Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Die Highlights vom Kongress des American College of Cardiology 2024

Im April diskutierten die Herz-Kreislauf-Spezialisten aus der ganzen Welt auf dem  Kongress des American College of Cardiology (ACC) u.a. neue Therapieansätze bei akutem Myokardinfarkt, koronarer Herzerkrankung, kardiogenem Schock oder Aortenklappenstenose. In unserem Kongress-Dossier haben wir für Sie Berichte über die „Late-Breaking Trials“ und andere wichtige Studien zusammengestellt. 
Erweiterte Suche
Anmelden
nach oben
Intensive Care Medicine
Erschienen in: Intensive Care Medicine 8/2005

01.08.2005 | Special Article

Inhaled nitric oxide therapy in adults: European expert recommendations

verfasst von: Peter Germann, Antonio Braschi, Giorgio Della Rocca, Anh Tuan Dinh-Xuan, Konrad Falke, Claes Frostell, Lars E. Gustafsson, Philippe Hervé, Philippe Jolliet, Udo Kaisers, Hector Litvan, Duncan J. Macrae, Marco Maggiorini, Nandor Marczin, Bernd Mueller, Didier Payen, Marco Ranucci, Dietmar Schranz, Rainer Zimmermann, Roman Ullrich

Erschienen in: Intensive Care Medicine | Ausgabe 8/2005

Einloggen, um Zugang zu erhalten

Abstract

Background

Inhaled nitric oxide (iNO) has been used for treatment of acute respiratory failure and pulmonary hypertension since 1991 in adult patients in the perioperative setting and in critical care.

Methods

This contribution assesses evidence for the use of iNO in this population as presented to a expert group jointly organised by the European Society of Intensive Care Medicine and the European Association of Cardiothoracic Anaesthesiologists.

Conclusions

Expert recommendations on the use of iNO in adults were agreed on following presentation of the evidence at the expert meeting held in June 2004.
Literatur
1.
Higenbottam T, Pepke-Zaba J, Scott J, Woolman P, Coutts C, Wallwork J (1988) Inhaled endothelial derived-relaxing factor (EDRF) in primary pulmonary hypertension (PPH). Am Rev Respir Dis [Suppl]:137:A107
2.
Pepke-Zaba J, Higenbottam TW, Dinh-Xuan AT, Stone D, Wallwork J (1991) Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension. Lancet 338:1173–1174PubMed
3.
Frostell C, Fratacci MD, Wain JC, Jones R, Zapol WM (1991) Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation 83:2038–2047PubMed
4.
Rossaint R, Falke KJ, Lopez F, Slama K, Pison U, Zapol WM (1993) Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 328:399–405PubMed
5.
Abman SH, Griebel JL, Parker DK, Schmidt JM, Swanton D, Kinsella JP (1994) Acute effects of inhaled nitric oxide in children with severe hypoxemic respiratory failure. J Pediatr 124:881–888PubMed
6.
Bigatello LM, Hurford WE, Kacmarek RM, Roberts JD Jr, Zapol WM (1994) Prolonged inhalation of low concentrations of nitric oxide in patients with severe adult respiratory distress syndrome. Effects on pulmonary hemodynamics and oxygenation. Anesthesiology 80:761–770PubMed
7.
Gerlach H, Pappert D, Lewandowski K, Rossaint R, Falke KJ (1993) Long-term inhalation with evaluated low doses of nitric oxide for selective improvement of oxygenation in patients with adult respiratory distress syndrome. Intensive Care Med 19:443–449PubMed
8.
Puybasset L, Stewart T, Rouby JJ, Cluzel P, Mourgeon E, Belin MF, Arthaud M, Landault C, Viars P (1994) Inhaled nitric oxide reverses the increase in pulmonary vascular resistance induced by permissive hypercapnia in patients with acute respiratory distress syndrome. Anesthesiology 80:1254–1267PubMed
9.
Young JD, Brampton WJ, Knighton JD, Finfer SR (1994) Inhaled nitric oxide in acute respiratory failure in adults. Br J Anaesth 73:499–502
10.
Lundin S, Mang H, Smithies M, Stenqvist O, Frostell C (1999) Inhalation of nitric oxide in acute lung injury: results of a European multicentre study. The European Study Group of Inhaled Nitric Oxide. Intensive Care Med 25:911–919PubMed
11.
Michael JR, Barton RG, Saffle JR, Mone M, Markewitz BA, Hillier K, Elstad MR, Campbell EJ, Troyer BE, Whatley RE, Liou TG, Samuelson WM, Carveth HJ, Hinson DM, Morris SE, Davis BL, Day RW (1998) Inhaled nitric oxide versus conventional therapy: effect on oxygenation in ARDS. Am J Respir Crit Care Med 157:1372–1380PubMed
12.
Troncy E, Collet JP, Shapiro S, Guimond JG, Blair L, Ducruet T, Francoeur M, Charbonneau M, Blaise G (1998) Inhaled nitric oxide in acute respiratory distress syndrome: a pilot randomized controlled study. Am J Respir Crit Care Med 157:1483–1488PubMed
13.
Dellinger RP, Zimmerman JL, Taylor RW, Straube RC, Hauser DL, Criner GJ, Davis K Jr, Hyers TM, Papadakos P (1998) Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial. Inhaled Nitric Oxide in ARDS Study Group. Crit Care Med 26:15–23PubMed
14.
Gerlach H, Rossaint R, Pappert D, Falke KJ (1993) Time-course and dose-response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome. Eur J Clin Invest 23:499–502PubMed
15.
Taylor RW, Zimmerman JL, Dellinger RP, Straube RC, Criner GJ, Davis K Jr, Kelly KM, Smith TC, Small RJ (2004) Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial. JAMA 291:1603–1609PubMed
16.
Beloucif S, Payen D (1998) A European survey of the use of inhaled nitric oxide in the ICU. Working Group on Inhaled NO in the ICU of the European Society of Intensive Care Medicine. Intensive Care Med 24:864–877PubMed
17.
Frostell CG, Blomqvist H, Hedenstierna G, Lundberg J, Zapol WM (1993) Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation. Anesthesiology 78:427–435PubMed
18.
Roberts JD Jr, Lang P, Bigatello LM, Vlahakes GJ, Zapol WM (1993) Inhaled nitric oxide in congenital heart disease. Circulation 87:447–453PubMed
19.
Girard C, Lehot JJ, Pannetier JC, Filley S, Ffrench P, Estanove S (1992) Inhaled nitric oxide after mitral valve replacement in patients with chronic pulmonary artery hypertension. Anesthesiology 77:880–883PubMed
20.
Miller OI, Tang SF, Keech A, Celermajer DS (1995) Rebound pulmonary hypertension on withdrawal from inhaled nitric oxide. Lancet 346:51–52
21.
Dupuy PM, Shore SA, Drazen JM, Frostell C, Hill WA, Zapol WM (1992) Bronchodilator action of inhaled nitric oxide in guinea pigs. J Clin Invest 90:421–428PubMed
22.
Hogman M, Frostell CG, Hedenstrom H, Hedenstierna G (1993) Inhalation of nitric oxide modulates adult human bronchial tone. Am Rev Respir Dis 148:1474–1478PubMed
23.
Wraight WM, Young JD (2001) Renal effects of inhaled nitric oxide in humans. Br J Anaesth 86:267–269
24.
Wennmalm A, Benthin G, Edlund A, Jungersten L, Kieler-Jensen N, Lundin S, Westfelt UN, Petersson AS, Waagstein F (1993) Metabolism and excretion of nitric oxide in humans. An experimental and clinical study. Circ Res 73:1121–1127PubMed
25.
Samama CM, Diaby M, Fellahi JL, Mdhafar A, Eyraud D, Arock M, Guillosson JJ, Coriat P, Rouby JJ (1995) Inhibition of platelet aggregation by inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesthesiology 83:56–65PubMed
26.
Kinsella JP, Walsh WF, Bose CL, Gerstmann DR, Labella JJ, Sardesai S, Walsh-Sukys MC, McCaffrey MJ, Cornfield DN, Bhutani VK, Cutter GR, Baier M, Abman SH (1999) Inhaled nitric oxide in premature neonates with severe hypoxaemic respiratory failure: a randomised controlled trial. Lancet 354:1061–1065PubMed
27.
Wan S, LeClerc JL, Vincent JL (1997) Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. Chest 112:676–692PubMed
28.
Olschewski H, Simonneau G, Galie N, Higenbottam T, Naeije R, Rubin LJ, Nikkho S, Speich R, Hoeper MM, Behr J, Winkler J, Sitbon O, Popov W, Ghofrani HA, Manes A, Kiely DG, Ewert R, Meyer A, Corris PA, Delcroix M, Gomez-Sanchez M, Siedentop H, Seeger W (2002) Inhaled iloprost for severe pulmonary hypertension. N Engl J Med 347:322–329CrossRefPubMed
29.
Ralevic V, Burnstock G (1998) Receptors for purines and pyrimidines. Pharmacol Rev 50:413–492PubMed
30.
Jolliet P, Bulpa P, Ritz M, Ricou B, Lopez J, Chevrolet JC (1997) Additive beneficial effects of the prone position, nitric oxide, and almitrine bismesylate on gas exchange and oxygen transport in acute respiratory distress syndrome. Crit Care Med 25:786–794PubMed
31.
Lu Q, Mourgeon E, Law-Koune JD, Roche S, Vezinet C, Abdennour L, Vicaut E, Puybasset L, Diaby M, Coriat P et al (1995) Dose-response curves of inhaled nitric oxide with and without intravenous almitrine in nitric oxide-responding patients with acute respiratory distress syndrome. Anesthesiology 83:929–943PubMed
32.
Gillart T, Bazin JE, Cosserant B, Guelon D, Aigouy L, Mansoor O, Schoeffler P (1998) Combined nitric oxide inhalation, prone positioning and almitrine infusion improve oxygenation in severe ARDS. Can J Anaesth 45:402–409PubMed
33.
Germann P, Poschl G, Leitner C, Urak G, Ullrich R, Faryniak B, Roder G, Kaider A, Sladen R (1998) Additive effect of nitric oxide inhalation on the oxygenation benefit of the prone position in the adult respiratory distress syndrome. Anesthesiology 89:1401–1406PubMed
34.
Gallart L, Lu Q, Puybasset L, Umamaheswara Rao GS, Coriat P, Rouby JJ (1998) Intravenous almitrine combined with inhaled nitric oxide for acute respiratory distress syndrome. The NO Almitrine Study Group. Am J Respir Crit Care Med 158:1770–1777PubMed
35.
Ziegler JW, Ivy DD, Wiggins JW, Kinsella JP, Clarke WR, Abman SH (1998) Effects of dipyridamole and inhaled nitric oxide in pediatric patients with pulmonary hypertension. Am J Respir Crit Care Med 158:1388–1395PubMed
36.
Kuhlen R, Walbert E, Frankel P, Thaden S, Behrendt W, Rossaint R (1999) Combination of inhaled nitric oxide and intravenous prostacyclin for successful treatment of severe pulmonary hypertension in a patient with acute respiratory distress syndrome. Intensive Care Med 25:752–754PubMed
37.
Rialp G, Betbese AJ, Perez-Marquez M, Mancebo J (2001) Short-term effects of inhaled nitric oxide and prone position in pulmonary and extrapulmonary acute respiratory distress syndrome. Am J Respir Crit Care Med 164:243–249PubMed
38.
Macrae DJ, Field D, Mercier JC, Moller J, Stiris T, Biban P, Cornick P, Goldman A, Gothberg S, Gustafsson LE, Hammer J, Lonnqvist PA, Sanchez-Luna M, Sedin G, Subhedar N (2004) Inhaled nitric oxide therapy in neonates and children: reaching a European consensus. Intensive Care Med 30:372–380
39.
Moraes DL, Colucci WS, Givertz MM (2000) Secondary pulmonary hypertension in chronic heart failure: the role of the endothelium in pathophysiology and management. Circulation 102:1718–1723PubMed
40.
Verma S, Anderson TJ (2002) Fundamentals of endothelial function for the clinical cardiologist. Circulation 105:546–549PubMed
41.
Celermajer DS, Cullen S, Deanfield JE (1993) Impairment of endothelium-dependent pulmonary artery relaxation in children with congenital heart disease and abnormal pulmonary hemodynamics. Circulation 87:440–446PubMed
42.
Bocchi EA, Bacal F, Auler Junior JO, Carmone MJ, Bellotti G, Pileggi F (1994) Inhaled nitric oxide leading to pulmonary edema in stable severe heart failure. Am J Cardiol 74:70–72PubMed
43.
Hare JM, Shernan SK, Body SC, Graydon E, Colucci WS, Couper GS (1997) Influence of inhaled nitric oxide on systemic flow and ventricular filling pressure in patients receiving mechanical circulatory assistance. Circulation 95:2250–2253PubMed
44.
Galie N, Seeger W, Naeije R, Simonneau G, Rubin LJ (2004) Comparative analysis of clinical trials and evidence-based treatment algorithm in pulmonary arterial hypertension. J Am Coll Cardiol 43:81S-88SPubMed
45.
Rich S, Kaufmann E, Levy PS (1992) The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. N Engl J Med 327:76–81PubMed
46.
Barst RJ, Rubin LJ, Long WA, McGoon MD, Rich S, Badesch DB, Groves BM, Tapson VF, Bourge RC, Brundage BH et al (1996) A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group. N Engl J Med 334:296–302CrossRefPubMed
47.
Simonneau G, Barst RJ, Galie N, Naeije R, Rich S, Bourge RC, Keogh A, Oudiz R, Frost A, Blackburn SD, Crow JW, Rubin LJ (2002) Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: a double-blind, randomized, placebo-controlled trial. Am J Respir Crit Care Med 165:800–804PubMed
48.
Hoeper MM, Schwarze M, Ehlerding S, Adler-Schuermeyer A, Spiekerkoetter E, Niedermeyer J, Hamm M, Fabel H (2000) Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue. N Engl J Med 342:1866–1870CrossRefPubMed
49.
Simonneau G, Galie N, Rubin LJ, Langleben D, Seeger W, Domenighetti G, Gibbs S, Lebrec D, Speich R, Beghetti M, Rich S, Fishman A (2004) Clinical classification of pulmonary hypertension. J Am Coll Cardiol 43:5S–12SCrossRefPubMed
50.
Morales-Blanhir J, Santos S, de Jover L, Sala E, Pare C, Roca J, Rodriguez-Roisin R, Barbera JA (2004) Clinical value of vasodilator test with inhaled nitric oxide for predicting long-term response to oral vasodilators in pulmonary hypertension. Respir Med 98:225–234PubMed
51.
Leuchte HH, Schwaiblmair M, Baumgartner RA, Neurohr CF, Kolbe T, Behr J (2004) Hemodynamic response to sildenafil, nitric oxide, and iloprost in primary pulmonary hypertension. Chest 125:580–586PubMed
52.
Sablotzki A, Hentschel T, Gruenig E, Schubert S, Friedrich I, Muhling J, Dehne MG, Czeslick E (2002) Hemodynamic effects of inhaled aerosolized iloprost and inhaled nitric oxide in heart transplant candidates with elevated pulmonary vascular resistance. Eur J Cardiothorac Surg 22:746–752PubMed
53.
Loscalzo J (2001) Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ Res 88:756–762PubMed
54.
Kermarrec N, Zunic P, Beloucif S, Benessiano J, Drouet L, Payen D (1998) Impact of inhaled nitric oxide on platelet aggregation and fibrinolysis in rats with endotoxic lung injury. Role of cyclic guanosine 5′-monophosphate. Am J Respir Crit Care Med 158:833–839PubMed
55.
Bottiger BW, Motsch J, Dorsam J, Mieck U, Gries A, Weimann J, Martin E (1996) Inhaled nitric oxide selectively decreases pulmonary artery pressure and pulmonary vascular resistance following acute massive pulmonary microembolism in piglets. Chest 110:1041–1047PubMed
56.
Estagnasie P, Le Bourdelles G, Mier L, Coste F, Dreyfuss D (1994) Use of inhaled nitric oxide to reverse flow through a patent foramen ovale during pulmonary embolism. Ann Intern Med 120:757–759PubMed
57.
Capellier G, Jacques T, Balvay P, Blasco G, Belle E, Barale F (1997) Inhaled nitric oxide in patients with pulmonary embolism. Intensive Care Med 23:1089–1092PubMed
58.
Schenk P, Mittermayer C, Ratheiser K (1999) Inhaled nitric oxide in a patient with severe pulmonary embolism. Ann Emerg Med 33:710–714PubMed
59.
Pinelli G, Mertes PM, Carteaux JP, Hubert T, Dopff C, Burtin P, Villemot JP (1996) Inhaled nitric oxide as an adjunct to pulmonary thromboendarterectomy. Ann Thorac Surg 61:227–229PubMed
60.
Bunn HF (1997) Pathogenesis and treatment of sickle cell disease. N Engl J Med 337:762–769PubMed
61.
Martinez-Ruiz R, Montero-Huerta P, Hromi J, Head CA (2001) Inhaled nitric oxide improves survival rates during hypoxia in a sickle cell (SAD) mouse model. Anesthesiology 94:1113–1118PubMed
62.
Atz AM, Wessel DL (1997) Inhaled nitric oxide in sickle cell disease with acute chest syndrome. Anesthesiology 87:988–990PubMed
63.
Sullivan KJ, Goodwin SR, Evangelist J, Moore RD, Mehta P (1999) Nitric oxide successfully used to treat acute chest syndrome of sickle cell disease in a young adolescent. Crit Care Med 27:2563–2568PubMed
64.
Weiner DL, Hibberd PL, Betit P, Cooper AB, Botelho CA, Brugnara C (2003) Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease. JAMA 289:1136–1142PubMed
65.
Adnot S, Kouyoumdjian C, Defouilloy C, Andrivet P, Sediame S, Herigault R, Fratacci MD (1993) Hemodynamic and gas exchange responses to infusion of acetylcholine and inhalation of nitric oxide in patients with chronic obstructive lung disease and pulmonary hypertension. Am Rev Respir Dis 148:310–316PubMed
66.
Barbera JA, Roger N, Roca J, Rovira I, Higenbottam TW, Rodriguez-Roisin R (1996) Worsening of pulmonary gas exchange with nitric oxide inhalation in chronic obstructive pulmonary disease. Lancet 347:436–440PubMed
67.
Ashutosh K, Phadke K, Jackson JF, Steele D (2000) Use of nitric oxide inhalation in chronic obstructive pulmonary disease. Thorax 55:109–113PubMed
68.
Baigorri F, Joseph D, Artigas A, Blanch L (1999) Inhaled nitric oxide does not improve cardiac or pulmonary function in patients with an exacerbation of chronic obstructive pulmonary disease. Crit Care Med 27:2153–2158PubMed
69.
Vonbank K, Ziesche R, Higenbottam TW, Stiebellehner L, Petkov V, Schenk P, Germann P, Block LH (2003) Controlled prospective randomised trial on the effects on pulmonary haemodynamics of the ambulatory long term use of nitric oxide and oxygen in patients with severe COPD. Thorax 58:289–293PubMed
70.
Morita K, Ihnken K, Buckberg GD, Sherman MP, Ignarro LJ (1996) Pulmonary vasoconstriction due to impaired nitric oxide production after cardiopulmonary bypass. Ann Thorac Surg 61:1775–1780PubMed
71.
Gianetti J, Del Sarto P, Bevilacqua S, Vassalle C, De Filippis R, Kacila M, Farneti PA, Clerico A, Glauber M, Biagini A (2004) Supplemental nitric oxide and its effect on myocardial injury and function in patients undergoing cardiac surgery with extracorporeal circulation. J Thorac Cardiovasc Surg 127:44–50PubMed
72.
Solina A, Papp D, Ginsberg S, Krause T, Grubb W, Scholz P, Pena LL, Cody R (2000) A comparison of inhaled nitric oxide and milrinone for the treatment of pulmonary hypertension in adult cardiac surgery patients. J Cardiothorac Vasc Anesth 14:12–17PubMed
73.
Schmid ER, Burki C, Engel MH, Schmidlin D, Tornic M, Seifert B (1999) Inhaled nitric oxide versus intravenous vasodilators in severe pulmonary hypertension after cardiac surgery. Anesth Analg 89:1108–1115
74.
Fullerton DA, Jones SD, Jaggers J, Piedalue F, Grover FL, McIntyre RC Jr (1996) Effective control of pulmonary vascular resistance with inhaled nitric oxide after cardiac operation. J Thorac Cardiovasc Surg 111:753–762–PubMed
75.
Solina AR, Ginsberg SH, Papp D, Pantin EJ, Denny J, Ghandivel I, Krause TJ (2002) Response to nitric oxide during adult cardiac surgery. J Invest Surg 15:5–14PubMed
76.
Stobierska-Dzierzek B, Awad H, Michler RE (2001) The evolving management of acute right-sided heart failure in cardiac transplant recipients. J Am Coll Cardiol 38:923–931PubMed
77.
Ardehali A, Hughes K, Sadeghi A, Esmailian F, Marelli D, Moriguchi J, Hamilton MA, Kobashigawa J, Laks H (2001) Inhaled nitric oxide for pulmonary hypertension after heart transplantation. Transplantation 72:638–641PubMed
78.
Mavroidis D, Sun BC, Pae WE Jr (1999) Bridge to transplantation: the Penn State experience. Ann Thorac Surg 68:684–67PubMed
79.
Oz MC, Argenziano M, Catanese KA, Gardocki MT, Goldstein DJ, Ashton RC, Gelijns AC, Rose EA, Levin HR (1997) Bridge experience with long-term implantable left ventricular assist devices. Are they an alternative to transplantation? Circulation 95:1844–1852PubMed
80.
Kavarana MN, Pessin-Minsley MS, Urtecho J, Catanese KA, Flannery M, Oz MC, Naka Y (2002) Right ventricular dysfunction and organ failure in left ventricular assist device recipients: a continuing problem. Ann Thorac Surg 73:745–750PubMed
81.
Macdonald PS, Keogh A, Mundy J, Rogers P, Nicholson A, Harrison G, Jansz P, Kaan AM, Spratt P (1998) Adjunctive use of inhaled nitric oxide during implantation of a left ventricular assist device. J Heart Lung Transplant 17:312–316PubMed
82.
Argenziano M, Choudhri AF, Moazami N, Rose EA, Smith CR, Levin HR, Smerling AJ, Oz MC (1998) Randomized, double-blind trial of inhaled nitric oxide in LVAD recipients with pulmonary hypertension. Ann Thorac Surg 65:340–345PubMed
83.
Costard-Jackle A, Hill I, Schroeder JS, Fowler MB (1991) The influence of preoperative patient characteristics on early and late survival following cardiac transplantation. Circulation 84:III329–III337PubMed
84.
Kieler-Jensen N, Milocco I, Ricksten SE (1993) Pulmonary vasodilation after heart transplantation. A comparison among prostacyclin, sodium nitroprusside, and nitroglycerin on right ventricular function and pulmonary selectivity. J Heart Lung Transplant 12:179–184PubMed
85.
Rajek A, Pernerstorfer T, Kastner J, Mares P, Grabenwoger M, Sessler DI, Grubhofer G, Hiesmayr M (2000) Inhaled nitric oxide reduces pulmonary vascular resistance more than prostaglandin E(1) during heart transplantation. Anesth Analg 90:523–530
86.
Benumof JL (1985) One-lung ventilation and hypoxic pulmonary vasoconstriction: implications for anesthetic management. Anesth Analg 64:821–833PubMed
87.
Ullrich R, Bloch KD, Ichinose F, Steudel W, Zapol WM (1999) Hypoxic pulmonary blood flow redistribution and arterial oxygenation in endotoxin-challenged NOS2-deficient mice. J Clin Invest 104:1421–1429PubMed
88.
Rich GF, Lowson SM, Johns RA, Daugherty MO, Uncles DR (1994) Inhaled nitric oxide selectively decreases pulmonary vascular resistance without impairing oxygenation during one-lung ventilation in patients undergoing cardiac surgery. Anesthesiology 80:57–62PubMed
89.
Wilson WC, Kapelanski DP, Benumof JL, Newhart 2nd JW, Johnson FW, Channick RN (1997) Inhaled nitric oxide (40 ppm) during one-lung ventilation, in the lateral decubitus position, does not decrease pulmonary vascular resistance or improve oxygenation in normal patients. J Cardiothorac Vasc Anesth 11:172–176PubMed
90.
Sticher J, Scholz S, Boning O, Schermuly RT, Schumacher C, Walmrath D, Hempelmann G (2002) Small-dose nitric oxide improves oxygenation during one-lung ventilation: an experimental study. Anesth Analg 95:1557–1562
91.
Fradj K, Samain E, Delefosse D, Farah E, Marty J (1999) Placebo-controlled study of inhaled nitric oxide to treat hypoxaemia during one-lung ventilation. Br J Anaesth 82:208–212
92.
Rocca GD, Passariello M, Coccia C, Costa MG, Di Marco P, Venuta F, Rendina EA, Pietropaoli P (2001) Inhaled nitric oxide administration during one-lung ventilation in patients undergoing thoracic surgery. J Cardiothorac Vasc Anesth 15:218–223PubMed
93.
Wysocki M, Delclaux C, Roupie E, Langeron O, Liu N, Herman B, Lemaire F, Brochard L (1994) Additive effect on gas exchange of inhaled nitric oxide and intravenous almitrine bismesylate in the adult respiratory distress syndrome. Intensive Care Med 20:254–259PubMed
94.
Moutafis M, Liu N, Dalibon N, Kuhlman G, Ducros L, Castelain MH, Fischler M (1997) The effects of inhaled nitric oxide and its combination with intravenous almitrine on Pao2 during one-lung ventilation in patients undergoing thoracoscopic procedures. Anesth Analg 85:1130–1135
95.
Payen DM, Gatecel C, Plaisance P (1993) Almitrine effect on nitric oxide inhalation in adult respiratory distress syndrome. Lancet 341:1664
96.
Williams EA, Quinlan GJ, Goldstraw P, Gothard JW, Evans TW (1998) Postoperative lung injury and oxidative damage in patients undergoing pulmonary resection. Eur Respir J 11:1028–1034PubMed
97.
Chiche JD, Canivet JL, Damas P, Joris J, Lamy M (1995) Inhaled nitric oxide for hemodynamic support after postpneumonectomy ARDS. Intensive Care Med 21:675–678PubMed
98.
Rabkin DG, Sladen RN, DeMango A, Steinglass KM, Goldstein DJ (2001) Nitric oxide for the treatment of postpneumonectomy pulmonary edema. Ann Thorac Surg 72:272–274PubMed
99.
Waldow T, Alexiou K, Witt W, Wagner FM, Kappert U, Knaut M, Matschke K (2004) Protection of lung tissue against ischemia/reperfusion injury by preconditioning with inhaled nitric oxide in an in situ pig model of normothermic pulmonary ischemia. Nitric Oxide 10:195–201PubMed
100.
Thabut G, Brugiere O, Leseche G, Stern JB, Fradj K, Herve P, Jebrak G, Marty J, Fournier M, Mal H (2001) Preventive effect of inhaled nitric oxide and pentoxifylline on ischemia/reperfusion injury after lung transplantation. Transplantation 71:1295–1300PubMed
101.
Meade MO, Granton JT, Matte-Martyn A, McRae K, Weaver B, Cripps P, Keshavjee SH (2003) A randomized trial of inhaled nitric oxide to prevent ischemia-reperfusion injury after lung transplantation. Am J Respir Crit Care Med 167:1483–1489PubMed
102.
Myles PS, Venema HR (1995) Avoidance of cardiopulmonary bypass during bilateral sequential lung transplantation using inhaled nitric oxide. J Cardiothorac Vasc Anesth 9:571–574PubMed
103.
McIntyre RC Jr, Moore FA, Moore EE, Piedalue F, Haenel JS, Fullerton DA (1995) Inhaled nitric oxide variably improves oxygenation and pulmonary hypertension in patients with acute respiratory distress syndrome. J Trauma 39:418–425PubMed
104.
Puybasset L, Rouby JJ, Mourgeon E, Cluzel P, Souhil Z, Law-Koune JD, Stewart T, Devilliers C, Lu Q, Roche S et al (1995) Factors influencing cardiopulmonary effects of inhaled nitric oxide in acute respiratory failure. Am J Respir Crit Care Med 152:318–328PubMed
105.
Papazian L, Bregeon F, Gaillat F, Thirion X, Gainnier M, Gregoire R, Saux P, Gouin F, Jammes Y, Auffray JP (1998) Respective and combined effects of prone position and inhaled nitric oxide in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 157:580–585PubMed
106.
Gerlach H, Keh D, Semmerow A, Busch T, Lewandowski K, Pappert DM, Rossaint R, Falke KJ (2003) Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome: a prospective, randomized, controlled study. Am J Respir Crit Care Med 167:1008–1015PubMed
107.
Sokol J, Jacobs SE, Bohn D (2000) Inhaled nitric oxide for acute hypoxemic respiratory failure in children and adults. Cochrane Database Syst Rev:CD002787
108.
Putensen C, Hormann C, Kleinsasser A, Putensen-Himmer G (1998) Cardiopulmonary effects of aerosolized prostaglandin E1 and nitric oxide inhalation in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 157:1743–1747PubMed
109.
Walmrath D, Schneider T, Schermuly R, Olschewski H, Grimminger F, Seeger W (1996) Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome. Am J Respir Crit Care Med 153:991–996PubMed
Metadaten
Titel
Inhaled nitric oxide therapy in adults: European expert recommendations
verfasst von
Peter Germann
Antonio Braschi
Giorgio Della Rocca
Anh Tuan Dinh-Xuan
Konrad Falke
Claes Frostell
Lars E. Gustafsson
Philippe Hervé
Philippe Jolliet
Udo Kaisers
Hector Litvan
Duncan J. Macrae
Marco Maggiorini
Nandor Marczin
Bernd Mueller
Didier Payen
Marco Ranucci
Dietmar Schranz
Rainer Zimmermann
Roman Ullrich
Publikationsdatum
01.08.2005
Verlag
Springer-Verlag
Erschienen in
Intensive Care Medicine / Ausgabe 8/2005
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-005-2675-4

Weitere Artikel der Ausgabe 8/2005

Intensive Care Medicine 8/2005 Zur Ausgabe

Original

Temporal changes in whole-blood and plasma glutathione in ICU patients with multiple organ failure

Pediatric Original

Effect of the Y-piece of the ventilation circuit on ventilation requirements in extremely low birth weight infants

Original

Safety and efficacy of colistin in Acinetobacter and Pseudomonas infections: a prospective cohort study

Original

Hemodynamic variables related to outcome in septic shock

Physiological Note

Mechanisms of hypoxemia

Brief Report

Nosocomial viral ventilator-associated pneumonia in the intensive care unit: a prospective cohort study

Neu im Fachgebiet AINS

Mehr Frauen im OP – weniger postoperative Komplikationen

21.05.2024 Allgemeine Chirurgie Nachrichten

Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Delir bei kritisch Kranken – Antipsychotika versus Placebo

16.05.2024 Delir Nachrichten

Um die Langzeitfolgen eines Delirs bei kritisch Kranken zu mildern, wird vielerorts auf eine Akuttherapie mit Antipsychotika gesetzt. Eine US-amerikanische Forschungsgruppe äußert jetzt erhebliche Vorbehalte gegen dieses Vorgehen. Denn es gibt neue Daten zum Langzeiteffekt von Haloperidol bzw. Ziprasidon versus Placebo.

Klinikreform soll zehntausende Menschenleben retten

15.05.2024 Klinik aktuell Nachrichten

Gesundheitsminister Lauterbach hat die vom Bundeskabinett beschlossene Klinikreform verteidigt. Kritik an den Plänen kommt vom Marburger Bund. Und in den Ländern wird über den Gang zum Vermittlungsausschuss spekuliert.

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

hier abonnieren
Bildnachweise