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Erschienen in: Intensive Care Medicine 8/2008

01.08.2008 | Original

Bedside adherence to clinical practice guidelines in the intensive care unit: the TECLA study

verfasst von: Jean-Pierre Quenot, Hervé Mentec, François Feihl, Djillali Annane, Christian Melot, Philippe Vignon, Christian Brun-Buisson, TECLA Study Group

Erschienen in: Intensive Care Medicine | Ausgabe 8/2008

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Abstract

Objective

To assess adherence to clinical practice guidelines for three interventions routinely used in critical care medicine.

Design and setting

Multicenter, 1-day cross-sectional observational study in 44 intensive care units in four countries.

Patients

A total of 419 patients hospitalized in participating ICUs on the day of the survey.

Measurements and results

Red blood cell transfusion (n = 29) was performed appropriately in 22 patients (76%), while among the 390 patients who received no transfusion 4 (1%) had a valid indication. Setting of tidal volume in acute respiratory distress syndrome, assessed in 45 patients, was deemed appropriate in 37 cases (82%). Prescription of stress ulcer prophylaxis (n = 128) was appropriate in only 24 patients (19%), while among the 268 patients who were not treated 28 (10%) had an indication.

Conclusions

The implementation of recommendations varies across different domains of care. While the adherence to current recommendations in routine practice is acceptable as regards tidal volume settings in acute respiratory distress syndrome, it is suboptimal for blood transfusion and prevention of upper gastrointestinal bleeding. Practice surveys are useful to inform strategies currently developed to assess practices of health-care professionals and develop strategies for more effective dissemination of medical knowledge.
Literatur
1.
Zurück zum Zitat Simes RJ (2002) Clinical trials and “real-world” medicine. Med J Aust 177:407–408 Simes RJ (2002) Clinical trials and “real-world” medicine. Med J Aust 177:407–408
2.
Zurück zum Zitat Kalassian KG, Dremsizov T, Angus DC (2002) Translating research evidence into clinical practice: new challenges for critical care. Crit Care 6:11–14PubMedCrossRef Kalassian KG, Dremsizov T, Angus DC (2002) Translating research evidence into clinical practice: new challenges for critical care. Crit Care 6:11–14PubMedCrossRef
3.
Zurück zum Zitat Davis D, O'Brien MA, Freemantle N, Wolf FM, Mazmanian P, Taylor-Vaisey A (1999) Impact of formal continuing medical education: do conferences, workshops, rounds, and other traditional continuing activities change physician behaviour or health care outcomes? JAMA 282:867–874PubMedCrossRef Davis D, O'Brien MA, Freemantle N, Wolf FM, Mazmanian P, Taylor-Vaisey A (1999) Impact of formal continuing medical education: do conferences, workshops, rounds, and other traditional continuing activities change physician behaviour or health care outcomes? JAMA 282:867–874PubMedCrossRef
4.
Zurück zum Zitat Mann H (2002) Research ethics committees and public dissemination of clinical trial results. Lancet 360:406–408PubMedCrossRef Mann H (2002) Research ethics committees and public dissemination of clinical trial results. Lancet 360:406–408PubMedCrossRef
5.
Zurück zum Zitat Pitch J, Carne X, Arnaiz JA, Gmoez B, Trilla A, Rodes J (2003) Role of research ethics committee in follow-up and publication of results. Lancet 361:1015–1016CrossRef Pitch J, Carne X, Arnaiz JA, Gmoez B, Trilla A, Rodes J (2003) Role of research ethics committee in follow-up and publication of results. Lancet 361:1015–1016CrossRef
6.
Zurück zum Zitat Alberti C, Brun-Buisson C, Burchardi H, Martin C, Goodman S, Artigas A, Sicignano A, Palazzo M, Moreno R, Boulmé R, Lapage E, Le Gall JR (2002) Epidemiology of sepsis and infection in ICU patients from an international multicenter cohort study. Intensive Care Med 28:108–121PubMedCrossRef Alberti C, Brun-Buisson C, Burchardi H, Martin C, Goodman S, Artigas A, Sicignano A, Palazzo M, Moreno R, Boulmé R, Lapage E, Le Gall JR (2002) Epidemiology of sepsis and infection in ICU patients from an international multicenter cohort study. Intensive Care Med 28:108–121PubMedCrossRef
7.
Zurück zum Zitat EPISEPSIS Study Group (2004) EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care Units. Intensive Care Med 30:580–588CrossRef EPISEPSIS Study Group (2004) EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care Units. Intensive Care Med 30:580–588CrossRef
8.
Zurück zum Zitat Sakr Y, Reinhart K, Vincent JL, Sprung CL, Moreno R, Ranieri M, De Baker D, Payen D (2006) Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) study. Crit Care Med 34:589–597PubMedCrossRef Sakr Y, Reinhart K, Vincent JL, Sprung CL, Moreno R, Ranieri M, De Baker D, Payen D (2006) Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) study. Crit Care Med 34:589–597PubMedCrossRef
9.
Zurück zum Zitat Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E (1999) A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 340:409–417PubMedCrossRef Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E (1999) A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 340:409–417PubMedCrossRef
10.
Zurück zum Zitat Sloane PJ, Gee MH, Gottlieb JE, Albertine KH, Peters SP, Burns JR, Machiedo G, Fish JE (1992) A multicenter registry of patients with acute respiratory distress syndrome: physiology and outcome. Am Rev Respir Dis 146:149–126 Sloane PJ, Gee MH, Gottlieb JE, Albertine KH, Peters SP, Burns JR, Machiedo G, Fish JE (1992) A multicenter registry of patients with acute respiratory distress syndrome: physiology and outcome. Am Rev Respir Dis 146:149–126
11.
Zurück zum Zitat Zilberberg MD, Epstein SK (1998) Acute lung injury in the medical ICU: comorbid conditions, age, etiology, and hospital outcome. Am J Respir Crit Care Med 157:1159–1164PubMed Zilberberg MD, Epstein SK (1998) Acute lung injury in the medical ICU: comorbid conditions, age, etiology, and hospital outcome. Am J Respir Crit Care Med 157:1159–1164PubMed
12.
Zurück zum Zitat Tsuno K, Miura K, Takeya M, Kolobow T, Morioka T (1991) Histopathologic pulmonary changes from mechanical ventilation at high peak airway pressures. Am Rev Respir Dis 143:1115–1120PubMed Tsuno K, Miura K, Takeya M, Kolobow T, Morioka T (1991) Histopathologic pulmonary changes from mechanical ventilation at high peak airway pressures. Am Rev Respir Dis 143:1115–1120PubMed
13.
Zurück zum Zitat Dreyfuss D, Basset G, Soler P, Saumon G (1985) Intermittent positive-pressure hyperventilation with high inflation pressures produces pulmonary microvascular injury in rats. Am Rev Respir Dis 132:880–884PubMed Dreyfuss D, Basset G, Soler P, Saumon G (1985) Intermittent positive-pressure hyperventilation with high inflation pressures produces pulmonary microvascular injury in rats. Am Rev Respir Dis 132:880–884PubMed
14.
Zurück zum Zitat Acute Respiratory Distress Syndrome NetWork (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308CrossRef Acute Respiratory Distress Syndrome NetWork (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308CrossRef
15.
Zurück zum Zitat Raynard B, Bernard B, Bleichner G, Fagon JY (2000) Prévention des hémorragies digestives hautes de stress en réanimation. Révision de la conférence de consensus de 1988. Reanimination Soins Intensifs Med Urgence 9:555–560 Raynard B, Bernard B, Bleichner G, Fagon JY (2000) Prévention des hémorragies digestives hautes de stress en réanimation. Révision de la conférence de consensus de 1988. Reanimination Soins Intensifs Med Urgence 9:555–560
16.
Zurück zum Zitat Le Gall JR, Lemeshow S, Saulnier F (1993) A new Simplified Acute Physiology Score (SAPS II) based on a European /North American multicenter study. JAMA 270:2957–2963PubMedCrossRef Le Gall JR, Lemeshow S, Saulnier F (1993) A new Simplified Acute Physiology Score (SAPS II) based on a European /North American multicenter study. JAMA 270:2957–2963PubMedCrossRef
17.
Zurück zum Zitat Kantorova I, Svoboda P, Scheer P, Doubek J, Rehorkova D, Bosakova H, Ochmann J (2004) Stress ulcer prophylaxis in critically ill patients: a randomized controlled trial. Hepatogastroenterology 51:757–761PubMed Kantorova I, Svoboda P, Scheer P, Doubek J, Rehorkova D, Bosakova H, Ochmann J (2004) Stress ulcer prophylaxis in critically ill patients: a randomized controlled trial. Hepatogastroenterology 51:757–761PubMed
18.
Zurück zum Zitat Daley RJ, Rebuck JA, Welage LS, Rogers FB (2004) Prevention of stress ulceration: current trends in critical care. Crit Care Med 32:2008–2013PubMedCrossRef Daley RJ, Rebuck JA, Welage LS, Rogers FB (2004) Prevention of stress ulceration: current trends in critical care. Crit Care Med 32:2008–2013PubMedCrossRef
19.
Zurück zum Zitat Faisy C, Guerot E, Diehl JL, Iftimovici E, Fagon JY (2003) Clinically significant gastrointestinal bleeding in critically ill patients with and without stress-ulcer prophylaxis. Intensive Care Med 29:1306–1313PubMedCrossRef Faisy C, Guerot E, Diehl JL, Iftimovici E, Fagon JY (2003) Clinically significant gastrointestinal bleeding in critically ill patients with and without stress-ulcer prophylaxis. Intensive Care Med 29:1306–1313PubMedCrossRef
20.
Zurück zum Zitat Cook D, Guyatt G, Marshall J, Leasa D, Fuller H, Hall R, Peters S, Rutledge F, Griffith L, McLellan A, Wood G, Kirby A (1998) A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care trials Group. N Engl J Med 338:791–797PubMedCrossRef Cook D, Guyatt G, Marshall J, Leasa D, Fuller H, Hall R, Peters S, Rutledge F, Griffith L, McLellan A, Wood G, Kirby A (1998) A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care trials Group. N Engl J Med 338:791–797PubMedCrossRef
21.
Zurück zum Zitat Cook DJ, Reeve BK, Guyatt GH, Heyland DK, Griffith LE, Buckingam L, Tryba M (1996) Stress ulcer prophylaxis in critically ill patients. Resolving discordant meta-analyses. JAMA 275:308–314PubMedCrossRef Cook DJ, Reeve BK, Guyatt GH, Heyland DK, Griffith LE, Buckingam L, Tryba M (1996) Stress ulcer prophylaxis in critically ill patients. Resolving discordant meta-analyses. JAMA 275:308–314PubMedCrossRef
22.
Zurück zum Zitat Hebert PC, Fergusson DA, Stather D, McInthyre L, Martin C, Doucette S, Blajchman M, Graham ID for the Canadian Critical Care Trials Group (2005) Revisiting transfusion practices in critically ill patients. Crit Care Med 33:7–12PubMedCrossRef Hebert PC, Fergusson DA, Stather D, McInthyre L, Martin C, Doucette S, Blajchman M, Graham ID for the Canadian Critical Care Trials Group (2005) Revisiting transfusion practices in critically ill patients. Crit Care Med 33:7–12PubMedCrossRef
23.
Zurück zum Zitat Weinert CR, Gross CR, Marinelli WA (2003) Impact of randomized trial results on acute lung injury ventilator therapy in teaching hospital. Am J Respir Crit Care Med 167:1304–1309PubMedCrossRef Weinert CR, Gross CR, Marinelli WA (2003) Impact of randomized trial results on acute lung injury ventilator therapy in teaching hospital. Am J Respir Crit Care Med 167:1304–1309PubMedCrossRef
24.
Zurück zum Zitat Esteban A, Anzuetto A, Frutos F, Alia I, Brochard L, Stewart TE, Benito S, Epstein SK, Apezteguia C, Nightingale P, Arroliga AC, Tobin MJ, Mechanical Ventilation International Study Group (2002) Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA 287:345–355PubMedCrossRef Esteban A, Anzuetto A, Frutos F, Alia I, Brochard L, Stewart TE, Benito S, Epstein SK, Apezteguia C, Nightingale P, Arroliga AC, Tobin MJ, Mechanical Ventilation International Study Group (2002) Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA 287:345–355PubMedCrossRef
25.
Zurück zum Zitat Brun-Buisson C, Minelli C, Bertolini G, Brazzi L, Pimentel J, Lewandowski K, Bion J, Romand JA, Villar J, Thorsteinsson A, Damas P, Armaganidis A, Lemaire F (2004) Epidemiology and outcome of ALI in European ICUs. Results from ALIVE study. Intensive Care Med 30:51–61PubMedCrossRef Brun-Buisson C, Minelli C, Bertolini G, Brazzi L, Pimentel J, Lewandowski K, Bion J, Romand JA, Villar J, Thorsteinsson A, Damas P, Armaganidis A, Lemaire F (2004) Epidemiology and outcome of ALI in European ICUs. Results from ALIVE study. Intensive Care Med 30:51–61PubMedCrossRef
26.
Zurück zum Zitat Fergusson ND, Frutos-Vivar F, Esteban A, Anzueto A, Alia I, Brower RG, Stewart TE, Apezteguia C, Gonzales M, Soto L, Abroug F, Brochard L, for the Mechanical Ventilation International Study Group (2005) Airway pressures, tidal volumes, and mortality with acute respiratory distress syndrome. Crit Care Med 33:21–30CrossRef Fergusson ND, Frutos-Vivar F, Esteban A, Anzueto A, Alia I, Brower RG, Stewart TE, Apezteguia C, Gonzales M, Soto L, Abroug F, Brochard L, for the Mechanical Ventilation International Study Group (2005) Airway pressures, tidal volumes, and mortality with acute respiratory distress syndrome. Crit Care Med 33:21–30CrossRef
27.
Zurück zum Zitat Kahn JM, Doctor JN, Rubenfeld GD (2006) Stress ulcer prophylaxis in mechanically ventilated patients: integrating evidence and judgment using a decision analysis. Intensive Care Med 32:1151–1158PubMedCrossRef Kahn JM, Doctor JN, Rubenfeld GD (2006) Stress ulcer prophylaxis in mechanically ventilated patients: integrating evidence and judgment using a decision analysis. Intensive Care Med 32:1151–1158PubMedCrossRef
28.
Zurück zum Zitat Pitimana-aree S, Forrest D, Brown G, Anis A, Wang XH, Dodek P (1998) Implementation of a clinical practice guideline for stress ulcer prophylaxis increases appropriateness and decreases cost of care. Intensive Care Med 24:217–223PubMedCrossRef Pitimana-aree S, Forrest D, Brown G, Anis A, Wang XH, Dodek P (1998) Implementation of a clinical practice guideline for stress ulcer prophylaxis increases appropriateness and decreases cost of care. Intensive Care Med 24:217–223PubMedCrossRef
29.
Zurück zum Zitat Cook DJ, Walter SD, Cook RJ, Grifith LE, Guyatt GH, Leasa D, Jaeschke RZ, Brun-Buisson C (1998) Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann Intern Med 129:433–440PubMed Cook DJ, Walter SD, Cook RJ, Grifith LE, Guyatt GH, Leasa D, Jaeschke RZ, Brun-Buisson C (1998) Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann Intern Med 129:433–440PubMed
30.
Zurück zum Zitat Grol R, Grimshaw J (2003) From best evidence to best practice: effective implementation of change in patient's care. Lancet 362:1225–1230PubMedCrossRef Grol R, Grimshaw J (2003) From best evidence to best practice: effective implementation of change in patient's care. Lancet 362:1225–1230PubMedCrossRef
Metadaten
Titel
Bedside adherence to clinical practice guidelines in the intensive care unit: the TECLA study
verfasst von
Jean-Pierre Quenot
Hervé Mentec
François Feihl
Djillali Annane
Christian Melot
Philippe Vignon
Christian Brun-Buisson
TECLA Study Group
Publikationsdatum
01.08.2008
Verlag
Springer-Verlag
Erschienen in
Intensive Care Medicine / Ausgabe 8/2008
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-008-1059-y

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