Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Häufige urologisch-sexualmedizinische Themen in der Praxis sind das Thema des MMW-Webinars am 5. Juni von 17.30 bis 19 Uhr. Konkret geht es um die Frage, wann bei Harnwegsinfektionen auf Antibiotika verzichtet werden kann, und um ein Update zur Therapie von Libido- und Potenzstörungen des Mannes. Der dritte Vortrag behandelt sexuell übertragbare Krankheiten. Stellen Sie Ihre Fragen an die Experten und sammeln Sie 2 CME-Punkte. Jetzt gleich anmelden!
Erweiterte Suche
Anmelden
nach oben
World Journal of Surgery
Erschienen in: World Journal of Surgery 9/2012

01.09.2012

The False-Negative Rate of Sentinel Node Biopsy in Patients with Breast Cancer: A Meta-Analysis

verfasst von: Sarah Pesek, Taka Ashikaga, Lars Erik Krag, David Krag

Erschienen in: World Journal of Surgery | Ausgabe 9/2012

Einloggen, um Zugang zu erhalten

Abstract

Background

In sentinel node surgery for breast cancer, procedural accuracy is assessed by calculating the false-negative rate. It is important to measure this since there are potential adverse outcomes from missing node metastases. We performed a meta-analysis of published data to assess which method has achieved the lowest false-negative rate.

Methods

We found 3,588 articles concerning sentinel nodes and breast cancer published from 1993 through mid-2011; 183 articles met our inclusion criteria. The studies described in these 183 articles included a total of 9,306 patients. We grouped the studies by injection material and injection location. The false-negative rates were analyzed according to these groupings and also by the year in which the articles were published.

Results

There was significant variation related to injection material. The use of blue dye alone was associated with the highest false-negative rate. Inclusion of a radioactive tracer along with blue dye resulted in a significantly lower false-negative rate. Although there were variations in the false-negative rate according to injection location, none were significant.

Conclusions

The use of blue dye should be accompanied by a radioactive tracer to achieve a significantly lower false-negative rate. Location of injection did not have a significant impact on the false-negative rate. Given the limitations of acquiring appropriate data, the false-negative rate should not be used as a metric for training or quality control.
Literatur
1.
Krag DN et al (2010) Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial. Lancet Oncol 11(10):927–933PubMedCrossRef
2.
Tanis PJ et al (2002) The illusion of the learning phase for lymphatic mapping. Ann Surg Oncol 9(2):142–147PubMedCrossRef
3.
Cox CE et al (2000) Lymphatic mapping and sentinel lymph node biopsy in patients with breast cancer. Annu Rev Med 51:525–542PubMedCrossRef
4.
Fraile M et al (2000) Sentinel node biopsy as a practical alternative to axillary lymph node dissection in breast cancer patients: an approach to its validity. Ann Oncol 11(6):701–705PubMedCrossRef
5.
Kim T, Giuliano AE, Lyman GH (2006) Lymphatic mapping and sentinel lymph node biopsy in early-stage breast carcinoma: a metaanalysis. Cancer 106(1):4–16PubMedCrossRef
6.
McMasters KM et al (1998) Sentinel-lymph-node biopsy for breast cancer: not yet the standard of care. N Engl J Med 339(14):990–995PubMedCrossRef
7.
Miltenburg DM et al (1999) Meta-analysis of sentinel lymph node biopsy in breast cancer. J Surg Res 84(2):138–142PubMedCrossRef
8.
Orr RK, Hoehn JL, Col NF (1999) The learning curve for sentinel node biopsy in breast cancer: practical considerations. Arch Surg 134(7):764–767PubMedCrossRef
9.
Dixon W, Massey F (1969) Introduction to statistical analysis, 3rd edn. McGraw-Hill, New York
10.
Borenstein M et al (2009) Introduction to meta-analysis. Wiley, ChichesterCrossRef
11.
Anan K et al (2006) Double mapping with subareolar blue dye and peritumoral green dye injections decreases the false-negative rate of dye-only sentinel node biopsy for early breast cancer: 2-site injection is more accurate than 1-site injection. Surgery 139(5):624–629PubMedCrossRef
12.
Heuts EM et al (2009) Results of tailored treatment for breast cancer patients with internal mammary lymph node metastases. Breast 18(4):254–258PubMedCrossRef
13.
Heuts EM et al (2009) Internal mammary lymph drainage and sentinel node biopsy in breast cancer—a study on 1008 patients. Eur J Surg Oncol 35(3):252–257PubMedCrossRef
14.
Giuliano AE et al (1994) Lymphatic mapping and sentinel lymphadenectomy for breast cancer. Ann Surg 220(3):391–398 discussion 398–401PubMedCrossRef
15.
Giuliano AE et al (1997) Sentinel lymphadenectomy in breast cancer. J Clin Oncol 15(6):2345–2350PubMed
16.
Turner RR et al (1997) Histopathologic validation of the sentinel lymph node hypothesis for breast carcinoma. Ann Surg 226(3):271–276 discussion 276–278PubMedCrossRef
17.
Guenther JM, Krishnamoorthy M, Tan LR (1997) Sentinel lymphadenectomy for breast cancer in a community managed care setting. Cancer J Sci Am 3(6):336–340PubMed
18.
Flett MM et al (1998) Sentinel node localization in patients with breast cancer. Br J Surg 85(7):991–993PubMedCrossRef
19.
Ratanawichitrasin A et al (1998) Experience with lymphatic mapping in breast cancer using isosulfan blue dye. J Womens Health 7(7):873–877PubMedCrossRef
20.
Kapteijn BA et al (1998) Identification and biopsy of the sentinel lymph node in breast cancer. Eur J Surg Oncol 24(5):427–430PubMedCrossRef
21.
Imoto S, Hasebe T (1999) Initial experience with sentinel node biopsy in breast cancer at the National Cancer Center Hospital East. Jpn J Clin Oncol 29(1):11–15PubMedCrossRef
22.
Cserni G (1999) Estimating the overlap between sentinel lymph nodes and axillary node samples in breast cancer. Pathol Oncol Res 5(2):129–133PubMedCrossRef
23.
Morgan A et al (1999) Initial experience in a community hospital with sentinel lymph node mapping and biopsy for evaluation of axillary lymph node status in palpable invasive breast cancer. J Surg Oncol 72(1):24–30 discussion 30–31PubMedCrossRef
24.
Bobin JY et al (1999) Tagging sentinel lymph nodes: a study of 100 patients with breast cancer. Eur J Cancer 35(4):569–573PubMedCrossRef
25.
Kern KA (1999) Sentinel lymph node mapping in breast cancer using subareolar injection of blue dye. J Am Coll Surg 189(6):539–545PubMedCrossRef
26.
27.
Motomura K et al (1999) Sentinel node biopsy guided by indocyanine green dye in breast cancer patients. Jpn J Clin Oncol 29(12):604–607PubMedCrossRef
28.
Canavese G et al (2000) Sentinel lymph node mapping in early-stage breast cancer: technical issues and results with vital blue dye mapping and radioguided surgery. J Surg Oncol 74(1):61–68PubMedCrossRef
29.
Altinyollar H et al (2000) Lymphatic mapping and sentinel lymphadenectomy in early stage breast carcinoma. J Exp Clin Cancer Res 19(2):141–144PubMed
30.
Ilum L et al (2000) Sentinel node localization in breast cancer patients using intradermal dye injection. Acta Oncol 39(3):423–428PubMedCrossRef
31.
32.
Noguchi M et al (1998) Dye-guided sentinel lymphadenectomy in clinically node-negative and node-positive breast cancer patients. Breast Cancer 5(4):381–387PubMedCrossRef
33.
Miyauchi M et al (1999) Computed tomography for preoperative evaluation of axillary nodal status in breast cancer. Breast Cancer 6(3):243–248PubMedCrossRef
34.
Motomura K et al (1999) Sentinel node biopsy in breast cancer patients with clinically negative lymph-nodes. Breast Cancer 6(3):259–262PubMedCrossRef
35.
Motomura K et al (2001) Combination technique is superior to dye alone in identification of the sentinel node in breast cancer patients. J Surg Oncol 76(2):95–99PubMedCrossRef
36.
Nos C et al (2001) Sentinel lymph node detection for breast cancer: which patients are best suited for the patent blue dye only method of identification? Ann Surg Oncol 8(5):438–443PubMedCrossRef
37.
Mokbel K, Mostafa A (2001) The role of subareolar blue dye in identifying the sentinel node in patients with invasive breast cancer. Curr Med Res Opin 17(2):93–95PubMed
38.
Shimazu K et al (2002) Comparison between periareolar and peritumoral injection of radiotracer for sentinel lymph node biopsy in patients with breast cancer. Surgery 131(3):277–286PubMedCrossRef
39.
40.
41.
Ozmen V et al (2002) Increased false negative rates in sentinel lymph node biopsies in patients with multi-focal breast cancer. Breast Cancer Res Treat 76(3):237–244PubMedCrossRef
42.
Nos C et al (2003) Macroscopic quality control improves the reliability of blue dye-only sentinel lymph node biopsy in breast cancer. Ann Surg Oncol 10(5):525–530PubMedCrossRef
43.
Aihara T, Takatsuka Y (2003) Dye-guided sentinel node biopsy revisited; validation and observational study from a single institute. Breast Cancer 10(3):254–259PubMedCrossRef
44.
Meyer-Rochow GY, Martin RC, Harman CR (2003) Sentinel node biopsy in breast cancer: validation study and comparison of blue dye alone with triple modality localization. ANZ J Surg 73(10):815–818PubMedCrossRef
45.
D’Eredita G et al (2003) Subareolar injection may be more accurate than other techniques for sentinel lymph node biopsy in breast cancer. Ann Surg Oncol 10(8):942–947PubMedCrossRef
46.
Shenoy V, Ravichandran D, Ralphs DN (2002) Is massage following dye injection necessary in sentinel node biopsy in breast cancer? Breast 11(3):273–274PubMedCrossRef
47.
Nour A (2004) Efficacy of methylene blue dye in localization of sentinel lymph node in breast cancer patients. Breast J 10(5):388–391PubMedCrossRef
48.
Radovanovic Z et al (2004) Blue dye versus combined blue dye-radioactive tracer technique in detection of sentinel lymph node in breast cancer. Eur J Surg Oncol 30(9):913–917PubMed
49.
Langer S et al (2004) Lymphatic mapping improves staging and reduces morbidity in women undergoing total mastectomy for breast carcinoma. Am Surg 70(10):881–885PubMed
50.
Deo S et al (2004) Sentinel lymph node biopsy assessment using intraoperative imprint cytology in breast cancer patients: results of a validation study. Asian J Surg 27(4):294–298PubMedCrossRef
51.
Peintinger F, Reitsamer R, Ralph G (2005) Implementation of sentinel lymph node biopsy with blue dye outside a specialized center: Can we improve quality assurance? Breast J 11(2):103–107PubMedCrossRef
52.
Ratanachaikanont T, Karalak A (2005) Sentinel node localization in breast cancer using intradermal dye injection: results, influencing factors and learning curve. J Med Assoc Thai 88(3):386–390PubMed
53.
Gui GP et al (2005) Continued axillary sampling is unnecessary and provides no further information to sentinel node biopsy in staging breast cancer. Eur J Surg Oncol 31(7):707–714PubMedCrossRef
54.
Asoglu O et al (2005) The role of sentinel lymph node biopsy with blue dye alone in breast cancer patients with excisional biopsy. Acta Chir Belg 105(3):291–296PubMed
55.
Kanwal S, Hussain R (2005) Sentinel lymph node biopsy in early carcinoma breast with blue dye. J Coll Physicians Surg Pak 15(8):515–516PubMed
56.
Gurleyik G et al (2005) Accuracy of sentinel lymph node biopsy for the assessment of axillary status in patients with early (T1) breast carcinoma. J Coll Physicians Surg Pak 15(11):697–700PubMed
57.
Hung WK et al (2005) Randomized clinical trial comparing blue dye with combined dye and isotope for sentinel lymph node biopsy in breast cancer. Br J Surg 92(12):1494–1497PubMedCrossRef
58.
D’Eredita G et al (2006) A further validation of subareolar injection technique for breast sentinel lymph node biopsy. Ann Surg Oncol 13(5):701–707PubMedCrossRef
59.
Lamichhane N et al (2007) Initial experience in a cancer hospital in Nepal with sentinel lymph node mapping and biopsy for evaluation of axillary lymph node status in palpable invasive breast cancer. Nepal Med Coll J 9(1):22–26PubMed
60.
Soares CT, Frederigue-Junior U, Luca LA (2007) Anatomopathological analysis of sentinel and nonsentinel lymph nodes in breast cancer: hematoxylin-eosin versus immunohistochemistry. Int J Surg Pathol 15(4):358–368PubMedCrossRef
61.
Kavallaris A, Camara O, Runnebaum IB (2008) Subareolar blue dye only injection sentinel lymph node biopsy could reduce the numbers of standard axillary lymph node dissection in environments without access to nuclear medicine. J Cancer Res Clin Oncol 134(6):667–672PubMedCrossRef
62.
Koukouraki S et al (2009) Is there any benefit from sentinel lymph node biopsy using the combined radioisotope/dye technique in breast cancer patients with clinically negative axilla? Nucl Med Commun 30(1):48–53PubMedCrossRef
63.
Hirche C et al (2010) ICG fluorescence-guided sentinel node biopsy for axillary nodal staging in breast cancer. Breast Cancer Res Treat 121(2):373–378PubMedCrossRef
64.
Yamashita K, Shimizu K (2009) Evaluation of sentinel lymph node metastasis alone guided by three-dimensional computed tomographic lymphography in video-assisted breast surgery. Surg Endosc 23(3):633–640PubMedCrossRef
65.
Chintamani et al (2011) Sentinel lymph node biopsy using dye alone method is reliable and accurate even after neo-adjuvant chemotherapy in locally advanced breast cancer—a prospective study. World J Surg Oncol 9:19. doi:10.​1186/​1477-7819-9-19 PubMedCrossRef
66.
Albertini JJ et al (1996) Lymphatic mapping and sentinel node biopsy in the patient with breast cancer. JAMA 276(22):1818–1822PubMedCrossRef
67.
Borgstein PJ, Meijer S, Pijpers R (1997) Intradermal blue dye to identify sentinel lymph-node in breast cancer. Lancet 349(9066):1668–1669PubMedCrossRef
68.
Barnwell JM et al (1998) Sentinel node biopsy in breast cancer. Ann Surg Oncol 5(2):126–130PubMedCrossRef
69.
O’Hea BJ et al (1998) Sentinel lymph node biopsy in breast cancer: initial experience at Memorial Sloan-Kettering Cancer Center. J Am Coll Surg 186(4):423–427PubMedCrossRef
70.
Nwariaku FE et al (1998) Sentinel lymph node biopsy, an alternative to elective axillary dissection for breast cancer. Am J Surg 176(6):529–531PubMedCrossRef
71.
Cox CE et al (1998) Sentinel lymphadenectomy: A safe answer to less axillary surgery? Recent Results Cancer Res 152:170–179PubMedCrossRef
72.
Hill AD et al (1999) Lessons learned from 500 cases of lymphatic mapping for breast cancer. Ann Surg 229(4):528–535PubMedCrossRef
73.
Carcoforo P et al (1999) Lymphatic mapping for the dissection of the sentinel node in the treatment of breast carcinoma. J Exp Clin Cancer Res 18(1):75–77PubMed
74.
Rehman S et al (1999) Sentinel lymph node mapping for staging breast cancer: preliminary results of a prospective study. Md Med J 48(3):105–110PubMed
75.
Burak WE Jr et al (1999) Routine preoperative lymphoscintigraphy is not necessary prior to sentinel node biopsy for breast cancer. Am J Surg 177(6):445–449PubMedCrossRef
76.
Jaderborg JM et al (1999) The feasibility and accuracy of the sentinel lymph node biopsy for breast carcinoma. Am Surg 65(8):699–703 discussion 704–705PubMed
77.
Bass SS et al (1999) The role of sentinel lymph node biopsy in breast cancer. J Am Coll Surg 189(2):183–194PubMedCrossRef
78.
Eary JF et al (1999) Sentinel lymph node mapping for breast cancer: analysis in a diverse patient group. Radiology 213(2):526–529PubMed
79.
Kollias J et al (1999) Reliability of sentinel node status in predicting axillary lymph node involvement in breast cancer. Med J Aust 171(9):461–465PubMed
80.
Molland JG, Dias MM, Gillett DJ (2000) Sentinel node biopsy in breast cancer: results of 103 cases. Aust N Z J Surg 70(2):98–102PubMedCrossRef
81.
Reintgen D et al (1997) The role of selective lymphadenectomy in breast cancer. Cancer Control 4(3):211–219PubMed
82.
Doting MH et al (2000) Lymphatic mapping with intralesional tracer administration in breast carcinoma patients. Cancer 88(11):2546–2552PubMedCrossRef
83.
Borgstein PJ et al (2000) Functional lymphatic anatomy for sentinel node biopsy in breast cancer: echoes from the past and the periareolar blue method. Ann Surg 232(1):81–89PubMedCrossRef
84.
Mariani G et al (2000) Mapping sentinel lymph node in breast cancer by combined lymphoscintigraphy, blue-dye, and intraoperative gamma-probe. Cancer Biother Radiopharm 15(3):245–252PubMedCrossRef
85.
Lauridsen MC et al (2000) Sentinel lymph node biopsy in breast cancer—the Aarhus experience. Acta Oncol 39(3):421–422PubMedCrossRef
86.
Villa G et al (2000) Localization of the sentinel lymph node in breast cancer by combined lymphoscintigraphy, blue dye and intraoperative gamma probe. Tumori 86(4):297–299PubMed
87.
Tsugawa K et al (2000) Dye- and gamma probe-guided sentinel lymph node biopsy in breast cancer patients: using patent blue dye and technetium-99m-labeled human serum albumin. Breast Cancer 7(1):87–94PubMedCrossRef
88.
Ikeda T et al (2000) Sentinel lymph node biopsy using tin colloid RI and blue dye method. Breast Cancer 7(4):284–286PubMedCrossRef
89.
Tafra L et al (2001) Multicenter trial of sentinel node biopsy for breast cancer using both technetium sulfur colloid and isosulfan blue dye. Ann Surg 233(1):51–59PubMedCrossRef
90.
Mann BG et al (2000) High incidence of micrometastases in breast cancer sentinel nodes. Aust N Z J Surg 70(11):786–790PubMedCrossRef
91.
Smith LF, Cross MJ, Klimberg VS (2000) Subareolar injection is a better technique for sentinel lymph node biopsy. Am J Surg 180(6):434–437 discussion 437–438PubMedCrossRef
92.
Boolbol SK et al (2001) Intradermal isotope injection: a highly accurate method of lymphatic mapping in breast carcinoma. Ann Surg Oncol 8(1):20–24PubMedCrossRef
93.
Hodgson N et al (2001) A new radiocolloid for sentinel node detection in breast cancer. Ann Surg Oncol 8(2):133–137PubMedCrossRef
94.
Frisell J et al (2001) Sentinel node in breast cancer—a Swedish pilot study of 75 patients. Eur J Surg 167(3):179–183PubMedCrossRef
95.
Dupont E et al (2001) Learning curves and breast cancer lymphatic mapping: institutional volume index. J Surg Res 97(1):92–96PubMedCrossRef
96.
McMasters KM et al (2001) Dermal injection of radioactive colloid is superior to peritumoral injection for breast cancer sentinel lymph node biopsy: results of a multiinstitutional study. Ann Surg 233(5):676–687PubMedCrossRef
97.
Canavese G et al (2001) Technical issues and pathologic implications of sentinel lymph node biopsy in early-stage breast cancer patients. J Surg Oncol 77(2):81–87 discussion 88PubMedCrossRef
98.
Smillie T et al (2001) Evaluation of feasibility and accuracy of sentinel node biopsy in early breast cancer. Am J Surg 181(5):427–430PubMedCrossRef
99.
Sabel MS et al (2001) Accuracy of sentinel node biopsy in predicting nodal status in patients with breast carcinoma. J Surg Oncol 77(4):243–246PubMedCrossRef
100.
Sato K et al (2001) Management of the axilla in breast cancer: a comparative study between sentinel lymph node biopsy and four-node sampling procedure. Jpn J Clin Oncol 31(7):318–321PubMedCrossRef
101.
Martin RC et al (2001) Intradermal isotope injection is superior to intramammary in sentinel node biopsy for breast cancer. Surgery 130(3):432–438PubMedCrossRef
102.
Xavier NL et al (2001) Sentinel lymph node identification and sampling in women with early breast cancer using 99mTc labelled dextran 500 and patent blue V dye. Nucl Med Commun 22(10):1109–1117PubMedCrossRef
103.
Kim R et al (2001) Significance of lymphoscintigraphic mapping with Tc-99m human serum albumin and tin colloid in sentinel lymph node biopsy in breast cancer. Int J Oncol 19(5):991–996PubMed
104.
Tavares MG et al (2001) The use of 99mTc-phytate for sentinel node mapping in melanoma, breast cancer and vulvar cancer: a study of 100 cases. Eur J Nucl Med 28(11):1597–1604PubMedCrossRef
105.
Donahue EJ (2001) Sentinel node imaging and biopsy in breast cancer patients. Am J Surg 182(4):426–428PubMedCrossRef
106.
Manecksha R et al (2001) Value of sentinel node biopsy in the management of breast cancer. Ir J Med Sci 170(4):233–235PubMedCrossRef
107.
Euhus DM et al (2002) Validating the performance of the mammary sentinel lymph node team. J Surg Oncol 79(4):209–215PubMedCrossRef
108.
Shivers S et al (2002) Final results of the department of defense multicenter breast lymphatic mapping trial. Ann Surg Oncol 9(3):248–255PubMedCrossRef
109.
Lloyd LR, Wesen CA, McCallum S (2002) An analysis of filtration and volume of radionucleotide in sentinel lymph node biopsy in breast cancer patients. Am Surg 68(4):373–375 discussion 375–376PubMed
110.
Sardi A et al (2002) The benefit of using two techniques for sentinel lymph node mapping in breast cancer. Am Surg 68(1):24–28PubMed
111.
Motomura K et al (2002) Patient age affects identification rate of sentinel nodes in breast cancer. Biomed Pharmacother 56(Suppl 1):209s–212sPubMedCrossRef
112.
Motomura K et al (2003) Intradermal radioisotope injection is superior to subdermal injection for the identification of the sentinel node in breast cancer patients. J Surg Oncol 82(2):91–96 discussion 96–97PubMedCrossRef
113.
Koizumi M et al (2003) Sentinel node detection using 99mTc-rhenium sulphide colloid in breast cancer patients: evaluation of 1 day and 2 day protocols, and a dose-finding study. Nucl Med Commun 24(6):663–670PubMedCrossRef
114.
Classe JM et al (2003) Learning curve for the detection of axillary sentinel lymph node in breast cancer. Eur J Surg Oncol 29(5):426–433PubMedCrossRef
115.
Yong WS et al (2003) Single institution’s initial experience with sentinel lymph node biopsy in breast cancer patients. ANZ J Surg 73(6):416–421PubMedCrossRef
116.
Hoar FJ, Stonelake PS (2003) A prospective study of the value of axillary node sampling in addition to sentinel lymph node biopsy in patients with breast cancer. Eur J Surg Oncol 29(6):526–531PubMedCrossRef
117.
Mahajna A et al (2003) Sentinel lymph node biopsy in early breast cancer: the first 100 cases performed in a teaching institute. Isr Med Assoc J 5(8):556–559PubMed
118.
Kennedy RJ et al (2003) Removal of two sentinel nodes accurately stages the axilla in breast cancer. Br J Surg 90(11):1349–1353PubMedCrossRef
119.
Hughes M et al (2004) Obesity and lymphatic mapping with sentinel lymph node biopsy in breast cancer. Am J Surg 187(1):52–57PubMedCrossRef
120.
McIntosh SA et al (2001) Sentinel lymph node biopsy in impalpable breast cancer. Breast 10(1):82–83PubMedCrossRef
121.
Snoj M et al (2003) Added value of blue dye in sentinel node biopsy for breast cancer. J Exp Clin Cancer Res 22(4):551–555PubMed
122.
Lauridsen MC et al (2004) Sentinel lymph node biopsy in breast cancer—experience with the combined use of dye and radioactive tracer at Aarhus University Hospital. Acta Oncol 43(1):20–26PubMedCrossRef
123.
Peley G et al (2004) Subareolar injection of radioactive colloid for sentinel lymph node identification in breast cancer patients. Am Surg 70(7):625–629PubMed
124.
van Wessem KJ, Meijer WS (2004) Sentinel lymph node biopsy in breast cancer: results of intradermal periareolar tracer injection and follow-up of sentinel lymph node-negative patients. Breast 13(4):290–296PubMedCrossRef
125.
Goyal A, Newcombe RG, Mansel RE (2005) Clinical relevance of multiple sentinel nodes in patients with breast cancer. Br J Surg 92(4):438–442PubMedCrossRef
126.
Knox SM, Ley CA (2002) Comparison of intraparenchymal and intradermal injection for identification of the sentinel node in patients with breast cancer. Proc (Bayl Univ Med Cent) 15(4):366–368
127.
Krag DN et al (2007) Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial. Lancet Oncol 8(10):881–888PubMedCrossRef
128.
Canavese G et al (2009) Sentinel node biopsy compared with complete axillary dissection for staging early breast cancer with clinically negative lymph nodes: results of randomized trial. Ann Oncol 20(6):1001–1007PubMedCrossRef
129.
Moghimi M et al (2009) Accuracy of sentinel node biopsy in breast cancer patients with a high prevalence of axillary metastases. Scand J Surg 98(1):30–33PubMed
130.
Nakashima K et al (2010) Preoperative dynamic lymphoscintigraphy predicts sentinel lymph node metastasis in patients with early breast cancer. Breast Cancer 17(1):17–21PubMedCrossRef
131.
Cheung TT, Suen DT, Kwong A (2009) Is sentinel lymph node biopsy after neoadjuvant chemotherapy feasible in Chinese patients with invasive breast cancers? ANZ J Surg 79(10):719–723PubMedCrossRef
132.
Nason KS et al (2000) Increased false negative sentinel node biopsy rates after preoperative chemotherapy for invasive breast carcinoma. Cancer 89(11):2187–2194PubMedCrossRef
133.
Martin RC 2nd et al (2000) Practical guidelines for optimal gamma probe detection of sentinel lymph nodes in breast cancer: results of a multi-institutional study. For the University of Louisville Breast Cancer Study Group. Surgery 128(2):139–144PubMedCrossRef
134.
de Kanter AY et al (2000) Controlled introduction of the sentinel node biopsy in breast cancer in a multi-centre setting: the role of a coordinator for quality control. Eur J Surg Oncol 26(7):652–656PubMedCrossRef
135.
Yalcin H et al (2010) Comparison of efficacy of Tc-99m HIG and Tc-99m nanocolloid on sentinel lymph node mapping in patients with breast cancer. Nucl Med Commun 31(10):903–909PubMed
136.
Dalus K et al (2011) Lymphoscintigraphy in breast cancer patients after neoadjuvant chemotherapy. Diagnostic value and the work-up of sentinel node negative patients. Nuklearmedizin 50(1):33–38PubMedCrossRef
137.
Krag DN et al (1993) Surgical resection and radiolocalization of the sentinel lymph node in breast cancer using a gamma probe. Surg Oncol 2(6):335–339 discussion 340PubMedCrossRef
138.
Pijpers R et al (1997) Impact of lymphoscintigraphy on sentinel node identification with technetium-99m-colloidal albumin in breast cancer. J Nucl Med 38(3):366–368PubMed
139.
Veronesi U et al (1997) Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes. Lancet 349(9069):1864–1867PubMedCrossRef
140.
Roumen RM, Valkenburg JG, Geuskens LM (1997) Lymphoscintigraphy and feasibility of sentinel node biopsy in 83 patients with primary breast cancer. Eur J Surg Oncol 23(6):495–502PubMedCrossRef
141.
Borgstein PJ et al (1998) Sentinel lymph node biopsy in breast cancer: guidelines and pitfalls of lymphoscintigraphy and gamma probe detection. J Am Coll Surg 186(3):275–283PubMedCrossRef
142.
Offodile R et al (1998) Minimally invasive breast carcinoma staging using lymphatic mapping with radiolabeled dextran. Cancer 82(9):1704–1708PubMedCrossRef
143.
Miner TJ et al (1998) Ultrasonographically guided injection improves localization of the radiolabeled sentinel lymph node in breast cancer. Ann Surg Oncol 5(4):315–321PubMedCrossRef
144.
Crossin JA et al (1998) Gamma-probe-guided resection of the sentinel lymph node in breast cancer. Am Surg 64(7):666–668 discussion 669PubMed
145.
Gulec SA et al (1998) Sentinel lymph node localization in early breast cancer. J Nucl Med 39(8):1388–1393PubMed
146.
Krag D et al (1998) The sentinel node in breast cancer—a multicenter validation study. N Engl J Med 339(14):941–946PubMedCrossRef
147.
Snider H et al (1998) Sentinel node biopsy in the staging of breast cancer. Am J Surg 176(4):305–310PubMedCrossRef
148.
Rubio IT et al (1998) Sentinel lymph node biopsy for staging breast cancer. Am J Surg 176(6):532–537PubMedCrossRef
149.
Feldman SM et al (1999) Limitation in gamma probe localization of the sentinel node in breast cancer patients with large excisional biopsy. J Am Coll Surg 188(3):248–254PubMedCrossRef
150.
Winchester DJ et al (1999) Sentinel lymphadenectomy for breast cancer: experience with 180 consecutive patients: efficacy of filtered technetium 99m sulphur colloid with overnight migration time. J Am Coll Surg 188(6):597–603PubMedCrossRef
151.
Miner TJ et al (1999) Sentinel lymph node biopsy for breast cancer: the role of previous biopsy on patient eligibility. Am Surg 65(6):493–498 discussion 498–499PubMed
152.
Bembenek A et al (1999) Sentinel lymph node dissection in breast cancer. Swiss Surg 5(5):217–221PubMedCrossRef
153.
Moffat FL Jr et al (1999) Unfiltered sulfur colloid and sentinel node biopsy for breast cancer: technical and kinetic considerations. Ann Surg Oncol 6(8):746–755PubMedCrossRef
154.
Zurrida S et al (2000) Radioguided sentinel node biopsy to avoid axillary dissection in breast cancer. Ann Surg Oncol 7(1):28–31PubMedCrossRef
155.
Weaver DL et al (2000) Pathologic analysis of sentinel and nonsentinel lymph nodes in breast carcinoma: a multicenter study. Cancer 88(5):1099–1107PubMedCrossRef
156.
Kowolik JH et al (2000) Detection of micrometastases in sentinel lymph nodes of the breast applying monoclonal antibodies AE1/AE3 to pancytokeratins. Oncol Rep 7(4):745–749PubMed
157.
Casalegno PS et al (2000) Sentinel lymph node and breast cancer staging: final results of the Turin Multicenter Study. Tumori 86(4):300–303PubMed
158.
Gucciardo G et al (2000) The success rate of identification of the sentinel lymph node in breast cancer: our training series. Tumori 86(4):312–313PubMed
159.
Galli A et al (2000) Study of sentinel lymph node in breast cancer: our experience in 46 cases. Tumori 86(4):317–319PubMed
160.
Mechella M et al (2000) A study of sentinel node biopsy in T1 breast cancer treatment: experience of 48 cases. Tumori 86(4):320–321PubMed
161.
Paolo de Rubeis G et al (2000) The sentinel lymph node in T1N0 breast cancer. Tumori 86(4):327–328PubMed
162.
Hsieh PP et al (2000) Histopathologic analysis of sentinel lymph nodes in breast carcinoma. Zhonghua Yi Xue Za Zhi (Taipei) 63(10):744–750
163.
Sato K et al (1998) Efficacy and significance of sentinel lymph node identification with technetium-99m-labeled tin colloids for breast cancer. Breast Cancer 5(4):389–393PubMedCrossRef
164.
Rink T et al (2001) Lymphoscintigraphic sentinel node imaging and gamma probe detection in breast cancer with Tc-99 m nanocolloidal albumin: results of an optimized protocol. Clin Nucl Med 26(4):293–298PubMedCrossRef
165.
Watanabe T et al (2001) Sentinel node biopsy with technetium-99m colloidal rhenium sulphide in patients with breast cancer. Br J Surg 88(5):704–707PubMedCrossRef
166.
167.
Rink T et al (2001) Results of a standardized protocol for sentinel node imaging in breast cancer with Tc-99m labeled nanocolloidal albumin. Nuklearmedizin 40(3):80–85PubMed
168.
Ishida M et al (2002) Detection of micrometastasis in the sentinel lymph nodes in breast cancer. Surgery 131(1 Suppl):S211–S216PubMedCrossRef
169.
Quan ML et al (2002) Biology of lymphatic metastases in breast cancer: lessons learned from sentinel node biopsy. Ann Surg Oncol 9(5):467–471PubMedCrossRef
170.
Fonti R et al (2002) Sentinel lymph node identification in breast cancer patients. Radiol Med 103(4):370–377PubMed
171.
Xu M et al (2002) Sentinel lymph nodes lymphoscintigraphy and biopsy in breast cancer. Chin Med J (Engl) 115(8):1137–1140
172.
Mariotti S et al (2002) Minimal sentinel node procedure for staging early breast cancer. Tumori 88(3):S45–S47PubMed
173.
Fernandez A et al (2002) Sentinel node localization in patients with non-palpable breast cancer. Nucl Med Commun 23(12):1165–1169PubMedCrossRef
174.
Maza S et al (2003) Peritumoural versus subareolar administration of technetium-99m nanocolloid for sentinel lymph node detection in breast cancer: preliminary results of a prospective intra-individual comparative study. Eur J Nucl Med Mol Imaging 30(5):651–656PubMedCrossRef
175.
Bourgeois P et al (2003) How ‘hot’ is the pathologically positive sentinel lymph node in breast cancer patients? Nucl Med Commun 24(5):513–518PubMedCrossRef
176.
Pargaonkar AS et al (2003) Evaluation of immunohistochemistry and multiple-level sectioning in sentinel lymph nodes from patients with breast cancer. Arch Pathol Lab Med 127(6):701–705PubMed
177.
Veronesi U et al (2003) A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer. N Engl J Med 349(6):546–553PubMedCrossRef
178.
179.
Ellis RL et al (2004) Periareolar injection for localization of sentinel nodes in breast cancer patients. Breast J 10(2):94–100PubMedCrossRef
180.
Lamichhane N et al (2004) Sentinel lymph node biopsy in breast cancer patients after overnight migration of radiolabelled sulphur colloid. Postgrad Med J 80(947):546–550PubMedCrossRef
181.
Classe JM et al (2005) Prospective comparison of 3 gamma-probes for sentinel lymph node detection in 200 breast cancer patients. J Nucl Med 46(3):395–399PubMed
182.
Kebudi A et al (2005) The safety and accuracy of sentinel-node biopsy in early-stage invasive breast cancer: Turkish experience. J Invest Surg 18(3):129–134PubMedCrossRef
183.
Bajen MT et al (2006) Subdermal re-injection: a method to increase surgical detection of the sentinel node in breast cancer without increasing the false-negative rate. Eur J Nucl Med Mol Imaging 33(3):338–343PubMedCrossRef
184.
Namwongprom S et al (2005) Breast lymphoscintigraphy for sentinel node identification in breast cancers with clinically-negative axillary nodes. Singapore Med J 46(12):688–692PubMed
185.
Lo YF et al (2006) Radioguided sentinel lymph node biopsy in early breast cancer: experience at Chang Gung Memorial Hospital. Chang Gung Med J 29(5):458–467PubMed
186.
Song XY et al (2007) Different criteria for radioactive sentinel lymph nodes has different impact on sentinel node biopsy in breast cancer patients. J Surg Oncol 95(8):635–639PubMedCrossRef
187.
Yen RF et al (2007) Radio-guided sentinel lymph node biopsy using periareolar injection technique for patients with early breast cancer. J Formos Med Assoc 106(1):44–50PubMedCrossRef
188.
Zavagno G et al (2008) Clinical impact of false-negative sentinel lymph nodes in breast cancer. Eur J Surg Oncol 34(6):620–625PubMedCrossRef
189.
Seok JW et al (2010) Sentinel lymph node identification with radiopharmaceuticals in patients with breast cancer: a comparison of 99mTc-tin colloid and 99mTc-phytate efficiency. Breast Cancer Res Treat 122(2):453–457PubMedCrossRef
190.
Veronesi U et al (2010) Sentinel lymph node biopsy in breast cancer: ten-year results of a randomized controlled study. Ann Surg 251(4):595–600PubMedCrossRef
191.
Seok JW et al (2009) Comparison of subareolar injection lymphoscintigraphy with the 1-day and the 2-day protocols for the detection of sentinel lymph nodes in patients with breast cancer. Ann Nucl Med 23(5):465–469PubMedCrossRef
192.
Mudun A et al (2008) Comparison of different injection sites of radionuclide for sentinel lymph node detection in breast cancer: single institution experience. Clin Nucl Med 33(4):262–267PubMedCrossRef
193.
Gimbergues P et al (2008) Sentinel lymph node biopsy after neoadjuvant chemotherapy is accurate in breast cancer patients with a clinically negative axillary nodal status at presentation. Ann Surg Oncol 15(5):1316–1321PubMedCrossRef
Metadaten
Titel
The False-Negative Rate of Sentinel Node Biopsy in Patients with Breast Cancer: A Meta-Analysis
verfasst von
Sarah Pesek
Taka Ashikaga
Lars Erik Krag
David Krag
Publikationsdatum
01.09.2012
Verlag
Springer-Verlag
Erschienen in
World Journal of Surgery / Ausgabe 9/2012
Print ISSN: 0364-2313
Elektronische ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-012-1623-z

Weitere Artikel der Ausgabe 9/2012

World Journal of Surgery 9/2012 Zur Ausgabe

OriginalPaper

Long-term Survival in Hilar Cholangiocarcinoma also Possible in Unresectable Patients

OriginalPaper

Microsatellite Instability Is Associated With a Better Prognosis for Gastric Cancer Patients After Curative Surgery

OriginalPaper

Acute Appendicitis in a Developing Country

OriginalPaper

A Single, Global Patient-Centered Measure from the SF-36 Instrument to Assess Surgical Outcomes and Quality of Life: A Pilot Study

OriginalPaper

Surgical Outcome of Liver Transection by the Crush-Clamping Technique Combined with Harmonic FOCUS™

Erratum

Erratum to: Predictors of the Development of Surgical Complications among Hematopoietic Stem Cell Transplantation Recipients

Neu im Fachgebiet Chirurgie

Häusliche Gewalt in der orthopädischen Notaufnahme oft nicht erkannt

28.05.2024 Häusliche Gewalt Nachrichten

In der Notaufnahme wird die Chance, Opfer von häuslicher Gewalt zu identifizieren, von Orthopäden und Orthopädinnen offenbar zu wenig genutzt. Darauf deuten die Ergebnisse einer Fragebogenstudie an der Sahlgrenska-Universität in Schweden hin.

Fehlerkultur in der Medizin – Offenheit zählt!

28.05.2024 Fehlerkultur Podcast

Darüber reden und aus Fehlern lernen, sollte das Motto in der Medizin lauten. Und zwar nicht nur im Sinne der Patientensicherheit. Eine negative Fehlerkultur kann auch die Behandelnden ernsthaft krank machen, warnt Prof. Dr. Reinhard Strametz. Ein Plädoyer und ein Leitfaden für den offenen Umgang mit kritischen Ereignissen in Medizin und Pflege.

Mehr Frauen im OP – weniger postoperative Komplikationen

21.05.2024 Allgemeine Chirurgie Nachrichten

Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.

TAVI versus Klappenchirurgie: Neue Vergleichsstudie sorgt für Erstaunen

21.05.2024 TAVI Nachrichten

Bei schwerer Aortenstenose und obstruktiver KHK empfehlen die Leitlinien derzeit eine chirurgische Kombi-Behandlung aus Klappenersatz plus Bypass-OP. Diese Empfehlung wird allerdings jetzt durch eine aktuelle Studie infrage gestellt – mit überraschender Deutlichkeit.

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Aktuelle BDC Leitlinien-Webinare

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.
Bildnachweise