Zoppoli, Anna Garuti, Gabriella Cirmena, Ludovica Verdun di Cantogno, Cristina Botta, Maurizio Gallo, Domenico Ferraioli, Enrico Carminati, Paola Baccini, Monica Curto, Piero Fregatti, Edoardo Isnaldi, Michela Lia, Roberto Murialdo, Daniele Friedman, Anna Sapino, Alberto Ballestrero

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer

Ina Chen, Lesley Mathews-Greiner, Dandan Li, Abisola Abisoye-Ogunniyan, Satyajit Ray, Yansong Bian, Vivek Shukla, Xiaohu Zhang, Raj Guha, Craig Thomas, Berkley Gryder, Athina Zacharia, Joal D. Beane, Sarangan Ravichandran, Marc Ferrer, Udo Rudloff

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Up-regulated expression of substance P in CD8+ T cells and NK1R on monocytes of atopic dermatitis

Zenan Zhang, Wenjiao Zheng, Hua Xie, Ruonan Chai, Junling Wang, Huiyun Zhang, Shaoheng He

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models

David M. Markusic, Timothy C. Nichols, Elizabeth P. Merricks, Brett Palaschak, Irene Zolotukhin, Damien Marsic, Sergei Zolotukhin, Arun Srivastava, Roland W. Herzog

01.12.2017 | Review | Ausgabe 1/2017 Open Access

A novel role of cellular interactions in vascular calcification

Adham Sameer A. Bardeesi, Jingwei Gao, Kun Zhang, Suntian Yu, Mengchao Wei, Pinming Liu, Hui Huang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Experimental approach to IGF-1 therapy in CCl4-induced acute liver damage in healthy controls and mice with partial IGF-1 deficiency

Luis A. Morales-Garza, Juan E. Puche, Gabriel A. Aguirre, Úrsula Muñoz, Mariano García-Magariño, Rocío G. De la Garza, Inma Castilla-Cortazar

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Role of estrogen receptors and Src signaling in mechanisms of bone metastasis by estrogen receptor positive breast cancers

Jen-Hwey Chiu, Che-Sheng Wen, Jir-You Wang, Chih-Yi Hsu, Yi-Fang Tsai, Shih-Chieh Hung, Ling-Ming Tseng, Yi-Ming Shyr

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Distinct gene expression profiles associated with Notch ligands Delta-like 4 and Jagged1 in plaque material from peripheral artery disease patients: a pilot study

Giorgio Aquila, Cinzia Fortini, Antonio Pannuti, Serena Delbue, Micaela Pannella, Marco Bruno Morelli, Cristiana Caliceti, Fausto Castriota, Monica de Mattei, Alessia Ongaro, Agnese Pellati, Pasquale Ferrante, Lucio Miele, Luigi Tavazzi, Roberto Ferrari, Paola Rizzo, Alberto Cremonesi

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Progress of stem/progenitor cell-based therapy for retinal degeneration

Zhimin Tang, Yi Zhang, Yuyao Wang, Dandan Zhang, Bingqiao Shen, Min Luo, Ping Gu

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Anti-inflammatory effects of H2S during acute bacterial infection: a review

Francesca Benedetti, Sabrina Curreli, Selvi Krishnan, Sergio Davinelli, Fiorenza Cocchi, Giovanni Scapagnini, Robert C. Gallo, Davide Zella

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Novel trigenic CACNA1C/DES/MYPN mutations in a family of hypertrophic cardiomyopathy with early repolarization and short QT syndrome

Yanhong Chen, Hector Barajas‑Martinez, Dongxiao Zhu, Xihui Wang, Chonghao Chen, Ruijuan Zhuang, Jingjing Shi, Xueming Wu, Yijia Tao, Weidong Jin, Xiaoyan Wang, Dan Hu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Whole blood gene expression in adolescent chronic fatigue syndrome: an exploratory cross-sectional study suggesting altered B cell differentiation and survival

Chinh Bkrong Nguyen, Lene Alsøe, Jessica M. Lindvall, Dag Sulheim, Even Fagermoen, Anette Winger, Mari Kaarbø, Hilde Nilsen, Vegard Bruun Wyller

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Analysis of necroptotic proteins in failing human hearts

Adrián Szobi, Eva Gonçalvesová, Zoltán V. Varga, Przemyslaw Leszek, Mariusz Kuśmierczyk, Michal Hulman, Ján Kyselovič, Péter Ferdinandy, Adriana Adameová

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A phase II trial of autologous dendritic cell vaccination and radiochemotherapy following fluorescence-guided surgery in newly diagnosed glioblastoma patients

Susana Inogés, Sonia Tejada, Ascensión López-Díaz de Cerio, Jaime Gállego Pérez-Larraya, Jaime Espinós, Miguel Angel Idoate, Pablo Daniel Domínguez, Reyes García de Eulate, Javier Aristu, Maurizio Bendandi, Fernando Pastor, Marta Alonso, Enrique Andreu, Felipe Prósper Cardoso, Ricardo Díez Valle

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Bovis Bacillus Calmette–Guerin (BCG) infection induces exosomal miRNA release by human macrophages

Shamila D. Alipoor, Esmaeil Mortaz, Payam Tabarsi, Parissa Farnia, Mehdi Mirsaeidi, Johan Garssen, Masoud Movassaghi, Ian M. Adcock

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Correlation of cell-free DNA plasma concentration with severity of non-alcoholic fatty liver disease

Thomas Karlas, Lara Weise, Stephanie Kuhn, Felix Krenzien, Matthias Mehdorn, David Petroff, Nicolas Linder, Alexander Schaudinn, Harald Busse, Volker Keim, Johann Pratschke, Johannes Wiegand, Katrin Splith, Moritz Schmelzle

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Standardization of platelet releasate products for clinical applications in cell therapy: a mathematical approach

Francesco Agostini, Jerry Polesel, Monica Battiston, Elisabetta Lombardi, Stefania Zanolin, Alessandro Da Ponte, Giuseppe Astori, Cristina Durante, Mario Mazzucato

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Effects of the intradiscal implantation of stromal vascular fraction plus platelet rich plasma in patients with degenerative disc disease

Kristin Comella, Robert Silbert, Michelle Parlo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Impact of legumes and plant proteins consumption on cognitive performances in the elderly

Elisa Mazza, Antonietta Fava, Yvelise Ferro, Marta Moraca, Stefania Rotundo, Carmela Colica, Francesco Provenzano, Rosa Terracciano, Marta Greco, Daniela Foti, Elio Gulletta, Diego Russo, Domenico Bosco, Arturo Pujia, Tiziana Montalcini

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications

Ning Ren, Manar Atyah, Wan-Yong Chen, Chen-Hao Zhou

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The spleen in liver cirrhosis: revisiting an old enemy with novel targets

Liang Li, Mubing Duan, Weisan Chen, An Jiang, Xiaoming Li, Jun Yang, Zongfang Li

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Blood metabolomic fingerprint is distinct in healthy coronary and in stenosing or microvascular ischemic heart disease

Martino Deidda, Cristina Piras, Christian Cadeddu Dessalvi, Damiana Congia, Emanuela Locci, Federica Ascedu, Gianfranco De Candia, Mauro Cadeddu, Giorgio Lai, Raimondo Pirisi, Luigi Atzori, Giuseppe Mercuro

01.12.2017 | Commentary | Ausgabe 1/2017 Open Access

The progressive fragmentation of the KIT/PDGFRA wild-type (WT) gastrointestinal stromal tumors (GIST)

Margherita Nannini, Milena Urbini, Annalisa Astolfi, Guido Biasco, Maria A. Pantaleo

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Recognition and treatment of sleep-disordered breathing: an important component of chronic disease management

Peter C. Farrell, Glenn Richards

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Dendritic cells combined with tumor cells and α-galactosylceramide induce a potent, therapeutic and NK-cell dependent antitumor immunity in B cell lymphoma

Laura Escribà-Garcia, Carmen Alvarez-Fernández, Marta Tellez-Gabriel, Jorge Sierra, Javier Briones

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Benefits of local tumor excision and pharyngectomy on the survival of nasopharyngeal carcinoma patients: a retrospective observational study based on SEER database

Jian Sun, Zhongying Huang, Zheyu Hu, Rui Sun

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Differential expression of microRNAs following cardiopulmonary bypass in children with congenital heart diseases

Masood Abu-Halima, Martin Poryo, Nicole Ludwig, Janine Mark, Ina Marsollek, Christian Giebels, Johannes Petersen, Hans-Joachim Schäfers, Ulrich Grundmann, Thomas Pickardt, Andreas Keller, Eckart Meese, Hashim Abdul-Khaliq

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Similar cardiometabolic effects of high- and moderate-intensity training among apparently healthy inactive adults: a randomized clinical trial

Robinson Ramírez-Vélez, Alejandra Tordecilla-Sanders, Luis Andrés Téllez-T, Diana Camelo-Prieto, Paula Andrea Hernández-Quiñonez, Jorge Enrique Correa-Bautista, Antonio Garcia-Hermoso, Rodrigo Ramirez-Campillo, Mikel Izquierdo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Non-caloric sweetener provides magnetic resonance imaging contrast for cancer detection

Puneet Bagga, Mohammad Haris, Kevin D’Aquilla, Neil E. Wilson, Francesco M. Marincola, Mitchell D. Schnall, Hari Hariharan, Ravinder Reddy

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Sphingosine kinase 1 expression enhances colon tumor growth

Hideki Furuya, Yoshiko Shimizu, Paulette M. Tamashiro, Kayoko Iino, Jacek Bielawski, Owen T. M. Chan, Ian Pagano, Toshihiko Kawamori

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Aberrant monocyte responses predict and characterize dengue virus infection in individuals with severe disease

Yean K. Yong, Hong Y. Tan, Soe Hui Jen, Esaki M. Shankar, Santha K. Natkunam, Jameela Sathar, Rishya Manikam, Shamala D. Sekaran

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Basal cell carcinoma: 10-year experience with electrochemotherapy

Luca G. Campana, Roberto Marconato, Sara Valpione, Sara Galuppo, Mauro Alaibac, Carlo R. Rossi, Simone Mocellin

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells

Hyo-Jin Kim, Ki-Eun Hwang, Do-Sim Park, Seon-Hee Oh, Hong Young Jun, Kwon-Ha Yoon, Eun-Taik Jeong, Hak-Ryul Kim, Young-Suk Kim

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Mathematical models for devising the optimal Ebola virus disease eradication

Shuo Jiang, Kaiqin Wang, Chaoqun Li, Guangbin Hong, Xuan Zhang, Menglin Shan, Hongbin Li, Jin Wang

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: The progressive fragmentation of the KIT/PDGFRA wild-type (WT) gastrointestinal stromal tumors (GIST)

Margherita Nannini, Milena Urbini, Annalisa Astolf, Guido Biasco, Maria A. Pantaleo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Distinct pathophysiological cytokine profiles for discrimination between autoimmune pancreatitis, chronic pancreatitis, and pancreatic ductal adenocarcinoma

Sahar Ghassem-Zadeh, Matthias M. Gaida, Szilard Szanyi, Hans Acha-Orbea, Jean-Louis Frossard, Ulf Hinz, Thilo Hackert, Oliver Strobel, Klaus Felix

01.12.2017 | Research | Ausgabe 1/2017 Open Access

CDK4/6 inhibitor-SHR6390 exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated Rb and inducing G1 cell cycle arrest

Jiayuan Wang, Qingqing Li, Jiajia Yuan, Jingyuan Wang, Zuhua Chen, Zhentao Liu, Zhongwu Li, Yumei Lai, Jing Gao, Lin Shen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Osteoclast profile of medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis

Christian Gross, Manuel Weber, Kay Creutzburg, Patrick Möbius, Raimund Preidl, Kerstin Amann, Falk Wehrhan

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Examining clinical similarities between myalgic encephalomyelitis/chronic fatigue syndrome and d-lactic acidosis: a systematic review

Amy Wallis, Michelle Ball, Sandra McKechnie, Henry Butt, Donald P. Lewis, Dorothy Bruck

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Exercise in claudicants increase or decrease walking ability and the response relates to mitochondrial function

Michel van Schaardenburgh, Martin Wohlwend, Øivind Rognmo, Erney J. R. Mattsson

01.12.2017 | Review | Ausgabe 1/2017 Open Access

State of play and clinical prospects of antibody gene transfer

Kevin Hollevoet, Paul J. Declerck

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Betaine promotes cell differentiation of human osteoblasts in primary culture

Isabella Villa, Pamela Senesi, Anna Montesano, Anita Ferraretto, Fernanda Vacante, Alice Spinello, Michela Bottani, Simona Bolamperti, Alessandro Rubinacci, Livio Luzi, Ileana Terruzzi

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Distinct expression profile of HCMV encoded miRNAs in plasma from oral lichen planus patients

Meng Ding, Xiang Wang, Cheng Wang, Xiaoshuang Liu, Ke Zen, Wenmei Wang, Chen-Yu Zhang, Chunni Zhang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Development of an objective gene expression panel as an alternative to self-reported symptom scores in human influenza challenge trials

Julius Muller, Eneida Parizotto, Richard Antrobus, James Francis, Campbell Bunce, Amanda Stranks, Marshall Nichols, Micah McClain, Adrian V. S. Hill, Adaikalavan Ramasamy, Sarah C. Gilbert

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Can psychobiotics intake modulate psychological profile and body composition of women affected by normal weight obese syndrome and obesity? A double blind randomized clinical trial

Antonino De Lorenzo, Micaela Costacurta, Giuseppe Merra, Paola Gualtieri, Giorgia Cioccoloni, Massimiliano Marchetti, Dimitrios Varvaras, Raffaella Docimo, Laura Di Renzo

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Similar cardiometabolic effects of high- and moderate-intensity training among apparently healthy inactive adults: a randomized clinical trial

Robinson Ramírez-Vélez, Alejandra Tordecilla-Sanders, Luis Andrés Téllez-T, Diana Camelo-Prieto, Paula Andrea Hernández-Quiñonez, Jorge Enrique Correa-Bautista, Antonio Garcia-Hermoso, Rodrigo Ramirez-Campillo, Mikel Izquierdo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Xenon in the treatment of panic disorder: an open label study

Alexander Dobrovolsky, Thomas E. Ichim, Daqing Ma, Santosh Kesari, Vladimir Bogin

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Synaptonemal complex protein 3 is associated with lymphangiogenesis in non-small cell lung cancer patients with lymph node metastasis

Haruhisa Kitano, Joon-Yong Chung, Kyung Hee Noh, Young-Ho Lee, Tae Woo Kim, Seok Hyung Lee, Soo-Heang Eo, Hyung Jun Cho, Chel Hun Choi, Shuhei Inoue, Jun Hanaoka, Junya Fukuoka, Stephen M. Hewitt

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Precision medicine in breast cancer: reality or utopia?

Ali Bettaieb, Catherine Paul, Stéphanie Plenchette, Jingxuan Shan, Lotfi Chouchane, François Ghiringhelli

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Molecular imaging biomarkers for cell-based immunotherapies

Mohammad Haris, Puneet Bagga, Hari Hariharan, Bevin McGettigan-Croce, Laura A. Johnson, Ravinder Reddy

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Intra-articular injection in the knee of adipose derived stromal cells (stromal vascular fraction) and platelet rich plasma for osteoarthritis

Himanshu Bansal, Kristin Comella, Jerry Leon, Poonam Verma, Diwaker Agrawal, Prasad Koka, Thomas Ichim

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The era of bioengineering: how will this affect the next generation of cancer immunotherapy?

Michele Graciotti, Cristiana Berti, Harm-Anton Klok, Lana Kandalaft

01.12.2017 | Research | Ausgabe 1/2017 Open Access

RETRACTED ARTICLE: Stromal vascular fraction cells for the treatment of critical limb ischemia: a pilot study

Adas Darinskas, Mindaugas Paskevicius, Gintaras Apanavicius, Gintaris Vilkevicius, Liutauras Labanauskas, Thomas E. Ichim, Rytis Rimdeika

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Imaging of αvβ3 integrin expression in experimental myocardial ischemia with [68Ga]NODAGA-RGD positron emission tomography

Maria Grönman, Miikka Tarkia, Tuomas Kiviniemi, Paavo Halonen, Antti Kuivanen, Timo Savunen, Tuula Tolvanen, Jarmo Teuho, Meeri Käkelä, Olli Metsälä, Mikko Pietilä, Pekka Saukko, Seppo Ylä-Herttuala, Juhani Knuuti, Anne Roivainen, Antti Saraste

01.12.2017 | Methodology | Ausgabe 1/2017 Open Access

Establishment of an orthotopic patient-derived xenograft mouse model using uveal melanoma hepatic metastasis

Ken Kageyama, Masahiro Ohara, Kengo Saito, Shinji Ozaki, Mizue Terai, Michael J. Mastrangelo, Paolo Fortina, Andrew E. Aplin, Takami Sato

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF-mutated melanoma treated in the randomized coBRIM study

Luis de la Cruz-Merino, Lorenza Di Guardo, Jean-Jacques Grob, Alfredo Venosa, James Larkin, Grant A. McArthur, Antoni Ribas, Paolo A. Ascierto, Jeffrey T. R. Evans, Antonio Gomez-Escobar, Giulio Barteselli, Susan Eng, Jessie J. Hsu, Anne Uyei, Brigitte Dréno

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Transplantation of human fetal pancreatic progenitor cells ameliorates renal injury in streptozotocin-induced diabetic nephropathy

Yongwei Jiang, Wenjian Zhang, Shiqing Xu, Hua Lin, Weiguo Sui, Honglin Liu, Liang Peng, Qing Fang, Li Chen, Jinning Lou

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Allergens in red ginseng extract induce the release of mediators associated with anaphylactoid reactions

Lu Wang, Yazheng Zhao, Ye Yang, Yuanjia Hu, Xiaohan Zou, Boyang Yu, Jin Qi

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Identification of clear cell renal cell carcinoma and oncocytoma using a three-gene promoter methylation panel

Ana Sílvia Pires-Luís, Pedro Costa-Pinheiro, Maria João Ferreira, Luís Antunes, Francisco Lobo, Jorge Oliveira, Rui Henrique, Carmen Jerónimo

01.12.2017 | Protocol | Ausgabe 1/2017 Open Access

A phase I/II trial of fixed-dose stereotactic body radiotherapy with sequential or concurrent pembrolizumab in metastatic urothelial carcinoma: evaluation of safety and clinical and immunologic response

Nora Sundahl, Katrien De Wolf, Sylvie Rottey, Karel Decaestecker, Daan De Maeseneer, Annabel Meireson, Els Goetghebeur, Valérie Fonteyne, Sofie Verbeke, Pieter De Visschere, Dries Reynders, Mireille Van Gele, Lieve Brochez, Piet Ost

01.12.2017 | Review | Ausgabe 1/2017 Open Access

CSPG4: a prototype oncoantigen for translational immunotherapy studies

Valeria Rolih, Giuseppina Barutello, Selina Iussich, Raffaella De Maria, Elena Quaglino, Paolo Buracco, Federica Cavallo, Federica Riccardo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The clinical importance of tumour-infiltrating macrophages and dendritic cells in periampullary adenocarcinoma differs by morphological subtype

Sebastian Lundgren, Emelie Karnevi, Jacob Elebro, Björn Nodin, Mikael C. I. Karlsson, Jakob Eberhard, Karin Leandersson, Karin Jirström

01.12.2017 | Protocol | Ausgabe 1/2017 Open Access

Effect of a 6-month pedometer-based walking intervention on functional capacity in patients with chronic heart failure with reduced (HFrEF) and with preserved (HFpEF) ejection fraction: study protocol for two multicenter randomized controlled trials

Tomas Vetrovsky, Michal Siranec, Jiri Parenica, Martin Griva, Jiri Stastny, Jan Precek, Radek Pelouch, Vaclav Bunc, Ales Linhart, Jan Belohlavek

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Identification of new MUC1 epitopes using HLA-transgenic animals: implication for immunomonitoring

Tanja Scheikl-Gatard, Caroline Tosch, François Lemonnier, Ronald Rooke

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Impaired B cell immunity in acute myeloid leukemia patients after chemotherapy

Meghali Goswami, Gabrielle Prince, Angelique Biancotto, Susan Moir, Lela Kardava, Brian H. Santich, Foo Cheung, Yuri Kotliarov, Jinguo Chen, Rongye Shi, Huizhi Zhou, Hana Golding, Jody Manischewitz, Lisa King, Lauren M. Kunz, Kimberly Noonan, Ivan M. Borrello, B. Douglas Smith, Christopher S. Hourigan

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Analysis of circulating microRNAs in patients with repaired Tetralogy of Fallot with and without heart failure

Masood Abu-Halima, Eckart Meese, Andreas Keller, Hashim Abdul-Khaliq, Tanja Rädle-Hurst

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Altered neuroendocrine control and association to clinical symptoms in adolescent chronic fatigue syndrome: a cross-sectional study

Vegard Bruun Wyller, Valeria Vitelli, Dag Sulheim, Even Fagermoen, Anette Winger, Kristin Godang, Jens Bollerslev

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Regulation of glucose uptake in lymphoma cell lines by c-MYC- and PI3K-dependent signaling pathways and impact of glycolytic pathways on cell viability

Martina Broecker-Preuss, Nina Becher-Boveleth, Andreas Bockisch, Ulrich Dührsen, Stefan Müller

01.12.2017 | Research | Ausgabe 1/2017 Open Access

High expression of ETS2 predicts poor prognosis in acute myeloid leukemia and may guide treatment decisions

Lin Fu, Huaping Fu, Qingyun Wu, Yifan Pang, Keman Xu, Lei Zhou, Jianlin Qiao, Xiaoyan Ke, Kailin Xu, Jinlong Shi

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives

Alexander Vaiserman, Oleh Lushchak

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Mesenchymal stem cells from sternum: the type of heart disease, ischemic or valvular, does not influence the cell culture establishment and growth kinetics

Lucinara Dadda Dias, Karina Rabello Casali, Carine Ghem, Melissa Kristocheck da Silva, Grasiele Sausen, Patrícia Bonini Palma, Dimas Tadeu Covas, Renato A. K. Kalil, Beatriz D. Schaan, Nance Beyer Nardi, Melissa Medeiros Markoski

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The European ME/CFS Biomarker Landscape project: an initiative of the European network EUROMENE

Carmen Scheibenbogen, Helma Freitag, Julià Blanco, Enrica Capelli, Eliana Lacerda, Jerome Authier, Mira Meeus, Jesus Castro Marrero, Zaiga Nora-Krukle, Elisa Oltra, Elin Bolle Strand, Evelina Shikova, Slobodan Sekulic, Modra Murovska

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Data-driven interdisciplinary mathematical modelling quantitatively unveils competition dynamics of co-circulating influenza strains

Bin-Shenq Ho, Kun-Mao Chao

01.12.2017 | Review | Ausgabe 1/2017 Open Access

RNAi therapy to the wall of arteries and veins: anatomical, physiologic, and pharmacological considerations

Christoph S. Nabzdyk, Leena Pradhan-Nabzdyk, Frank W. LoGerfo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Coiled-coil domain containing 109B is a HIF1α-regulated gene critical for progression of human gliomas

Ran Xu, Mingzhi Han, Yangyang Xu, Xin Zhang, Chao Zhang, Di Zhang, Jianxiong Ji, Yuzhen Wei, Shuai Wang, Bin Huang, Anjing Chen, Qing Zhang, Wenjie Li, Tao Sun, Feng Wang, Xingang Li, Jian Wang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Estimating the survival advantage based on telomere length and serum biomarkers of aging

Yilin Zhao, Shijun Li, Hui Liu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Comparative analysis of the EGFR, HER2, c-MYC, and MET variations in colorectal cancer determined by three different measures: gene copy number gain, amplification status and the 2013 ASCO/CAP guideline criterion for HER2 testing of breast cancer

Yoonjin Kwak, Sumi Yun, Soo Kyung Nam, An Na Seo, Kyu Sang Lee, Eun Shin, Heung-Kwon Oh, Duck Woo Kim, Sung Bum Kang, Woo Ho Kim, Hye Seung Lee

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Survival impact of pre-treatment neutrophils on oropharyngeal and laryngeal cancer patients undergoing definitive radiotherapy

Whitney A. Sumner, William A. Stokes, Ayman Oweida, Kiersten L. Berggren, Jessica D. McDermott, David Raben, Diana Abbott, Bernard Jones, Gregory Gan, Sana D. Karam

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Tough decoy targeting of predominant let-7 miRNA species in adult human hematopoietic cells

Jaira F. de Vasconcellos, Colleen Byrnes, Y. Terry Lee, Joshua M. Allwardt, Megha Kaushal, Antoinette Rabel, Jeffery L. Miller

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Temperature variability in the day–night cycle is associated with further intracranial pressure during therapeutic hypothermia

Adriano Barreto Nogueira, Eva Annen, Oliver Boss, Faraneh Farokhzad, Christopher Sikorski, Emanuela Keller

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma

Chao Cao, Wen Li, Wen Hua, Fugui Yan, Hao Zhang, Huaqiong Huang, Yinghua Ying, Na Li, Fen Lan, Shaobin Wang, Xiao Chen, Jing Li, Jinkai Liu, Tianwen Lai, Zhengqiang Bao, Yuan Cao, Yun Zhao, Gang Huang, Lili Huang, Yaqing Huang, Ping Wu, Chao Peng, Zhihua Chen, Kian Fan Chung, Nanshan Zhong, Songmin Ying, Huahao Shen

01.12.2017 | Protocol | Ausgabe 1/2017 Open Access

Inorganic nitrate as a treatment for acute heart failure: a protocol for a single center, randomized, double-blind, placebo-controlled pilot and feasibility study

Roman Falls, Michael Seman, Sabine Braat, Joshua Sortino, Jason D. Allen, Christopher J. Neil

01.12.2017 | Commentary | Ausgabe 1/2017 Open Access

Checkpoint inhibitors in melanoma and early phase development in solid tumors: what’s the future?

Paolo A. Ascierto, Grant A. McArthur

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Erythrocyte depletion from bone marrow: performance evaluation after 50 clinical-scale depletions with Spectra Optia BMC

Soo-Zin Kim-Wanner, Gesine Bug, Juliane Steinmann, Salem Ajib, Nadine Sorg, Carolin Poppe, Milica Bunos, Eva Wingenfeld, Christiane Hümmer, Beate Luxembourg, Erhard Seifried, Halvard Bonig

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Quantification of mutant SPOP proteins in prostate cancer using mass spectrometry-based targeted proteomics

Hui Wang, Christopher E. Barbieri, Jintang He, Yuqian Gao, Tujin Shi, Chaochao Wu, Athena A. Schepmoes, Thomas L. Fillmore, Sung-Suk Chae, Dennis Huang, Juan Miguel Mosquera, Wei-Jun Qian, Richard D. Smith, Sudhir Srivastava, Jacob Kagan, David G. Camp II, Karin D. Rodland, Mark A. Rubin, Tao Liu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Role of IQGAP3 in metastasis and epithelial–mesenchymal transition in human hepatocellular carcinoma

Yongjie Shi, Nan Qin, Qiang Zhou, Yanqiu Chen, Sicong Huang, Bo Chen, Gang Shen, Hongyun Jia

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Gene mutational pattern and expression level in 560 acute myeloid leukemia patients and their clinical relevance

Yong-Mei Zhu, Pan-Pan Wang, Jin-Yan Huang, Yun-Shuo Chen, Bing Chen, Yu-Jun Dai, Han Yan, Yi Hu, Wen-Yan Cheng, Ting-Ting Ma, Sai-Juan Chen, Yang Shen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

PIM-1 mRNA expression is a potential prognostic biomarker in acute myeloid leukemia

Hui Cheng, Chongmei Huang, Xiaoqian Xu, Xiaoxia Hu, Shenglan Gong, Gusheng Tang, Xianmin Song, Weiping Zhang, Jianmin Wang, Li Chen, Jianmin Yang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Vaccine-draining lymph nodes of cancer patients for generating anti-cancer antibodies

Girja S. Shukla, Walter C. Olson, Stephanie C. Pero, Yu-jing Sun, Chelsea L. Carman, Craig L. Slingluff Jr., David N. Krag

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Glucocorticoid attenuates acute lung injury through induction of type 2 macrophage

Guo-wei Tu, Yi Shi, Yi-jun Zheng, Min-jie Ju, Hong-yu He, Guo-guang Ma, Guang-wei Hao, Zhe Luo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

In silico prediction of novel therapeutic targets using gene–disease association data

Enrico Ferrero, Ian Dunham, Philippe Sanseau

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Molecular targeting in acute myeloid leukemia

Seah H. Lim, Patrycja M. Dubielecka, Vikram M. Raghunathan

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Ruxolitinib/nilotinib cotreatment inhibits leukemia-propagating cells in Philadelphia chromosome-positive ALL

Yuan Kong, Yi-Lin Wu, Yang Song, Min-Min Shi, Xie-Na Cao, Hong-Yan Zhao, Ya-Zhen Qin, Yue-Yun Lai, Hao Jiang, Qian Jiang, Xiao-Jun Huang

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Multiple therapeutic effect of endothelial progenitor cell regulated by drugs in diabetes and diabetes related disorder

Rashmi K. Ambasta, Harleen Kohli, Pravir Kumar

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Genome-wide computational analysis of potential long noncoding RNA mediated DNA:DNA:RNA triplexes in the human genome

Saakshi Jalali, Amrita Singh, Souvik Maiti, Vinod Scaria

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Altered Semmes–Weinstein monofilament test results are associated with oxidative stress markers in type 2 diabetic subjects

Sergio Martinez-Hervás, Mercedes Molina Mendez, José Folgado, Carmen Tormos, Pilar Ascaso, Marta Peiró, Jose T. Real, Juan F. Ascaso

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Absolute quantification of microparticles by flow cytometry in ascites of patients with decompensated cirrhosis: a cohort study

Cornelius Engelmann, Katrin Splith, Sandra Krohn, Adam Herber, Albrecht Boehlig, Stephan Boehm, Johann Pratschke, Thomas Berg, Moritz Schmelzle

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Over-expression of BAG-1 in head and neck squamous cell carcinomas (HNSCC) is associated with cisplatin-resistance

Shutong Liu, Bo Ren, Hang Gao, Suchan Liao, Ying-Xian Zhai, Shirong Li, Xue-Jin Su, Ping Jin, David Stroncek, Zhixiang Xu, Qinghua Zeng, Yulin Li

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Cancer heterogeneity: converting a limitation into a source of biologic information

Albert Rübben, Arturo Araujo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Transcriptomic meta-analysis identifies gene expression characteristics in various samples of HIV-infected patients with nonprogressive disease

Le-Le Zhang, Zi-Ning Zhang, Xian Wu, Yong-Jun Jiang, Ya-Jing Fu, Hong Shang

01.12.2017 | Editorial | Ausgabe 1/2017 Open Access

JTM advances in uncharted territories: diseases and disorders of unknown etiology

Monica C. Panelli

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Expression of Concern to: Therapeutic potential of human embryonic stem cell transplantation in patients with cerebral palsy

Geeta Shroff, Anupama Gupta, Jitender Kumar Barthakur

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Ockham’s razor for the MET-driven invasive growth linking idiopathic pulmonary fibrosis and cancer

Giulia M. Stella, Alessandra Gentile, Alice Balderacchi, Federica Meloni, Melissa Milan, Silvia Benvenuti

01.12.2017 | Review | Ausgabe 1/2017 Open Access

p53: key conductor of all anti-acne therapies

Bodo C. Melnik

01.12.2017 | Research | Ausgabe 1/2017 Open Access

BDNF/TrkB axis activation promotes epithelial–mesenchymal transition in idiopathic pulmonary fibrosis

Emanuela Cherubini, Salvatore Mariotta, Davide Scozzi, Rita Mancini, Giorgia Osman, Michela D’Ascanio, Pierdonato Bruno, Giuseppe Cardillo, Alberto Ricci

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy

Christopher Centeno, Jason Markle, Ehren Dodson, Ian Stemper, Christopher J. Williams, Matthew Hyzy, Thomas Ichim, Michael Freeman

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Statistically controlled identification of differentially expressed genes in one-to-one cell line comparisons of the CMAP database for drug repositioning

Jun He, Haidan Yan, Hao Cai, Xiangyu Li, Qingzhou Guan, Weicheng Zheng, Rou Chen, Huaping Liu, Kai Song, Zheng Guo, Xianlong Wang

01.12.2017 | Meeting report | Ausgabe 1/2017 Open Access

Report on the first SLFN11 monothematic workshop: from function to role as a biomarker in cancer

Alberto Ballestrero, Davide Bedognetti, Domenico Ferraioli, Paola Franceschelli, Sana Intidhar Labidi-Galy, Elisabetta Leo, Junko Murai, Yves Pommier, Petros Tsantoulis, Valerio Gaetano Vellone, Gabriele Zoppoli

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Impact of mesenchymal stem cells’ secretome on glioblastoma pathophysiology

Joana Vieira de Castro, Eduardo D. Gomes, Sara Granja, Sandra I. Anjo, Fátima Baltazar, Bruno Manadas, António J. Salgado, Bruno M. Costa

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A lipidated peptide of Mycobacterium tuberculosis resuscitates the protective efficacy of BCG vaccine by evoking memory T cell immunity

Pradeep K. Rai, Sathi Babu Chodisetti, Weiguang Zeng, Sajid Nadeem, Sudeep K. Maurya, Susanta Pahari, Ashok K. Janmeja, David C. Jackson, Javed N. Agrewala

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension

Mariann Gyöngyösi, Noemi Pavo, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Denise Traxler, Georg Goliasch, Ljubica Mandic, Jutta Bergler-Klein, Alfred Gugerell, Andras Jakab, Zsuzsanna Szankai, Levente Toth, Rita Garamvölgyi, Gerald Maurer, Frederic Jaisser, Faiez Zannad, Thomas Thum, Sándor Bátkai, Johannes Winkler

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Metastatic pathway and the microvascular and physicochemical microenvironments of human melanoma xenografts

Ruixia Huang, Lise Mari K. Andersen, Einar K. Rofstad

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies

Calvin R. Justus, Edward J. Sanderlin, Lixue Dong, Tianai Sun, Jen-Tsan Chi, Kvin Lertpiriyapong, Li V. Yang

01.12.2017 | Meeting report | Ausgabe 1/2017 Open Access

Perspectives in immunotherapy: meeting report from the “Immunotherapy Bridge”, Napoli, November 30th 2016

Paolo A. Ascierto, Bruno Daniele, Hans Hammers, Vera Hirsh, Joseph Kim, Lisa Licitra, Rita Nanda, Sandro Pignata

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry

Le Ying, Feng Yan, Qiaohong Meng, Xiangliang Yuan, Liang Yu, Bryan R. G. Williams, David W. Chan, Liyun Shi, Yugang Tu, Peihua Ni, Xuefeng Wang, Dakang Xu, Yiqun Hu

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The pathophysiological role of mitochondrial oxidative stress in lung diseases

Xiaojing Liu, Zhihong Chen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Association of red cell distribution width with all-cause and cardiovascular-specific mortality in African American and white adults: a prospective cohort study

Salman M. Tajuddin, Mike A. Nalls, Alan B. Zonderman, Michele K. Evans

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Prediction of microbe–disease association from the integration of neighbor and graph with collaborative recommendation model

Yu-An Huang, Zhu-Hong You, Xing Chen, Zhi-An Huang, Shanwen Zhang, Gui-Ying Yan

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma

Venkata Yenugonda, Natsuko Nomura, Valentina Kouznetsova, Igor Tsigelny, Valentina Fogal, Elmar Nurmemmedov, Santosh Kesari, Ivan Babic

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A Yin-Yang 1/miR-30a regulatory circuit modulates autophagy in pancreatic cancer cells

Chuang Yang, Jing-Jing Zhang, Yun-Peng Peng, Yi Zhu, Ling-Di Yin, Ji-Shu Wei, Wen-Tao Gao, Kui-Rong Jiang, Yi Miao

01.12.2017 | Meeting report | Ausgabe 1/2017 Open Access

World-Wide Immunoscore Task Force: meeting report from the “Melanoma Bridge”, Napoli, November 30th–December 3rd, 2016

Jerome Galon, Alessandro Lugli, Carlo Bifulco, Franck Pages, Giuseppe Masucci, Francesco M. Marincola, Paolo A. Ascierto

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Effect of Infla-Kine supplementation on the gene expression of inflammatory markers in peripheral mononuclear cells and on C-reactive protein in blood

Nina A. Mikirova, Santosh Kesari, Thomas E. Ichim, Neil H. Riordan

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Flow cytometric immunobead assay for quantitative detection of platelet autoantibodies in immune thrombocytopenia patients

Juping Zhai, Mengyuan Ding, Tianjie Yang, Bin Zuo, Zhen Weng, Yunxiao Zhao, Jun He, Qingyu Wu, Changgeng Ruan, Yang He

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The effect of renal denervation in an experimental model of chronic renal insufficiency, The REmnant kidney Denervation In Pigs study (REDIP study)

Jean-Claude Lubanda, Miroslav Chochola, Mikuláš Mlček, Petr Neužil, Josef Marek, Štěpán Havránek, Sylvie Kuchynková, Zdeňka Fingrová, Kao-Hsuan Aimee Huang, Aleš Linhart

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Haemoadsorption reduces the inflammatory response and improves blood flow during ex vivo renal perfusion in an experimental model

Sarah A. Hosgood, Tom Moore, Theresa Kleverlaan, Tom Adams, Michael L. Nicholson

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Detecting the tipping points in a three-state model of complex diseases by temporal differential networks

Pei Chen, Yongjun Li, Xiaoping Liu, Rui Liu, Luonan Chen

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Therapeutic application of T regulatory cells in composite tissue allotransplantation

Jeong-Hee Yang, Seok-Chan Eun

01.12.2017 | Review | Ausgabe 1/2017 Open Access

GlycA, a novel biomarker of systemic inflammation and cardiovascular disease risk

Margery A. Connelly, James D. Otvos, Irina Shalaurova, Martin P. Playford, Nehal N. Mehta

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Veritable antiviral capacity of natural killer cells in chronic HBV infection: an argument for an earlier anti-virus treatment

Xiaoyan Li, Liang Zhou, Lin Gu, Yurong Gu, Lubiao Chen, Yifan Lian, Yuehua Huang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Systemic immune-inflammation index predicting chemoradiation resistance and poor outcome in patients with stage III non-small cell lung cancer

Yu-Suo Tong, Juan Tan, Xi-Lei Zhou, Ya-Qi Song, Ying-Jian Song

01.12.2017 | Commentary | Ausgabe 1/2017 Open Access

The need for a network to establish and validate predictive biomarkers in cancer immunotherapy

Giuseppe V. Masucci, Alessandra Cesano, Alexander Eggermont, Bernard A. Fox, Ena Wang, Francesco M. Marincola, Gennaro Ciliberto, Kevin Dobbin, Igor Puzanov, Janis Taube, Jennifer Wargo, Lisa H. Butterfield, Lisa Villabona, Magdalena Thurin, Michael A. Postow, Paul M. Sondel, Sandra Demaria, Sanjiv Agarwala, Paolo A. Ascierto

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Efficient generation of P53 biallelic knockout Diannan miniature pigs via TALENs and somatic cell nuclear transfer

Youfeng Shen, Kaixiang Xu, Zaimei Yuan, Jianxiong Guo, Heng Zhao, Xuezeng Zhang, Lu Zhao, Yubo Qing, Honghui Li, Weirong Pan, Baoyu Jia, Hong-Ye Zhao, Hong-Jiang Wei

01.12.2017 | Research | Ausgabe 1/2017 Open Access

DCE-MRI of patient-derived xenograft models of uterine cervix carcinoma: associations with parameters of the tumor microenvironment

Anette Hauge, Catherine S. Wegner, Jon-Vidar Gaustad, Trude G. Simonsen, Lise Mari K. Andersen, Einar K. Rofstad

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Translatability score revisited: differentiation for distinct disease areas

Alexandra Wendler, Martin Wehling

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Clinicopathological predictors of recurrence in nodular and superficial spreading cutaneous melanoma: a multivariate analysis of 214 cases

Maria A. Pizzichetta, Daniela Massi, Mario Mandalà, Paola Queirolo, Ignazio Stanganelli, Vincenzo De Giorgi, Giovanni Ghigliotti, Stefano Cavicchini, Pietro Quaglino, Maria T. Corradin, Pietro Rubegni, Mauro Alaibac, Stefano Astorino, Fabrizio Ayala, Serena Magi, Laura Mazzoni, Maria Ausilia Manganoni, Renato Talamini, Diego Serraino, Giuseppe Palmieri, on behalf of the Italian Melanoma Intergroup (IMI)

01.12.2017 | Methodology | Ausgabe 1/2017 Open Access

GMP-production of purified human B lymphocytes for the adoptive transfer in patients after allogeneic hematopoietic stem cell transplantation

Hannes Tittlbach, Andrea Schneider, Julian Strobel, Robert Zimmermann, Stefanie Maas, Bernd Gebhardt, Georg Rauser, Michael Mach, Andreas Mackensen, Thomas H. Winkler, Julia Winkler

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Management and potentialities of primary cancer cultures in preclinical and translational studies

Giacomo Miserocchi, Laura Mercatali, Chiara Liverani, Alessandro De Vita, Chiara Spadazzi, Federica Pieri, Alberto Bongiovanni, Federica Recine, Dino Amadori, Toni Ibrahim

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Comparison of 68Ga-PSMA-11 PET-CT with mpMRI for preoperative lymph node staging in patients with intermediate to high-risk prostate cancer

Qing Zhang, Shiming Zang, Chengwei Zhang, Yao Fu, Xiaoyu Lv, Qinglei Zhang, Yongming Deng, Chuan Zhang, Rui Luo, Xiaozhi Zhao, Wei Wang, Feng Wang, Hongqian Guo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Improving precision of glomerular filtration rate estimating model by ensemble learning

Xun Liu, Ningshan Li, Linsheng Lv, Yongmei Fu, Cailian Cheng, Caixia Wang, Yuqiu Ye, Shaomin Li, Tanqi Lou

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Radioprotective agents to prevent cellular damage due to ionizing radiation

Tyler A. Smith, Daniel R. Kirkpatrick, Sean Smith, Trevor K. Smith, Tate Pearson, Aparna Kailasam, Kortney Z. Herrmann, Johanna Schubert, Devendra K. Agrawal

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A murine model for developmental dysplasia of the hip: ablation of CX3CR1 affects acetabular morphology and gait

George Feldman, Arlene Offemaria, Hind Sawan, Javad Parvizi, Theresa A. Freeman

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The macrophage C-type lectin receptor CLEC5A (MDL-1) expression is associated with early plaque progression and promotes macrophage survival

Weixin Xiong, Haibo Wang, Lin Lu, Rui Xi, Fang Wang, Gang Gu, Rong Tao

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Polymorphisms at microRNA binding sites of Ara-C and anthracyclines-metabolic pathway genes are associated with outcome of acute myeloid leukemia patients

Hai-xia Cao, Chao-feng Miao, Liang Yan, Ping Tang, Li-rong Zhang, Ling Sun

01.12.2017 | Meeting report | Ausgabe 1/2017 Open Access

Future perspectives in melanoma research “Melanoma Bridge”, Napoli, November 30th–3rd December 2016

Paolo A. Ascierto, Sanjiv S. Agarwala, Gennaro Ciliberto, Sandra Demaria, Reinhard Dummer, Connie P. M. Duong, Soldano Ferrone, Silvia C. Formenti, Claus Garbe, Ruth Halaban, Samir Khleif, Jason J. Luke, Lluis M. Mir, Willem W. Overwijk, Michael Postow, Igor Puzanov, Paul Sondel, Janis M. Taube, Per Thor Straten, David F. Stroncek, Jennifer A. Wargo, Hassane Zarour, Magdalena Thurin

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Phenolic compounds apigenin, hesperidin and kaempferol reduce in vitro lipid accumulation in human adipocytes

Saioa Gómez-Zorita, Arrate Lasa, Naiara Abendaño, Alfredo Fernández-Quintela, Andrea Mosqueda-Solís, Maria Pilar Garcia-Sobreviela, Jose M. Arbonés-Mainar, Maria P. Portillo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Autocrine parathyroid hormone-like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK-ATF2-cyclinD1 signaling

Jing Tang, Yan Liao, Shuying He, Jie Shi, Liang Peng, Xiaoping Xu, Fang Xie, Na Diao, Jinlan Huang, Qian Xie, Chuang Lin, Xiaoying Luo, Kaili Liao, Juanjuan Ma, Jingyi Li, Daichao Zhou, Zhijun Li, Jun Xu, Chao Zhong, Guozhen Wang, Lan Bai

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Cytokine and autoantibody clusters interaction in systemic lupus erythematosus

Yovana Pacheco, Julián Barahona-Correa, Diana M. Monsalve, Yeny Acosta-Ampudia, Manuel Rojas, Yhojan Rodríguez, Juliana Saavedra, Mónica Rodríguez-Jiménez, Rubén D. Mantilla, Carolina Ramírez-Santana, Nicolás Molano-González, Juan-Manuel Anaya

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Application of survival tree analysis for exploration of potential interactions between predictors of incident chronic kidney disease: a 15-year follow-up study

Azra Ramezankhani, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Vascular abnormalities and development of hypoxia in microscopic melanoma xenografts

Jon-Vidar Gaustad, Trude G. Simonsen, Lise Mari K. Andersen, Einar K. Rofstad

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Evaluation of B1 inhomogeneity effect on DCE-MRI data analysis of brain tumor patients at 3T

Anirban Sengupta, Rakesh Kumar Gupta, Anup Singh

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Identification of coexistence of BRAF V600E mutation and EZH2 gain specifically in melanoma as a promising target for combination therapy

Huan Yu, Meng Ma, Junya Yan, Longwen Xu, Jiayi Yu, Jie Dai, Tianxiao Xu, Huan Tang, Xiaowen Wu, Siming Li, Bin Lian, Lili Mao, Zhihong Chi, Chuanliang Cui, Jun Guo, Yan Kong

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Soluble CD73 as biomarker in patients with metastatic melanoma patients treated with nivolumab

Silvana Morello, Mariaelena Capone, Claudia Sorrentino, Diana Giannarelli, Gabriele Madonna, Domenico Mallardo, Antonio M. Grimaldi, Aldo Pinto, Paolo Antonio Ascierto

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Transforming growth factor beta (TGF-β) in adolescent chronic fatigue syndrome

Vegard Bruun Wyller, Chinh Bkrong Nguyen, Judith Anita Ludviksen, Tom Eirik Mollnes

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Next-generation sequencing: recent applications to the analysis of colorectal cancer

Filippo Del Vecchio, Valentina Mastroiaco, Antinisca Di Marco, Chiara Compagnoni, Daria Capece, Francesca Zazzeroni, Carlo Capalbo, Edoardo Alesse, Alessandra Tessitore

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Evaluation of the effect of d-amino acid incorporation into amyloid-reactive peptides

Emily B. Martin, Angela Williams, Tina Richey, Craig Wooliver, Alan Stuckey, James S. Foster, Stephen J. Kennel, Jonathan S. Wall

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease

V. J. A. A. Nuij, M. P. Peppelenbosch, C. J. van der Woude, G. M. Fuhler

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Effects of a multi-strain probiotic supplement for 12 weeks in circulating endotoxin levels and cardiometabolic profiles of medication naïve T2DM patients: a randomized clinical trial

Shaun Sabico, Ayah Al-Mashharawi, Nasser M. Al-Daghri, Sobhy Yakout, Abdullah M. Alnaami, Majed S. Alokail, Philip G. McTernan

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage explants ex vivo

Ditte Reker, Cecilie F. Kjelgaard-Petersen, Anne Sofie Siebuhr, Martin Michaelis, Anne Gigout, Morten A. Karsdal, Christoph Ladel, Anne C. Bay-Jensen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

MKRMDA: multiple kernel learning-based Kronecker regularized least squares for MiRNA–disease association prediction

Xing Chen, Ya-Wei Niu, Guang-Hui Wang, Gui-Ying Yan

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Molecular and histological effects of MR-guided pulsed focused ultrasound to the rat heart

Kee W. Jang, Tsang-Wei Tu, Matthew E. Nagle, Bobbi K. Lewis, Scott R. Burks, Joseph A. Frank

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Gimatecan exerts potent antitumor activity against gastric cancer in vitro and in vivo via AKT and MAPK signaling pathways

Zuhua Chen, Zhentao Liu, Wenwen Huang, Zhongwu Li, Jianling Zou, Jingyuan Wang, Xiaoting Lin, Beifang Li, Dongshao Chen, Yanting Hu, Jiafu Ji, Jing Gao, Lin Shen

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Identification of potential transcriptomic markers in developing pediatric sepsis: a weighted gene co-expression network analysis and a case–control validation study

Yiping Li, Yanhong Li, Zhenjiang Bai, Jian Pan, Jian Wang, Fang Fang

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The use of the tyrosine kinase inhibitor Nilotinib in Spondyloarthritis: does targeting inflammatory pathways with a treatment lead to vascular toxicity?

Loukman Omarjee, Vincent Jaquinandi, Guillaume Mahe

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The impact of antiretroviral therapy on iron homeostasis and inflammation markers in HIV-infected patients with mild anemia

Eugenia Quiros-Roldan, Francesco Castelli, Paola Lanza, Chiara Pezzoli, Marika Vezzoli, Giorgio Biasiotto, Isabella Zanella, Inflammation in HIV Study Group

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Disruption of the c-Myc/miR-200b-3p/PRDX2 regulatory loop enhances tumor metastasis and chemotherapeutic resistance in colorectal cancer

Zhenbing Lv, Jinlai Wei, Wenxian You, Rong Wang, Jingkun Shang, Yongfu Xiong, Hua Yang, Xuanhua Yang, Zhongxue Fu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Water T2 as an early, global and practical biomarker for metabolic syndrome: an observational cross-sectional study

Michelle D. Robinson, Ina Mishra, Sneha Deodhar, Vipulkumar Patel, Katrina V. Gordon, Raul Vintimilla, Kim Brown, Leigh Johnson, Sid O’Bryant, David P. Cistola

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Increased CD127+ and decreased CD57+ T cell expression levels in HIV-infected patients on NRTI-sparing regimens

A. Gonzalez-Serna, S. Ferrando-Martinez, L. Tarancon-Diez, R. S. De Pablo-Bernal, B. Dominguez-Molina, J. L. Jiménez, M. Á. Muñoz-Fernández, M. Leal, E. Ruiz-Mateos

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Prostate cancer small non-coding RNA transcriptome in Arabs

Jingxuan Shan, Khalid Al-Rumaihi, Karim Chouchane, Issam Al-Bozom, Danny Rabah, Karim Farhat, Lotfi Chouchane

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Structure based drug discovery for designing leads for the non-toxic metabolic targets in multi drug resistant Mycobacterium tuberculosis

Divneet Kaur, Shalu Mathew, Chinchu G. S. Nair, Azitha Begum, Ashwin K. Jainanarayan, Mukta Sharma, Samir K. Brahmachari

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Exhaled breath condensate metabolome clusters for endotype discovery in asthma

Anirban Sinha, Koundinya Desiraju, Kunal Aggarwal, Rintu Kutum, Siddhartha Roy, Rakesh Lodha, S. K. Kabra, Balaram Ghosh, Tavpritesh Sethi, Anurag Agrawal

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Bone regeneration using composite non-demineralized xenogenic dentin with beta-tricalcium phosphate in experimental alveolar cleft repair in a rabbit model

Mohammad Kamal, Lars Andersson, Rene Tolba, Adel Al-Asfour, Alexander K. Bartella, Felix Gremse, Stefanie Rosenhain, Frank Hölzle, Peter Kessler, Bernd Lethaus

01.12.2017 | Methodology | Ausgabe 1/2017 Open Access

9.4 T small animal MRI using clinical components for direct translational studies

Jörg Felder, A. Avdo Celik, Chang-Hoon Choi, Stefan Schwan, N. Jon Shah

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Design and validation of a disease network of inflammatory processes in the NSG-UC mouse model

Henrika Jodeleit, Pia Palamides, Florian Beigel, Thomas Mueller, Eckhard Wolf, Matthias Siebeck, Roswitha Gropp

01.12.2017 | Research | Ausgabe 1/2017 Open Access

R-100 improves pulmonary function and systemic fluid balance in sheep with combined smoke-inhalation injury and Pseudomonas aeruginosa sepsis

Hiroshi Ito, Erik Malgerud, Sven Asmussen, Ernesto Lopez, Andrew L. Salzman, Perenlei Enkhbaatar

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Cytokine signatures in chronic fatigue syndrome patients: a Case Control Study and the effect of anakinra treatment

Megan E. Roerink, Hans Knoop, Ewald M. Bronkhorst, Henk A. Mouthaan, Luuk J. A. C. Hawinkels, Leo A. B. Joosten, Jos W. M. van der Meer

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Hypermethylation of MEG3 promoter correlates with inactivation of MEG3 and poor prognosis in patients with retinoblastoma

Yali Gao, Peng Huang, Jun Zhang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Comprehensive molecular biomarker identification in breast cancer brain metastases

Hans-Juergen Schulten, Mohammed Bangash, Sajjad Karim, Ashraf Dallol, Deema Hussein, Adnan Merdad, Fatma K. Al-Thoubaity, Jaudah Al-Maghrabi, Awatif Jamal, Fahad Al-Ghamdi, Hani Choudhry, Saleh S. Baeesa, Adeel G. Chaudhary, Mohammed H. Al-Qahtani

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