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European Archives of Psychiatry and Clinical Neuroscience

Erschienen in:

01.08.2007 | SPECIAL ISSUE

Changes in neurogenesis in dementia and Alzheimer mouse models: are they functionally relevant?

verfasst von: H. Georg Kuhn, Christi M. Cooper-Kuhn, Karin Boekhoorn, Paul J. Lucassen

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 5/2007

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Abstract

Alzheimer’s disease and related dementias are devastating disorders that lead to the progressive decline of cognitive functions. Characteristic features are severe brain atrophy, paralleled by accumulation of beta amyloid and neurofibrillary tangles. With the discovery of neurogenesis in the adult brain, the hopes have risen that these neurodegenerative conditions could be overcome, or at least ameliorated, by the generation of new neurons. The location of the adult neurogenic zones in the hippocampus and the lateral ventricle wall, close to corpus callosum and neocortex, indicates strategic positions for potential repair processes. However, we also need to consider that the generation of new neurons is possibly involved in cognitive functions and could, therefore, be influenced by disease pathology. Moreover, aberrant neurogenic mechanisms could even be a part of the pathological events of neurodegenerative diseases. It is the scope of this review to summarize and analyze the recent data from neurogenesis research with respect to Alzheimer’s disease and its animal models.

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Titel: Changes in neurogenesis in dementia and Alzheimer mouse models: are they functionally relevant?
verfasst von: H. Georg Kuhn
Christi M. Cooper-Kuhn
Karin Boekhoorn
Paul J. Lucassen
Publikationsdatum: 01.08.2007
Verlag: D. Steinkopff-Verlag
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 5/2007
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-007-0732-4

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