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Virchows Archiv

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01.02.2010 | Review and Perspective

Genomic characteristics of soft tissue sarcomas

verfasst von: Fredrik Mertens, Ioannis Panagopoulos, Nils Mandahl

Erschienen in: Virchows Archiv | Ausgabe 2/2010

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Abstract

Studies on the molecular mechanisms behind soft tissue sarcoma development have disclosed that these malignancies are as genetically heterogeneous as they are clinically and morphologically diverse. Much of the genetic information on soft tissue sarcomas is still limited to the genomic level, as detected by chromosome banding analysis or comparative genomic hybridization. Based on the results of such studies, soft tissue sarcomas may be broadly dichotomized into one group, accounting for approximately 20% of the cases, characterized by specific balanced translocations, and one group typically showing massive chromosomal rearrangements leading to recurrent, but non-specific, structural and numerical rearrangements. As summarized in this review, the genomic characterization of soft tissue sarcomas has not only provided cell biologists with decisive information on the parts of the genome that may harbor genes that are essential for tumor development but also given the clinicians involved in the management of these patients a valuable diagnostic tool.

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Titel: Genomic characteristics of soft tissue sarcomas
verfasst von: Fredrik Mertens
Ioannis Panagopoulos
Nils Mandahl
Publikationsdatum: 01.02.2010
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 2/2010
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-009-0736-8

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Genomic characteristics of soft tissue sarcomas

Abstract

Neu im Fachgebiet Pathologie

Assistierter Suizid durch Infusion von Thiopental

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

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