nach oben

Virchows Archiv

Erschienen in:

01.03.2007 | Original Article

Sertoli–Leydig cell tumours of the ovary and testis: a CGH and FISH study

verfasst von: I. Verdorfer, D. Horst, A. Höllrigl, H. Rogatsch, G. Mikuz

Erschienen in: Virchows Archiv | Ausgabe 3/2007

Einloggen, um Zugang zu erhalten

Abstract

We present two malignant cases of Sertoli–Leydig cell tumours (SLCT) of the testis and one ovarian SLCT with benign behaviour. The DNA copy number changes affected chromosome 1, 8, 9p, 10, 11, 12, 16, 19, 22 and X. The present study is the first molecular–cytogenetic analysis of Sertoli–Leydig cell tumours of the testis.

De Giorgi U, Turci D, Crisanti E, Cantù MG, Cappellini A, Marangolo M (2003) Ovarian Sertoli–Leydig cell tumor, endometrioid-like yolk sac tumor, and Y-chromosomal material. Oncology 64:370–373PubMedCrossRef

Glaser D, Nienhaus H, Kohler R, Walther G, Pawlowitzki IH (1988) A sex cord stromal tumour in a woman with X0/XX/XXX-mosaicism. Arch Gynecol Obstet 243:115–118PubMedCrossRef

Hitosugi M, Matsuoka Y, Irimajiri S, Fukuda J (1997) Sertoli–Leydig cell tumour complicated by X chromosomal mosaicisms. Clin Endocrinol (Oxf) 47:619–622CrossRef

Hittmair A, Zelger BG, Obrist P, Dirnhofer S (1997) Ovarian Sertoli–Leydig cell tumor: a SRY gene-independent pathway of pseudomale gonadal differentiation. Hum Pathol 28:1206–1210PubMedCrossRef

Kawauchi S, Tsuji T, Kaku T, Kamura T, Nakano H, Tsuneyoshi M (1998) Sclerosing stromal tumor of the ovary: a clinicopathologic, immunohistochemical, ultrastructural, and cytogenetic analysis with special reference to its vasculature. Am J Surg Pathol 22:83–92PubMedCrossRef

Lindgren V, Waggoner S, Rotmensch J (1996) Monosomy 22 in two ovarian granulosa cell tumors. Cancer Genet Cytogenet 89:93–97PubMedCrossRef

Manegold E, Tietze L, Günther K, Fleischer A, Amo-Takyi BK, Schröder W, Handt S (2001) Trisomy 8 as sole karyotypic aberration in an ovarian metastasizing Sertoli–Leydig cell tumor. Human Pathol 32:559–562CrossRef

Mayr D, Kaltz-Wittmer C, Arbogast S, Amann G, Aust DE, Diebold J (2002) Characteristic pattern of genetic aberrations in ovarian granulosa cell tumors. Mod Path 15:951–957CrossRef

Panagiotou JP, Polychronopoulou S, Sofou K, Vanvliet-Constantinidou C, Papandreou E, Haidas S (2006) Second and third malignant solid tumor in a girl with ovarian Sertoli–Leydig tumor. Pediatr Blood Cancer 46:654–656PubMedCrossRef

10.

Perito PE, Ciancio G, Civantos F, Politano VA (1992) Sertoli–Leydig cell testicular tumor: case report and review of sex cord/gonadal stromal tumor histogenesis. J Urol 148:883–885PubMed

11.

Persons DL, Hartmann LC, Herath JF, Keeney GL, Jenkins RB (1994) Fluorescence in situ hybridization analysis of trisomy 12 in ovarian tumors. Am J Clin Pathol 102:775–779PubMed

12.

Sesterhenn IA, Cheville J, Wooward PJ, Damjanov I, Jacobsen GK, Nistal M, Paniagua R, Renshaw AA (2004) Germ cell tumours. In: Eble JN, Sauter G, Epstein JI, Sesterhenn IA (eds) Pathology and genetics: tumours of the urinary system and male genital organs. IARC Press, Lyon, pp 251–258

13.

Shashi V, Golden WL, von Kap-Herr C, Andersen WA, Gaffey MJ (1994) Interphase fluorescence in situ hybridization for trisomy 12 on archival ovarian sex cord-stromal tumors. Gynecol Oncol 55:349–354PubMedCrossRef

14.

Taruscio D, Carcangiu ML, Ward DC (1993) Detection of trisomy 12 on ovarian sex cord stromal tumors by fluorescence in situ hybridization. Diagn Mol Pathol 2:94–98PubMed

15.

Truss L, Dobin SM, Rao A, Donner LR (2004) Overexpression of the BCL2 gene in a Sertoli–Leydig cell tumor of the ovary: a pathologic and cytogenetic study. Cancer Genet Cytogenet 148:118–122PubMedCrossRef

16.

Tsuji T, Kawauchi S, Utsunomija T, Nagata Y, Tsuneyoshi M (1997) Fibrosarcoma versus cellular fibroma of the ovary: a comparative study of their proliferative activity and chromosome aberrations using MIB-1 immunostaining, DNA flow cytometry, and fluorescence in situ hybridization. Am J Surg Pathol 21:52–59PubMedCrossRef

17.

Wolff E, Girod S, Liehr T, Vorderwulbecke U, Ries J, Steininger H, Gebhart E (1998) Oral squamous cell carcinomas are characterized by a rather uniform pattern of genomic imbalances detected by comparative genomic hybridisation. Oral Oncol 34:186–190PubMedCrossRef

18.

Young RH (1993) Sertoli–Leydig cell tumors of the ovary: review with emphasis on historical aspects and unusual variants. Int J Gynecol Pathol 12:141–147PubMedCrossRef

Titel: Sertoli–Leydig cell tumours of the ovary and testis: a CGH and FISH study
verfasst von: I. Verdorfer
D. Horst
A. Höllrigl
H. Rogatsch
G. Mikuz
Publikationsdatum: 01.03.2007
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 3/2007
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-006-0344-9

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Sertoli–Leydig cell tumours of the ovary and testis: a CGH and FISH study

Abstract

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2007

Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer

The expression of receptor for advanced glycation end products is associated with angiogenesis in human oral squamous cell carcinoma

Sertoli cell tumor of the testis, not otherwise specified, presenting extensive hemorrhage and overexpression of α-methylacyl-CoA racemase (AMACR/P504S)

MYH, OGG1, MTH1, and APC alterations involved in the colorectal tumorigenesis of Korean patients with multiple adenomas

Expression microarray analysis of papillary thyroid carcinoma and benign thyroid tissue: emphasis on the follicular variant and potential markers of malignancy

Co-expression of EGF receptor, TGFα and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren