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Virchows Archiv

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01.12.2008 | Original Article

Caveolin-1 immuno-expression in human gastric cancer: histopathogenetic hypotheses

verfasst von: V. Barresi, G. Giuffre’, E. Vitarelli, P. Todaro, G. Tuccari

Erschienen in: Virchows Archiv | Ausgabe 6/2008

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Abstract

The immunohistochemical expression of caveolin-1 (cav-1) was evaluated in a series of gastric carcinomas (GC) and in the adjacent normal gastric mucosa. Cav-1 immuno-expression was found in most GC (94%) with a significantly higher amount in the Lauren intestinal type in comparison to the diffuse-type carcinomas. Interestingly, gastric intestinal metaplasia as well as the cells at the base and neck of gastric pits within all fundic mucosal fragments showed an evident cav-1 immuno-staining, suggesting a histogenetic derivation of these lesions from the trans-differentiation of chief cells or from a cryptic progenitor population at the base of fundic glands, as recently hypothesized by other authors. The absence of significant correlations between cav-1 immuno-expression and the other clinico-pathological parameters, such as the stage of disease or the patients overall survival, indicates that the role of cav-1 in GC is neither stage-specific nor related to prognosis.

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Titel: Caveolin-1 immuno-expression in human gastric cancer: histopathogenetic hypotheses
verfasst von: V. Barresi
G. Giuffre’
E. Vitarelli
P. Todaro
G. Tuccari
Publikationsdatum: 01.12.2008
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 6/2008
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-008-0681-y

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Caveolin-1 immuno-expression in human gastric cancer: histopathogenetic hypotheses

Abstract

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Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

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Abstract

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